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2018-11-22 02:51:06, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_182776               2996 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens minichromosome maintenance complex component 7 (MCM7),
            transcript variant 2, mRNA.
ACCESSION   NM_182776
VERSION     NM_182776.2  GI:518830595
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Fristrup,N., Birkenkamp-Demtroder,K., Reinert,T.,
            Sanchez-Carbayo,M., Segersten,U., Malmstrom,P.U., Palou,J.,
            Alvarez-Mugica,M., Pan,C.C., Ulhoi,B.P., Borre,M., Orntoft,T.F. and
            Dyrskjot,L.
  TITLE     Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as
            prognostic protein markers in non-muscle-invasive bladder cancer
  JOURNAL   Am. J. Pathol. 182 (2), 339-349 (2013)
   PUBMED   23201130
  REMARK    GeneRIF: the expression of cyclin D1, MCM7, TRIM29, and UBE2C was
            found to be significantly associated with progression to
            muscle-invasive bladder cancer.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Zhou,Y.M., Zhang,X.F., Cao,L., Li,B., Sui,C.J., Li,Y.M. and
            Yin,Z.F.
  TITLE     MCM7 expression predicts post-operative prognosis for
            hepatocellular carcinoma
  JOURNAL   Liver Int. 32 (10), 1505-1509 (2012)
   PUBMED   22784096
  REMARK    GeneRIF: MCM7 expression may be a useful predictor of prognosis in
            patients with hepatocellular carcinoma after resection.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Liu,Y.Z., Jiang,Y.Y., Hao,J.J., Lu,S.S., Zhang,T.T., Shang,L.,
            Cao,J., Song,X., Wang,B.S., Cai,Y., Zhan,Q.M. and Wang,M.R.
  TITLE     Prognostic significance of MCM7 expression in the bronchial
            brushings of patients with non-small cell lung cancer (NSCLC)
  JOURNAL   Lung Cancer 77 (1), 176-182 (2012)
   PUBMED   22456526
  REMARK    GeneRIF: MCM7 and Ki67 in tumor tissues may be potential markers of
            a poor prognosis for non-small cell lung cancer patients
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Marnerides,A., Vassilakopoulos,T.P., Boltetsou,E., Levidou,G.,
            Angelopoulou,M.K., Thymara,I., Kyrtsonis,M.C., Pappi,V., Tsopra,O.,
            Panayiotidis,P., Pangalis,G.A., Beris,P., Patsouris,E. and
            Korkolopoulou,P.
  TITLE     Immunohistochemical expression and prognostic significance of
            CCND3, MCM2 and MCM7 in Hodgkin lymhoma
  JOURNAL   Anticancer Res. 31 (10), 3585-3594 (2011)
   PUBMED   21965782
  REMARK    GeneRIF: Lymph node sections from 138 HL patients were
            immunohistochemically stained for cyclin D3 (CCND3), MCM2 and MCM7
            aiming to investigate clinical outcome.
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Toyokawa,G., Masuda,K., Daigo,Y., Cho,H.S., Yoshimatsu,M.,
            Takawa,M., Hayami,S., Maejima,K., Chino,M., Field,H.I., Neal,D.E.,
            Tsuchiya,E., Ponder,B.A., Maehara,Y., Nakamura,Y. and Hamamoto,R.
  TITLE     Minichromosome Maintenance Protein 7 is a potential therapeutic
            target in human cancer and a novel prognostic marker of non-small
            cell lung cancer
  JOURNAL   Mol. Cancer 10, 65 (2011)
   PUBMED   21619671
  REMARK    GeneRIF: elevated expression of MCM7 to be associated with poor
            prognosis for patients with non-small cell lung cancer
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Suzuki,S., Adachi,A., Hiraiwa,A., Ohashi,M., Ishibashi,M. and
            Kiyono,T.
  TITLE     Cloning and characterization of human MCM7 promoter
  JOURNAL   Gene 216 (1), 85-91 (1998)
   PUBMED   9714754
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Fujita,M., Kiyono,T., Hayashi,Y. and Ishibashi,M.
  TITLE     hCDC47, a human member of the MCM family. Dissociation of the
            nucleus-bound form during S phase
  JOURNAL   J. Biol. Chem. 271 (8), 4349-4354 (1996)
   PUBMED   8626784
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Musahl,C., Schulte,D., Burkhart,R. and Knippers,R.
  TITLE     A human homologue of the yeast replication protein Cdc21.
            Interactions with other Mcm proteins
  JOURNAL   Eur. J. Biochem. 230 (3), 1096-1101 (1995)
   PUBMED   7601140
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Nakatsuru,S., Sudo,K. and Nakamura,Y.
  TITLE     Isolation and mapping of a human gene (MCM2) encoding a product
            homologous to yeast proteins involved in DNA replication
  JOURNAL   Cytogenet. Cell Genet. 68 (3-4), 226-230 (1995)
   PUBMED   7842741
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Hu,B., Burkhart,R., Schulte,D., Musahl,C. and Knippers,R.
