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2024-04-20 13:18:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_198977 3137 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1
(ARHGEF1), transcript variant 3, mRNA.
ACCESSION NM_198977
VERSION NM_198977.1 GI:39777603
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3137)
AUTHORS Hu,Y., Ou,Y., Wu,K., Chen,Y. and Sun,W.
TITLE miR-143 inhibits the metastasis of pancreatic cancer and an
associated signaling pathway
JOURNAL Tumour Biol. 33 (6), 1863-1870 (2012)
PUBMED 23070684
REMARK GeneRIF: High GEF1 expression is associated with metastasis of
pancreatic cancer.
REFERENCE 2 (bases 1 to 3137)
AUTHORS Chen,Z., Guo,L., Hadas,J., Gutowski,S., Sprang,S.R. and
Sternweis,P.C.
TITLE Activation of p115-RhoGEF requires direct association of Galpha13
and the Dbl homology domain
JOURNAL J. Biol. Chem. 287 (30), 25490-25500 (2012)
PUBMED 22661716
REMARK GeneRIF: Activation of p115-RhoGEF requires direct association of
Galpha13 and the Dbl homology domain.
REFERENCE 3 (bases 1 to 3137)
AUTHORS Ma,X., Zhao,Y., Daaka,Y. and Nie,Z.
TITLE Acute activation of beta2-adrenergic receptor regulates focal
adhesions through betaArrestin2- and p115RhoGEF protein-mediated
activation of RhoA
JOURNAL J. Biol. Chem. 287 (23), 18925-18936 (2012)
PUBMED 22500016
REMARK GeneRIF: Upon beta(2)AR activation, both betaArrestin2 and
p115RhoGEF translocate to the plasma membrane, with concomitant
activation of RhoA and formation of focal adhesions and stress
fibers.
REFERENCE 4 (bases 1 to 3137)
AUTHORS Hartney,J.M., Gustafson,C.E., Bowler,R.P., Pelanda,R. and
Torres,R.M.
TITLE Thromboxane receptor signaling is required for fibronectin-induced
matrix metalloproteinase 9 production by human and murine
macrophages and is attenuated by the Arhgef1 molecule
JOURNAL J. Biol. Chem. 286 (52), 44521-44531 (2011)
PUBMED 22086927
REMARK GeneRIF: Thromboxane receptor signaling is required for
fibronectin-induced matrix metalloproteinase 9 production by human
and murine macrophages and is attenuated by the Arhgef1 molecule.
REFERENCE 5 (bases 1 to 3137)
AUTHORS Jaiswal,M., Gremer,L., Dvorsky,R., Haeusler,L.C., Cirstea,I.C.,
Uhlenbrock,K. and Ahmadian,M.R.
TITLE Mechanistic insights into specificity, activity, and regulatory
elements of the regulator of G-protein signaling (RGS)-containing
Rho-specific guanine nucleotide exchange factors (GEFs) p115,
PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)
JOURNAL J. Biol. Chem. 286 (20), 18202-18212 (2011)
PUBMED 21454492
REMARK GeneRIF: Mechanistic insights into specificity, activity, and
regulatory elements of the regulator of G-protein signaling
(RGS)-containing Rho-specific guanine nucleotide exchange factors
(GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF
(LARG).
REFERENCE 6 (bases 1 to 3137)
AUTHORS Azim,A.C., Barkalow,K., Chou,J. and Hartwig,J.H.
TITLE Activation of the small GTPases, rac and cdc42, after ligation of
the platelet PAR-1 receptor
JOURNAL Blood 95 (3), 959-964 (2000)
PUBMED 10648409
REFERENCE 7 (bases 1 to 3137)
AUTHORS Hart,M.J., Jiang,X., Kozasa,T., Roscoe,W., Singer,W.D.,
Gilman,A.G., Sternweis,P.C. and Bollag,G.
TITLE Direct stimulation of the guanine nucleotide exchange activity of
p115 RhoGEF by Galpha13
JOURNAL Science 280 (5372), 2112-2114 (1998)
PUBMED 9641916
REFERENCE 8 (bases 1 to 3137)
AUTHORS Kozasa,T., Jiang,X., Hart,M.J., Sternweis,P.M., Singer,W.D.,
Gilman,A.G., Bollag,G. and Sternweis,P.C.
TITLE p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13
JOURNAL Science 280 (5372), 2109-2111 (1998)
PUBMED 9641915
REFERENCE 9 (bases 1 to 3137)
AUTHORS Aasheim,H.C., Pedeutour,F. and Smeland,E.B.
