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2024-04-26 02:26:06, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_203463 6844 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens ceramide synthase 6 (CERS6), transcript variant 2,
mRNA.
ACCESSION NM_203463 XM_371579
VERSION NM_203463.2 GI:371122579
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6844)
AUTHORS Hoeferlin,L.A., Fekry,B., Ogretmen,B., Krupenko,S.A. and
Krupenko,N.I.
TITLE Folate stress induces apoptosis via p53-dependent de novo ceramide
synthesis and up-regulation of ceramide synthase 6
JOURNAL J. Biol. Chem. 288 (18), 12880-12890 (2013)
PUBMED 23519469
REMARK GeneRIF: folate withdrawal also induced CerS6/C16-ceramide
elevation accompanied by p53 accumulation. Overall, these novel
findings link folate and de novo ceramide pathways in cellular
stress response.
REFERENCE 2 (bases 1 to 6844)
AUTHORS Schiffmann,S., Ferreiros,N., Birod,K., Eberle,M., Schreiber,Y.,
Pfeilschifter,W., Ziemann,U., Pierre,S., Scholich,K., Grosch,S. and
Geisslinger,G.
TITLE Ceramide synthase 6 plays a critical role in the development of
experimental autoimmune encephalomyelitis
JOURNAL J. Immunol. 188 (11), 5723-5733 (2012)
PUBMED 22544924
REMARK GeneRIF: The transiently increased expression of ceramide synthase
(CerS6) correlates to the clinical finding that C(16:0)-Cer levels
are increased 1.9-fold in cerebrospinal fluid of multiple sclerosis
patients.
REFERENCE 3 (bases 1 to 6844)
AUTHORS Senkal,C.E., Ponnusamy,S., Manevich,Y., Meyers-Needham,M.,
Saddoughi,S.A., Mukhopadyay,A., Dent,P., Bielawski,J. and
Ogretmen,B.
TITLE Alteration of ceramide synthase 6/C16-ceramide induces activating
transcription factor 6-mediated endoplasmic reticulum (ER) stress
and apoptosis via perturbation of cellular Ca2+ and ER/Golgi
membrane network
JOURNAL J. Biol. Chem. 286 (49), 42446-42458 (2011)
PUBMED 22013072
REMARK GeneRIF: Alteration of ceramide synthase 6/C16-ceramide induces
activating transcription factor 6-mediated endoplasmic reticulum
(ER) stress and apoptosis via perturbation of cellular Ca2+ and
ER/Golgi membrane network
REFERENCE 4 (bases 1 to 6844)
AUTHORS Mesicek,J., Lee,H., Feldman,T., Jiang,X., Skobeleva,A.,
Berdyshev,E.V., Haimovitz-Friedman,A., Fuks,Z. and Kolesnick,R.
TITLE Ceramide synthases 2, 5, and 6 confer distinct roles in
radiation-induced apoptosis in HeLa cells
JOURNAL Cell. Signal. 22 (9), 1300-1307 (2010)
PUBMED 20406683
REMARK GeneRIF: ionizing radiation induces de novo synthesis of ceramide
to influence HeLa cell apoptosis by specifically activating CerS
isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic
ceramides in mitochondrial membranes.
REFERENCE 5 (bases 1 to 6844)
AUTHORS Yacoub,A., Hamed,H.A., Allegood,J., Mitchell,C., Spiegel,S.,
Lesniak,M.S., Ogretmen,B., Dash,R., Sarkar,D., Broaddus,W.C.,
Grant,S., Curiel,D.T., Fisher,P.B. and Dent,P.
TITLE PERK-dependent regulation of ceramide synthase 6 and thioredoxin
play a key role in mda-7/IL-24-induced killing of primary human
glioblastoma multiforme cells
JOURNAL Cancer Res. 70 (3), 1120-1129 (2010)
PUBMED 20103619
REMARK GeneRIF: Findings indicate that mda-7/IL-24 induces PERK activation
that triggers production of ceramide, ceramide synthase 6 and
thioredoxin, which in turn promote glioma cell autophagy and cell
death.
