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2024-04-25 19:08:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_182710 2347 bp mRNA linear PRI 08-JUL-2013
DEFINITION Homo sapiens K(lysine) acetyltransferase 5 (KAT5), transcript
variant 1, mRNA.
ACCESSION NM_182710
VERSION NM_182710.2 GI:332205929
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2347)
AUTHORS Kaidi,A. and Jackson,S.P.
TITLE KAT5 tyrosine phosphorylation couples chromatin sensing to ATM
signalling
JOURNAL Nature 498 (7452), 70-74 (2013)
PUBMED 23708966
REMARK GeneRIF: tyrosine phosphorylation of KAT5 increases after DNA
damage in a manner that promotes KAT5 binding to the histone mark
H3K9me3; this triggers KAT5-mediated acetylation of the ATM kinase,
promoting DNA-damage-checkpoint activation and cell survival
REFERENCE 2 (bases 1 to 2347)
AUTHORS Jha,S., Gupta,A., Dar,A. and Dutta,A.
TITLE RVBs are required for assembling a functional TIP60 complex
JOURNAL Mol. Cell. Biol. 33 (6), 1164-1174 (2013)
PUBMED 23297341
REMARK GeneRIF: RVBs are also required for heat stability of TIP60.com by
a p400-independent pathway.
REFERENCE 3 (bases 1 to 2347)
AUTHORS Muller,T., Schrotter,A., Loosse,C., Pfeiffer,K., Theiss,C.,
Kauth,M., Meyer,H.E. and Marcus,K.
TITLE A ternary complex consisting of AICD, FE65, and TIP60
down-regulates Stathmin1
JOURNAL Biochim. Biophys. Acta 1834 (1), 387-394 (2013)
PUBMED 22902274
REMARK GeneRIF: A ternary complex consisting of AICD, FE65, and TIP60
down-regulates Stathmin1.
REFERENCE 4 (bases 1 to 2347)
AUTHORS Laurberg,J.R., Brems-Eskildsen,A.S., Nordentoft,I., Fristrup,N.,
Schepeler,T., Ulhoi,B.P., Agerbaek,M., Hartmann,A., Bertz,S.,
Wittlinger,M., Fietkau,R., Rodel,C., Borre,M., Jensen,J.B.,
Orntoft,T. and Dyrskjot,L.
TITLE Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic
recombination 11 homolog) predict treatment-specific outcome of
localised invasive bladder cancer
JOURNAL BJU Int. 110 (11 PT C), E1228-E1236 (2012)
PUBMED 23046361
REMARK GeneRIF: TIP60 protein expression was a predictive marker for DSS
after cystectomy in two independent cohorts. This novel marker was
the strongest predictive factor in multivariate analysis in
patients receiving cystectomy.
REFERENCE 5 (bases 1 to 2347)
AUTHORS Coffey,K., Blackburn,T.J., Cook,S., Golding,B.T., Griffin,R.J.,
Hardcastle,I.R., Hewitt,L., Huberman,K., McNeill,H.V., Newell,D.R.,
Roche,C., Ryan-Munden,C.A., Watson,A. and Robson,C.N.
TITLE Characterisation of a Tip60 specific inhibitor, NU9056, in prostate
cancer
JOURNAL PLoS ONE 7 (10), E45539 (2012)
PUBMED 23056207
REMARK GeneRIF: Studies indicate histone acetyltransferase Tip60 as a
potential therapeutic target for the treatment of prostate cancer.
REFERENCE 6 (bases 1 to 2347)
AUTHORS Brady,M.E., Ozanne,D.M., Gaughan,L., Waite,I., Cook,S., Neal,D.E.
and Robson,C.N.
TITLE Tip60 is a nuclear hormone receptor coactivator
JOURNAL J. Biol. Chem. 274 (25), 17599-17604 (1999)
PUBMED 10364196
REFERENCE 7 (bases 1 to 2347)
AUTHORS Dechend,R., Hirano,F., Lehmann,K., Heissmeyer,V., Ansieau,S.,
Wulczyn,F.G., Scheidereit,C. and Leutz,A.
TITLE The Bcl-3 oncoprotein acts as a bridging factor between
NF-kappaB/Rel and nuclear co-regulators
JOURNAL Oncogene 18 (22), 3316-3323 (1999)
PUBMED 10362352
REFERENCE 8 (bases 1 to 2347)
AUTHORS Kimura,A. and Horikoshi,M.
