Home |
Help |
Advanced search
2024-04-25 10:24:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_182575 1621 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens izumo sperm-egg fusion 1 (IZUMO1), mRNA.
ACCESSION NM_182575
VERSION NM_182575.2 GI:194097474
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1621)
AUTHORS Chu,A.Y., Workalemahu,T., Paynter,N.P., Rose,L.M., Giulianini,F.,
Tanaka,T., Ngwa,J.S., Qi,Q., Curhan,G.C., Rimm,E.B., Hunter,D.J.,
Pasquale,L.R., Ridker,P.M., Hu,F.B., Chasman,D.I. and Qi,L.
CONSRTM CHARGE Nutrition Working Group; DietGen Consortium
TITLE Novel locus including FGF21 is associated with dietary
macronutrient intake
JOURNAL Hum. Mol. Genet. 22 (9), 1895-1902 (2013)
PUBMED 23372041
REFERENCE 2 (bases 1 to 1621)
AUTHORS Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
Vermeire,S., Barrett,J.C. and Cho,J.H.
CONSRTM International IBD Genetics Consortium (IIBDGC)
TITLE Host-microbe interactions have shaped the genetic architecture of
inflammatory bowel disease
JOURNAL Nature 491 (7422), 119-124 (2012)
PUBMED 23128233
REFERENCE 3 (bases 1 to 1621)
AUTHORS Grayson,P. and Civetta,A.
TITLE Positive Selection and the Evolution of izumo Genes in Mammals
JOURNAL Int J Evol Biol 2012, 958164 (2012)
PUBMED 22957301
REFERENCE 4 (bases 1 to 1621)
CONSRTM Psychiatric GWAS Consortium Bipolar Disorder Working Group
TITLE Large-scale genome-wide association analysis of bipolar disorder
identifies a new susceptibility locus near ODZ4
JOURNAL Nat. Genet. 43 (10), 977-983 (2011)
PUBMED 21926972
REMARK Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
[added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
[corrected to Meng, Fan]]
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1621)
AUTHORS Ikram,M.K., Sim,X., Jensen,R.A., Cotch,M.F., Hewitt,A.W.,
Ikram,M.A., Wang,J.J., Klein,R., Klein,B.E., Breteler,M.M.,
Cheung,N., Liew,G., Mitchell,P., Uitterlinden,A.G., Rivadeneira,F.,
Hofman,A., de Jong,P.T., van Duijn,C.M., Kao,L., Cheng,C.Y.,
Smith,A.V., Glazer,N.L., Lumley,T., McKnight,B., Psaty,B.M.,
Jonasson,F., Eiriksdottir,G., Aspelund,T., Harris,T.B.,
Launer,L.J., Taylor,K.D., Li,X., Iyengar,S.K., Xi,Q.,
Sivakumaran,T.A., Mackey,D.A., Macgregor,S., Martin,N.G.,
Young,T.L., Bis,J.C., Wiggins,K.L., Heckbert,S.R., Hammond,C.J.,
Andrew,T., Fahy,S., Attia,J., Holliday,E.G., Scott,R.J.,
Islam,F.M., Rotter,J.I., McAuley,A.K., Boerwinkle,E., Tai,E.S.,
Gudnason,V., Siscovick,D.S., Vingerling,J.R. and Wong,T.Y.
CONSRTM Global BPgen Consortium
TITLE Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the
microcirculation in vivo
JOURNAL PLoS Genet. 6 (10), E1001184 (2010)
PUBMED 21060863
REMARK Erratum:[PLoS Genet. 2010;6(11). doi:
10.1371/annotation/841bfadf-85d1-4059-894f-2863d73fa963. Xueling,
Sim [corrected to Sim, Xueling]]
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1621)
AUTHORS Ellerman,D.A., Pei,J., Gupta,S., Snell,W.J., Myles,D. and
Primakoff,P.
TITLE Izumo is part of a multiprotein family whose members form large
complexes on mammalian sperm
JOURNAL Mol. Reprod. Dev. 76 (12), 1188-1199 (2009)
PUBMED 19658160
REFERENCE 7 (bases 1 to 1621)
AUTHORS Inoue,N., Ikawa,M. and Okabe,M.
