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2019-03-23 03:30:28, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_153378               2960 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens solute carrier family 22 (organic anion/urate
            transporter), member 12 (SLC22A12), transcript variant 2, mRNA.
ACCESSION   NM_153378
VERSION     NM_153378.2  GI:444299634
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Nakanishi,T., Ohya,K., Shimada,S., Anzai,N. and Tamai,I.
  TITLE     Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in
            renal reabsorption of urate
  JOURNAL   Nephrol. Dial. Transplant. 28 (3), 603-611 (2013)
   PUBMED   23291366
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Hinohara,Y., Naito,M., Okada,R., Yin,G., Higashibata,T., Tamura,T.,
            Kawai,S., Morita,E., Wakai,K., Matsuo,H., Mori,A. and Hamajima,N.
  TITLE     No association between MTHFR C677T and serum uric acid levels among
            Japanese with ABCG2 126QQ and SLC22A12 258WW
  JOURNAL   Nagoya J Med Sci 75 (1-2), 93-100 (2013)
   PUBMED   23544272
  REMARK    GeneRIF: Report no association between serum uric acid and MTHFR
            C677T genotype, after the influences of ABCG2 Q126X and SLC22A12
            W258X were removed.
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark
            C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T,
            Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg
            RP, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T,
            Huffman J, Yengo L, Zhao JH, Demirkan A, Feitosa MF, Liu X, Malerba
            G, Lopez LM, van der Harst P, Li X, Kleber ME, Hicks AA, Nolte IM,
            Johansson A, Murgia F, Wild SH, Bakker SJ, Peden JF, Dehghan A,
            Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose LM, Lehtimaki
            T, Woodward OM, Okada Y, Tin A, Muller C, Oldmeadow C, Putku M,
            Czamara D, Kraft P, Frogheri L, Thun GA, Grotevendt A, Gislason GK,
            Harris TB, Launer LJ, McArdle P, Shuldiner AR, Boerwinkle E, Coresh
            J, Schmidt H, Schallert M, Martin NG, Montgomery GW, Kubo M,
            Nakamura Y, Tanaka T, Munroe PB, Samani NJ, Jacobs DR Jr, Liu K,
            D'Adamo P, Ulivi S, Rotter JI, Psaty BM, Vollenweider P, Waeber G,
            Campbell S, Devuyst O, Navarro P, Kolcic I, Hastie N, Balkau B,
            Froguel P, Esko T, Salumets A, Khaw KT, Langenberg C, Wareham NJ,
            Isaacs A, Kraja A, Zhang Q, Wild PS, Scott RJ, Holliday EG, Org E,
            Viigimaa M, Bandinelli S, Metter JE, Lupo A, Trabetti E, Sorice R,
            Doring A, Lattka E, Strauch K, Theis F, Waldenberger M, Wichmann
            HE, Davies G, Gow AJ, Bruinenberg M, Stolk RP, Kooner JS, Zhang W,
            Winkelmann BR, Boehm BO, Lucae S, Penninx BW, Smit JH, Curhan G,
            Mudgal P, Plenge RM, Portas L, Persico I, Kirin M, Wilson JF, Mateo
            Leach I, van Gilst WH, Goel A, Ongen H, Hofman A, Rivadeneira F,
            Uitterlinden AG, Imboden M, von Eckardstein A, Cucca F, Nagaraja R,
            Piras MG, Nauck M, Schurmann C, Budde K, Ernst F, Farrington SM,
            Theodoratou E, Prokopenko I, Stumvoll M, Jula A, Perola M, Salomaa
            V, Shin SY, Spector TD, Sala C, Ridker PM, Kahonen M, Viikari J,
            Hengstenberg C, Nelson CP, Meschia JF, Nalls MA, Sharma P,
            Singleton AB, Kamatani N, Zeller T, Burnier M, Attia J, Laan M,
            Klopp N, Hillege HL, Kloiber S, Choi H, Pirastu M, Tore S,
            Probst-Hensch NM, Volzke H, Gudnason V, Parsa A, Schmidt R,
            Whitfield JB, Fornage M, Gasparini P, Siscovick DS, Polasek O,
            Campbell H, Rudan I, Bouatia-Naji N, Metspalu A, Loos RJ, van Duijn
            CM, Borecki IB, Ferrucci L, Gambaro G, Deary IJ, Wolffenbuttel BH,
            Chambers JC, Marz W, Pramstaller PP, Snieder H, Gyllensten U,
            Wright AF, Navis G, Watkins H, Witteman JC, Sanna S, Schipf S,
            Dunlop MG, Tonjes A, Ripatti S, Soranzo N, Toniolo D, Chasman DI,
            Raitakari O, Kao WH, Ciullo M, Fox CS, Caulfield M, Bochud M and
            Gieger C.
