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2024-04-24 04:31:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_203318 7546 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens myosin XVIIIA (MYO18A), transcript variant 2, mRNA.
ACCESSION NM_203318
VERSION NM_203318.1 GI:42794778
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7546)
AUTHORS Matsui,K., Parameswaran,N., Bagheri,N., Willard,B. and Gupta,N.
TITLE Proteomics analysis of the ezrin interactome in B cells reveals a
novel association with Myo18aalpha
JOURNAL J. Proteome Res. 10 (9), 3983-3992 (2011)
PUBMED 21751808
REMARK GeneRIF: Myo18aalpha as a novel binding partner of ezrin; the
Myo18aalpha/ezrin complex may facilitate B cell receptor-mediated
signaling
REFERENCE 2 (bases 1 to 7546)
AUTHORS Hsu,R.M., Tsai,M.H., Hsieh,Y.J., Lyu,P.C. and Yu,J.S.
TITLE Identification of MYO18A as a novel interacting partner of the
PAK2/betaPIX/GIT1 complex and its potential function in modulating
epithelial cell migration
JOURNAL Mol. Biol. Cell 21 (2), 287-301 (2010)
PUBMED 19923322
REMARK GeneRIF: MYO18A is a novel binding partner of the PAK2/betaPIX/GIT1
complex and suggest that MYO18A may play an important role in
regulating epithelial cell migration via affecting multiple cell
machineries.
REFERENCE 3 (bases 1 to 7546)
AUTHORS Dippold,H.C., Ng,M.M., Farber-Katz,S.E., Lee,S.K., Kerr,M.L.,
Peterman,M.C., Sim,R., Wiharto,P.A., Galbraith,K.A.,
Madhavarapu,S., Fuchs,G.J., Meerloo,T., Farquhar,M.G., Zhou,H. and
Field,S.J.
TITLE GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to
stretch and shape the Golgi to promote budding
JOURNAL Cell 139 (2), 337-351 (2009)
PUBMED 19837035
REMARK GeneRIF: GOLPH3 bridges phosphatidylinositol-4- phosphate and
actomyosin (via MYO18A) to stretch and shape the Golgi to promote
budding.
REFERENCE 4 (bases 1 to 7546)
AUTHORS Walz,C., Haferlach,C., Hanel,A., Metzgeroth,G., Erben,P.,
Gosenca,D., Hochhaus,A., Cross,N.C. and Reiter,A.
TITLE Identification of a MYO18A-PDGFRB fusion gene in an
eosinophilia-associated atypical myeloproliferative neoplasm with a
t(5;17)(q33-34;q11.2)
JOURNAL Genes Chromosomes Cancer 48 (2), 179-183 (2009)
PUBMED 19006078
REMARK GeneRIF: Study used a DNA-based long-distance inverse PCR (LDI-PCR)
to identify a new MYO18A-PDGFRB fusion gene in an Eos-MPN
(eosinophilia-associated atypical myeloproliferative neoplasms)
with associated t(5;17)(q33-34;q11.2).
REFERENCE 5 (bases 1 to 7546)
AUTHORS Tan,I., Yong,J., Dong,J.M., Lim,L. and Leung,T.
TITLE A tripartite complex containing MRCK modulates lamellar actomyosin
retrograde flow
JOURNAL Cell 135 (1), 123-136 (2008)
PUBMED 18854160
REFERENCE 6 (bases 1 to 7546)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
PUBMED 15302935
REFERENCE 7 (bases 1 to 7546)
AUTHORS Mori,K., Furusawa,T., Okubo,T., Inoue,T., Ikawa,S., Yanai,N.,
Mori,K.J. and Obinata,M.
TITLE Genome structure and differential expression of two isoforms of a
novel PDZ-containing myosin (MysPDZ) (Myo18A)
JOURNAL J. Biochem. 133 (4), 405-413 (2003)
PUBMED 12761286
REFERENCE 8 (bases 1 to 7546)
AUTHORS Ji,H., Zhai,Q., Zhu,J., Yan,M., Sun,L., Liu,X. and Zheng,Z.