TITLE Tip60 acetylates six lysines of a specific class in core histones
in vitro
JOURNAL Genes Cells 3 (12), 789-800 (1998)
PUBMED 10096020
REFERENCE 9 (bases 1 to 2347)
AUTHORS Yamamoto,T. and Horikoshi,M.
TITLE Novel substrate specificity of the histone acetyltransferase
activity of HIV-1-Tat interactive protein Tip60
JOURNAL J. Biol. Chem. 272 (49), 30595-30598 (1997)
PUBMED 9388189
REFERENCE 10 (bases 1 to 2347)
AUTHORS Kamine,J., Elangovan,B., Subramanian,T., Coleman,D. and
Chinnadurai,G.
TITLE Identification of a cellular protein that specifically interacts
with the essential cysteine region of the HIV-1 Tat transactivator
JOURNAL Virology 216 (2), 357-366 (1996)
PUBMED 8607265
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB003934.1, DB103287.1,
BC013211.1 and BU737532.1.
This sequence is a reference standard in the RefSeqGene project.
On May 6, 2011 this sequence version replaced gi:36287068.
Summary: The protein encoded by this gene belongs to the MYST
family of histone acetyl transferases (HATs) and was originally
isolated as an HIV-1 TAT-interactive protein. HATs play important
roles in regulating chromatin remodeling, transcription and other
nuclear processes by acetylating histone and nonhistone proteins.
This protein is a histone acetylase that has a role in DNA repair
and apoptosis and is thought to play an important role in signal
transduction. Alternative splicing of this gene results in multiple
transcript variants. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) encodes the longest protein
(isoform 1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC013211.1, U40989.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-110 DB003934.1 1-110
111-282 DB103287.1 78-249
283-2314 BC013211.1 1-2032
2315-2347 BU737532.1 1-33 c
FEATURES Location/Qualifiers
source 1..2347
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13"
gene 1..2347
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="K(lysine) acetyltransferase 5"
/db_xref="GeneID:10524"
/db_xref="HGNC:5275"
/db_xref="HPRD:03245"
/db_xref="MIM:601409"
exon 1..444
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 35..36
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace=""
/replace="cc"
/db_xref="dbSNP:139060964"
variation 35
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:4645910"
variation 106
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace=""
/replace="c"
/db_xref="dbSNP:373551156"
variation 118
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="t"
/db_xref="dbSNP:4645911"
variation 156
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112313136"
variation 185
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375270159"
misc_feature 222..224
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="upstream in-frame stop codon"
variation 234
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:71455780"
variation 251
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201205470"
variation 255
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:186911544"
variation 259
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:375275397"
variation 262
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367676300"
CDS 267..1907
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/EC_number="2.3.1.48"
/note="isoform 1 is encoded by transcript variant 1; cPLA2
interacting protein; HIV-1 Tat interactive protein, 60kDa;
K-acetyltransferase 5; Tat interacting protein, 60kDa;
histone acetyltransferase KAT5; cPLA(2)-interacting
protein; 60 kDa Tat-interactive protein; histone
acetyltransferase HTATIP"
/codon_start=1
/product="histone acetyltransferase KAT5 isoform 1"
/protein_id="NP_874369.1"
/db_xref="GI:36287069"
/db_xref="CCDS:CCDS8110.1"
/db_xref="GeneID:10524"
/db_xref="HGNC:5275"
/db_xref="HPRD:03245"
/db_xref="MIM:601409"
/translation="
MAEVVSPVPGAGRREPGEVGRARGPPVADPGVALSPQGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
"
misc_feature 435..593
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="Chromatin organization modifier (chromo) domain is
a conserved region of around 50 amino acids found in a
variety of chromosomal proteins, which appear to play a
role in the functional organization of the eukaryotic
nucleus. Experimental evidence...; Region: CHROMO;
cd00024"
/db_xref="CDD:28908"
misc_feature order(441..443,498..500,504..506,513..515,525..527,
537..539,549..554)
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="histone binding site; other site"
/db_xref="CDD:28908"
misc_feature 621..623
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00302"
misc_feature 621..623
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00454"
misc_feature 633..635
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00302"
misc_feature 633..635
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00454"
misc_feature 1020..1883
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="probable histone acetyltransferase MYST;
Provisional; Region: PLN03238"
/db_xref="CDD:178776"
misc_feature 1167..1169
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:02534"
misc_feature 1167..1169
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:04078"
misc_feature 1209..1211
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:04078"
misc_feature 1209..1211
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/experiment="experimental evidence, no additional details
recorded"
/note="acetylation site"
/db_xref="HPRD:02534"
misc_feature 1218..1796
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/note="MOZ/SAS family; Region: MOZ_SAS; pfam01853"
/db_xref="CDD:202012"
variation 273
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:71455781"
variation 285
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:371801645"
variation 345
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149844051"
variation 351
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:202097241"
variation 361
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="t"