  CONSRTM   LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
            ICBP Consortium; MAGIC Consortium
  TITLE     Genome-wide association analyses identify 18 new loci associated
            with serum urate concentrations
  JOURNAL   Nat. Genet. 45 (2), 145-154 (2013)
   PUBMED   23263486
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Takagi,S., Omae,R., Makanga,J.O., Kawahara,T. and Inazu,T.
  TITLE     Simple and rapid detection method for the mutations in SLC22A12
            that cause hypouricemia by allele-specific real-time polymerase
            chain reaction
  JOURNAL   Clin. Chim. Acta 415, 330-333 (2013)
   PUBMED   23148994
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Wempe,M.F., Lightner,J.W., Miller,B., Iwen,T.J., Rice,P.J.,
            Wakui,S., Anzai,N., Jutabha,P. and Endou,H.
  TITLE     Potent human uric acid transporter 1 inhibitors: in vitro and in
            vivo metabolism and pharmacokinetic studies
  JOURNAL   Drug Des Devel Ther 6, 323-339 (2012)
   PUBMED   23152669
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Anzai,N., Miyazaki,H., Noshiro,R., Khamdang,S., Chairoungdua,A.,
            Shin,H.J., Enomoto,A., Sakamoto,S., Hirata,T., Tomita,K., Kanai,Y.
            and Endou,H.
  TITLE     The multivalent PDZ domain-containing protein PDZK1 regulates
            transport activity of renal urate-anion exchanger URAT1 via its C
            terminus
  JOURNAL   J. Biol. Chem. 279 (44), 45942-45950 (2004)
   PUBMED   15304510
  REMARK    GeneRIF: PDZK1 plays a role in regulating the functional activity
            of URAT1-mediated urate transport in the apical membrane of renal
            proximal tubules.
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   Iwai,N., Mino,Y., Hosoyamada,M., Tago,N., Kokubo,Y. and Endou,H.
  TITLE     A high prevalence of renal hypouricemia caused by inactive SLC22A12
            in Japanese
  JOURNAL   Kidney Int. 66 (3), 935-944 (2004)
   PUBMED   15327384
  REMARK    GeneRIF: SLC22A12 is a major gene for hypouricemia but not
            hyperuricemia in Japanese.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Ichida,K., Hosoyamada,M., Hisatome,I., Enomoto,A., Hikita,M.,
            Endou,H. and Hosoya,T.
  TITLE     Clinical and molecular analysis of patients with renal hypouricemia
            in Japan-influence of URAT1 gene on urinary urate excretion
  JOURNAL   J. Am. Soc. Nephrol. 15 (1), 164-173 (2004)
   PUBMED   14694169
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Gisler,S.M., Pribanic,S., Bacic,D., Forrer,P., Gantenbein,A.,
            Sabourin,L.A., Tsuji,A., Zhao,Z.S., Manser,E., Biber,J. and
            Murer,H.
  TITLE     PDZK1: I. a major scaffolder in brush borders of proximal tubular
            cells
  JOURNAL   Kidney Int. 64 (5), 1733-1745 (2003)
   PUBMED   14531806
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Enomoto,A., Kimura,H., Chairoungdua,A., Shigeta,Y., Jutabha,P.,
            Cha,S.H., Hosoyamada,M., Takeda,M., Sekine,T., Igarashi,T.,
            Matsuo,H., Kikuchi,Y., Oda,T., Ichida,K., Hosoya,T., Shimokata,K.,
            Niwa,T., Kanai,Y. and Endou,H.