  TITLE     The P1 family: a new class of nuclear mammalian proteins related to
            the yeast Mcm replication proteins
  JOURNAL   Nucleic Acids Res. 21 (23), 5289-5293 (1993)
   PUBMED   8265339
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA253520.1, AK055379.1 and
            AK226175.1.
            On Jun 30, 2013 this sequence version replaced gi:33469921.
            
            Summary: The protein encoded by this gene is one of the highly
            conserved mini-chromosome maintenance proteins (MCM) that are
            essential for the initiation of eukaryotic genome replication. The
            hexameric protein complex formed by the MCM proteins is a key
            component of the pre-replication complex (pre_RC) and may be
            involved in the formation of replication forks and in the
            recruitment of other DNA replication related proteins. The MCM
            complex consisting of this protein and MCM2, 4 and 6 proteins
            possesses DNA helicase activity, and may act as a DNA unwinding
            enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate
            with this protein, and may regulate the binding of this protein
            with the tumorsuppressor protein RB1/RB. Alternatively spliced
            transcript variants encoding distinct isoforms have been reported.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs at the 5' end,
            contains an additional internal segment, and initiates translation
            from an in-frame downstream AUG compared to variant 1. The
            resulting isoform (2) has a shorter N-terminus compared to isoform
            1. Variants 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA253520.1         1-23
            24-2923             AK055379.1         1-2900
            2924-2996           AK226175.1         2463-2535
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3-q22.1"
     gene            1..2996
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /note="minichromosome maintenance complex component 7"
                     /db_xref="GeneID:4176"
                     /db_xref="HGNC:6950"
                     /db_xref="HPRD:01154"
                     /db_xref="MIM:600592"
     exon            1..568
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            569..648
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            649..813
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            814..1194
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     STS             830..1041
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /standard_name="WI-19563"
                     /db_xref="UniSTS:67073"
     misc_feature    994..996
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /note="upstream in-frame stop codon"
     CDS             1141..2772
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /EC_number="3.6.4.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     minichromosome maintenance deficient 7; DNA replication
                     licensing factor MCM7; homolog of S. cerevisiae Cdc47;
                     CDC47 homolog"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM7 isoform 2"
                     /protein_id="NP_877577.1"
                     /db_xref="GI:33469922"
                     /db_xref="CCDS:CCDS5684.1"
                     /db_xref="GeneID:4176"
                     /db_xref="HGNC:6950"
                     /db_xref="HPRD:01154"
                     /db_xref="MIM:600592"
                     /translation="
MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
"
     misc_feature    1141..2535
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /note="minichromosome maintenance proteins; Region: MCM;
                     smart00350"
                     /db_xref="CDD:197672"
     misc_feature    1738..2157
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /note="P-loop containing Nucleoside Triphosphate
                     Hydrolases; Region: P-loop_NTPase; cl09099"
                     /db_xref="CDD:213113"
     misc_feature    2257..2259
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            1195..1332
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            1333..1482
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     STS             1373..1524
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /standard_name="RH65692"
                     /db_xref="UniSTS:23889"
     exon            1483..1597
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     STS             1490..1643
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /standard_name="RH47672"
                     /db_xref="UniSTS:21589"
     exon            1598..1729
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            1730..1813
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     STS             1808..1948
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /standard_name="D7S2929"
                     /db_xref="UniSTS:33096"
     exon            1814..2207
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            2208..2291
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            2292..2460
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     exon            2461..2570
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     STS             2570..2721
