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2019-03-24 19:52:11, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_182398               2343 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 5
            (RPS6KA5), transcript variant 2, mRNA.
ACCESSION   NM_182398
VERSION     NM_182398.1  GI:32528296
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Terazawa,S., Nakajima,H., Shingo,M., Niwano,T. and Imokawa,G.
  TITLE     Astaxanthin attenuates the UVB-induced secretion of prostaglandin
            E2 and interleukin-8 in human keratinocytes by interrupting MSK1
            phosphorylation in a ROS depletion-independent manner
  JOURNAL   Exp. Dermatol. 21 (SUPPL 1), 11-17 (2012)
   PUBMED   22626465
  REMARK    GeneRIF: Astaxanthin attenuates the UVB-induced secretion of
            prostaglandin E2 and interleukin-8 in human keratinocytes by
            interrupting MSK1 phosphorylation in a ROS depletion-independent
            manner
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat. Genet. 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Sundar,I.K., Chung,S., Hwang,J.W., Lapek,J.D. Jr., Bulger,M.,
            Friedman,A.E., Yao,H., Davie,J.R. and Rahman,I.
  TITLE     Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette
            smoke-induced histone modifications on NF-kappaB-dependent genes
  JOURNAL   PLoS ONE 7 (2), E31378 (2012)
   PUBMED   22312446
  REMARK    GeneRIF: MSK1 is an important downstream kinase involved in
            CS-induced NF-kappaB activation
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Lau,P.N. and Cheung,P.
  TITLE     Histone code pathway involving H3 S28 phosphorylation and K27
            acetylation activates transcription and antagonizes polycomb
            silencing
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (7), 2801-2806 (2011)
   PUBMED   21282660
  REMARK    GeneRIF: MSK1 is a direct and potent transcriptional activator when
            targeted to c-fos promotor, and when targeted to alpha-globin
            promoter induces H3 S28 phosphorylation reactivating expression of
            this polycomb-silenced gene.
REFERENCE   5  (bases 1 to 2343)
  AUTHORS   Gehani,S.S., Agrawal-Singh,S., Dietrich,N., Christophersen,N.S.,
            Helin,K. and Hansen,K.
  TITLE     Polycomb group protein displacement and gene activation through
            MSK-dependent H3K27me3S28 phosphorylation
  JOURNAL   Mol. Cell 39 (6), 886-900 (2010)
   PUBMED   20864036
  REMARK    GeneRIF: MSK1- and MSK2-mediated H3K27me3S28 phosphorylation serves
            as a mechanism to activate a subset of PcG target genes determined
            by the biological stimuli and thereby modulate the gene expression
            program determining cell fate.
REFERENCE   6  (bases 1 to 2343)
  AUTHORS   Thomson,S., Clayton,A.L., Hazzalin,C.A., Rose,S., Barratt,M.J. and
            Mahadevan,L.C.
  TITLE     The nucleosomal response associated with immediate-early gene
            induction is mediated via alternative MAP kinase cascades: MSK1 as
            a potential histone H3/HMG-14 kinase
  JOURNAL   EMBO J. 18 (17), 4779-4793 (1999)
   PUBMED   10469656
REFERENCE   7  (bases 1 to 2343)
  AUTHORS   New,L., Zhao,M., Li,Y., Bassett,W.W., Feng,Y., Ludwig,S.,
            Padova,F.D., Gram,H. and Han,J.
  TITLE     Cloning and characterization of RLPK, a novel RSK-related protein
            kinase
  JOURNAL   J. Biol. Chem. 274 (2), 1026-1032 (1999)
   PUBMED   9873047
REFERENCE   8  (bases 1 to 2343)
  AUTHORS   Jain,N., Zhang,T., Fong,S.L., Lim,C.P. and Cao,X.