  TITLE     Molecular identification of a renal urate anion exchanger that
            regulates blood urate levels
  JOURNAL   Nature 417 (6887), 447-452 (2002)
   PUBMED   12024214
  REMARK    GeneRIF: Molecular identification of a renal urate anion exchanger
            that regulates blood urate levels
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB050269.1, AP001092.5,
            AK055737.1, BC053348.1 and BX104022.1.
            On Jan 30, 2013 this sequence version replaced gi:24497486.
            
            Summary: The protein encoded by this gene is a member of the
            organic anion transporter (OAT) family, and it acts as a urate
            transporter to regulate urate levels in blood. This protein is an
            integral membrane protein primarily found in epithelial cells of
            the proximal tubule of the kidney. An elevated level of serum
            urate, hyperuricemia, is associated with increased incidences of
            gout, and mutations in this gene cause renal hypouricemia type 1.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) contains alternate 5' exon
            structure, lacks a portion of the 5' coding region, and uses a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (b) is shorter at the N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055737.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AB050269.1         1-323
            324-324             AP001092.5         34063-34063
            325-528             AB050269.1         325-528
            529-893             AK055737.1         111-475
            894-894             AP001092.5         34744-34744
            895-1061            AK055737.1         477-643
            1062-1062           AP001092.5         35732-35732
            1063-1728           AK055737.1         645-1310
            1729-1729           AP001092.5         42783-42783
            1730-2936           BC053348.1         1539-2745
            2937-2960           BX104022.1         228-251
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2960
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /note="solute carrier family 22 (organic anion/urate
                     transporter), member 12"
                     /db_xref="GeneID:116085"
                     /db_xref="HGNC:17989"
                     /db_xref="MIM:607096"
     exon            1..738
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       30
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9734313"
     STS             94..350
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="REN55630"
                     /db_xref="UniSTS:380430"
     variation       202
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191101229"
     variation       279
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71581770"
     variation       282
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138511904"
     variation       324
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:559946"
     variation       337
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182715759"
     variation       338
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79768170"
     variation       339
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75351039"
     STS             348..588
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="REN55631"
                     /db_xref="UniSTS:380431"
     STS             392..575
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="stSG635523"
                     /db_xref="UniSTS:460781"
     variation       394
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191077837"
     variation       438
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372424252"
     variation       514
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72922827"
     variation       528
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3825018"
     variation       624
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369334634"
     variation       642
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71581771"
     variation       673
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369153816"
     variation       703
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201365068"
     exon            739..1038
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       746
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369459384"
     variation       759
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144313367"
     variation       762
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148378818"
     variation       765
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3802948"
     variation       779
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200499531"
     variation       829
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12800450"
     variation       856
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200961759"
     variation       860
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141570522"
     variation       870
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377022807"
     variation       882
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3825017"
     variation       894
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3825016"
     variation       902
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201567912"
     variation       905
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:121907896"
     variation       910
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144328876"
     variation       941
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61737613"
     variation       963
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371053482"
     variation       969
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146095398"
     variation       1027
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150428327"
     exon            1039..1142
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1048
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149722479"
     variation       1062
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11231825"
     misc_feature    1067..1069
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /note="upstream in-frame stop codon"
     variation       1067
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148915713"
     variation       1112
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374684921"
     variation       1122
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376212424"
     variation       1126
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201181059"
     variation       1130
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370851012"