TITLE Characterization, expression and chromosomal localization of a
human gene homologous to the mouse Lsc oncogene, with strongest
expression in hematopoetic tissues
JOURNAL Oncogene 14 (14), 1747-1752 (1997)
PUBMED 9135076
REFERENCE 10 (bases 1 to 3137)
AUTHORS Hart,M.J., Sharma,S., elMasry,N., Qiu,R.G., McCabe,P., Polakis,P.
and Bollag,G.
TITLE Identification of a novel guanine nucleotide exchange factor for
the Rho GTPase
JOURNAL J. Biol. Chem. 271 (41), 25452-25458 (1996)
PUBMED 8810315
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BM147791.1 and BC011726.2.
Summary: Rho GTPases play a fundamental role in numerous cellular
processes that are initiated by extracellular stimuli that work
through G protein coupled receptors. The encoded protein may form
complex with G proteins and stimulate Rho-dependent signals.
Multiple alternatively spliced transcript variants have been found
for this gene, but the full-length nature of some variants has not
been defined. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) has an alternate 5' exon and
lacks an in-frame internal exon, as compared to variant 1. The
encoded isoform 3 thus has a shorter N-terminus and lacks an
internal segment, as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC011726.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085, ERS025093 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-25 BM147791.1 2-26
26-3137 BC011726.2 1-3112
FEATURES Location/Qualifiers
source 1..3137
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.13"
gene 1..3137
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/note="Rho guanine nucleotide exchange factor (GEF) 1"
/db_xref="GeneID:9138"
/db_xref="HGNC:681"
/db_xref="HPRD:03511"
/db_xref="MIM:601855"
exon 1..90
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 64
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:3745224"
exon 91..133
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
CDS 110..2749
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/note="isoform 3 is encoded by transcript variant 3; Lsc
homolog; 115-kD protein; Rho guanine nucleotide exchange
factor 1; p115RhoGEF; 115 kDa guanine nucleotide exchange
factor"
/codon_start=1
/product="rho guanine nucleotide exchange factor 1 isoform
3"
/protein_id="NP_945328.1"
/db_xref="GI:39777604"
/db_xref="CCDS:CCDS12592.1"
/db_xref="GeneID:9138"
/db_xref="HGNC:681"
/db_xref="HPRD:03511"
/db_xref="MIM:601855"
/translation="
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
"
misc_feature 263..742
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/note="Regulator of G protein signaling (RGS) domain
superfamily; Region: RGS; cl02565"
/db_xref="CDD:207646"
misc_feature 1259..1819
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/note="Guanine nucleotide exchange factor for
Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
(DH) domain. It appears that PH domains invariably occur
C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160"
/db_xref="CDD:29100"
misc_feature order(1277..1279,1289..1291,1589..1591,1673..1678,
1685..1690,1694..1699,1706..1711,1718..1723,1730..1732,
1805..1807,1817..1819)
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:29100"
variation 122
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150821873"
variation 126
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:183598386"
variation 132
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370219647"
exon 134..220
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 170
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:139550350"
variation 181
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2288509"
variation 208
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:41306984"
exon 221..334
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 241
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:199744295"
variation 270
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367720737"
variation 283
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371961260"
variation 305
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200954009"
variation 329
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:146097065"
variation 331
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201383072"
exon 335..377
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 342
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:139897494"
variation 349
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201880696"
variation 362
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367629635"
variation 365
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371771035"
exon 378..624
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 380
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369826806"
variation 415
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373367437"
variation 420
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:376815607"
variation 425
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368913647"
variation 465
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:200573860"
variation 475
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372670738"
variation 489
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199623203"
variation 581
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:193119387"
variation 586
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:367971459"
exon 625..654
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
exon 655..754
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 662
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149720220"
variation 670
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:374531075"
variation 673
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145590918"
variation 682
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200476944"
variation 686
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:202012713"
variation 695
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:148901384"
variation 729
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368940793"
exon 755..851
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 767
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142729688"
variation 774
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:370981860"
variation 778
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:202000253"
variation 808
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:374051481"
variation 821
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:147557273"
variation 823
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141980059"
exon 852..887
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 870
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145833533"
exon 888..1025
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 895
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199574398"
variation 896
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372800039"