REFERENCE 6 (bases 1 to 6844)
AUTHORS Erez-Roman,R., Pienik,R. and Futerman,A.H.
TITLE Increased ceramide synthase 2 and 6 mRNA levels in breast cancer
tissues and correlation with sphingosine kinase expression
JOURNAL Biochem. Biophys. Res. Commun. 391 (1), 219-223 (2010)
PUBMED 19912991
REMARK GeneRIF: CerS2 and CerS6 mRNA was significantly elevated in breast
cancer tissue compared to paired normal tissue, with approximately
half of the individuals showing elevated CerS2 and CerS6 mRNA.
REFERENCE 7 (bases 1 to 6844)
AUTHORS Senkal,C.E., Ponnusamy,S., Bielawski,J., Hannun,Y.A. and
Ogretmen,B.
TITLE Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide
via selective regulation of the ATF6/CHOP arm of ER-stress-response
pathways
JOURNAL FASEB J. 24 (1), 296-308 (2010)
PUBMED 19723703
REMARK GeneRIF: Mechanistically, regulation of ER-stress-induced apoptosis
by CerS6/C(16)-ceramide was linked to the activation of a specific
arm, ATF6/CHOP, of the unfolded protein response pathway.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK172775.1, AC009475.5 and BM968545.1.
On Jan 6, 2012 this sequence version replaced gi:45007001.
Transcript Variant: This variant (2) lacks an alternate in-frame
exon in the 3' coding region, compared to variant 1, resulting in
an isoform (2) that is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK172775.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1954 AK172775.1 1-1954
1955-6245 AC009475.5 128263-132553
6246-6844 BM968545.1 1-599 c
FEATURES Location/Qualifiers
source 1..6844
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q24.3"
gene 1..6844
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/note="ceramide synthase 6"
/db_xref="GeneID:253782"
/db_xref="HGNC:23826"
/db_xref="HPRD:17258"
exon 1..370
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
STS 151..1405
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/db_xref="UniSTS:490081"
CDS 201..1355
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/note="isoform 2 is encoded by transcript variant 2; LAG1
homolog, ceramide synthase 6; longevity assurance homolog
6"
/codon_start=1
/product="ceramide synthase 6 isoform 2"
/protein_id="NP_982288.1"
/db_xref="GI:45007002"
/db_xref="CCDS:CCDS2228.1"
/db_xref="GeneID:253782"
/db_xref="HGNC:23826"
/db_xref="HPRD:17258"
/translation="
MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
"
misc_feature 303..365
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZMG9.1);
transmembrane region"
misc_feature 438..581
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(477..479,495..497,534..536,540..545,552..557,
561..569,573..578)
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(543..545,552..557,564..566)
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 588..1193
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/note="TRAM, LAG1 and CLN8 homology domains; Region: TLC;
smart00724"
/db_xref="CDD:128963"
misc_feature 732..794
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZMG9.1);
transmembrane region"
misc_feature 813..875
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZMG9.1);
transmembrane region"
misc_feature 987..1049
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZMG9.1);
transmembrane region"
misc_feature 1107..1169
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZMG9.1);
transmembrane region"
