GGRNA | NM_173536.3

LOCUS       NM_173536               6769 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 1
            (GABRG1), mRNA.
ACCESSION   NM_173536
VERSION     NM_173536.3  GI:59889570
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6769)
  AUTHORS   Ittiwut,C., Yang,B.Z., Kranzler,H.R., Anton,R.F., Hirunsatit,R.,
            Weiss,R.D., Covault,J., Farrer,L.A. and Gelernter,J.
  TITLE     GABRG1 and GABRA2 variation associated with alcohol dependence in
            African Americans
  JOURNAL   Alcohol. Clin. Exp. Res. 36 (4), 588-593 (2012)
   PUBMED   21919924
  REMARK    GeneRIF: we genotyped 13 single nucleotide polymorphisms spanning
            GABRG1 and GABRA2 in African Americans with alcohol dependence
REFERENCE   2  (bases 1 to 6769)
  AUTHORS   Bloss,C.S., Berrettini,W., Bergen,A.W., Magistretti,P., Duvvuri,V.,
            Strober,M., Brandt,H., Crawford,S., Crow,S., Fichter,M.M.,
            Halmi,K.A., Johnson,C., Kaplan,A.S., Keel,P., Klump,K.L.,
            Mitchell,J., Treasure,J., Woodside,D.B., Marzola,E., Schork,N.J.
            and Kaye,W.H.
  TITLE     Genetic association of recovery from eating disorders: the role of
            GABA receptor SNPs
  JOURNAL   Neuropsychopharmacology 36 (11), 2222-2232 (2011)
   PUBMED   21750581
  REMARK    GeneRIF: An intronic single nucleotide polymorphism (SNP)
            (rs17536211) in GABRG1 shows the strongest statistical evidence of
            association of recovery from eating disorders.
REFERENCE   3  (bases 1 to 6769)
  AUTHORS   Green,E.K., Grozeva,D., Moskvina,V., Hamshere,M.L., Jones,I.R.,
            Jones,L., Forty,L., Caesar,S., Gordon-Smith,K., Fraser,C.,
            Russell,E., St Clair,D., Young,A.H., Ferrier,N., Farmer,A.,
            McGuffin,P., Holmans,P.A., Owen,M.J., O'Donovan,M.C. and
            Craddock,N.
  TITLE     Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated
            with susceptibility to bipolar schizoaffective disorder
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (7), 1347-1349
            (2010)
   PUBMED   20583128
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 6769)
  AUTHORS   Pinheiro,A.P., Bulik,C.M., Thornton,L.M., Sullivan,P.F., Root,T.L.,
            Bloss,C.S., Berrettini,W.H., Schork,N.J., Kaye,W.H., Bergen,A.W.,
            Magistretti,P., Brandt,H., Crawford,S., Crow,S., Fichter,M.M.,
            Goldman,D., Halmi,K.A., Johnson,C., Kaplan,A.S., Keel,P.K.,
            Klump,K.L., La Via,M., Mitchell,J.E., Strober,M., Rotondo,A.,
            Treasure,J. and Woodside,D.B.
  TITLE     Association study of 182 candidate genes in anorexia nervosa
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080
            (2010)
   PUBMED   20468064
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 6769)
  AUTHORS   Guilmatre,A., Dubourg,C., Mosca,A.L., Legallic,S., Goldenberg,A.,
            Drouin-Garraud,V., Layet,V., Rosier,A., Briault,S.,
            Bonnet-Brilhault,F., Laumonnier,F., Odent,S., Le Vacon,G.,
            Joly-Helas,G., David,V., Bendavid,C., Pinoit,J.M., Henry,C.,
            Impallomeni,C., Germano,E., Tortorella,G., Di Rosa,G.,
            Barthelemy,C., Andres,C., Faivre,L., Frebourg,T., Saugier Veber,P.
            and Campion,D.
  TITLE     Recurrent rearrangements in synaptic and neurodevelopmental genes
            and shared biologic pathways in schizophrenia, autism, and mental
            retardation
  JOURNAL   Arch. Gen. Psychiatry 66 (9), 947-956 (2009)
   PUBMED   19736351
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Review article
REFERENCE   6  (bases 1 to 6769)
  AUTHORS   Covault,J., Gelernter,J., Jensen,K., Anton,R. and Kranzler,H.R.
