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2020-10-24 07:02:29, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_194359               5172 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens ring finger protein 41 (RNF41), transcript variant 3,
            mRNA.
ACCESSION   NM_194359
VERSION     NM_194359.2  GI:338827615
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Zhou,A., Pan,D., Yang,X. and Zhou,J.
  TITLE     Overexpression of Nrdp1/FLRF sensitizes cells to oxidative stress
  JOURNAL   Biochem. Biophys. Res. Commun. 410 (4), 771-774 (2011)
   PUBMED   21693106
  REMARK    GeneRIF: these data provide insights into understanding the
            potential role of Nrdp1 in cell growth, apoptosis and oxidative
            stress, and in the pathogenesis of Parkinson's disease.
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Fry,W.H., Simion,C., Sweeney,C. and Carraway,K.L. III.
  TITLE     Quantity control of the ErbB3 receptor tyrosine kinase at the
            endoplasmic reticulum
  JOURNAL   Mol. Cell. Biol. 31 (14), 3009-3018 (2011)
   PUBMED   21576364
  REMARK    GeneRIF: Data demonstrate that Nrdp1 preferentially associates with
            the nascent form of ErbB3 to accelerate its degradation, and that
            the two proteins colocalize at the endoplasmic reticulum.
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Wauman,J., De Ceuninck,L., Vanderroost,N., Lievens,S. and
            Tavernier,J.
  TITLE     RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and
            ectodomain shedding
  JOURNAL   J. Cell. Sci. 124 (PT 6), 921-932 (2011)
   PUBMED   21378310
  REMARK    GeneRIF: RNF41 interacts with JAK2-associated cytokine receptor
            complexes and modulates their cell surface exposure and signalling.
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Ingalla,E.Q., Miller,J.K., Wald,J.H., Workman,H.C., Kaur,R.P.,
            Yen,L., Fry,W.H., Borowsky,A.D., Young,L.J., Sweeney,C. and
            Carraway,K.L. III.
  TITLE     Post-transcriptional mechanisms contribute to the suppression of
            the ErbB3 negative regulator protein Nrdp1 in mammary tumors
  JOURNAL   J. Biol. Chem. 285 (37), 28691-28697 (2010)
   PUBMED   20628057
  REMARK    GeneRIF: Post-transcriptional mechanisms contribute to the
            suppression of the ErbB3 negative regulator protein Nrdp1 in
            mammary tumors.
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Chen,L., Siddiqui,S., Bose,S., Mooso,B., Asuncion,A., Bedolla,R.G.,
            Vinall,R., Tepper,C.G., Gandour-Edwards,R., Shi,X., Lu,X.H.,
            Siddiqui,J., Chinnaiyan,A.M., Mehra,R., Devere White,R.W.,
            Carraway,K.L. III and Ghosh,P.M.
  TITLE     Nrdp1-mediated regulation of ErbB3 expression by the androgen
            receptor in androgen-dependent but not castrate-resistant prostate
            cancer cells
  JOURNAL   Cancer Res. 70 (14), 5994-6003 (2010)
   PUBMED   20587519
  REMARK    GeneRIF: Observations point to a model of CRPC development in which
            progression of PCa to castration resistance is associated with the
            inability of AR to transcriptionally regulate Nrdp1, and predict
            that inhibition of ErbB3 during AW may impair CRPC development.
REFERENCE   6  (bases 1 to 5172)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J. Biol. Chem. 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 5172)
  AUTHORS   Qiu,X.B., Markant,S.L., Yuan,J. and Goldberg,A.L.
  TITLE     Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
            pathway for triggering apoptosis
  JOURNAL   EMBO J. 23 (4), 800-810 (2004)
   PUBMED   14765125
  REMARK    GeneRIF: Nrdp1 can be important in the initiation of apoptosis by
            catalyzing ubiquitination and degradation of BRUCE.
REFERENCE   8  (bases 1 to 5172)
  AUTHORS   Qiu,X.B. and Goldberg,A.L.
  TITLE     Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and
            degradation of the epidermal growth factor receptor family member,
            ErbB3
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (23), 14843-14848 (2002)
   PUBMED   12411582
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17220.]
REFERENCE   9  (bases 1 to 5172)
  AUTHORS   Diamonti,A.J., Guy,P.M., Ivanof,C., Wong,K., Sweeney,C. and
            Carraway,K.L. III.
  TITLE     An RBCC protein implicated in maintenance of steady-state
            neuregulin receptor levels
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (5), 2866-2871 (2002)
   PUBMED   11867753
REFERENCE   10 (bases 1 to 5172)
  AUTHORS   Abdullah,J.M., Li,X., Nachtman,R.G. and Jurecic,R.
  TITLE     FLRF, a novel evolutionarily conserved RING finger gene, is
            differentially expressed in mouse fetal and adult hematopoietic
            stem cells and progenitors
  JOURNAL   Blood Cells Mol. Dis. 27 (1), 320-333 (2001)
   PUBMED   11358394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP201682.1, BC032637.1 and
            AC073896.41.
            On Jun 30, 2011 this sequence version replaced gi:37588860.
            
            Summary: This gene encodes an E3 ubiquitin ligase. The encoded
            protein plays a role in type 1 cytokine receptor signaling by
            controlling the balance between JAK2-associated cytokine receptor
            degradation and ectodomain shedding. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032637.1, AK314811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               BP201682.1         1-386
            387-2189            BC032637.1         340-2142
            2190-5172           AC073896.41        128296-131278
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..5172
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /note="ring finger protein 41"
                     /db_xref="GeneID:10193"
                     /db_xref="HGNC:18401"
                     /db_xref="HPRD:11520"
     exon            1..67
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     exon            68..252
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     exon            253..365
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    270..272
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /note="upstream in-frame stop codon"
     CDS             276..1229
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /EC_number="6.3.2.-"
                     /note="isoform 1 is encoded by transcript variant 3;
                     neuregulin receptor degradation protein-1; fetal liver
                     ring finger; E3 ubiquitin-protein ligase NRDP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NRDP1 isoform 1"
                     /protein_id="NP_919340.1"
                     /db_xref="GI:37588861"
                     /db_xref="CCDS:CCDS8909.1"
                     /db_xref="GeneID:10193"
                     /db_xref="HGNC:18401"
                     /db_xref="HPRD:11520"
                     /translation="
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
"
     misc_feature    315..449
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /note="Zinc finger, C3HC4 type (RING finger); Region:
                     zf-C3HC4_2; pfam13923"
                     /db_xref="CDD:206094"
     misc_feature    327..440
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /note="RING-finger (Really Interesting New Gene) domain, a
                     specialized type of Zn-finger of 40 to 60 residues that
                     binds two atoms of zinc; defined by the 'cross-brace'
                     motif C-X2-C-X(9-39)-C-X(1-3)-
                     H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region:
                     RING; cd00162"
                     /db_xref="CDD:238093"
     misc_feature    order(327..329,336..338,375..377,381..383,390..392,
                     399..401,432..434)
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:238093"
     misc_feature    684..1220
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /note="USP8 interacting; Region: USP8_interact; pfam08941"
                     /db_xref="CDD:149875"
     exon            366..637
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     exon            638..773
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     exon            774..877
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     exon            878..5172
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /inference="alignment:Splign:1.39.8"
     variation       932
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:703822"
     STS             2493..3283
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="RNF41_1849"
                     /db_xref="UniSTS:280974"
     STS             2956..3102
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="A002D43"
                     /db_xref="UniSTS:3098"
     STS             2956..3102
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="G19966"
                     /db_xref="UniSTS:3099"
     polyA_signal    3149..3154
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
     polyA_site      3175
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
     variation       3416
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:773654"
     STS             3694..3796
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D11S3114"
                     /db_xref="UniSTS:152207"
     STS             3739..4158
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D10S16"
                     /db_xref="UniSTS:155756"
     STS             3773..4179
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D8S2278"
                     /db_xref="UniSTS:473906"
     STS             3773..3875
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D8S2278"
                     /db_xref="UniSTS:473906"
     STS             3778..4171
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             3778..3867
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             3833..4226
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="PMC156606P1"
                     /db_xref="UniSTS:271408"
     STS             3847..4026
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="GDB:434012"
                     /db_xref="UniSTS:157204"
     variation       3877
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:773655"
     STS             3922..4096
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="L17971"
                     /db_xref="UniSTS:43966"
     variation       3940
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:773656"
     STS             4084..4179
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /standard_name="D8S2278"
                     /db_xref="UniSTS:473906"
     variation       4481
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:773657"
     polyA_site      5172
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
ORIGIN      
gagcttccgccgggttgcgtagcagcggtgggcggggcaaaggatccgtctgaggcggcgacgagtgagtactcctgattgtgacatcacattcatcccctgggcgatggagcttgtcactgggaaggaatactcagtcggagaatagccaacaagatgggttactgggagaatctcttcagtggcactgagtggaggcatcagggggttggagccttgtgaacagggaacctgccccccaacacttggaaggacctgggtttcagtgatgagacatggggtatgatgtaacccgtttccagggggatgttgacgaagatcttatctgccctatttgcagtggagtcttggaggagccagtacaggcacctcattgtgaacatgctttctgcaacgcctgcatcacccagtggttctctcagcaacagacatgtccagtggaccgtagtgttgtgacggtcgcccatctgcgcccagtacctcggatcatgcggaacatgttgtcaaagctgcagattgcctgtgacaacgctgtgttcggctgtagtgccgttgtccggcttgacaacctcatgtctcacctcagcgactgtgagcacaacccgaagcggcctgtgacctgtgaacagggctgtggcctggagatgcccaaagatgagctgcccaaccataactgcattaagcacctgcgctcagtggtacagcagcagcagacacgcatcgcagagctggagaagacgtcagctgaacacaaacaccagctggcggagcagaagcgagacatccagctgctaaaggcatacatgcgtgcaatccgcagtgtcaaccccaaccttcagaacctggaggagacaattgaatacaacgagatcctagagtgggtgaactcccttcagccagcaagagtgacccgctggggagggatgatctcgactcctgatgctgtgctccaggctgtaatcaagcgctccctggtggagagtggctgtcctgcttctattgtcaacgagctgattgaaaatgcccacgagcgtagctggccccagggtctggccacactagagactagacagatgaaccgacgctactatgagaactacgtggccaagcgcatccctggcaagcaggctgttgtcgtgatggcctgtgagaaccagcacatgggggatgacatggtgcaagagccaggccttgtcatgatatttgcgcatggcgtggaagagatataagagaactcgactggctatcaggaagagatggaaatcagaaaatcccatcactccagcagctgggacctgagtcctacccaccattcttaatactgtggcttatacctgagccacacatctccctgcccttctggcactgaagggccttggggtagtttgctcagcctttcaggtgggaaacccagatttcctccctttgccatattcccctaaaatgtctataaattatcagtctgggtgggaaagcccccacctccatccattttcctgcttagggtccctggttccagttattttcagaaagcacaaagagattcaatttccctggaggatcaggacagaggaaggaatctctaatcgtccctctcctccaaaaccagggaatcagagcagtcaggcctgttgactctaagcagcagacatcctgaagaaatggtaagggtggagccaaatctctagaaataagtagtgaggccgttaattggccatcactgatggcccttagggaaagactggacctctgtgccaagcagtatccctgttcagcccaccttaaaggtgtaggcacccactgggtctaccagtatgcaggttgggatactgaaaatttccagatgagctcttctttcctacaagttttcataattagggaatgccagggtttagggtaggggttaatctgttgggggttgatgtgtttagcaagaagctactcctagcttttgctaaaatatggttggcactgcctcttgtggcacaggccataattgttccatagacccctctctagccctgtgactgtagttagttactttgataattttctttggccattgtttgtttatatttcacaaactccacctactgcccccccccctcttttttttaagaatggcctgatcatggctatctcagccacattgttggcaatttaatttatttacttcctttttttttttttaagaaaggaaaaaagaaaaaaaaatcaaacttgaaacttttcttttgatgttcctattgtgggggttctggatagggtgggacagggatgggggtgtgttttatattttttccttttcagcacaacctttggctttaatataggaagagccaagggagtcctcggctgaacttacgatatctgccccaaacctctgtaaccccaactgaaatgaggagcttcctctcttcctgtgaaggatatgacagtccagcatcgatgcctgtgccctctggaaaaatttcctcctagcccttccagggccttatcataaaactctggatttagagtattcattttgaaggcaactcccccttccccaagtttccttggagctgtatagctgggttctaagcttcaccatgcaaatcagaaattttatctctaagtacaggctgtgccgtgtctcacccacacccccctggggacttcagttccatttcaggttacctggggtataccttgatccctagagtgactggcagagtaagagaaggggagagataataggtgtgattattttaatatggaggtgggagtgtggttggagatagaaaggctcctccccaccatgtaatggcttcctctcagaattttattccaggctagcttgctgcaggtctgggtagttggatcatggctccactgggattggggtggaaagcttgaggggagtagggttccagctctgggacattgtgctcaggaatttgaaaacgctgctatacttactctggttactacatttcttccactcccctttcccctacctgccttaaccaaggctcatactgtcctgtccttaccctcagatggagccaggaagctcagtgaaaggcttccctaccctttgcactagtgtctctgcaggttgctggttgtgttgtatgtgctgttccatggtgttgactgcactaataataaaccttttactcaactctctaaattcttcagcattactccctttcttgagaaggtttcccctctgcttttgcctttctctcaccttaattccctttcttccttactttgttacctacccttatcttagtgctaacttctctttcaggaggatgtctgggagtagtgtgcacttcacagctgctttcccatgtaccctcctgcattcttccctcctatctcctgttctgtagcagccaaagctctctagtgatctgaactgtgtgcttcccagggtctgcctttatcctaaattccatgtcttccctgagtggtcctgagtttttgggataatttctacagaagatatgtatatatctttttcctttgtcccacaagcaactttgctttagaatctagaattcctttgcaggcagagaagtctctacctcccagtgtttcctagctaagaacgtaaatgtgaggagggaaatgtacttgcagaggtttcataattatttacttataaaaatagtcttcatagccgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggtgggtggatcacaaggtcaggagttcgagaccatcctggctaacacagtgaaaccccgtctctactaaaaatacaaaaaattagccgggcgtggtggcaggcacctgtagtcccagctacttaggaggctgaggcaggagaatggcgtgaacccgggaggcagagcttgcagtgagcagagattgggccactgcattccagcctgggcgacagagcaaggctccgtctaaaaaaaaaaaaaaaaaaaaaagtcttcataggccgggcacggtggctcacgtctgtaatcccagcactttgggaggccaaggtgggtggatcacaacgtcaggagatcgagaccatcctggctaacatggtgaaaccctgtctctactaaaaatataaataaattagccggacaggcgcctgtcctcccagctactcaggaggctgaggcaggagaatggtgtgaacctgggaggcggagcttgcagtgagctgagatcacgccactgcactccagcctgggcaacagagcaagactccgtctcaaaaaaaaaaaaaaaaaaaccagtcttcataagtatttgctgctacctttccctgtcataagaaaaaggatagccagacatggtgggacgccactatgatcccagctccttggaaggctaaggcacaagaatcgcttgaacctgggaggtggaggttgcagtgagctgagatcatgccactgcactccagcctggtgacagagcaagagcctgtctcaaaaaaaaaaaagaaaagaaaagaaaaagggatatcttttcctcctcccagaagtttgttttaaatttgagcatttatcatgcacctgatgtaaacctaatagtactcttgatactctagtggcttgaaaaaaaaaaaaaaggcatttctgtgctgagtctgcgcttctatgcacacaaggtatgtttataaaatactgataagcatgtcacagtatagagcataagaggcaatgtatgtatcctagtgacattagcagtgcttttccccccttaaactcctttaaaattacttttagaacttgctgctcattcttgtgaatgttatgaatggtgtcatattgtccttttacagaagatacgatttttagaaacaaatattcattgaatgtctgccctgtgagatactcactagagtgaacatgaggaggcttatgtagcaaaatggcacctacctgcaaagaacttagtccctaatggagatgaatatataataagggatcataaatgtgctaagtggatttactagtaatatgtgagccaaggacgataaagctcctgattctgatgggtatcaggaaaggcttttcaggaagtgttacttgttataggtcagaggtcagcaaactacaggttacaaccccactgcctgcttttgtaaaaaactttattggaatacagttatgcccacttgtttata
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10193 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
            GeneID:10193 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS
            GeneID:10193 -> Molecular function: GO:0005128 [erythropoietin receptor binding] evidence: IEA
            GeneID:10193 -> Molecular function: GO:0005135 [interleukin-3 receptor binding] evidence: IEA
            GeneID:10193 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:10193 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:10193 -> Molecular function: GO:0031386 [protein tag] evidence: IEA
            GeneID:10193 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: IDA
            GeneID:10193 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
            GeneID:10193 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IMP
            GeneID:10193 -> Biological process: GO:0043408 [regulation of MAPK cascade] evidence: IDA
            GeneID:10193 -> Biological process: GO:0045619 [regulation of lymphocyte differentiation] evidence: IEA
            GeneID:10193 -> Biological process: GO:0045637 [regulation of myeloid cell differentiation] evidence: IEA
            GeneID:10193 -> Biological process: GO:0051896 [regulation of protein kinase B signaling cascade] evidence: IDA
            GeneID:10193 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IDA
            GeneID:10193 -> Biological process: GO:2000377 [regulation of reactive oxygen species metabolic process] evidence: IMP
            GeneID:10193 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_919340 -> EC 6.3.2.-

by @meso_cacase at DBCLS
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