  TITLE     Repression of Stat3 activity by activation of mitogen-activated
            protein kinase (MAPK)
  JOURNAL   Oncogene 17 (24), 3157-3167 (1998)
   PUBMED   9872331
REFERENCE   9  (bases 1 to 2343)
  AUTHORS   Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
  TITLE     Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
            activated by MAPK and SAPK2/p38, and may mediate activation of CREB
  JOURNAL   EMBO J. 17 (15), 4426-4441 (1998)
   PUBMED   9687510
REFERENCE   10 (bases 1 to 2343)
  AUTHORS   Chung,J., Uchida,E., Grammer,T.C. and Blenis,J.
  TITLE     STAT3 serine phosphorylation by ERK-dependent and -independent
            pathways negatively modulates its tyrosine phosphorylation
  JOURNAL   Mol. Cell. Biol. 17 (11), 6508-6516 (1997)
   PUBMED   9343414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG699153.1, AF074393.1 and BC017187.2.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            segment in the 3' coding region, compared to variant 1. Isoform b
            has a shorter C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017187.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               BG699153.1         34-238
            206-1688            AF074393.1         156-1638
            1689-1882           BC017187.2         1640-1833
            1883-2343           BC017187.2         1835-2295
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31-q32.1"
     gene            1..2343
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="ribosomal protein S6 kinase, 90kDa, polypeptide 5"
                     /db_xref="GeneID:9252"
                     /db_xref="HGNC:10434"
                     /db_xref="MIM:603607"
     exon            1..318
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(150)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142744185"
     variation       complement(181)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201279993"
     misc_feature    183..185
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="upstream in-frame stop codon"
     variation       complement(186)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375495496"
     variation       complement(189)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372229821"
     CDS             216..1865
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2;
                     RSK-like protein kinase; nuclear mitogen- and
                     stress-activated protein kinase 1; ribosomal protein S6
                     kinase alpha-5; RSKL; S6K-alpha-5; 90 kDa ribosomal
                     protein S6 kinase 5"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-5 isoform b"
                     /protein_id="NP_872198.1"
                     /db_xref="GI:32528297"
                     /db_xref="CCDS:CCDS45149.1"
                     /db_xref="GeneID:9252"
                     /db_xref="HGNC:10434"
                     /db_xref="MIM:603607"
                     /translation="
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPEV
"
     misc_feature    357..1226
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="N-terminal catalytic domain of the Protein
                     Serine/Threonine Kinase, Mitogen and stress-activated
                     kinase 1; Region: STKc_MSK1_N; cd05613"
                     /db_xref="CDD:173704"
     misc_feature    360..1169
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(378..392,402..404,450..452,456..458,558..560,
                     606..611,615..617,627..629,633..635,744..746,750..752,
                     756..761,765..767,795..800,807..809,852..869,954..956,
                     972..974,981..983)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="active site"
                     /db_xref="CDD:173704"
     misc_feature    order(378..392,402..404,450..452,456..458,558..560,
                     609..617,627..629,744..746,750..752,756..761,765..767,
                     795..800)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173704"
     misc_feature    order(390..392,627..629,633..635,744..746,750..752,
                     756..758,807..809,852..869,954..956,972..974,981..983)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173704"
     misc_feature    order(795..827,834..869)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173704"
     misc_feature    1173..1352
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="Extension to Ser/Thr-type protein kinases; Region:
                     S_TK_X; smart00133"
                     /db_xref="CDD:197531"
     misc_feature    1341..1343
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03479"
     misc_feature    1341..1343
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01496"
     misc_feature    1341..1343
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02619"
     misc_feature    1503..>1859
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    1509..>1859
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="Catalytic domain of Protein Kinases; Region: PKc;
                     cd00180"
                     /db_xref="CDD:173623"
     misc_feature    order(1509..1523,1533..1535,1572..1574,1578..1580,
                     1659..1661,1707..1718,1728..1730,1734..1736,1845..1847,
                     1851..1853,1857..1859)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(1509..1523,1533..1535,1572..1574,1578..1580,
                     1659..1661,1707..1718,1728..1730,1845..1847,1851..1853,
                     1857..1859)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(1521..1523,1728..1730,1734..1736,1845..1847,
                     1851..1853,1857..1859)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     variation       complement(237)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372919173"
     variation       complement(240)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375911233"
     variation       complement(261)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202148951"
     variation       complement(275)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367668503"