TITLE A novel protein MAJN binds to Jak3 and inhibits apoptosis induced
by IL-2 deprival
JOURNAL Biochem. Biophys. Res. Commun. 270 (1), 267-271 (2000)
PUBMED 10733938
REFERENCE 9 (bases 1 to 7546)
AUTHORS Chang,N.S., Mattison,J., Cao,H., Pratt,N., Zhao,Y. and Lee,C.
TITLE Cloning and characterization of a novel transforming growth
factor-beta1-induced TIAF1 protein that inhibits tumor necrosis
factor cytotoxicity
JOURNAL Biochem. Biophys. Res. Commun. 253 (3), 743-749 (1998)
PUBMED 9918798
REFERENCE 10 (bases 1 to 7546)
AUTHORS Chroneos,Z.C., Abdolrasulnia,R., Whitsett,J.A., Rice,W.R. and
Shepherd,V.L.
TITLE Purification of a cell-surface receptor for surfactant protein A
JOURNAL J. Biol. Chem. 271 (27), 16375-16383 (1996)
PUBMED 8663107
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
D86970.2, AF252258.1 and BM544214.1.
Transcript Variant: This variant (2) lacks an alternate in-frame
exon compared to variant 1. The resulting isoform (b) has the same
N- and C-termini but is shorter compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CR933614.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-5971 D86970.2 24-5994
5972-7527 AF252258.1 270-1825
7528-7546 BM544214.1 362-380
FEATURES Location/Qualifiers
source 1..7546
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q11.2"
gene 1..7546
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="myosin XVIIIA"
/db_xref="GeneID:399687"
/db_xref="HGNC:31104"
/db_xref="HPRD:10106"
/db_xref="MIM:610067"
exon 1..77
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 78..1157
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
misc_feature 117..119
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="upstream in-frame stop codon"
CDS 159..6278
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="isoform b is encoded by transcript variant 2;
myosin 18A; myosin containing PDZ domain; myosin-XVIIIa;
SP-A receptor subunit SP-R210 alphaS; MAJN; myosin
containing a PDZ domain; molecule associated with JAK3
N-terminus; unconventional myosin-XVIIIa"
/codon_start=1
/product="unconventional myosin-XVIIIa isoform b"
/protein_id="NP_976063.1"
/db_xref="GI:42794779"
/db_xref="CCDS:CCDS45641.1"
/db_xref="GeneID:399687"
/db_xref="HGNC:31104"
/db_xref="HPRD:10106"
/db_xref="MIM:610067"
/translation="
MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRGFFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASSSDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDSDTEAKLTETNA
"
misc_feature 405..407
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 498..512
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q92614.3);
Region: Interaction with actin"
misc_feature 576..578
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 576..578
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 843..1082
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; Region: PDZ_signaling;
cd00992"
/db_xref="CDD:29049"
misc_feature order(846..857,861..863,1032..1037,1044..1049)
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29049"
misc_feature 858..860
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1356..3713
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="Myosin. Large ATPases; Region: MYSc; smart00242"
/db_xref="CDD:197599"
misc_feature 1374..3710
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="Myosin motor domain, type XVIII myosins. This
catalytic (head) domain has ATPase activity and belongs to
the larger group of P-loop NTPases. Myosins are
actin-dependent molecular motors that play important roles
in muscle contraction, cell motility, and...; Region:
MYSc_type_XVIII; cd01386"
/db_xref="CDD:30108"
misc_feature order(1494..1505,1509..1514,1656..1679)
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:30108"
misc_feature 1815..1829
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="switch I region; other site"
/db_xref="CDD:30108"
misc_feature 2544..2567