TITLE Putative sperm fusion protein IZUMO and the role of N-glycosylation
JOURNAL Biochem. Biophys. Res. Commun. 377 (3), 910-914 (2008)
PUBMED 18952059
REFERENCE 8 (bases 1 to 1621)
AUTHORS Granados-Gonzalez,V., Aknin-Seifer,I., Touraine,R.L., Chouteau,J.,
Wolf,J.P. and Levy,R.
TITLE Preliminary study on the role of the human IZUMO gene in
oocyte-spermatozoa fusion failure
JOURNAL Fertil. Steril. 90 (4), 1246-1248 (2008)
PUBMED 18082733
REMARK GeneRIF: We observed in our populations two combinations of four
polymorphisms that appeared to be preferentially linked (CGG-CG and
TAA-TT) without any significant difference between different
genotype repartitions.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 9 (bases 1 to 1621)
AUTHORS Yatsenko,A.N., Roy,A., Chen,R., Ma,L., Murthy,L.J., Yan,W.,
Lamb,D.J. and Matzuk,M.M.
TITLE Non-invasive genetic diagnosis of male infertility using
spermatozoal RNA: KLHL10 mutations in oligozoospermic patients
impair homodimerization
JOURNAL Hum. Mol. Genet. 15 (23), 3411-3419 (2006)
PUBMED 17047026
REFERENCE 10 (bases 1 to 1621)
AUTHORS Inoue,N., Ikawa,M., Isotani,A. and Okabe,M.
TITLE The immunoglobulin superfamily protein Izumo is required for sperm
to fuse with eggs
JOURNAL Nature 434 (7030), 234-238 (2005)
PUBMED 15759005
REMARK GeneRIF: human sperm contain Izumo and addition of the antibody
against human Izumo left the sperm unable to fuse with zona-free
hamster eggs [Izumo]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC034769.1 and AC009002.5.
On Jul 11, 2008 this sequence version replaced gi:32698979.
Summary: The sperm-specific protein Izumo, named for a Japanese
shrine dedicated to marriage, is essential for sperm-egg plasma
membrane binding and fusion (Inoue et al., 2005 [PubMed
15759005]).[supplied by OMIM, Mar 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because transcript sequence consistent with
the reference genome assembly was not available for all regions of
the RefSeq transcript. The extent of this transcript is supported
by transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC034769.1, AB195682.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-278 BC034769.1 1-278
279-469 AC009002.5 21297-21487
470-868 BC034769.1 470-868
869-869 AC009002.5 23399-23399
870-1545 BC034769.1 870-1545
1546-1621 AC009002.5 26965-27040
FEATURES Location/Qualifiers
source 1..1621
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.33"
gene 1..1621
/gene="IZUMO1"
/gene_synonym="IZUMO"
/note="izumo sperm-egg fusion 1"
/db_xref="GeneID:284359"
/db_xref="HGNC:28539"
/db_xref="MIM:609278"
exon 1..475
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(24)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:17297777"
variation complement(50)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="g"
/replace="t"
/db_xref="dbSNP:375845746"
variation complement(136)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:55812753"
variation complement(140)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="g"
/db_xref="dbSNP:75493092"
variation complement(177)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace=""
/replace="a"
/db_xref="dbSNP:67937924"
variation complement(252)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:62132783"
variation complement(263)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:372872009"
variation complement(279)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:8105137"
variation complement(353)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="g"
/replace="t"
/db_xref="dbSNP:8104897"
variation complement(372)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:8102032"
variation complement(380)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:189105725"
variation complement(414)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:367885175"
misc_feature 441..443
/gene="IZUMO1"
/gene_synonym="IZUMO"
/note="upstream in-frame stop codon"
variation complement(458)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:75438094"
variation complement(459)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:78876642"
variation complement(460)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:80198213"
variation complement(469)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:12975781"
exon 476..783
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(500)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:375493750"
variation complement(532)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:367687317"
variation complement(541)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:200883332"