     variation       complement(278)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199916387"
     variation       complement(308)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200700842"
     exon            319..390
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     exon            391..609
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(414)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151225102"
     variation       complement(453)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367694592"
     variation       complement(534)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142061817"
     variation       complement(596)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199516088"
     exon            610..725
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(648)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201222390"
     variation       complement(668)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:7143758"
     variation       complement(686)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374545017"
     variation       complement(710)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56369401"
     variation       complement(717)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200296811"
     exon            726..833
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(742)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199633732"
     variation       complement(764)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200169986"
     variation       complement(775)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148618662"
     variation       complement(784)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34699345"
     variation       complement(785)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145964101"
     variation       complement(829)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77756213"
     exon            834..917
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(900)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144064383"
     exon            918..1021
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(947)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201424443"
     variation       complement(950)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372452750"
     variation       complement(994)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140126863"
     exon            1022..1172
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1046)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146107979"
     variation       complement(1054)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371531566"
     variation       complement(1088)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149616968"
     variation       complement(1090)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200357482"
     variation       complement(1107)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138308039"
     variation       complement(1135)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150910355"
     variation       complement(1137)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370238703"
     exon            1173..1334
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1197)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376247617"
     variation       complement(1201)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375770844"
     variation       complement(1283)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200895075"
     variation       complement(1298)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141403978"
     variation       complement(1310)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:55936408"
     variation       complement(1312)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146532003"
     variation       complement(1331)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373348904"
     exon            1335..1460
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1361)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55985734"
     exon            1461..1594
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1483)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:141570904"
     variation       complement(1506)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143530311"
     variation       complement(1530)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200091410"
     variation       complement(1537)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369503281"
     variation       complement(1590)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201610483"
     exon            1595..1688
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1606)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372449079"
     variation       complement(1613)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:191930267"
     variation       complement(1668)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148385885"
     variation       complement(1673)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367954583"
     variation       complement(1688)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374856978"
     exon            1689..2298
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1696)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374156204"
     variation       complement(1772)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150175403"
     variation       complement(1779)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200260836"
     variation       complement(1805)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371247192"
     variation       complement(1853)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376401703"
     variation       complement(1878)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112103131"
     variation       complement(1881)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200609371"
     variation       complement(1882..1883)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:77438853"