exon 371..476
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 477..607
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 608..665
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 666..716
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 717..809
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 810..938
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 939..1045
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 1046..1202
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
exon 1203..6827
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/inference="alignment:Splign:1.39.8"
STS 1771..1892
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="RH91148"
/db_xref="UniSTS:87635"
STS 1790..1906
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="SHGC-61991"
/db_xref="UniSTS:69314"
STS 1827..1899
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="D2S2127"
/db_xref="UniSTS:60130"
STS 2307..2444
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="WI-13837"
/db_xref="UniSTS:73569"
STS 3776..3909
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="RH16666"
/db_xref="UniSTS:26584"
STS 3801..3949
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="D2S1544E"
/db_xref="UniSTS:150630"
STS 4651..4834
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="HUM0S12B10"
/db_xref="UniSTS:44987"
STS 4840..4942
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="WI-15844"
/db_xref="UniSTS:22511"
variation complement(5675)
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/replace="a"
/replace="c"
/db_xref="dbSNP:3814378"
STS 6057..6335
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="D2S2660"
/db_xref="UniSTS:47670"
STS 6074..6330
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="A005N32"
/db_xref="UniSTS:60974"
STS 6074..6330
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="G20356"
/db_xref="UniSTS:60973"
STS 6082..6220
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="D2S1648E"
/db_xref="UniSTS:67815"
STS 6517..6675
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="RH68290"
/db_xref="UniSTS:53184"
STS 6626..6761
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="RH35853"
/db_xref="UniSTS:80041"
STS 6626..6759
/gene="CERS6"
/gene_synonym="CERS5; LASS6"
/standard_name="LOC253782"
/db_xref="UniSTS:266383"
ORIGIN
gcggccagagggaggagagaaccggggctcgccgcgagccttcgagagcagcggccgcggaggaggcggcggcggcgggcgggagcagcggcggcggcggcacaggctcggggccagccgggcgcgcatccccgggcgccctgcgcggtggagagcttggcgggctgcgggtgccgcaggacaggagtggacaaagcaagatggcagggatcttagcctggttctggaacgagaggttttggctcccgcacaatgtcacctgggcggacctgaagaacacggaggaggccaccttcccgcaggctgaggacctctatctcgcttttcccctggccttctgtatcttcatggtgcggctcatcttcgagagatttgtagccaaaccgtgcgccatagccctcaacattcaggccaatggaccacaaattgctccgcccaatgccattctggaaaaggtcttcactgcaattacaaagcatcctgatgaaaagagattggaaggcctctccaagcaactggactgggatgttcgaagcattcagcgctggtttcgacaaagacgcaatcaggagaagccaagcacgctgacgaggttctgtgagagcatgtggagattttcattttacctttatgtatttacctacggagtcagattcctgaaaaagaccccctggttgtggaatacgaggcattgctggtacaactacccctatcagccactcacaactgaccttcactactattacatcctggagctgtcgttttattggtctttgatgttttctcagttcactgatatcaaaagaaaggactttggcattatgttcctgcaccaccttgtatctattttcttgattaccttttcatatgtcaacaatatggcccgagtaggaacgctggtcctttgtcttcatgattcagctgatgctcttctggaggctgccaaaatggcaaattatgccaagtttcagaaaatgtgtgatctcctgtttgttatgtttgccgtggtttttatcaccacacgactgggtatatttcctctctgggtgttaaataccacattatttgaaagctgggagatcgttggaccttacccttcctggtgggtttttaacctactgctattgctagtacaagggttgaactgcttctggtcttacttgattgtgaaaatagcttgcaaagctgtttcaagaggcaaggtgtccaaggatgatcgaagtgatattgagtctagctcagatgaggaggactcagaacctccgggaaagaatccccacactgcgacaaccaccaatgggaccagtggtaccaacgggtatctcctgactggctcctgctccatggatgattaattactcaaaactacaagtcccaagcaaagtgaactatttgttcctggaagtatttaataagttgcaaatgcagttcctttcataatatctcagcaccagaaacaaaaattaagattatcaaagcattttgaatagtgcactgccatgtgtcctgtctgtgaatgaagaagaattaccattctctctttgtaggcatgctgtatgtaattgacacaagggaacagtatttgcatttgtactgtcttagaatattatttatttttttgtatttgtaaatctgtggacaaaagagggtttcctcactccttttactcactgggctcatgacagtgaaggagatgctccatctgcttctccccctttctcttgctgtagtccaatgtgctatgagcatcagcttactttgtcacttagagcaagcaaaacccagtgcaagagtctcgttcagctctaaataggtttgctttcttttagttacagtgcccattttgaaattgcctatacagtcttagtgaccatttaaaccggacgaactaggtgtttaattttcactcttcatgttcaattagcagttcaaattaaagaagatggttattggagaacttttttgaatggttttgtattaaattgctttgaaatagatttcatttcttgtgcacacagccaagatttcttcaatgggtgtgagctagttgagggttaaccttgtaggttgcagagtgtatttgtttgtttgtttgtttttctctgtgatgaggtcagtgctctgattttgaaggaggatattcactgaagctcatagttataaacaaggaaatcactgttaagaatgggaatttgtcctgtgttctgggaataacataaagagagcaactgatttcagccaggttttgccactaccctataattagtgcagtcttatgttataaaagaaagaagttaactatatttggggacaaaaaaatatttcaagagttgataaagattacctgtgcagtgcagagcactttaatgcaaccagctttcaagaaaaagccctatctagtacttgatgttgatgtttttattttgctgagcaaaataaagccaatgggagaaagactattttaccctttgcttttctccttaaacgtaatccagatgactttcctgttactaaacactgagcagcattacactacaatgcttctttggtttccaggaatttttttcaaatggggctgtttctggaaaaatgaaaaattctattggacaatggcaatatcaacaatgaggaaaattactgaagaataagtttccataagtctcctacatagcagtgttatttatgtacagataagaaaaccatatgtcagccaaagattttatctcttcttctaacttttagtaagaggaaaaagggattataaaacccttcataaatcaagaaggccatcacttagaacgaaccccaaacaaaaatgccataatataaatgtgtgaatcagggctgtgaagacaacagcagaaatgctaacaagcgtgcagaaacaccagagagtgcgtatcctgctcagaaccattcacatttaattcaattcttggaaaaaattaaagctttttgcccacaatttgcaatctgtgggttaatagttaaaagaatgttcccaaccaaaaaattcttaccgtaatattatatcttgccctacttatttacaaaataatatgtttctgttatggtccttagtaataattgaagaggcttagaaatacatctgcttgtttattgagaaaacgatgcaaataattctgcttttagagccttgttattttatttcacaaaacaggcatatgtctaggagtgtaatttgtggatggttgagtttgtaagaacaatcataaaaggacttgttagtctccagaacatctgctaaaatgcaagtatatgtataaggtaatagcatattacagctgaaaattttgagaaggtaaaagtttcttaattaaaatatgaacatatttagcttgctttagtgtctggggcaagtcctctcaatggctaaaattaactttagagatccatgtgttcaggtttagatcatatgacactcgagcacagaagaataatttcaaggaggtcatcttgtaaattaaaggtttagaagaattgcataaaacgtagtaaatggggtctgtcattagcaaaggcaaatctaagcaatcatttttccccccagaagttacttagaaggagaactgggaacacttggggtctctctaactgatggcattcacttcacacagtcgtctatgttatccagagatttttatttcattttacattttagggcacagttctttggggctaattaaaatggggtttgcaggctttttatggtgaagaataatatatctctgtctatagctttcccatggtagcctgataaggctgagagagaaaaatatgtgcagtatctcatcctccccctgtaccaggccatagctttgaagtgtattttgtaaattcaactataggttagtcagaatgctgtttttcgttaattaacttagcctgtgttgatatctcctccttcctggtcacattcaaaccttcccagagtacaaaggggtatgtagaaaggattccagaagaagtaatactttattctctaatgttaatagcttttctggatctcttagtagggggaaagtagaaaatcgagtagaatttggcctcaggtcaataaatgatataaaaacatgtgttctatttatgtatatatatgtatgtttctccaaaaagtgataaaaccaaaatatcactgactcatccctacccatattcttttcataaaacccactcaccaggtacaatagaaacttccctccttgtttgtcagcctcctgttcatgttccccacacacctgaaggtggtagaatcttttcagcctcttagccagtgagctaaatatggctaagcacaggtcataagagcacctaaggccagcatataagccaactacagttcacctttccaaatttggtcctatggatgttgagcatagggaagcaactctcagtattttggattattcaagtgtatgtggtaaaaatgcagatgattgctgctttaccccagggtttattagcatcctacttctgctgggctgcatcattatataatgccacaggcatctagtcaaggtaaagaagccagaaaggttaggcaagaagtgagataaaatcagatcacctttgatcaaaatggttggtgaacctccacatgtccagttctgttgccaaactttccattcagagtatttggtggagtttgaatttgagcaaactaaatgccttcatcttaggtagaaagggcctgaatcttccattttatattcaaacctcattgttatttggcctaagtaaaaagtcagatttcatttccatttacctgagttcgctttaaagagcttttcaaagagagctttatagacacccacaattgtccccaatctcttcatgatgttgcattaatagttgtttttgtccctttcttggaaatgttaatgccaaagttgcctgaacattgggcggttttcttaatttgaagtataaaaattataaagagtaattccaaaggtattaaaagattgtttaacagtatgtgtggtgatgtcattatctccagagaggcttcaagaaatcctttggaaataaaaagttaaatgtttacatttcatgtggtatttcaggtcttcaggttctgattagcttacttttttcctttgtctttggctgatttctgctttgtagataaataataatagccctgagatgtttctaacatttaaataagaaaaaaatcaaatcgaagtcagcctgctggaaaagtgatcacatggcagttgcagtaacttgtatggaaagagaaaatgcaatgagcccagttactgcacttgccactaccatgctgtccatggaaggaataatcagcagttcagttgtcacaagccgcccttgaagaaaacgcagcaaaatattttaaaatgaagatattgcagtccccagagccagtgaaggtttcttttggtaaaatgaaattgtgccattgtcaaagtaccccgtagtgatgagcactgactggttcactggccacattttagttcttcataataataggccacaaaagggctctgtggtttgcctccatgtgcactggcccctccccacccctagggggcactcagtagctgctgagaaggcctgtccacgaggctgttggaacccctccaataaatacttagaggtagtgtatctgatgcttgttttcgtggagaaaattgtattggagaacttaaaacatcacgaatatttttaataggatccgcagacacccaaaggagaagcttggtcttttccaggtatttccaacttgagttcaacccaaagcctttgaaaggaatgcattaccacatgaccacatgctgagaccccatggggtctaacacgggacctaagaaagtctctgcagccagatagtacatggtgtctccacaaaactaggcattctggagattgcccagaaagggatgtgaggggaccgttaagatctgtcttgcttatctcatgcactcacattccttcagcctcctggagttcctgataaaaggaagccagggtgtggacattttttagctattgatttcccaatagcttgtggatcagttgtacacccacacttccttctctgcctaattccgtttttctggaaaaagtagtatgcccatgtatgtgtgtttttcttaacacaggtccatgaaagtttggcttcctggtttgatgtctgttgcgtggcctggaaaccagggagcagcaactattgagatggtttctgtgttcagtgaaaaattctatttcattgagacaattttttctttatccacagtaattttttgacactgtcatcatgaaactacccttaggaaaataagattacctgcaaaaaaaaaaaagaaatgagttatggaataggaacagttatgtgatgattctgaaactttaacttagagcttcattactttaagaatggaaaacaacctctgagtttgatttcccaaagtttcataaagcccctaagctcatgattttcatcaactctttgcccacatagtcatttacctccacagccgtttgttgtcatagaaggggtggtggtgtttggatttgatttttttcaacttgcagtgagaaataggataggtgacaaaaccttacttgttttcttaagacaattcagtgcttgagcatctctgtcagaaatggaatgaaatactgttagccaattagaattattttatgtattgttattgtgttttgctgatttttatatgaaaatataattattcattcttgatctctggaagcaatcattattatgaggatcattttactttggaaacactttcataataaagataagtattaagagtgcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:253782 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:253782 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:253782 -> Molecular function: GO:0050291 [sphingosine N-acyltransferase activity] evidence: IEA
GeneID:253782 -> Biological process: GO:0006665 [sphingolipid metabolic process] evidence: TAS
GeneID:253782 -> Biological process: GO:0030148 [sphingolipid biosynthetic process] evidence: TAS
GeneID:253782 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:253782 -> Biological process: GO:0046513 [ceramide biosynthetic process] evidence: IEA
GeneID:253782 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:253782 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:253782 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IEA
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