variation 906
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:377228645"
variation 911
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147318287"
variation 912
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200700112"
variation 923
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201550936"
variation 928
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:181351585"
variation 945
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373754668"
variation 952
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142488956"
variation 964
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150244320"
variation 1017
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371972574"
exon 1026..1131
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1033
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:113064588"
variation 1034
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200492200"
variation 1062
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370209568"
variation 1080
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:138912380"
variation 1092
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:373879693"
variation 1104
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199751095"
variation 1111
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199929341"
variation 1121
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:370619761"
exon 1132..1277
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1134
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2303797"
variation 1150
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:201815694"
variation 1159
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371689333"
variation 1164
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:202008400"
variation 1167
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:191166480"
variation 1198
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:182862957"
variation 1214
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201158983"
variation 1219
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:200140005"
variation 1231
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371778569"
variation 1238
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376409694"
exon 1278..1424
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1303
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:377396950"
variation 1306
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:149426435"
variation 1327
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:373961323"
variation 1346
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368172499"
variation 1360
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371715160"
variation 1372
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138184809"
exon 1425..1507
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1436
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:372151277"
variation 1444
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:35481465"
variation 1447
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146077930"
variation 1451
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375512672"
variation 1487
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371904102"
variation 1492
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:140077307"
variation 1506
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375242613"
exon 1508..1633
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1513
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:150767918"
variation 1516
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375730550"
variation 1563
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:139162951"
variation 1593
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149949574"
variation 1596
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369550986"
variation 1633
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:55795616"
exon 1634..1748
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1689
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375320551"
variation 1735
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147645001"
exon 1749..1849
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1777
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:141918053"
variation 1783
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:201193337"
variation 1786
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200795172"
variation 1787
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144202833"
variation 1792
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:61747623"
variation 1796
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371642301"
exon 1850..1927
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1863
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199766882"
exon 1928..2003
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 1929
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:147783681"
variation 1974
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201743928"
variation 1975
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:148847706"
exon 2004..2171
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2039
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143516030"
variation 2062
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:11083640"
variation 2095
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201201704"
variation 2159
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201127336"
exon 2172..2259
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2179
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200018783"
variation 2189
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:140559109"
variation 2215
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:150472038"
variation 2224
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201928871"
variation 2247
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:138482475"
variation 2253
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376994500"
exon 2260..2346
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2269
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:41307033"
variation 2287
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372665100"
variation 2293
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:139829972"
variation 2310
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:113256397"
variation 2323
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:200947112"
variation 2327
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375701795"
variation 2338
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:1131874"
variation 2340
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146058052"
exon 2347..2414
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2380
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376174015"
variation 2381
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138831877"
variation 2383
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:1131875"
variation 2385
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199780248"
variation 2401
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149372116"
variation 2412
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:374563734"
exon 2415..2501
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2422
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144745694"
variation 2423
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376841668"
variation 2468
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369443387"
exon 2502..2665
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2505
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:370160335"
variation 2516
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:45580632"
variation 2532
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375950739"
variation 2555
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:148445682"
variation 2562
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370594565"
variation 2606
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201989159"
variation 2607
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368646630"
variation 2624
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372187004"
variation 2659
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:375584355"
exon 2666..2766
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2688
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369952369"
variation 2719
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="g"
/replace="t"
/db_xref="dbSNP:376680966"
variation 2735
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="c"
/db_xref="dbSNP:141738557"
variation 2756
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372273800"
variation 2757
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369026490"
exon 2767..3114
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/inference="alignment:Splign:1.39.8"
variation 2926
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:192515803"
variation 2937
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="g"
/db_xref="dbSNP:80083367"
STS 2964..3092
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/standard_name="WI-15934"
/db_xref="UniSTS:175"
variation 2996
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/replace="c"
/replace="t"
/db_xref="dbSNP:183053810"
polyA_site 3112
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 3114
/gene="ARHGEF1"
/gene_synonym="GEF1; LBCL2; LSC; P115-RHOGEF; SUB1.5"
ORIGIN
agagccaggaagcgggagccgggacccagggcccgggatcgccgagcccgacctcgggcgccccgccggtcacctccgcgcggacaccagccctgcagagcccagggagatggaagacttcgcccgaggggcggcctccccaggcccctcccggcctggcctggttcccgtcagcatcatcggggctgaggatgaggattttgagaacgagctggagacaaactcagaagagcaaaacagccagttccagagcctggagcaggtgaagcggcgcccagcccacctcatggccctcctgcagcacgtggccctgcagtttgagccaggacccctggttctccgggtgccggtccctcccaacgtcgcctttgaacttgaccgcactagggctgacctcatctccgaggatgtccagcggcggttcgtgcaggaggtggtgcaaagccagcaggtagccgtgggccggcagctggaggacttccgttccaagcggctcatgggcatgacgccctgggagcaggagctggcccagctggaggcttgggttgggcgggaccgagccagctacgaggcccgggagcggcacgtggcggagcggctgctcatgcacctggaggagatgcaacataccatctctaccgacgaagaaaagagtgctgccgtggtcaacgccattggcctgtacatgcgccaccttggggtgcggaccaagagtggagacaagaagtcggggaggaacttcttccggaaaaaggtgatggggaaccggcggtcggacgagcctgccaagaccaagaaggggctgagcagcatcctggatgccgcccgctggaaccggggagagccccaggttccagattttcgacacctcaaagcagaggttgatgccgagaagccaggtgctacagaccggaagggaggcgtggggatgccctctcgggaccggaatatcggggctcctgggcaggacacccctggagtctctctgcaccctctgtccctggacagcccagaccgggaaccaggtgctgacgcccccctggagctgggggactcatccccgcagggcccaatgagcctggagtccttggcgcccccagagagtaccgacgagggggccgaaaccgagagccccgagcctggagatgagggggagccggggcggtcgggactggagcttgaaccagaagagcctcccggctggcgggaactcgtccccccagacaccctgcacagcctgcccaagagccaggtgaagcggcaggaggtcatcagcgagctgctggtgacagaggcggcccacgtgcgcatgctgcgggtgctgcacgacctcttcttccagcccatggcagaatgcctgttcttccccttggaggagctgcagaacatcttccccagcctggacgagctcatcgaggtgcattccctgttcctcgatcgcctgatgaagcggaggcaggagagtggctacctcatcgaggagatcggagacgtgctgctggcccggtttgatggtgctgagggctcctggttccagaaaatctcctcccgcttctgcagccgccagtcatttgccttagagcagctcaaagccaagcaacgcaaggaccctcggttctgtgccttcgtgcaggaagctgagagccgcccgcggtgccgccgcctgcagctgaaggacatgatccccacggagatgcagcggctgaccaagtaccccctgctcctgcagagcatcgggcagaacacagaagagcccacagaacgggagaaagtggagctggcagccgagtgctgccgggaaattctacaccacgtcaaccaagccgtgcgtgacatggaggacctgctgaggctcaaggactatcagcggcgcctggacttgtcccaccttcggcagagcagcgaccctatgctgagcgagttcaagaacctggacatcaccaagaagaaattggtccacgagggcccactgacgtggcgggtgactaaggacaaggcagtggaggtgcatgtgctgctgctggacgacctgctgctgctgctccagcgccaggacgagcggctgctgctcaagtcccatagccggacactgacgcccacgcccgatggcaagaccatgctgcggcccgtgctgcggctcacctccgccatgacccgcgaggtggccaccgatcacaaagccttctacgtcctttttacctgggaccaggaggcccagatatacgagctggtggcacagactgtgtcggagcggaaaaactggtgtgctctcatcactgagactgccggatccctgaaagtccctgcccctgcctctcgccctaagccccggcccagcccgagcagcacccgagaacccctcctcagcagctctgagaacggcaatggtggccgagagacgtctccagctgatgcccggaccgagagaatcctcagtgacctcctgcccttctgcagaccaggccccgagggccagctcgctgccacggcccttcggaaagtgctgtccctgaagcagcttctgtttccggcggaggaagacaatggggcggggcctcctcgagatggggatggggtcccagggggcggccccctgagcccagcacggacccaggaaatccaggagaacctgctcagcttggaggagaccatgaagcagctggaggagttggaggaggaattttgccgcctgagacccctcctgtctcagcttggggggaactctgtcccccagcctggctgcacttgaggttcccgcccaggaaggccttttgcaagaaggagaggaatgggggagaggacgtgagggaccacccccacccacacagctgccgcagcatctcacaccccgagggcctgaggagagggagctgtgggccacgcctgggaggggcccagctggggttactggccccgcatgagcctcggccatctctccctcctgccctctgcttgggggactcagggctccattctggagggcaccacggtgacccgggccatctcagtattgcctgtgggggccacccctccacccccacccccaagtgccttcgctctgtttttataccctgaattggaggtttattttttaatatatattatctaagaagaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9138 -> Molecular function: GO:0005089 [Rho guanyl-nucleotide exchange factor activity] evidence: IEA
GeneID:9138 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IEA
GeneID:9138 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9138 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:9138 -> Biological process: GO:0007266 [Rho protein signal transduction] evidence: TAS
GeneID:9138 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:9138 -> Biological process: GO:0035023 [regulation of Rho protein signal transduction] evidence: IEA
GeneID:9138 -> Biological process: GO:0038032 [termination of G-protein coupled receptor signaling pathway] evidence: IEA
GeneID:9138 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:9138 -> Biological process: GO:0050770 [regulation of axonogenesis] evidence: TAS
GeneID:9138 -> Biological process: GO:0050771 [negative regulation of axonogenesis] evidence: TAS
GeneID:9138 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:9138 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:9138 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
by
@meso_cacase at
DBCLS
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