     exon            1143..1311
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     CDS             1145..2143
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /note="isoform b is encoded by transcript variant 2;
                     solute carrier family 22 (organic anion/cation
                     transporter), member 12; urate transporter 1; urate anion
                     exchanger 1; renal-specific transporter; organic anion
                     transporter 4-like protein"
                     /codon_start=1
                     /product="solute carrier family 22 member 12 isoform b"
                     /protein_id="NP_700357.1"
                     /db_xref="GI:24497487"
                     /db_xref="GeneID:116085"
                     /db_xref="HGNC:17989"
                     /db_xref="MIM:607096"
                     /translation="
MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
"
     misc_feature    <1148..2059
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /note="cation transport protein; Region: 2A0119;
                     TIGR00898"
                     /db_xref="CDD:162097"
     misc_feature    <1607..2029
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /note="The Major Facilitator Superfamily (MFS) is a large
                     and diverse group of secondary transporters that includes
                     uniporters, symporters, and antiporters. MFS proteins
                     facilitate the transport across cytoplasmic or internal
                     membranes of a variety of...; Region: MFS; cd06174"
                     /db_xref="CDD:119392"
     variation       1158
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145738825"
     variation       1160
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201136391"
     variation       1164
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376338940"
     variation       1165
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377128267"
     variation       1213
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371087747"
     variation       1234
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373029817"
     variation       1241
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376297536"
     variation       1255
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:121907892"
     variation       1259
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200690486"
     variation       1294
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200680754"
     variation       1310
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139316841"
     exon            1312..1435
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1327
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71581775"
     variation       1342
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140154051"
     variation       1361
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183246258"
     variation       1375
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121907894"
     variation       1376
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199992707"
     variation       1406
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367678216"
     exon            1436..1551
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1454
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150255373"
     variation       1455
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375040493"
     variation       1484
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138889743"
     variation       1506
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140376651"
     variation       1513
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370083633"
     variation       1520
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374858585"
     variation       1542
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371005496"
     exon            1552..1766
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1556
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201322494"
     variation       1563
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121907897"
     variation       1564
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368451526"
     variation       1581
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372794965"
     variation       1616
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372225207"
     variation       1635
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149438001"
     variation       1643
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146388519"
     variation       1666
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138457974"
     variation       1690
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142769893"
     variation       1698
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372595086"
     variation       1704
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146048999"
     variation       1705
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201081275"
     variation       1706
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77159242"
     variation       1712
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370100606"
     variation       1729
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1630320"
     variation       1734
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121907895"
     variation       1735
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142344676"
     variation       1752
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150779326"
     variation       1753
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183551522"
     variation       1766
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139140123"
     exon            1767..1875
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1781
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145200251"
     variation       1782
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147647315"
     variation       1790
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7932775"
     variation       1810
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61743169"
     variation       1819
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145454847"
     variation       1830
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201423508"
     exon            1876..2079
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1876
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200515227"
     variation       1881
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200104135"
     variation       1882
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368443880"
     variation       1894
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199607711"
