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2019-03-23 04:07:26, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_177949               2858 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens armadillo repeat containing, X-linked 2 (ARMCX2),
            mRNA.
ACCESSION   NM_177949
VERSION     NM_177949.2  GI:157427677
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Zeller,C., Dai,W., Steele,N.L., Siddiq,A., Walley,A.J.,
            Wilhelm-Benartzi,C.S., Rizzo,S., van der Zee,A., Plumb,J.A. and
            Brown,R.
  TITLE     Candidate DNA methylation drivers of acquired cisplatin resistance
            in ovarian cancer identified by methylome and expression profiling
  JOURNAL   Oncogene 31 (42), 4567-4576 (2012)
   PUBMED   22249249
  REMARK    GeneRIF: Data indicate that ARMCX2, COL1A1, MDK, MEST and MLH1
            genes acquired methylation in drug-resistant ovarian
            cancer-sustaining (side population) cells.
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol. Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Kurochkin,I.V., Yonemitsu,N., Funahashi,S.I. and Nomura,H.
  TITLE     ALEX1, a novel human armadillo repeat protein that is expressed
            differentially in normal tissues and carcinomas
  JOURNAL   Biochem. Biophys. Res. Commun. 280 (1), 340-347 (2001)
   PUBMED   11162520
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG548388.1, AB011084.1,
            BX648494.1, Z83131.1 and BM676866.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 24, 2007 this sequence version replaced gi:29540561.
            
            Summary: This gene encodes a member of the ALEX family of proteins
            and may play a role in tumor suppression. The encoded protein
            contains a potential N-terminal transmembrane domain and a single
            Armadillo (arm) repeat. Other proteins containing the arm repeat
            are involved in development, maintenance of tissue integrity, and
            tumorigenesis. This gene is closely localized with other family
            members, including ALEX1 and ALEX3, on the X chromosome. Two
            alternative transcripts that encode the same protein but differ in
            the 5' UTR have been described. Additional alternative transcripts
            may exist but their full length natures have not been determined. A
            pseudogene for this locus is located on chromosome 7. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291342.1, AB011084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BG548388.1         15-55
            42-457              AB011084.1         1-416
            458-2047            BX648494.1         418-2007
            2048-2049           Z83131.1           8751-8752           c
            2050-2797           BX648494.1         2010-2757
            2798-2858           BM676866.1         1-61                c
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.33-q22.2"
     gene            1..2858
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /note="armadillo repeat containing, X-linked 2"
                     /db_xref="GeneID:9823"
                     /db_xref="HGNC:16869"
                     /db_xref="HPRD:02293"
                     /db_xref="MIM:300363"
     exon            1..121
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="alignment:Splign:1.39.8"
     exon            122..204
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="alignment:Splign:1.39.8"
     exon            205..277
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="alignment:Splign:1.39.8"
     exon            278..342
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    303..305
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /note="upstream in-frame stop codon"
     exon            343..412
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="alignment:Splign:1.39.8"
     exon            413..2847
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="alignment:Splign:1.39.8"
     CDS             540..2438
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /note="armadillo repeat protein ALEX2; arm protein lost in
                     epithelial cancers, X chromosome, 2; ARM protein lost in
                     epithelial cancers on chromosome X 2"
                     /codon_start=1
                     /product="armadillo repeat-containing X-linked protein 2"
                     /protein_id="NP_808818.1"
                     /db_xref="GI:29540562"
                     /db_xref="CCDS:CCDS14490.1"
                     /db_xref="GeneID:9823"
                     /db_xref="HGNC:16869"
                     /db_xref="HPRD:02293"
                     /db_xref="MIM:300363"
                     /translation="
MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF
"
     misc_feature    558..614
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
                     transmembrane region"
     misc_feature    1662..2393
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /note="Armadillo-like; Region: Arm_2; pfam04826"
                     /db_xref="CDD:191105"
     misc_feature    1665..1787
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
                     Region: ARM 1"
     misc_feature    1677..2030