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /standard_name="RH78474"
                     /db_xref="UniSTS:37137"
     exon            2571..2976
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    2901..2906
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
     polyA_site      2924
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
     polyA_signal    2949..2954
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
     polyA_site      2976
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146"
ORIGIN      
agtggcgcgaggaggctggagggagtgtcgtgtaaacagtgtccttccgcgcggcggccgcggagagagctgcggcccgggggggcgtgcctgggatccggagcttcgctcgggcccgggaaaggcggcagtgggctgggatcgcggtgtctctgggtgtgatggccaatggctggactggctcccgccctgggcggaggaatcccgagctgtgaagcggctggaatccgggcccatgtgcttctttgtttactaagagcggaagcgatggcgggagcgggggtggggtgcggtggcggggtgcggtggcggaggtcccggtgaaatcaggggctaaggggacccaaagaaggcgggggatcataggggtggaaagaaagctgagaaccttgagaccggagtgtgaggggccaacggggaagggcgctagaattttaaactaaagtagggaccggaattcccctggggagatgttggatggccctgtgcactgccacgggctctttattcttcgctggttagaaacagacttgtgaaaaagagttatgcccactttggggagacttcgaaaaggttaagaagttcttacaagagttctaccaggatgatgaactcgggaagaagcagttcaagtatgggaaccagttggttcggctggctcatcgggaacaggtggctctgtatgtggacctggacgacgtagccgaggatgaccccgagttggtggactcaatttgtgagaatgccaggcgctacgcgaagctctttgctgatgccgtacaagagctgctgcctcagtacaaggagagggaagtggtaaataaagatgtcctggacgtttacattgagcatcggctaatgatggagcagcggagtcgggaccctgggatggtccgaagcccccagaaccagtaccctgctgaactcatgcgcagattgtgagtggtctctgtcgggaaagatgtagggattggttctccaggatcttgtttgtgactgttttctccccttagtgagctgtattttcaaggccctagcagcaacaagcctcgtgtgatccgggaagtgcgggctgactctgtggggaagttggtaactgtgcgtggaatcgtcactcgtgtctctgaagtcaaacccaagatggtggtggccacttacacttgtgaccagtgtggggcagagacctaccagccgatccagtctcccactttcatgcctctgatcatgtgcccaagccaggagtgccaaaccaaccgctcaggagggcggctgtatctgcagacacggggctccagattcatcaaattccaggagatgaagatgcaagaacatagtgatcaggtgcctgtgggaaatatccctcgtagtatcacggtgctggtagaaggagagaacacaaggattgcccagcctggagaccacgtcagcgtcactggtattttcttgccaatcctgcgcactgggttccgacaggtggtacagggtttactctcagaaacctacctggaagcccatcggattgtgaagatgaacaagagtgaggatgatgagtctggggctggagagctcaccagggaggagctgaggcaaattgcagaggaggatttctacgaaaagctggcagcttcaatcgccccagaaatatacgggcatgaagatgtgaagaaggcactgctgctcctgctagtcgggggtgtggaccagtctcctcgaggcatgaaaatccggggcaacatcaacatctgtctgatgggggatcctggtgtggccaagtctcagctcctgtcatacattgatcgactggcgcctcgcagccagtacacaacaggccggggctcctcaggagtggggcttacggcagctgtgctgagagactccgtgagtggagaactgaccttagagggtggggccctggtgctggctgaccagggtgtgtgctgcattgatgagttcgacaagatggctgaggccgaccgcacagccatccacgaggtcatggagcagcagaccatctccattgccaaggccggcattctcaccacactcaatgcccgctgctccatcctggctgccgccaaccctgcctacgggcgctacaaccctcgccgcagcctggagcagaacatacagctacctgctgcactgctctcccggtttgacctcctctggctgattcaggaccggcccgaccgagacaatgacctacggttggcccagcacatcacctatgtgcaccagcacagccggcagcccccctcccagtttgaacctctggacatgaagctcatgaggcgttacatagccatgtgccgcgagaagcagcccatggtgccagagtctctggctgactacatcacagcagcatacgtggagatgaggcgagaggcttgggctagtaaggatgccacctatacttctgcccggaccctgctggctatcctgcgcctttccactgctctggcacgtctgagaatggtggatgtggtggagaaagaagatgtgaatgaagccatcaggctaatggagatgtcaaaggactctcttctaggagacaaggggcagacagctaggactcagagaccagcagatgtgatatttgccaccgtccgtgaactggtctcagggggccgaagtgtccggttctctgaggcagagcagcgctgtgtatctcgtggcttcacacccgcccagttccaggcggctctggatgaatatgaggagctcaatgtctggcaggtcaatgcttcccggacacggatcacttttgtctgattccagcctgcttgcaaccctggggtcctcttgttccctgctggcctgccccttgggaaggggcagtgatgcctttgaggggaaggaggagcccctctttctcccatgctgcacttactccttttgctaataaaagtgtttgtagattgtcatcttctagcctgggcctgacttccattaaaacagggttttgtgcgttttttaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4176 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
            GeneID:4176 -> Molecular function: GO:0003697 [single-stranded DNA binding] evidence: IEA
            GeneID:4176 -> Molecular function: GO:0004003 [ATP-dependent DNA helicase activity] evidence: IDA
            GeneID:4176 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4176 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:4176 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:4176 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:4176 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
            GeneID:4176 -> Biological process: GO:0006268 [DNA unwinding involved in DNA replication] evidence: IEA
            GeneID:4176 -> Biological process: GO:0006270 [DNA replication initiation] evidence: IEA
            GeneID:4176 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS
            GeneID:4176 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
            GeneID:4176 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
            GeneID:4176 -> Biological process: GO:0042325 [regulation of phosphorylation] evidence: IMP
            GeneID:4176 -> Biological process: GO:0042493 [response to drug] evidence: IEA
            GeneID:4176 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA
            GeneID:4176 -> Cellular component: GO:0000785 [chromatin] evidence: TAS
            GeneID:4176 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:4176 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:4176 -> Cellular component: GO:0042555 [MCM complex] evidence: IDA
            GeneID:4176 -> Cellular component: GO:0042555 [MCM complex] evidence: IMP
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_877577 -> EC 3.6.4.12

by @meso_cacase at DBCLS
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