variation complement(545)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:201820078"
CDS 549..1601
/gene="IZUMO1"
/gene_synonym="IZUMO"
/note="izumo sperm-egg fusion protein 1; sperm-specific
protein Izumo; OBF; oocyte binding/fusion factor"
/codon_start=1
/product="izumo sperm-egg fusion protein 1 precursor"
/protein_id="NP_872381.2"
/db_xref="GI:194097475"
/db_xref="CCDS:CCDS12732.1"
/db_xref="GeneID:284359"
/db_xref="HGNC:28539"
/db_xref="MIM:609278"
/translation="
MGPHFTLLCAALAGCLLPAEGCVICDPSVVLALKSLEKDYLPGHLDAKHHKAMMERVENAVKDFQELSLNEDAYMGVVDEATLQKGSWSLLKDLKRITDSDVKGDLFVKELFWMLHLQKETFATYVARFQKEAYCPNKCGVMLQTLIWCKNCKKEVHACRKSYDCGERNVEVPQMEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLPKMIKEEKPSPNIVTPGEATTESSISLQPLQPEKMLASRLLGLLICGSLALITGLTFAIFRRRKVIDFIKSSLFGLGSGAAEQTQVPKEKATDSRQQ
"
sig_peptide 549..611
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 612..1598
/gene="IZUMO1"
/gene_synonym="IZUMO"
/product="Izumo sperm-egg fusion protein 1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8IYV9.2)"
misc_feature <666..803
/gene="IZUMO1"
/gene_synonym="IZUMO"
/note="Putative peptidoglycan binding domain; Region:
PG_binding_1; pfam01471"
/db_xref="CDD:216518"
misc_feature 1425..1487
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8IYV9.2);
transmembrane region"
variation complement(549)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="t"
/db_xref="dbSNP:141638354"
variation complement(578)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:200076575"
variation complement(588)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:201483135"
variation complement(597)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="c"
/db_xref="dbSNP:370772919"
variation complement(608)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:376346026"
variation complement(615)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="g"
/db_xref="dbSNP:149121500"
variation complement(618)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:373691999"
variation complement(637)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:370695018"
variation complement(693)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:377755047"
variation complement(701)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:113163107"
variation complement(705)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:374385533"
variation complement(735)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:147003407"
variation complement(740)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:368997286"
variation complement(748)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="t"
/db_xref="dbSNP:141352192"
variation complement(774)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:147813550"
variation complement(778)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:201790934"
exon 784..858
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(814)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:373136061"
variation complement(841)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="g"
/db_xref="dbSNP:144725353"
variation complement(845)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:368906261"
exon 859..945
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(869)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:8108468"
variation complement(870)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:151047643"
variation complement(906)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:112625145"
exon 946..966
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(946)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:199766108"
exon 967..1047
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(969)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:142778758"
variation complement(983)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="t"
/db_xref="dbSNP:148592878"
variation complement(1026)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:146399718"
variation complement(1027)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:372951604"
exon 1048..1148
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(1051)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:140133186"
variation complement(1117)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:146107337"
variation complement(1118)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:149283178"
exon 1149..1302
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(1180)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="g"
/db_xref="dbSNP:201848636"
variation complement(1208)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:150517605"
variation complement(1209)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:141642542"
variation complement(1229)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:137873508"
variation complement(1262)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="g"
/db_xref="dbSNP:147013345"
variation complement(1292)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace=""
/replace="t"
/db_xref="dbSNP:368029036"
variation complement(1294)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="t"
/db_xref="dbSNP:201149176"
exon 1303..1480
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(1328)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:142844138"
variation complement(1338)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:138875475"
variation complement(1378)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="c"
/db_xref="dbSNP:145934248"
variation complement(1402)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:149174447"
variation complement(1421)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="c"
/db_xref="dbSNP:145235451"
variation complement(1445)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:150421537"
variation complement(1457)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:140453631"
exon 1481..1621
/gene="IZUMO1"
/gene_synonym="IZUMO"
/inference="alignment:Splign:1.39.8"
variation complement(1489)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="g"
/replace="t"
/db_xref="dbSNP:375884119"
variation complement(1496)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="g"
/db_xref="dbSNP:146773714"
variation complement(1546)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="cg"
/replace="tt"
/db_xref="dbSNP:66877153"
variation complement(1546)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307019"
variation complement(1547)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="g"
/replace="t"
/db_xref="dbSNP:2307018"
variation complement(1549)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="a"
/replace="c"
/db_xref="dbSNP:371512927"
variation complement(1588)
/gene="IZUMO1"
/gene_synonym="IZUMO"
/replace="c"
/replace="t"
/db_xref="dbSNP:146618238"
ORIGIN
ggaatatctataaaggaattcgggcccctacgtgagaagctcggagggggtggtttcaggagttccttgtggagaggggatcgtccgtgactcagaccccgtcgaaaagctctcgatttcacgcaaccaaccttaccctcgtccccaacacaatccttgattttacccctgggaaaattagcgtaggtggtcatgaccccggcttcctctttaaaagccctcagaacctggaccgggctcctcaatgaaccctagtgttagaggccacaaatcgggaaccaaggtcggggagcggctgtttagggtgcatcactgttcaggatgcatcggggctcctttttctaagcggaagggtgcgccctgcaaattgggagcccgttagttttggggaagggtgaacaagggccccctaggtctagaggaccgcatggagtctcgcttaagtgttagtggggtcctcagttctaggaatctgcgttctcctgctctcggtttggggtgagagcacccttcctaacggtcttcgggaactgtgcgcgccggctgcaatggggccgcattttaccctcctgtgtgcggcgctggccggttgcttgcttcctgccgaggggtgtgttatatgtgacccgtctgtcgtgctggcgctaaagtccctggagaaagattacctgcctggccacctggatgcgaagcatcacaaagccatgatggaaagggtagagaatgccgtgaaggatttccaggaactgtcgcttaatgaggatgcctatatgggggtcgttgatgaggccacactgcaaaaggggtcctggagtttgctgaaggatctgaaacgcatcacagacagtgatgtaaaaggcgatctcttcgtgaaggagctattttggatgttgcacttgcaaaaggaaacctttgccacctatgttgctcgattccaaaaagaggcttattgtcccaacaaatgtggtgtgatgttgcaaactctgatctggtgcaagaactgcaaaaaggaggttcacgcttgtcgaaagtcctacgattgcggggagcggaatgtggaagttcctcaaatggaagacatgatcctggactgtgagttaaactggcatcaggcttcggaaggcctcactgattacagcttttacagggtttgggggaacaatacggagaccttggtgtccaaggggaaagaggccaccctgaccaagcccatggtgggtccagaggatgcaggcagctaccgctgcgagctgggctctgtgaattccagcccagccacgatcatcaattttcacgtcacagtgttgcccaaaatgatcaaggaggaaaaaccttctccaaatatcgtaaccccgggggaggcgaccacggagtcgtccataagcctccagcctctgcagcccgagaaaatgctggcaagccgccttctggggctgctgatctgcggctccctagcactgataaccggccttacctttgcgatatttcgtcgaaggaaggtgatcgatttcatcaaatcctcactgtttggccttggcagtggagcggccgagcaaacccaggtcccaaaagaaaaggccacagattcgaggcaacaataaagatttatcttgttgtctaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:284359 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
GeneID:284359 -> Biological process: GO:0007155 [cell adhesion] evidence: IC
GeneID:284359 -> Biological process: GO:0007338 [single fertilization] evidence: TAS
GeneID:284359 -> Biological process: GO:0007342 [fusion of sperm to egg plasma membrane] evidence: IDA
GeneID:284359 -> Biological process: GO:0007342 [fusion of sperm to egg plasma membrane] evidence: TAS
GeneID:284359 -> Biological process: GO:0032504 [multicellular organism reproduction] evidence: TAS
GeneID:284359 -> Cellular component: GO:0002080 [acrosomal membrane] evidence: IEA
GeneID:284359 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:284359 -> Cellular component: GO:0016021 [integral to membrane] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.