  TITLE     Markers in the 5'-region of GABRG1 associate to alcohol dependence
            and are in linkage disequilibrium with markers in the adjacent
            GABRA2 gene
  JOURNAL   Neuropsychopharmacology 33 (4), 837-848 (2008)
   PUBMED   17507911
  REMARK    GeneRIF: Logistic regression analysis indicated that genetic
            elements in the GABRG1 haplotype block likely contribute to alcohol
            dependence risk in an additive manner.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6769)
  AUTHORS   Ma,D.Q., Whitehead,P.L., Menold,M.M., Martin,E.R.,
            Ashley-Koch,A.E., Mei,H., Ritchie,M.D., Delong,G.R., Abramson,R.K.,
            Wright,H.H., Cuccaro,M.L., Hussman,J.P., Gilbert,J.R. and
            Pericak-Vance,M.A.
  TITLE     Identification of significant association and gene-gene interaction
            of GABA receptor subunit genes in autism
  JOURNAL   Am. J. Hum. Genet. 77 (3), 377-388 (2005)
   PUBMED   16080114
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6769)
  AUTHORS   Nymann-Andersen,J., Wang,H., Chen,L., Kittler,J.T., Moss,S.J. and
            Olsen,R.W.
  TITLE     Subunit specificity and interaction domain between GABA(A)
            receptor-associated protein (GABARAP) and GABA(A) receptors
  JOURNAL   J. Neurochem. 80 (5), 815-823 (2002)
   PUBMED   11948245
REFERENCE   9  (bases 1 to 6769)
  AUTHORS   Bonnert,T.P., McKernan,R.M., Farrar,S., le Bourdelles,B.,
            Heavens,R.P., Smith,D.W., Hewson,L., Rigby,M.R.,
            Sirinathsinghji,D.J., Brown,N., Wafford,K.A. and Whiting,P.J.
  TITLE     theta, a novel gamma-aminobutyric acid type A receptor subunit
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (17), 9891-9896 (1999)
   PUBMED   10449790
REFERENCE   10 (bases 1 to 6769)
  AUTHORS   Wilcox,A.S., Warrington,J.A., Gardiner,K., Berger,R., Whiting,P.,
            Altherr,M.R., Wasmuth,J.J., Patterson,D. and Sikela,J.M.
  TITLE     Human chromosomal localization of genes encoding the gamma 1 and
            gamma 2 subunits of the gamma-aminobutyric acid receptor indicates
            that members of this gene family are often clustered in the genome
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (13), 5857-5861 (1992)
   PUBMED   1321425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK122845.1 and AC095058.3.
            On Feb 16, 2005 this sequence version replaced gi:31742489.
            
            Summary: The protein encoded by this gene belongs to the
            ligand-gated ionic channel family. It is an integral membrane
            protein and plays an important role in inhibiting neurotransmission
            by binding to the benzodiazepine receptor and opening an integral
            chloride channel. This gene is clustered with three other family
            members on chromosome 4. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648937.1, AK122845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1965              AK122845.1         17-1981
            1966-6769           AC095058.3         124359-129162       c
FEATURES             Location/Qualifiers
     source          1..6769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..6769
                     /gene="GABRG1"
                     /note="gamma-aminobutyric acid (GABA) A receptor, gamma 1"
                     /db_xref="GeneID:2565"
                     /db_xref="HGNC:4086"
                     /db_xref="HPRD:15923"