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="switch II region; other site"
/db_xref="CDD:30108"
misc_feature order(2628..2663,2670..2699)
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="relay loop; other site"
/db_xref="CDD:30108"
misc_feature 3360..3362
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3363..3365
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3366..3368
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 3450..3494
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="SH1 helix; other site"
/db_xref="CDD:30108"
misc_feature order(3489..3494,3501..3503,3519..3521,3528..3533,
3540..3542,3645..3647,3654..3656,3660..3665,3669..3677,
3687..3689,3696..3704)
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="converter subdomain; other site"
/db_xref="CDD:30108"
misc_feature 3966..5453
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="Plant protein of unknown function (DUF827); Region:
DUF827; pfam05701"
/db_xref="CDD:191347"
misc_feature 5295..>5489
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/note="Spc24 subunit of Ndc80; Region: Spc24; pfam08286"
/db_xref="CDD:149373"
misc_feature 6021..6023
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6033..6035
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6105..6107
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6105..6107
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
misc_feature 6117..6119
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6132..6134
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6171..6173
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6171..6173
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6225..6227
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6228..6230
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6234..6236
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6234..6236
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6240..6242
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92614.3); phosphorylation site"
misc_feature 6240..6242
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6240..6242
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6246..6248
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q92614.3); phosphorylation site"
misc_feature 6246..6248
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 1158..1245
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 1246..1352
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 1353..1529
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 1530..1743
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 1744..1886
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 1887..1987
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 1988..2051
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2052..2196
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2197..2208
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2209..2385
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2386..2476
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2477..2669
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2670..2756
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2757..2898
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 2899..3058
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3059..3245
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3246..3489
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3490..3599
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3600..3665
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3666..3794
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3795..3938
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 3939..4028
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 4029..4148
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 4149..4260
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 4261..4388