/db_xref="dbSNP:146788368"
variation 383
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:140468859"
variation 395
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145735863"
variation 413
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138317008"
exon 445..513
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 458
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149093594"
variation 464
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:4645914"
exon 514..650
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 591
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:369527314"
variation 597
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:11541271"
variation 599
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:11541269"
variation 608
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372595844"
variation 615
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:115896676"
variation 616
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:11541270"
variation 632
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:116830965"
variation 641
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201415653"
exon 651..806
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 655
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201831239"
variation 661
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369250083"
variation 687
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201410482"
variation 708
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148238235"
variation 722
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:141373536"
variation 723
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:78447196"
variation 725
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377518842"
variation 757
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200103121"
exon 807..881
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 851
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147419775"
variation 860
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:137945879"
exon 882..956
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 889
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143413716"
variation 904
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:386834229"
variation 910
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369137034"
variation 922
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372880133"
variation 935
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201879725"
exon 957..1205
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 974
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368421147"
variation 979
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:200974760"
variation 1023
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:4645921"
variation 1031
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371854405"
variation 1062
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:139506891"
variation 1081
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200620312"
variation 1086
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149683297"
variation 1097
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144349144"
variation 1134
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:114058675"
variation 1139
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368796194"
variation 1172
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:111345240"
variation 1175
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148757761"
exon 1206..1295
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1210
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:111512947"
variation 1248
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143910658"
exon 1296..1436
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1310
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376820640"
variation 1330
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368959604"
variation 1349
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146875234"
variation 1376
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/db_xref="dbSNP:140561633"
variation 1383
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199667540"
variation 1389
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377274648"
variation 1406
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144191296"
exon 1437..1530
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1463
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200248772"
variation 1508
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146588319"
variation 1526
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201020447"
exon 1531..1690
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1562
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:11227272"
variation 1632
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370970433"
variation 1652
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150212692"
variation 1663
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:375524599"
variation 1664
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:114460328"
variation 1682
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:368492530"
exon 1691..1772
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1753
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200625753"
exon 1773..2332
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/inference="alignment:Splign:1.39.8"
variation 1828
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145568166"
variation 1851
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199674306"
variation 1853
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:11385"
variation 1936
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199779470"
variation 1937
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200332583"
variation 1939
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201309659"
variation 1957
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370375120"