                     /db_xref="MIM:137166"
     exon            1..256
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    123..125
                     /gene="GABRG1"
                     /note="upstream in-frame stop codon"
     CDS             153..1550
                     /gene="GABRG1"
                     /note="gamma-1 polypeptide; gamma-aminobutyric acid
                     receptor subunit gamma-1; GABA(A) receptor subunit
                     gamma-1; GABA(A) receptor, gamma"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit gamma-1
                     precursor"
                     /protein_id="NP_775807.2"
                     /db_xref="GI:31742490"
                     /db_xref="CCDS:CCDS3470.1"
                     /db_xref="GeneID:2565"
                     /db_xref="HGNC:4086"
                     /db_xref="HPRD:15923"
                     /db_xref="MIM:137166"
                     /translation="

MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL

"
     sig_peptide     153..257
                     /gene="GABRG1"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    345..962
                     /gene="GABRG1"
                     /note="Neurotransmitter-gated ion-channel ligand binding
                     domain; Region: Neur_chan_LBD; pfam02931"
                     /db_xref="CDD:202473"
     misc_feature    348..1538
                     /gene="GABRG1"
                     /note="Cation transporter family protein; Region: LIC;
                     TIGR00860"
                     /db_xref="CDD:162072"
     misc_feature    969..1034
                     /gene="GABRG1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N1C3.2);
                     transmembrane region"
     misc_feature    981..1529
                     /gene="GABRG1"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; Region: Neur_chan_memb; pfam02932"
                     /db_xref="CDD:202474"
     misc_feature    1047..1112
                     /gene="GABRG1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N1C3.2);
                     transmembrane region"
     misc_feature    1146..1214
                     /gene="GABRG1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N1C3.2);
                     transmembrane region"
     misc_feature    1485..1547
                     /gene="GABRG1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N1C3.2);
                     transmembrane region"
     exon            257..405
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            406..473
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            474..694
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            695..777
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            778..915
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            916..1068
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            1069..1283
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            1284..6769
                     /gene="GABRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       1426
                     /gene="GABRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75184362"
     STS             3173..3398
                     /gene="GABRG1"
                     /standard_name="RH106541"
                     /db_xref="UniSTS:209618"
     STS             6262..6423
                     /gene="GABRG1"
                     /standard_name="RH102865"
