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2024-04-19 23:21:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_173587 2621 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens REST corepressor 2 (RCOR2), mRNA.
ACCESSION NM_173587
VERSION NM_173587.3 GI:269847039
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2621)
AUTHORS Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
TITLE Full-length transcriptome analysis of human retina-derived cell
lines ARPE-19 and Y79 using the vector-capping method
JOURNAL Invest. Ophthalmol. Vis. Sci. 52 (9), 6662-6670 (2011)
PUBMED 21697133
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2621)
AUTHORS Yang,P., Wang,Y., Chen,J., Li,H., Kang,L., Zhang,Y., Chen,S.,
Zhu,B. and Gao,S.
TITLE RCOR2 is a subunit of the LSD1 complex that regulates ESC property
and substitutes for SOX2 in reprogramming somatic cells to
pluripotency
JOURNAL Stem Cells 29 (5), 791-801 (2011)
PUBMED 21433225
REMARK GeneRIF: Ectopic expression of Rcor2 in both mouse and human
somatic cells effectively substituted the requirement for exogenous
Sox2 expression in somatic cell reprogramming.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC023587.2, AP003780.3 and BM678625.1.
On Nov 24, 2009 this sequence version replaced gi:34222235.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC023587.2, AB593132.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1191 BC023587.2 1-1191
1192-1192 AP003780.3 75037-75037 c
1193-1927 BC023587.2 1193-1927
1928-1928 AP003780.3 72893-72893 c
1929-2595 BC023587.2 1929-2595
2596-2621 BM678625.1 1-26 c
FEATURES Location/Qualifiers
source 1..2621
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13.1"
gene 1..2621
/gene="RCOR2"
/note="REST corepressor 2"
/db_xref="GeneID:283248"
/db_xref="HGNC:27455"
exon 1..515
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(19)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:144843394"
variation complement(86)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:374905473"
misc_feature 275..277
/gene="RCOR2"
/note="upstream in-frame stop codon"
variation complement(359)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149337452"
variation complement(363)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201647626"
CDS 389..1960
/gene="RCOR2"
/codon_start=1
/product="REST corepressor 2"
/protein_id="NP_775858.2"
/db_xref="GI:269847040"
/db_xref="CCDS:CCDS8052.1"
/db_xref="GeneID:283248"
/db_xref="HGNC:27455"
/translation="
MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL
"
misc_feature 479..481
/gene="RCOR2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8IZ40.2); phosphorylation site"
misc_feature 491..493
/gene="RCOR2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8IZ40.2); phosphorylation site"
misc_feature 494..496
/gene="RCOR2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8IZ40.2); phosphorylation site"
misc_feature 524..688
/gene="RCOR2"
/note="ELM2 domain; Region: ELM2; pfam01448"
/db_xref="CDD:201801"
misc_feature 788..922
/gene="RCOR2"
/note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
Tandem copies of the domain bind telomeric DNA tandem
repeatsas part of the capping complex. Binding is sequence
dependent for repeats which contain the G/C rich motif
[C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl15779"
/db_xref="CDD:212629"
misc_feature order(791..793,878..883,887..892,896..904,908..916)
/gene="RCOR2"
/note="putative DNA binding site [nucleotide binding];
other site"
/db_xref="CDD:212559"
misc_feature 1379..1516
/gene="RCOR2"
/note="SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding
domains; Region: SANT; smart00717"
/db_xref="CDD:197842"
misc_feature 1379..1507
/gene="RCOR2"
/note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
Tandem copies of the domain bind telomeric DNA tandem
repeatsas part of the capping complex. Binding is sequence
dependent for repeats which contain the G/C rich motif
[C2-3 A (CA)1-6]. The domain is...; Region: SANT; cd00167"
/db_xref="CDD:29107"
misc_feature order(1382..1384,1469..1474,1478..1483,1487..1495,
1499..1507)
/gene="RCOR2"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:29107"
variation complement(428)
/gene="RCOR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:372768915"
variation complement(470)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200098023"
variation complement(474)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149356483"
variation complement(505)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:56366122"
exon 516..572
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(530)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145688255"
variation complement(547)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370851174"
variation complement(551)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143904903"
exon 573..653
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(631)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377453287"
exon 654..706
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(684)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:375233137"
exon 707..868
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(708)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201965783"
variation complement(712)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140610632"
variation complement(751)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146976071"
variation complement(754)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143245678"
variation complement(757)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:185084699"
variation complement(766)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149210640"
variation complement(797)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370116723"
exon 869..993
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(901)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:377722799"
variation complement(922)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145394702"
variation complement(928)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150072584"
variation complement(933)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140081088"
variation complement(959)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201796742"
exon 994..1063
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(1003)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375240729"
variation complement(1014)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199984646"
variation complement(1020)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369985290"
variation complement(1022)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375295805"
variation complement(1039)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200698022"
variation complement(1040)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371327834"
exon 1064..1279
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(1077)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370485478"
variation complement(1092)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376063920"
variation complement(1158)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373028969"
variation complement(1185)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200277380"
variation complement(1192)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:10897461"
variation complement(1200)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:145089060"
variation complement(1201)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140107613"
variation complement(1212)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150712250"
variation complement(1219)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368117259"
variation complement(1233)
/gene="RCOR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:141140296"
variation complement(1237)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375093342"
variation complement(1262)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:188747389"
exon 1280..1357
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(1315)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:56085529"
variation complement(1330)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148620245"
variation complement(1337)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376904142"
variation complement(1346)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144132231"
variation complement(1354)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371946091"
exon 1358..1415
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(1369)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373594298"
variation complement(1393)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142707103"
variation complement(1396)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:367591677"
exon 1416..1645
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(1434)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146698777"
variation complement(1450)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368244868"
variation complement(1475)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:144368985"
variation complement(1493)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375898467"
variation complement(1508)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:111279077"
variation complement(1528)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372331562"
variation complement(1593)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:202226917"
variation complement(1594)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202007775"
variation complement(1607)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200852972"
exon 1646..2604
/gene="RCOR2"
/inference="alignment:Splign:1.39.8"
variation complement(1657)
/gene="RCOR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:373028741"
variation complement(1669)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372630675"
variation complement(1741)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369913031"
variation complement(1771)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375356864"
variation complement(1928)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:320108"
variation complement(1977)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:371099264"
variation complement(2070)
/gene="RCOR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:181720436"
variation complement(2096)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:368290555"
variation complement(2170..2171)
/gene="RCOR2"
/replace=""
/replace="g"
/db_xref="dbSNP:371440060"
variation complement(2392)
/gene="RCOR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:375243455"
variation complement(2456)
/gene="RCOR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190063549"
variation complement(2485)
/gene="RCOR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:184945124"
variation complement(2505)
/gene="RCOR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:56124041"
variation complement(2527)
/gene="RCOR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:139708507"
variation complement(2571)
/gene="RCOR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:12289877"
variation complement(2592)
/gene="RCOR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:151311457"
ORIGIN
gcgcccagccgctgaacggcgtgggcaggtgggcggtggggttccagggcgccccgaggacagggggccccgacttcaggggaaccccaaccctgaggggcgtacatagtaatcacgccccagccgcaccggaccttgcgctcatcccttgcgtcccccacttctgcacaaacttttctgacgccctggctcgtgggggtcgtggagagcgctggggctaccaggtgggctcccaccccgccggaccctagccacgctgacctcctgcctctcctaacctcagtggcgacctctccaggccgggccgggctcggcactcggagcgagtgcggcaaccactgtcgctctccgaaggctcctgcgccccccggggcagctgggcggggtaatgccctcagtgatggagaagccgagcgcgggctctgggatcctgtcccgtagccgggccaagacggtgcccaacggcggacagccccactcggaggatgacagcagcgaggaggagcactcgcacgacagcatgatccgcgttggaaccaattaccaggccgtaattccggagtgcaagcctgagagccccgcacgctacagcaacaaggagctgaaggggatgctggtgtggtcacccaaccactgtgtgtcagatgccaagcttgacaagtacattgcgatggccaaggagaagcatggctacaacattgagcaggcgctgggcatgcttctgtggcataagcacgatgtggagaagtcgctggccgacctggccaacttcaccccattccctgacgagtggacagtagaggacaaggtgctgtttgaacaggcctttggcttccatggcaaatgcttccagcggatccagcagatgctgcctgacaagttgattcccagcctggtgaaatactactactcttggaagaagacccgcagccgaactagtgtgatggacagacaggcccggcggctggggggccgcaaggacaaagaagacagtgatgagctcgaagagggtcgaggaggcgtgagtgagggagagcccgatcctgcagatcccaagagagagcctctaccctctcggcccctgaatgcacgcccaggccctgggaaaaaggaggtccaggtgtctcagtaccgccaccatcccttgcgaacccggcgtcgcccacccaagggcatgtacctgagccctgaaggcctcacggcagtgtcaggaagcccggaccttgccaacctcacgctccgaggtcttgactctcagctcatctccctcaagcgccaggtacagagcatgaagcagacgaacagcagcctgcgccaagccctggagggcggtattgatccactacgccccccggaggccaacaccaagttcaactcccgctggaccacagatgagcagcttttggctgttcaagccatccgtaggtatggcaaagactttggggctattgcagaggtgattgggaacaagactctgacccaggtgaagactttctttgtgagctaccggcgccgcttcaatctggaggaggtgctgcaggaatgggaggctgagcaggatggggcccctggagccccagtccccatggaggaggctaggagaggggctccattgccagccccagccctagaggaagatgatgaggtccagattacatcggtctccacgtccgtgccccgatcagtgccccctgcgccaccaccccctccacctcccacctcgctgtcccagccacccccgctgctgaggccacctttgcccacggctcccactctgctccgacagccacccccactgcagcagggccgcttcctccagccccggctggcccccaaccagcccccaccgcctctcatccgccccgctctggctgccccccgccacagcgcccgccctggccctcagcccccacccaccctgattggaacccctctggagcccccagcaccctcactctgagccctgacgtcctccaccaaccacgggctccaggacccctttgctggccatccccaggcatctctggtgtcactgaggacagaagggactagggctctggcggggtctttgtaagaccagagtttcggacagcccagccccgccctttgggttctgcatgtgttcctggcagctgggcctgtctcctggggccatggccgggctcaggggcctttgagctggcctgagggcactttcgcttcctggccggtactggaatggctgtgtcctagtctgctggggcttggcctctgggtcctgccctttgtgtgtccggggtagtgaccttagcgtggagtggggagagggcagttgggtgtgctggctgttctcattcctctttcccttcttttagcaataagtctggggtgaggtggggagggaggctgcagggggggaggtgggcagaggggccttacagcagcagaggctggaagagaagctctgtcttcaggggccagctgggaaatgctaaggagctgagggtgcccaccaagcccaccttccagaaacttggagaaatgggggttgggaacttatgcagacatggatttatttttcaacattttttaaaaattaaaaaaaataaaatctaagcttactgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:283248 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:283248 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:283248 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:283248 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IEA
GeneID:283248 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:283248 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IEA
GeneID:283248 -> Cellular component: GO:0000785 [chromatin] evidence: IEA
GeneID:283248 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
by
@meso_cacase at
DBCLS
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