LOCUS       NM_173860                849 bp    mRNA    linear   PRI 24-MAR-2012
DEFINITION  Homo sapiens homeobox C12 (HOXC12), mRNA.
ACCESSION   NM_173860
VERSION     NM_173860.1  GI:27804314
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Flagiello,D., Gibaud,A., Dutrillaux,B., Poupon,M.F. and Malfoy,B.
  TITLE     Distinct patterns of all-trans retinoic acid dependent expression
            of HOXB and HOXC homeogenes in human embryonal and small-cell lung
            carcinoma cell lines
  JOURNAL   FEBS Lett. 415 (3), 263-267 (1997)
   PUBMED   9357979
REFERENCE   3  (bases 1 to 849)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   4  (bases 1 to 849)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF328963.1 and AF328962.1.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXC genes located in a cluster on
            chromosome 12. [provided by RefSeq, Jul 2008].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               AF328963.1         63-672
            611-849             AF328962.1         44-282
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..849
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /note="homeobox C12"
                     /db_xref="GeneID:3228"
                     /db_xref="HGNC:5124"
                     /db_xref="HPRD:00861"
                     /db_xref="MIM:142975"
     CDS             1..849
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /note="homeo box C12; homeo box 3F; homeobox protein
                     Hox-3F"
                     /codon_start=1
                     /product="homeobox protein Hox-C12"
                     /protein_id="NP_776272.1"
                     /db_xref="GI:27804315"
                     /db_xref="CCDS:CCDS8866.1"
                     /db_xref="GeneID:3228"
                     /db_xref="HGNC:5124"
                     /db_xref="HPRD:00861"
                     /db_xref="MIM:142975"
                     /translation="

MGEHNLLNPGFVGPLVNIHTGDTFYFPNFRASGAQLPGLPSLSYPRRDNVCSLSWPSAEPCNGYPQPYLGSPVSLNPPFGRTCELARVEDGKGYYREPCAEGGGGGLKREERGRDPGAGPGAALLPLEPSGPPALGFKYDYAAGGGGGDGGGGAGPPHDPPSCQSLESDSSSSLLNEGNKGAGAGDPGSLVSPLNPGGGLSASGAPWYPINSRSRKKRKPYSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNRRMKKKRLLLREQALSFF

"
     misc_feature    673..792
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(778..780,787..792)
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            1..610
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /inference="alignment:Splign:1.39.8"
     variation       1
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369761927"
     STS             15..98
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /standard_name="Hoxc12"
                     /db_xref="UniSTS:536659"
     variation       59
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201275773"
     variation       74
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143512230"
     variation       81
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146751372"
     variation       112
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372108293"
     variation       156
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140362270"
     variation       169
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372388280"
     variation       178
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377143793"
     variation       194
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143550250"
     variation       209
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200211899"
     variation       240
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368526027"
     variation       246
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150971865"
     variation       310
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199737087"
     variation       372
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34894813"
     variation       424
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34810584"
     variation       426
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34884331"
     variation       429
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34108612"
     variation       470..471
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34957565"
     variation       528
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189468720"
     exon            611..849
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /inference="alignment:Splign:1.39.8"
     variation       614
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140782486"
     variation       636
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374562830"
     variation       679
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144078525"
     variation       693
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138682181"
     variation       720
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377346613"
     variation       730
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368956035"
     variation       762
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142687276"
     variation       769
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146914178"
     variation       793
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186089788"
     variation       794
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146523432"
     variation       814
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199571419"
     variation       826
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373624523"
     variation       832
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76569642"
     variation       833
                     /gene="HOXC12"
                     /gene_synonym="HOC3F; HOX3; HOX3F"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149417796"
ORIGIN      

atgggcgagcataatctcctgaatcccgggtttgtggggccgctggtaaacatccacacgggagacaccttctacttccccaacttccgcgcgtccggggcgcagcttcccgggctgccttcgctgtcctacccacgccgcgacaacgtgtgctccctgtcctggccgtcggcggagccgtgcaatggctacccgcagccctacctcggcagcccagtgtctctcaaccctcccttcggccgcacgtgcgagctggcgcgcgtggaggacggcaagggttactaccgcgagccgtgcgccgagggtggcggcgggggcctgaagcgtgaggagcgcgggcgcgacccgggagccgggcccggggcagcgctgctcccgctggagccgtcggggccgcctgcgctcggcttcaagtacgactacgcggcgggcggcggcggtggcgacggcggcggcggcgcaggacctccgcacgacccgccctcctgccagtcgctggaatccgactccagttcgtccctgctcaacgagggcaacaagggcgccggcgcaggcgaccccggcagcttggtatcgccgttgaaccccggcggcgggctctcggccagcggcgcgccctggtacccgatcaacagccgctctcggaagaagcgcaagccctattcgaagttgcaactggcagagctggagggcgagtttctggtcaacgagttcatcacacgccagcgccggagggaactctcagaccgcttgaatcttagtgaccagcaggtcaagatctggtttcagaaccggagaatgaaaaagaaaagacttctgttgagggagcaagctctctccttcttttaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3228 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3228 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3228 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3228 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
            GeneID:3228 -> Cellular component: GO:0005634 [nucleus] evidence: IEA