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /note="Armadillo/beta-catenin-like repeats. An
                     approximately 40 amino acid long tandemly repeated
                     sequence motif first identified in the Drosophila segment
                     polarity gene armadillo; these repeats were also found in
                     the mammalian armadillo homolog beta-catenin; Region: ARM;
                     cd00020"
                     /db_xref="CDD:28904"
     misc_feature    order(1752..1754,1764..1766,1776..1778,1866..1868,
                     1878..1880,1887..1889,1899..1901,1998..2000,2010..2012,
                     2019..2024)
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /note="protein binding surface [polypeptide binding];
                     other site"
                     /db_xref="CDD:28904"
     misc_feature    1791..1910
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
                     Region: ARM 2"
     misc_feature    2031..2150
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7L311.1);
                     Region: ARM 3"
     STS             1933..2657
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /standard_name="ARMCX2_8998"
                     /db_xref="UniSTS:468291"
     STS             2603..2755
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /standard_name="RH46199"
                     /db_xref="UniSTS:52966"
     STS             2656..2775
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /standard_name="A001V26"
                     /db_xref="UniSTS:784"
     STS             2656..2775
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /standard_name="G19687"
                     /db_xref="UniSTS:783"
     STS             2661..2814
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /standard_name="DXS7453"
                     /db_xref="UniSTS:99408"
     STS             2708..2813
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /standard_name="SGC30561"
                     /db_xref="UniSTS:17375"
     polyA_signal    2818..2823
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
     variation       2842
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3177613"
     polyA_site      2847
                     /gene="ARMCX2"
                     /gene_synonym="ALEX2"
ORIGIN      
cttaaagccctgaccgtcgttctccgtcctcctctgggtaccaactctattgcgcagctcgctgccgtgcgtttaacccaggcgaggaggaggaggagaaaattcccccagattcgggcaggcccgcaccccacattccgtcctgttttgagaggaggagggaagagaaataaacgtggcagcgcatagaaggccagcagggagactgctttccagacacctccggcccacacagccgttcaccccccgtcttttcagtcctggaaaaggaattcggtctgtccttaggatgaagctctaactgaactgaagtaaggagaaacagccttgaatctttggagggtctgtcttccttttgggctctgtgcaactgcagctacagtggaaaaaagcaaactgctcttgatcccaggccctgcctaagcctcagcagaacttgtaagcctaaactgaagagcctcacccggacgagcaggcatcccttaaccttaagcaatccagttccacgccctggatcagtgaataaccccagctgcaccatgagccgcgttcgggatgctggctgtgtagcggcggggatagtgataggggctggtgcctggtactgtgtctacaaatacaccagggggagagaccagaccaagaagagaatggccaagcccaaaaaccgggctgtggctgggactggagccagggctagagctgggctaagagccggattcacaatcgaccttgggtcaggattcagtcccccaaccccagtccgtgctgaagcagaggacagggcccaggatgaagcctctgctctggacacagttggagctgaggcagtggccccagctgcatccagcgctgaggctcagagtggggcaggcagtcaggcccaagaggcagatggagccggggttgggcctaaggccgaatcagtagttggggctgcaatggcttctgcaatagcaccacctcccggggtgacagaggcccttggggctgcagaagcccctgcaatggcaggggctcccaaagtggcagaagctcccagagaagcggagacttccagggcagcggtgcctcctgggacagtggtgcctaccgaagcggcagcacccactgaggtgaccgagggtcctggggtagcagcacctaccaaggtagctgaagctcccggggtggcatcgcctaccgaggcagctgaggctcctgtgcccgcaacgcctactggggctgcagcacctactggggctgcagagtctcctggaacttctggttcccctagaacagcggtggttcctggaacatcagctgccaagaaagcaacccctggggctcacactggggctataccgaaagccacatcagcgactggagcggtacccaaaggtggaggcaagggtgtaaccaggtcccggaatgggggcaagggcaagggcaagaaaagcaaagttgaagtagacgaactggggatgggcttccgtcctggagatggggctgcagcagctgctgcagcctctgctaatggcggacaggctttcctggcagaggtccctgattctgaggaaggggagtccgggtggactgacacagagtcagattcagactctgagcccgagacccagcgcagagggaggggaagaagacccgttgccatgcagaagcgcccctttccttatgaaattgatgagattctgggtgtccgcgatctcaggaaggtccttgccttgcttcagaaatctgatgatcctttcatccaacaggtagctttgctcactctgagcaacaatgccaattattcatgcaatcaagagacaatccgcaaattgggaggcctcccaattattgcaaacatgatcaacaaaactgatccacacattaaggaaaaagccttaatggccatgaataacctgagtgagaattatgaaaatcagggccggcttcaggtgtacatgaataaagtgatggatgatatcatggcctctaacctgaactcagcagttcaagtagttggactaaaatttctaacaaacatgactattactaatgactaccagcacctgcttgtcaattccattgcaaactttttccgtttgctatctcagggaggtggaaaaatcaaggttgagattttgaaaatcctttcgaattttgctgaaaatccagatatgttgaagaaacttctcagtacccaagtgccagcatcatttagttccctctataattcttacgtggaatcagaaatccttattaatgcccttactctatttgagattatctatgacaatctcagagcagaagtgtttaactatagagaattcaataaaggttcccttttttacttatgcactacatctggagtgtgtgttaagaaaattagagccttagcaaatcaccatgacctcttagtgaaagtgaaagttataaaactagtgaacaaattctgattggttatgtaccgtcaaaagacttgaagaaatttcatgattttgcagtgtggaagcgttgaaaattgaaagttactgcttttccacttgctcatatagtaaagggatcctttcagctgccagtgttgaataatgtatcatccagagtgatgttatctgtgacagtcaccagctttaagctgaaccattttatgaataccaaataaatagacctcttgtactgaaaacatatttgtgactttaatcgtgctgcttggatagaaatatttttactggttcttctgaattgacagtaaacctgtccattatgaatggcctactgttctattatttgttttgacttgaatttatccaccaaagacttcatttgtgtatcatcaataaagttgtatgtttcaactgacaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9823 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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