                     /db_xref="UniSTS:97199"
     polyA_signal    6746..6751
                     /gene="GABRG1"
     polyA_site      6769
                     /gene="GABRG1"
ORIGIN

aattctgctgggagtcgcatcctacctgtttgggaggtgcactgcctttccacactctcccttctgtactcagccagctgctgctgaggtgggaggaaaagtcctggctgggagaattgagctagtgcagcacacgtaaaaaagcgattccgatgggtcctttgaaagcttttctcttctccccttttcttctgcggagtcaaagtagaggggtgaggttggtcttcttgttactgaccctgcatttgggaaactgtgttgataaggcagatgatgaagatgatgaggatttaacggtgaacaaaacctgggtcttggccccaaaaattcatgaaggagatatcacacaaattctgaattcattgcttcaaggctatgacaataaacttcgtccagatataggagtgaggcccacagtaattgaaactgatgtttatgtaaacagcattggaccagttgatccaattaatatggaatatacaatagatataatttttgcccaaacctggtttgacagtcgtttaaaattcaatagtaccatgaaagtgcttatgcttaacagtaatatggttggaaaaatttggattcctgacactttcttcagaaactcaagaaaatctgatgctcactggataacaactcctaatcgtctgcttcgaatttggaatgatggacgagttctgtatactctaagattgacaattaatgcagaatgttatcttcagcttcataactttcccatggatgaacattcctgtccactggaattttcaagctatggataccctaaaaatgaaattgagtataagtggaaaaagccctccgtagaagtggctgatcctaaatactggagattatatcagtttgcatttgtagggttacggaactcaactgaaatcactcacacgatctctggggattatgttatcatgacaattttttttgacctgagcagaagaatgggatatttcactattcagacctacattccatgcattctgacagttgttctttcttgggtgtctttttggatcaataaagatgcagtgcctgcaagaacatcgttgggtatcactacagttctgactatgacaaccctgagtacaattgccaggaagtctttacctaaggtttcttatgtgactgcgatggatctctttgtttctgtttgtttcatttttgtttttgcagccttgatggaatatggaaccttgcattattttaccagcaaccaaaaaggaaagactgctactaaagacagaaagctaaaaaataaagcctcgatgactcctggtctccatcctggatccactctgattccaatgaataatatttctgtgccgcaagaagatgattatgggtatcagtgtttggagggcaaagattgtgccagcttcttctgttgctttgaagactgcagaacaggatcttggagggaaggaaggatacacatacgcattgccaaaattgactcttattctagaatatttttcccaaccgcttttgccctgttcaacttggtttattgggttggctatctttacttataaaatctacttcataagcaaaaatcaaaagaagtctgactaaattcagtagaatcttttgtgcttcagtaacttgaagtttaaatttaaaatgcagagagaccaatggttaaaatgtgaatagtattgtaactattttaaggccttcagaagtaaataaagtagcagctttcaggctaatttacgtgaaactgattagttgcaaaatccagtaggttaaaatactcacatatttttacttaaattttctttaatttacttatatgttattataattttgaatttttaagttctatgattcatgttttaaagatggaataattttaatacatattttgtttaaatataatctataattgttttgtaatgtaagactaattactaatatttatgtagcaacttttgtgccagaaaaaagactgttaatttgttttttcttgcttttcatttgattaccctgcttgaaatacagttagttgataacataaagccatagttttcttggattttcttccaagatattgtattcccaagaagaaattgatttatttttaaactatcagttactgaagacttatgaaaaggtcaatttttacctgtcttttaatccagtccattttctgacacaatattaaacagaacgccagttgcatttactttggtgatttgcaaacttggaatgaagccaccagtcattttttaagaatgcaagatgaaaaaatcaggtaaaatctaaccattttattctctgcttcatagcatttataatgtatgatgaggttaacactgaaatattaaaatctgcaaatgcacattaatgcaaattaaatgcagagagaaatgattatttttttctttatgttttatgaaagtgttgcagtccctaaaataaaaatattgaggaacattgcttgtatttactcacgtggttaaaaaattattacctggcaaactgagttgccggtcatattgaggacaaaatcttaaatatgtgctattagcattgtttttagactagtaatatgcagaaaacagttttaggcctgcgttacatattgcctcttccagctccaaagttttggaccctgtcagttttgcaactacattatacattattataatattcttttttttttctagaaactgggggcagcctcaaaatcatgttaaagagggagttttgttagaggcatctttaatgaacatgaatgtgagtgctctctaaattcttagcatctcactggatgtaaaatctatcagttaatagttttaaaaatgtctcttttgttaagaataaatttaggcttcaatcattataatcctgtaagtagcttgacataccaattgtttataagattcatcacataaatttctggagaaccaccaggtttagcttggaaataacctttaaagattgtttctgttgccaagaccaatgaccatgatgaagagttttatgatcacagcctatcttacttaaggtttgagaggaaacctgtcacctctgcaattgttactctagtttttaatgttataattccgctgcgtggttagtgaatgtctggcatgattatacacgtgtattggaaatatctagttttttaaatttttaattaatttatttataatttactgtgtgttcccagctaactctattttttttttcacttgctcataaacttctggaaaaaaataagcatgaatcaaatggtaatgcccaatatccaccgacactgcttttcttgaatgaacagccaaactaaactttggccatctatatattcatttacagattattcatacattcattttaataacattgagtactgatggatgttttgaaagtgagcattcatttaaggataaataaaaaataaagtagtaataaagaataaaatactttactaaaatattgtatggctattttcatgtttgaagctatagcttactatcatgagacagttttgattttgggactctttcaagtgtatctgagcatgactgtattttaaaatacttaaaagtgcttgatataaatagcttttccttctgaaccacgttctatgtaaaagaaaaaaaatagctttgattttctcactggtgtttcattaacttggttttaaatgttgacaatatttacaagtggaaataaaatttgtaaatatatgaaagatgcctttccttgtatataccatcaagcaagcactttgttttcaaagcaagtggtattttgatcagttttatttaaatgtgtgatcagaaagaatggcgtacaaatcttattatttctaaaaataagaataaaaaggtaaaactacatttagacttctttctcaagaaatcaaatacagctttttttcaaagctgattcagttcatttcctgttcctctattccaagtataagtttcaccaccttgagaaataatttttttaaaaaatcttcctctttctctggggagttatataataatttattgaatttattggaacttgattttcctggatgctttcaatgtttttaatgctaacatagaccccaaaattagatataaagaattgggaaggatacctggagcacaaggaataagatcatttgtaaaaatgtttgtttatatagacctatcctctaaatatgtgacaaggatctagaaattctgagaggggaaaatgtgattttggatttacaatgacagggtaatattttatttatcttcgaattccatggacaaaattaggctcacttaaattaatttttgtaaacccaagtaagttctaaaaaaaagtaaaaaatacatagaatacttgagaatttagcagggacagggaaaaatttcccagtaagtctgaagtcttgatgtaagtgggaattagataactaattggaggcattttattttaagttaaagacagatttctttaataagtttttaaaattgatcaactttaaattaagcacagtaaatgtgtataaatatgaaggcaatcataaggattttttcacttgtgtttccatattctggcattagtatatcatcataaaatagacaatgtttttgtctcaagaacaagaataaaattgaaatctgcattcatgccaattcagcataaaaaagaataggctacagttctctcacaccaagggccccatagttataaatgtgaaattatattccaggtcaaaatttgtgaaaaatacacaaaacactttgattttacaagagaggagctttaaataagatgattttagtagattgaaataaataaccagtatttaagtaaatgtataacgaatgaataaatacatgcataatattttcaaagttctataccagtacctatttttactcttacaaaatttcctgtaaaaaaatactacatttgaaattatttcattggttttagaactggcattgaaggtacccagtagactcttaagcctttactgcttgtctcactagaaacatttatttctgacctaccaagttttcttcacatcatcaaatttattcagcttctcagtgctgtaccgtatgatggcaagacatacttggtatttccatttttgttggtcattctttattgctttttactgctaggaaggtcttgccaggcttctatacagttacaaaaaccattaccaaactttatcaaggactttccaaatggagttttcaaatactattgaccacattgctctagttaatgtaaggtcagctctgactttttgtgtttgcatttcggaagtgaggtaacctcattcaaatatatatgcagcactttctgtgtacaaagtactgttctaaatacaaaagggaatataaagatgactttcaaggaacatataatgtagtcagaaagatgagaggattagttatacaatttaaggaagggaggataactttgggaaggttttgtggaggatatgtgtttagagatgcgagctggggattcaacaggtaagagggagagagatcacaatttccaactgggtaaacagcttgaaaaaagaaacagaagcctgggcacaaatgaaaattccatattaattggaagttaagattcatatagagacaatgaaaggttaggttagaacaataaactgagaagtacgaatgtggacttcaggaggctaggggaaattacgaagtcataaaaagttcacagagatacttgagtacaaaagatacattattaaaatttctgcagaagtttcatcttatttgtgtgtgatggtttggaatataacaagccagttaggcgtataagcttatagtggctaatatgaggatgaaatccgtactcttgtgacacaagtcttcagcggagatgggggatgataggcccaaatagaaagaaaagtggcagacattaagctttgactaacagacaacataactgagagacatggtgtgttgggtggaagggatcctgtagtagatacttgcttgcatgtagatgggtacaaagacaccataaggaaattctgaatgtaatacaaaggcttatttttcctgttgatttatctttttcacacataaaagatgaagaaaaaaataatctgaaatgtaaatcctaaagtgatctgtctagattcttattttttgaaaaatgttcctcactaaaagagttttctattcaaataaccatttccagttttctaactgagacatacatacatatatatatgtataaaattatatatatatttggacaaagagaataagagaattgcaggtagaaatagtctactgtgtgtagacaaatccagaaagttgatttctgttcctcaaacaatttctgaaatatttatgtcagaataaataaaagaattgttattgttggacaatgaaacatacctggaccctttgagtgtgtgaatagtaaaggctgtgataactgaaatgcagctaagcaaaaagggctaattagaagacttttgagacatgatttacctaaatggaaatagtttggttttcaatccttcactgtaataacaattatttgcatctattaagtgtttgtagtcactttgtataataaagttttatggcttgtgattataatggcttctgttattctgctactgcctcattgttttgaggaacatttgtaattttgtggcaaaggtgtctcaatttttcagtgttctttactctcatgatccttagaacaaaaaaaataccagtaacttgttataaataaagagtcacattctcttaaa

//

Annotations: