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2024-04-26 04:34:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_182776 2996 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens minichromosome maintenance complex component 7 (MCM7),
transcript variant 2, mRNA.
ACCESSION NM_182776
VERSION NM_182776.2 GI:518830595
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2996)
AUTHORS Fristrup,N., Birkenkamp-Demtroder,K., Reinert,T.,
Sanchez-Carbayo,M., Segersten,U., Malmstrom,P.U., Palou,J.,
Alvarez-Mugica,M., Pan,C.C., Ulhoi,B.P., Borre,M., Orntoft,T.F. and
Dyrskjot,L.
TITLE Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as
prognostic protein markers in non-muscle-invasive bladder cancer
JOURNAL Am. J. Pathol. 182 (2), 339-349 (2013)
PUBMED 23201130
REMARK GeneRIF: the expression of cyclin D1, MCM7, TRIM29, and UBE2C was
found to be significantly associated with progression to
muscle-invasive bladder cancer.
REFERENCE 2 (bases 1 to 2996)
AUTHORS Zhou,Y.M., Zhang,X.F., Cao,L., Li,B., Sui,C.J., Li,Y.M. and
Yin,Z.F.
TITLE MCM7 expression predicts post-operative prognosis for
hepatocellular carcinoma
JOURNAL Liver Int. 32 (10), 1505-1509 (2012)
PUBMED 22784096
REMARK GeneRIF: MCM7 expression may be a useful predictor of prognosis in
patients with hepatocellular carcinoma after resection.
REFERENCE 3 (bases 1 to 2996)
AUTHORS Liu,Y.Z., Jiang,Y.Y., Hao,J.J., Lu,S.S., Zhang,T.T., Shang,L.,
Cao,J., Song,X., Wang,B.S., Cai,Y., Zhan,Q.M. and Wang,M.R.
TITLE Prognostic significance of MCM7 expression in the bronchial
brushings of patients with non-small cell lung cancer (NSCLC)
JOURNAL Lung Cancer 77 (1), 176-182 (2012)
PUBMED 22456526
REMARK GeneRIF: MCM7 and Ki67 in tumor tissues may be potential markers of
a poor prognosis for non-small cell lung cancer patients
REFERENCE 4 (bases 1 to 2996)
AUTHORS Marnerides,A., Vassilakopoulos,T.P., Boltetsou,E., Levidou,G.,
Angelopoulou,M.K., Thymara,I., Kyrtsonis,M.C., Pappi,V., Tsopra,O.,
Panayiotidis,P., Pangalis,G.A., Beris,P., Patsouris,E. and
Korkolopoulou,P.
TITLE Immunohistochemical expression and prognostic significance of
CCND3, MCM2 and MCM7 in Hodgkin lymhoma
JOURNAL Anticancer Res. 31 (10), 3585-3594 (2011)
PUBMED 21965782
REMARK GeneRIF: Lymph node sections from 138 HL patients were
immunohistochemically stained for cyclin D3 (CCND3), MCM2 and MCM7
aiming to investigate clinical outcome.
REFERENCE 5 (bases 1 to 2996)
AUTHORS Toyokawa,G., Masuda,K., Daigo,Y., Cho,H.S., Yoshimatsu,M.,
Takawa,M., Hayami,S., Maejima,K., Chino,M., Field,H.I., Neal,D.E.,
Tsuchiya,E., Ponder,B.A., Maehara,Y., Nakamura,Y. and Hamamoto,R.
TITLE Minichromosome Maintenance Protein 7 is a potential therapeutic
target in human cancer and a novel prognostic marker of non-small
cell lung cancer
JOURNAL Mol. Cancer 10, 65 (2011)
PUBMED 21619671
REMARK GeneRIF: elevated expression of MCM7 to be associated with poor
prognosis for patients with non-small cell lung cancer
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2996)
AUTHORS Suzuki,S., Adachi,A., Hiraiwa,A., Ohashi,M., Ishibashi,M. and
Kiyono,T.
TITLE Cloning and characterization of human MCM7 promoter
JOURNAL Gene 216 (1), 85-91 (1998)
PUBMED 9714754
REFERENCE 7 (bases 1 to 2996)
AUTHORS Fujita,M., Kiyono,T., Hayashi,Y. and Ishibashi,M.
TITLE hCDC47, a human member of the MCM family. Dissociation of the
nucleus-bound form during S phase
JOURNAL J. Biol. Chem. 271 (8), 4349-4354 (1996)
PUBMED 8626784
REFERENCE 8 (bases 1 to 2996)
AUTHORS Musahl,C., Schulte,D., Burkhart,R. and Knippers,R.
TITLE A human homologue of the yeast replication protein Cdc21.
Interactions with other Mcm proteins
JOURNAL Eur. J. Biochem. 230 (3), 1096-1101 (1995)
PUBMED 7601140
REFERENCE 9 (bases 1 to 2996)
AUTHORS Nakatsuru,S., Sudo,K. and Nakamura,Y.
TITLE Isolation and mapping of a human gene (MCM2) encoding a product
homologous to yeast proteins involved in DNA replication
JOURNAL Cytogenet. Cell Genet. 68 (3-4), 226-230 (1995)
PUBMED 7842741
REFERENCE 10 (bases 1 to 2996)
AUTHORS Hu,B., Burkhart,R., Schulte,D., Musahl,C. and Knippers,R.
TITLE The P1 family: a new class of nuclear mammalian proteins related to
the yeast Mcm replication proteins
JOURNAL Nucleic Acids Res. 21 (23), 5289-5293 (1993)
PUBMED 8265339
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA253520.1, AK055379.1 and
AK226175.1.
On Jun 30, 2013 this sequence version replaced gi:33469921.
Summary: The protein encoded by this gene is one of the highly
conserved mini-chromosome maintenance proteins (MCM) that are
essential for the initiation of eukaryotic genome replication. The
hexameric protein complex formed by the MCM proteins is a key
component of the pre-replication complex (pre_RC) and may be
involved in the formation of replication forks and in the
recruitment of other DNA replication related proteins. The MCM
complex consisting of this protein and MCM2, 4 and 6 proteins
possesses DNA helicase activity, and may act as a DNA unwinding
enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate
with this protein, and may regulate the binding of this protein
with the tumorsuppressor protein RB1/RB. Alternatively spliced
transcript variants encoding distinct isoforms have been reported.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) differs at the 5' end,
contains an additional internal segment, and initiates translation
from an in-frame downstream AUG compared to variant 1. The
resulting isoform (2) has a shorter N-terminus compared to isoform
1. Variants 2 and 3 encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK055379.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-23 DA253520.1 1-23
24-2923 AK055379.1 1-2900
2924-2996 AK226175.1 2463-2535
FEATURES Location/Qualifiers
source 1..2996
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q21.3-q22.1"
gene 1..2996
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/note="minichromosome maintenance complex component 7"
/db_xref="GeneID:4176"
/db_xref="HGNC:6950"
/db_xref="HPRD:01154"
/db_xref="MIM:600592"
exon 1..568
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 569..648
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 649..813
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 814..1194
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
STS 830..1041
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/standard_name="WI-19563"
/db_xref="UniSTS:67073"
misc_feature 994..996
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/note="upstream in-frame stop codon"
CDS 1141..2772
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/EC_number="3.6.4.12"
/note="isoform 2 is encoded by transcript variant 2;
minichromosome maintenance deficient 7; DNA replication
licensing factor MCM7; homolog of S. cerevisiae Cdc47;
CDC47 homolog"
/codon_start=1
/product="DNA replication licensing factor MCM7 isoform 2"
/protein_id="NP_877577.1"
/db_xref="GI:33469922"
/db_xref="CCDS:CCDS5684.1"
/db_xref="GeneID:4176"
/db_xref="HGNC:6950"
/db_xref="HPRD:01154"
/db_xref="MIM:600592"
/translation="
MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
"
misc_feature 1141..2535
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/note="minichromosome maintenance proteins; Region: MCM;
smart00350"
/db_xref="CDD:197672"
misc_feature 1738..2157
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/note="P-loop containing Nucleoside Triphosphate
Hydrolases; Region: P-loop_NTPase; cl09099"
/db_xref="CDD:213113"
misc_feature 2257..2259
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 1195..1332
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 1333..1482
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
STS 1373..1524
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/standard_name="RH65692"
/db_xref="UniSTS:23889"
exon 1483..1597
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
STS 1490..1643
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/standard_name="RH47672"
/db_xref="UniSTS:21589"
exon 1598..1729
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 1730..1813
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
STS 1808..1948
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/standard_name="D7S2929"
/db_xref="UniSTS:33096"
exon 1814..2207
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 2208..2291
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 2292..2460
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
exon 2461..2570
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
STS 2570..2721
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/standard_name="RH78474"
/db_xref="UniSTS:37137"
exon 2571..2976
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
/inference="alignment:Splign:1.39.8"
polyA_signal 2901..2906
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
polyA_site 2924
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
polyA_signal 2949..2954
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
polyA_site 2976
/gene="MCM7"
/gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
PNAS146"
ORIGIN
agtggcgcgaggaggctggagggagtgtcgtgtaaacagtgtccttccgcgcggcggccgcggagagagctgcggcccgggggggcgtgcctgggatccggagcttcgctcgggcccgggaaaggcggcagtgggctgggatcgcggtgtctctgggtgtgatggccaatggctggactggctcccgccctgggcggaggaatcccgagctgtgaagcggctggaatccgggcccatgtgcttctttgtttactaagagcggaagcgatggcgggagcgggggtggggtgcggtggcggggtgcggtggcggaggtcccggtgaaatcaggggctaaggggacccaaagaaggcgggggatcataggggtggaaagaaagctgagaaccttgagaccggagtgtgaggggccaacggggaagggcgctagaattttaaactaaagtagggaccggaattcccctggggagatgttggatggccctgtgcactgccacgggctctttattcttcgctggttagaaacagacttgtgaaaaagagttatgcccactttggggagacttcgaaaaggttaagaagttcttacaagagttctaccaggatgatgaactcgggaagaagcagttcaagtatgggaaccagttggttcggctggctcatcgggaacaggtggctctgtatgtggacctggacgacgtagccgaggatgaccccgagttggtggactcaatttgtgagaatgccaggcgctacgcgaagctctttgctgatgccgtacaagagctgctgcctcagtacaaggagagggaagtggtaaataaagatgtcctggacgtttacattgagcatcggctaatgatggagcagcggagtcgggaccctgggatggtccgaagcccccagaaccagtaccctgctgaactcatgcgcagattgtgagtggtctctgtcgggaaagatgtagggattggttctccaggatcttgtttgtgactgttttctccccttagtgagctgtattttcaaggccctagcagcaacaagcctcgtgtgatccgggaagtgcgggctgactctgtggggaagttggtaactgtgcgtggaatcgtcactcgtgtctctgaagtcaaacccaagatggtggtggccacttacacttgtgaccagtgtggggcagagacctaccagccgatccagtctcccactttcatgcctctgatcatgtgcccaagccaggagtgccaaaccaaccgctcaggagggcggctgtatctgcagacacggggctccagattcatcaaattccaggagatgaagatgcaagaacatagtgatcaggtgcctgtgggaaatatccctcgtagtatcacggtgctggtagaaggagagaacacaaggattgcccagcctggagaccacgtcagcgtcactggtattttcttgccaatcctgcgcactgggttccgacaggtggtacagggtttactctcagaaacctacctggaagcccatcggattgtgaagatgaacaagagtgaggatgatgagtctggggctggagagctcaccagggaggagctgaggcaaattgcagaggaggatttctacgaaaagctggcagcttcaatcgccccagaaatatacgggcatgaagatgtgaagaaggcactgctgctcctgctagtcgggggtgtggaccagtctcctcgaggcatgaaaatccggggcaacatcaacatctgtctgatgggggatcctggtgtggccaagtctcagctcctgtcatacattgatcgactggcgcctcgcagccagtacacaacaggccggggctcctcaggagtggggcttacggcagctgtgctgagagactccgtgagtggagaactgaccttagagggtggggccctggtgctggctgaccagggtgtgtgctgcattgatgagttcgacaagatggctgaggccgaccgcacagccatccacgaggtcatggagcagcagaccatctccattgccaaggccggcattctcaccacactcaatgcccgctgctccatcctggctgccgccaaccctgcctacgggcgctacaaccctcgccgcagcctggagcagaacatacagctacctgctgcactgctctcccggtttgacctcctctggctgattcaggaccggcccgaccgagacaatgacctacggttggcccagcacatcacctatgtgcaccagcacagccggcagcccccctcccagtttgaacctctggacatgaagctcatgaggcgttacatagccatgtgccgcgagaagcagcccatggtgccagagtctctggctgactacatcacagcagcatacgtggagatgaggcgagaggcttgggctagtaaggatgccacctatacttctgcccggaccctgctggctatcctgcgcctttccactgctctggcacgtctgagaatggtggatgtggtggagaaagaagatgtgaatgaagccatcaggctaatggagatgtcaaaggactctcttctaggagacaaggggcagacagctaggactcagagaccagcagatgtgatatttgccaccgtccgtgaactggtctcagggggccgaagtgtccggttctctgaggcagagcagcgctgtgtatctcgtggcttcacacccgcccagttccaggcggctctggatgaatatgaggagctcaatgtctggcaggtcaatgcttcccggacacggatcacttttgtctgattccagcctgcttgcaaccctggggtcctcttgttccctgctggcctgccccttgggaaggggcagtgatgcctttgaggggaaggaggagcccctctttctcccatgctgcacttactccttttgctaataaaagtgtttgtagattgtcatcttctagcctgggcctgacttccattaaaacagggttttgtgcgttttttaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4176 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:4176 -> Molecular function: GO:0003697 [single-stranded DNA binding] evidence: IEA
GeneID:4176 -> Molecular function: GO:0004003 [ATP-dependent DNA helicase activity] evidence: IDA
GeneID:4176 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4176 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4176 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:4176 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:4176 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:4176 -> Biological process: GO:0006268 [DNA unwinding involved in DNA replication] evidence: IEA
GeneID:4176 -> Biological process: GO:0006270 [DNA replication initiation] evidence: IEA
GeneID:4176 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS
GeneID:4176 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
GeneID:4176 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
GeneID:4176 -> Biological process: GO:0042325 [regulation of phosphorylation] evidence: IMP
GeneID:4176 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:4176 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA
GeneID:4176 -> Cellular component: GO:0000785 [chromatin] evidence: TAS
GeneID:4176 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:4176 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:4176 -> Cellular component: GO:0042555 [MCM complex] evidence: IDA
GeneID:4176 -> Cellular component: GO:0042555 [MCM complex] evidence: IMP
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_877577 -> EC 3.6.4.12
by
@meso_cacase at
DBCLS
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