variation 1967
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:186106053"
STS 2086..2301
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="IB3011"
/db_xref="UniSTS:46906"
STS 2087..2317
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="STS-U40989"
/db_xref="UniSTS:64845"
STS 2129..2328
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="HSC0AE062"
/db_xref="UniSTS:47861"
variation 2138
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375782368"
STS 2159..2292
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/standard_name="RH18259"
/db_xref="UniSTS:56059"
variation 2199
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:190723966"
variation 2251
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="g"
/db_xref="dbSNP:554051"
variation 2254
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="g"
/replace="t"
/db_xref="dbSNP:199982885"
polyA_signal 2309..2314
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
variation 2321
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="c"
/replace="t"
/db_xref="dbSNP:3177082"
polyA_site 2330
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
variation 2331
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
/replace="a"
/replace="g"
/db_xref="dbSNP:3180585"
polyA_site 2332
/gene="KAT5"
/gene_synonym="cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP;
TIP60; ZC2HC5"
ORIGIN
gcacccggtgggcgtcacgtgacggactcagtagaccgccactggctgtgcacgttatggggtttccacctagggctcggcctgaggcttgtaacactccgttttcccccgagtcacaggggcagtcttgcccctcgcagctgggtcgcggtgtctctcaaaggtccccctctacaggggcttcgtgaggcccgggcccacagggcgctcggtcccggaagtgacgtctcccagaggggccggaagtggcagtggagggagggaagatggcggaggtggtgagtccggtgcccggggcggggcggagggagccaggggaggtgggtagagcccgaggccccccagtagccgaccctggcgtcgcgctgtctccccagggggagataatcgagggctgccgcctacccgtgctgcggcggaaccaggacaacgaagatgagtggcccctggccgagatcctgagcgtgaaggacatcagtggccggaagcttttctacgtccattacattgacttcaacaaacgtctggatgaatgggtgacgcatgagcggctggacctaaagaagatccagttccccaagaaagaggccaagacccccactaagaacggacttcctgggtcccgtcctggctctccagagagagaggtgccggcctcggcgcaggccagcgggaagaccttgccaatcccggtccagatcacactccgcttcaacctgcccaaggagcgggaggccattcccggtggcgagcctgaccagccgctctcctccagctcctgcctgcagcccaaccaccgctcaacgaaacggaaggtggaggtggtttcaccagcaactccagtgcccagcgagacagccccggcctcggtttttccccagaatggagccgcccgtagggcagtggcagcccagccaggacggaagcgaaaatcgaattgtttgggcactgatgaggactcccaggacagctctgatggaataccgtcagcaccacgcatgactggcagcctggtgtctgatcgaagccacgacgacatcgtcacccggatgaagaacattgagtgcattgagctgggccggcaccgcctcaagccgtggtacttctccccgtacccacaggaactcaccacattgcctgtcctctacctgtgcgagttctgcctcaagtacggccgtagtctcaagtgtcttcagcgtcatttgaccaagtgtgacctacgacatcctccaggcaatgagatttaccgcaagggcaccatctccttctttgagattgatggacgtaagaacaagagttattcccagaacctgtgtcttttggccaagtgtttccttgaccataagacactgtactatgacacagaccctttcctcttctacgtcatgacagagtatgactgtaagggcttccacatcgtgggctacttctccaaggagaaagaatcaacggaagactacaatgtggcctgcatcctaaccctgcctccctaccagcgccggggctacggcaagctgctgatcgagttcagctatgaactctccaaagtggaagggaaaacagggacccctgagaagcccctctcagaccttggcctcctatcctatcgaagctactggtcccagaccatcctggagatcctgatggggctgaagtcggagagcggggagaggccacagatcaccatcaatgagattagtgaaatcaccagcatcaagaaggaggatgtcatctccactctgcagtacctcaatctcatcaactactacaagggccagtacatcctcacactgtcagaggacatcgtggatggccatgagcgggccatgctcaagcggctcctgcggatcgactccaagtgtctgcacttcactcccaaggactggagcaagagggggaagtggtgaccagacactgcccactgcagtgccaagacggcagcaggactggggctgatagcccaccccgcccccactgcagctcccacaaagcactctaagggagatggggctgaggacagctcaaaaaggagaggacaggcctggcaggggcccactggtgcccagcaccaaggcgagctccgggctcagaccaactccaaggtcagctggccacaggcccaggcctcctctgaagcagggaccagagggagccaggcagctgtgtacagtgagaagggatccggatgggggagctctgtacagagggctggtgattgtaaaaatttcttttgtaaagtagaagttgggggtggggtgggtgctggctgcaaaaatttctggcttctcttacccctattgcccccggcaataaattgtttctatatgccagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10524 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: IDA
GeneID:10524 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS
GeneID:10524 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
GeneID:10524 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10524 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
GeneID:10524 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:10524 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: NAS
GeneID:10524 -> Molecular function: GO:0070491 [repressing transcription factor binding] evidence: IPI
GeneID:10524 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:10524 -> Biological process: GO:0006302 [double-strand break repair] evidence: IMP
GeneID:10524 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:10524 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IDA
GeneID:10524 -> Biological process: GO:0016573 [histone acetylation] evidence: IDA
GeneID:10524 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:10524 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: NAS
GeneID:10524 -> Biological process: GO:0032703 [negative regulation of interleukin-2 production] evidence: IDA
GeneID:10524 -> Biological process: GO:0040008 [regulation of growth] evidence: IEA
GeneID:10524 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:10524 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:10524 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
GeneID:10524 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:10524 -> Cellular component: GO:0000785 [chromatin] evidence: IEA
GeneID:10524 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10524 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:10524 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:10524 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:10524 -> Cellular component: GO:0032777 [Piccolo NuA4 histone acetyltransferase complex] evidence: IDA
GeneID:10524 -> Cellular component: GO:0035267 [NuA4 histone acetyltransferase complex] evidence: IDA
GeneID:10524 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_874369 -> EC 2.3.1.48
by
@meso_cacase at
DBCLS
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