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 4389..4543
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
variation 4414
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="a"
/replace="c"
/db_xref="dbSNP:4994919"
variation 4417
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="a"
/replace="c"
/db_xref="dbSNP:4994920"
exon 4544..4667
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 4668..4868
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 4869..4979
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
STS 4923..5035
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/standard_name="MARC_23519-23520:1046465531:1"
/db_xref="UniSTS:268718"
exon 4980..5084
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 5085..5231
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 5232..5345
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 5346..5462
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 5463..5546
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 5547..5684
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 5685..5870
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
STS 5767..5982
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/standard_name="RH98718"
/db_xref="UniSTS:91135"
exon 5871..6010
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 6011..6133
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
exon 6134..7538
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/inference="alignment:Splign:1.39.8"
variation 6555
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539071"
STS 6763..6918
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/standard_name="D17S1502E"
/db_xref="UniSTS:151707"
variation 6890
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="c"
/replace="g"
/db_xref="dbSNP:1049848"
STS 6898..7068
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/standard_name="RH68312"
/db_xref="UniSTS:87897"
variation 6994
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049849"
variation 7245
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="a"
/replace="t"
/db_xref="dbSNP:1803474"
variation 7287
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049864"
STS 7323..7506
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/standard_name="RH67783"
/db_xref="UniSTS:92386"
variation 7339
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="c"
/replace="t"
/db_xref="dbSNP:11539070"
variation 7357
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="a"
/replace="c"
/db_xref="dbSNP:1049869"
STS 7384..7514
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/standard_name="RH39291"
/db_xref="UniSTS:86988"
variation 7386
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="a"
/replace="c"
/db_xref="dbSNP:1049870"
variation 7444
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049877"
variation 7446
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049878"
polyA_signal 7506..7511
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
polyA_site 7527
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 7529
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 7538
/gene="MYO18A"
/gene_synonym="MYSPDZ; SPR210"
ORIGIN
tccatccctgaccgggccgaggctgctggatgccgcgtctccgcttctgctgcctgccgggcgggctccggtggccgcagcaaagtggggcaccaaggccctgtgctaagcactcataatcctctgggggtgctacccctacaaacagcacccccaccatgtttaacctaatgaagaaagacaaggacaaagatggcgggcggaaggagaagaaggagaaaaaggagaaaaaggagcggatgtcagcggcagagcttcggagcctggaggagatgagcctgcgacgtggcttcttcaacctgaaccgctcctccaagcgtgaatccaagacgcgcctggaaatctccaaccccatccccatcaaggtggccagcggctctgacctgcacctgactgacattgactccgatagtaaccggggcagcgtcatcctggactcgggccacctaagtacagccagctccagcgatgacctcaagggtgaggagggtagcttccgtggctcggtgctgcagcgggcagccaagttcggctcactggccaagcagaactcacagatgattgtcaagcgcttttccttctcccagcgtagccgggatgagagcgcctcagaaacctcgacgccctcagagcactctgccgccccctcgccacaggtggaggtgaggactctagagggacagctggtgcagcatcctggcccaggcatccctcgaccagggcaccgatcccgagcccctgagctagtgactaaaaagttcccagtcgacctgcgcctgccccccgtggtgcccctgcccccacctaccctccgggagctggagctgcaacgacggcccactggagactttggcttctccctgcggcgcacaaccatgctggatcggggccccgagggccaggcctgtcggcgtgtggtccactttgctgagcctggtgcaggcaccaaggacctggccctggggctggtgccaggagatcgactggtggagattaatgggcacaatgtggagagcaagtccagggatgagattgtggagatgatccggcagtcaggggacagcgtgcggctcaaggtgcagcccattccagagctcagcgagctcagcaggagctggctgcggagcggcgagggacctcgcagggagccatccgatgcgaaaacagaagaacagattgcagcagaagaggcctggaatgagacggagaaggtgtggctggtccatagggacggcttctcactggccagtcaactcaaatctgaggagctcaacttgcctgaggggaaggtgcgtgtgaagctggaccacgatggggccatcctggatgtggatgaggatgacgttgagaaggctaatgctccctcctgcgaccgtctggaggatctggcctcactggtgtacctcaatgagtccagcgtcctgcacaccttgcgccagcgctatggcgctagcctgctgcacacgtatgctggccccagcctgctggttcttggcccccgtggggcccctgctgtgtactctgagaaggtgatgcacatgttcaagggttgtcggcgggaggacatggcaccccacatctatgcagtggcccagaccgcatacagggcgatgctgatgagccgtcaggatcagtcaatcatcctcctgggcagtagtggcagtggcaagaccaccagctgccagcatctggtgcagtacctggccaccatcgcgggcatcagcgggaacaaggtgttttctgtggagaagtggcaggctctgtacaccctcctggaagcctttgggaacagccccaccatcattaatggcaatgccacccgcttctcccagatcctctccctggactttgaccaagctggccaggtggcctcagcctccattcagacaatgcttctggagaagctgcgtgtggctcggcgcccagccagtgaagccacattcaacgtcttctactacctgctggcctgtggggatggcaccctcaggacagagctccacctcaaccacttggcagagaacaatgtgtttgggattgtgccactggccaagcctgaggaaaagcagaaggcagctcagcagtttagtaagctgcaggcggccatgaaggtgctgggcatctcccccgatgaacagaaggcctgctggttcattctggctgccatctaccacctgggggctgcgggagccaccaaagaagctgctgaagctgggcgcaagcagtttgcccgccatgagtgggcccagaaggctgcgtacctactgggctgcagcctggaggagctgtcctcagccatcttcaagcaccagcacaagggtggcaccctgcagcgctccacctccttccgccagggccccgaggagagtggcctgggagatgggacaggcccgaaactgagtgcactggagtgccttgagggcatggcggccggcctctacagcgagctcttcacccttctcgtctccctggtgaatagggctctcaagtccagccagcactcactctgctccatgatgattgtcgacaccccgggcttccagaaccctgagcagggtgggtcagcccgcggagcctcctttgaggagctgtgccacaactacacccaagaccggctgcagaggctcttccacgagcgcaccttcgtgcaggagttggaaagatacaaggaggagaacatcgagctggcgtttgacgacttggaacccccgacggatgactctgtggctgctgtggaccaggcctcccatcagtccctggtccgctcgctggcccgcacagacgaggcgaggggcctgctctggctattggaagaggaggctctggtgccaggggccagtgaggacaccctcctggagcgccttttctcctattatggcccccaggaaggtgacaaaaaaggccaaagcccccttctgcacagcagcaaaccacaccactttctcctgggccacagccatggcaccaactgggtagagtacaatgtgactggctggctgaactacaccaagcagaacccagccacccagaatgccccccggctcctgcaggactcccagaaaaaaatcatcagcaacctgtttctgggccgcgcaggcagtgccacggtgctctctggctccatcgcgggcctggagggcggctcgcagctggcactgcgccgggccaccagcatgcggaaaacctttaccacaggcatggcggctgtcaaaaagaagtcactgtgcatccagatgaagctacaggtggacgccctcatcgacaccatcaagaagtcaaagctgcattttgtgcactgcttcctgcctgtagctgagggctgggctggggagccccgttccgcctcctcccgccgagtcagcagcagcagtgagctggacctgccctcgggagaccactgcgaggctgggctcctgcagctcgacgtgcccctgctccgcacccagctccgcggctcccgcctgctcgatgccatgcgcatgtaccgccaaggttaccctgaccacatggtgttttccgagttccgccgccgctttgatgtcctggccccgcacctgaccaagaaacacgggcgtaactacatcgtggtggatgaaaggcgggcagtggaggagctgctggagtgcttggatctggagaagagcagctgctgcatgggcctgagccgggtgttcttccgggcgggcaccttggcacggctggaggagcagcgggatgaacaaaccagcaggaacctaaccctgttccaagcagcctgcaggggctacctggcccgccagcacttcaagaagagaaagatccaggacctggccattcgctgtgtacagaagaacatcaagaagaacaaaggggtgaaggactggccctggtggaagctttttaccacagtgaggcccctcatcgaagtacagctgtcagaggagcagatccggaacaaagacgaggagatccagcagctgcggagcaagctcgagaaggcggagaaggagaggaacgagctgcggctcaacagtgaccggctggagagccggatctcagagctgacatcggagctgacagatgagcgtaacacaggagagtccgcctcccagctgctggacgcggagacagcagagaggctccgggctgagaaggagatgaaggaactgcagacccagtacgatgcactgaagaagcagatggaggttatggaaatggaggtgatggaggcccgtctcatccgggcagcggagatcaacggggaagtggatgatgatgatgcaggtggcgagtggcggctgaagtatgagcgggctgtgcgggaggtggacttcaccaagaaacggctccagcaggagtttgaggacaagctggaggtggagcagcagaacaagaggcagctggaacggcggctcggggacctgcaggcagatagtgaggagagtcagcgggctctgcagcagctcaagaagaagtgccagcgactgacggctgagctgcaagacaccaagctgcacctggagggccagcaggtccgcaaccacgaactggagaagaagcagaggaggtttgacagtgagctctcgcaggcgcatgaggaggcccagcgggagaagctgcagcgggagaagctgcagcgggagaaggacatgctcctcgctgaggctttcagcctgaagcagcaactagaggaaaaagacatggacattgcagggttcacccagaaggttgtgtctctagaggcagagctccaggacatttcttcccaagagtccaaggatgaggcttctctggccaaggtcaagaaacagctccgggacctggaggccaaagtcaaggatcaggaagaagagctggatgagcaggcagggaccatccagatgctggaacaggccaagctgcgtctggagatggagatggagcggatgagacagacccattctaaggagatggagagtcgggatgaggaggtggaggaggcccggcagtcgtgtcagaagaagttaaaacagatggaggtgcagctagaggaagagtatgaggacaagcagaaggttctgcgagagaagcgggagctggagggcaagctcgccaccctcagcgaccaggtgaaccggcgggactttgagtcagagaagcggctgcggaaggacctgaagcgcaccaaggccctgctggcagatgcccagctcatgctggaccacctgaagaacagtgctcccagcaagcgagagattgcccagctcaagaaccagctggaggagtcagagttcacctgtgcggcagccgtgaaagcacggaaagcaatggaggtggagatcgaagacctgcacctgcagattgatgacatcgccaaagccaagacagcgctggaggagcagctgagccgccttcagcgtgagaagaatgagatccagaaccggctggaggaagatcaggaagacatgaacgaattgatgaagaagcacaaggctgccgtggctcaggcttcccgggacctggctcagataaatgatctccaagctcagctagaagaagccaacaaagagaagcaggagctgcaggagaagctacaagccctccagagccaggtggagttcctggagcagtccatggtggacaagtccctggtgagcaggcaggaagctaagatacgggagctggagacacgcctggagtttgaaaggacgcaagtgaaacggctggagagcctggctagccgtctcaaggaaaacatggagaagctgactgaggagcgggatcagcgcattgcagccgagaaccgggagaaggaacagaacaagcggctacagaggcagctccgggacaccaaggaggagatgggcgagcttgccaggaaggaggccgaggcgagccgcaagaagcacgaactggagatggatctagaaagcctggaggctgctaaccagagcctgcaggctgacctaaagttggcattcaagcgcatcggggacctgcaggctgccattgaggatgagatggagagtgatgagaatgaggacctcatcaacagtgagggagactctgatgtggactcggagctggaggaccgtgttgacggggtcaagtcctggttgtcaaaaaacaagggaccttccaaggcagcttctgatgatggcagcttaaagagttccagccccaccagctactggaagtcccttgcccctgatcggtcagatgatgagcacgaccctctcgacaacacctccagaccgcgatactcccacagttatctgagtgacagcgacacagaggccaagctgacggagactaacgcatagcccaggggagtggttggcagccctctcaccccagggcctgtggctgcctgggcacctctcccaggaagtggtggggcaccggtctcccccacccgactgctgatctgcatgggaaacaccctgaccttcttctgtcaggggcactttccaggctatgggtgtctgatgtctccacgtggaagaggtgggggaaagaggagtttctgaagagaactttttgctcctctgtctcaaaatgccagactcttggcttctaccctgtgtcaccgtgggcagtggcaggtggcctggcactgcatggagccagcacgttgacctccctctcagctccctgctcagggacggtggacaggttgcctactgggacactctaggttgctgggtccatggggaggattgggggaggagaagcagtgccttccctctcgtgtggggtgggggctctctcttcttggtgcctgctgtctttctactttttaatttaaatacccaacctctccatcacagctgcatccctgagagtgggagggggctgtagtggtagctggggctcccaagaacgactcgggaatgtcatctccatcttcacccttcagagagcagtcctttctctgtgcagctggagacgctggtgaggagagccgggtccaggttcttaagaatgaggtgcggaggggctctccggtgctgctgggctgggttgagcaagcctacgcagacaagtgtgtgtgtggaccatccgcacctccagcccccaccccaccctctttgtctcagcgtgttatgtgcaatgacctatttaaggtaaacccattccaactacagcagttcagggctgatccaagcactgcctccctcctgctctgtccaggtggtctggaccataaactcaacttgagagggaaggcttggggttgaggacttgtgatcagaaaaactgaagatggaagttttggccggtgctcattagacatgagtcctcactctgtgtcctgagcccgtgtcattcttccaacctccctgcccccacacacttatcccagacacaacaccatgtggtctggaggtcccagcccccaccctaaaaaggttatccctgagaactccaccagacttgggagcccaagtgcagtgcctggtgctgctcccatctgccgccccccttctctcctgcaattggtttgtactcactgggctgtgctctcccctgtttacccgatgtatggaaataaaggcccttttcctcctggctgcgccagtaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:399687 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:399687 -> Molecular function: GO:0003774 [motor activity] evidence: IEA
GeneID:399687 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:399687 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:399687 -> Molecular function: GO:0008094 [DNA-dependent ATPase activity] evidence: IEA
GeneID:399687 -> Biological process: GO:0006259 [DNA metabolic process] evidence: IEA
GeneID:399687 -> Biological process: GO:0016477 [cell migration] evidence: IMP
GeneID:399687 -> Biological process: GO:0031032 [actomyosin structure organization] evidence: IMP
GeneID:399687 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:399687 -> Cellular component: GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] evidence: IEA
GeneID:399687 -> Cellular component: GO:0016459 [myosin complex] evidence: IEA
GeneID:399687 -> Cellular component: GO:0042641 [actomyosin] evidence: IDA
by
@meso_cacase at
DBCLS
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