     variation       complement(1883)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200539689"
     variation       complement(1904)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111312472"
     variation       complement(1906)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373420636"
     variation       complement(2109)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190520019"
     variation       complement(2115..2116)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34712536"
     variation       complement(2188)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138378240"
     variation       complement(2209)
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:148205780"
     polyA_signal    2270..2275
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
     polyA_site      2299
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
ORIGIN      
ttggttgcgcggtactagcggtgcccgccgaagggggaggaggcgaggagcgagccgtgcggccagagcgggaaagagactcgtctttgcgtccgagttctggagccgccgcaccccgactcctggggccgcggcagcggctgcgaggggacgggcgtccgctgtctcctgggttcccctcgtagcgacccgcgggatcggaaaaaaaggagaagatggaggaggagggtggcagcagcggcggcgccgcggggaccagcgcggacggcggcgacggaggagagcagctcctcactgtcaagcacgagctgcggactgctaatttgacaggacatgctgagaaggtgggaatagaaaattttgagctcctgaaggtcctaggaactggagcttatggaaaagtatttctagttcgtaaaataagtggccatgatactggaaagctgtatgccatgaaagttttgaaaaaggcaacaatcgttcaaaaggccaaaaccacagagcatacaaggacagaacgacaagtcctggaacacattaggcagtcgccatttttggtaacattacattatgctttccagacagaaaccaaacttcatctcattttagattatataaatggtggtgaactttttactcatctttctcaaagagagcgtttcacagagcatgaggtgcagatttatgttggagagattgtgcttgccctcgaacatctccacaagttggggattatatatcgtgatattaagcttgagaatattctacttgattctaatggccatgtggtgctgacagattttggtctgagtaaggagtttgtggctgatgaaactgaaagagcatattccttttgtggaactattgaatacatggcaccagatattgtcagagggggagattcaggacatgacaaggcagttgactggtggagtttgggtgttctaatgtatgaattactaactggagcatctcctttcactgttgatggagaaaaaaattcccaagctgagatatctaggagaatattaaaaagtgagcctccatatccccaagaaatgagtgctttagcgaaagacctaattcagcgtcttttgatgaaagatcccaagaagagattgggatgtggtccacgtgatgcagatgaaatcaaagaacatctcttctttcagaaaataaattgggatgatttagccgccaaaaaagtgcctgcaccatttaagccagtcattcgagatgaattagatgtgagtaactttgcagaagagttcacagaaatggatcccacttattctcccgcagccctgccccagagttctgagaagctgtttcagggctattcctttgttgctccttccatcctattcaagcgtaatgcagctgtcatagaccctcttcagtttcacatgggagttgaacgtcctggagtgacaaatgttgccaggagtgcaatgatgaaggactctccattctatcaacactatgacctagatttgaaggacaaacccctgggagaaggtagtttttcaatttgtcgaaagtgtgtgcataaaaaaagtaaccaagcttttgcagtcaaaataatcagcaaaaggatggaagccaatactcaaaaggaaataacagctctgaaactctgtgaaggacaccccaatattgtgaagttgcatgaagtttttcatgatcagcttcacacgtttctagtgatggaacttctgaatggaggagaactgtttgagcgcattaagaaaaagaagcacttcagtgagacggaagccagctacatcatgaggaagcttgtttcagctgtaagccacatgcatgatgttggagtggtgcacagggatctgaaacctgaggtataaaatcactggatctcttacgtaattcagtctagcaccattattaaagatctcccaaacatgggggaagtttctggggaggtttccttatttttttacttttcaaggctgttaaatagataattgaaaatacgtttctttgatgttttttcttttatatttcagtctaaaataaatttgtctttgtttattttttgccagctgatcatcttgaggttatatttgtaagtgtgagaaccttttatggaaaaaatactttatgcaacagttgtggactaaaaatagcaatggaaatttttatagcagaaaataatatctcttacatataattttagagggttttttttccaaatgatgtattttgaaaacttattttttacatttgtaatcaaattggttagctcatgaataaaaatgtatataattctattctaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9252 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IEA
            GeneID:9252 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
            GeneID:9252 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9252 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IMP
            GeneID:9252 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9252 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:9252 -> Biological process: GO:0001818 [negative regulation of cytokine production] evidence: TAS
            GeneID:9252 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:9252 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:9252 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:9252 -> Biological process: GO:0006950 [response to stress] evidence: IEP
            GeneID:9252 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
            GeneID:9252 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
            GeneID:9252 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
            GeneID:9252 -> Biological process: GO:0009605 [response to external stimulus] evidence: IEP
            GeneID:9252 -> Biological process: GO:0016572 [histone phosphorylation] evidence: IDA
            GeneID:9252 -> Biological process: GO:0016572 [histone phosphorylation] evidence: TAS
            GeneID:9252 -> Biological process: GO:0032793 [positive regulation of CREB transcription factor activity] evidence: TAS
            GeneID:9252 -> Biological process: GO:0033129 [positive regulation of histone phosphorylation] evidence: IMP
            GeneID:9252 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0035066 [positive regulation of histone acetylation] evidence: IMP
            GeneID:9252 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0043987 [histone H3-S10 phosphorylation] evidence: IMP
            GeneID:9252 -> Biological process: GO:0043988 [histone H3-S28 phosphorylation] evidence: IMP
            GeneID:9252 -> Biological process: GO:0043990 [histone H2A-S1 phosphorylation] evidence: IDA
            GeneID:9252 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:9252 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:9252 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:9252 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:9252 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IMP
            GeneID:9252 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:9252 -> Biological process: GO:0070498 [interleukin-1-mediated signaling pathway] evidence: IMP
            GeneID:9252 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:9252 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
            GeneID:9252 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:9252 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_872198 -> EC 2.7.11.1

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.