     variation       1908
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148862453"
     variation       1909
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146694365"
     variation       1919
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200599563"
     variation       1941
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151308640"
     variation       1957
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200072517"
     variation       1972
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139224371"
     variation       1990
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140671173"
     variation       2029
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145764379"
     variation       2053
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138485972"
     variation       2054
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372091940"
     variation       2056..2058
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="cac"
                     /db_xref="dbSNP:368190173"
     variation       2063
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375375872"
     exon            2080..2945
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /inference="alignment:Splign:1.39.8"
     variation       2087..2088
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="agaaggcaacacatggca"
                     /replace="agaaggcacacatggta"
                     /db_xref="dbSNP:143874752"
     variation       2093
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199535450"
     variation       2097
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369797157"
     variation       2107
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143053863"
     variation       2168
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373528077"
     variation       2173
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376221325"
     STS             2176..2430
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="REN55672"
                     /db_xref="UniSTS:380472"
     variation       2189
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:71583717"
     variation       2210
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139851336"
     variation       2213
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141655625"
     variation       2266
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375484950"
     variation       2275
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370769782"
     variation       2295
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146221674"
     variation       2308..2309
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:139299506"
     variation       2387..2388
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="ccctg"
                     /db_xref="dbSNP:150284736"
     variation       2391..2392
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="gccct"
                     /db_xref="dbSNP:61157735"
     STS             2403..2649
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="REN55673"
                     /db_xref="UniSTS:380473"
     variation       2411
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148845071"
     variation       2414
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184983393"
     variation       2430
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:200439262"
     variation       2434
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:3832794"
     variation       2434
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201187954"
     STS             2586..2846
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="REN55674"
                     /db_xref="UniSTS:380474"
     variation       2593
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146963319"
     variation       2660
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:476037"
     STS             2759..2919
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /standard_name="RH98949"
                     /db_xref="UniSTS:90688"
     variation       2790
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200126462"
     polyA_signal    2919..2924
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
     polyA_site      2945
                     /gene="SLC22A12"
                     /gene_synonym="OAT4L; RST; URAT1"
ORIGIN      
ccacagcaggtgagtggaggcaggagccacgggtggggccaggccacacagcctgggaggcgcaggggctgggcagctgccagtgacccaagcccacacagagacttgcacagctgccccagccccaaattagggggatcccctggcccaccttctcttggctcagccactctgggaggtgggcacacaggggcaccgaagggagcaggcagccctggcatcccacagccgccaggagaaaaacttaggcctccccaagacctggcacagagcaggccggccctggcccccaagcagaggaggctgcacctccctcgcgtctgtgcctgcctcaacgcgggttaaactttgaccaaggaaatgattgctaaactcgattccataagtgtcaccggtcacactttaattccagtctaaaattaaagtcttcagtctccacattccctactttccaaattcagctttcccgggaggtctggagcagctgcctctctggggagatgctggaggtctcggaatcacctcacgcggcctcagggcccagttggagccaccccaagtgacaccagcaggcagatgaccagagagcctgagcctccggccccgagtctgtgaagcctagccgctgggctggagaagccactgtgggcaccaccgtgggggaaacaggcccgttgccctggcctctttgccctgggccagcctttgtgaagtgggcccctcttctgggccccttgaagcatgctggagaacttctcggccgccgtgcccagccaccgctgctgggcacccctcctggacaacagcacggctcaggccagcatcctagggagcttgagtcctgaggccctcctggctatttccatcccgccgggccccaaccagaggccccaccagtgccgccgcttccgccagccacagtggcagctcttggaccccaatgccacggccaccagctggagcgaggccgacacggagccgtgtgtggatggctgggtctatgaccgcagcatcttcacctccacaatcgtggccaagtggaacctcgtgtgtgactctcatgctctgaagcccatggcccagtccatctacctggctgggattctggtgggagctgctgcgtgcggccctgcctcagacagtgatggagtggacggcggcacgggcccgacccttggtgatgaccttgaactctctgggcttcagcttcggccatggcctgacagctgcagtggcctacggtgtgcgggactggacactgctgcagctggtggtctcggtccccttcttcctctgctttttgtactcctggtggctggcagagtcggcacgatggctcctcaccacaggcaggctggattggggcctgcaggagctgtggagggtggctgccatcaacggaaagggggcagtgcaggacaccctgacccctgaggtcttgctttcagccatgcgggaggagctgagcatgggccagcctcctgccagcctgggcaccctgctccgcatgcccggactgcgcttccggacctgtatctccacgttgtgctggttcgcctttggcttcaccttcttcggcctggccctggacctgcaggccctgggcagcaacatcttcctgctccaaatgttcattggtgtcgtggacatcccagccaagatgggcgccctgctgctgctgagccacctgggccgccgccccacgctggccgcatccctgttgctggcagggctctgcattctggccaacacgctggtgccccacgaaatgggggctctgcgctcagccttggccgtgctggggctgggcggggtgggggctgccttcacctgcatcaccatctacagcagcgagctcttccccactgtgctcaggatgacggcagtgggcttgggccagatggcagcccgtggaggagccatcctggggcctctggtccggctgctgggtgtccatggcccctggctgcccttgctggtgtatgggacggtgccagtgctgagtggcctggccgcactgcttctgcccgagacccagagcttgccgctgcccgacaccatccaagatgtgcagaaccaggcagtaaagaaggcaacacatggcacgctggggaactctgtcctaaaatccacacagttttagcctcctggggaacctgcgatgggacggtcagaggaagagacttcttctgttctctggagaaggcaggaggaaagcaaagacctccatttccagaggcccagaggctgccctctgaggtccccactctcccccagggctgcccctccaggtgagccctgcccctctcacagtccaaggggcccccttcaatactgaaggggaaaaggacagtttgattggcaggaggtgacccagtgcaccatcaccctgccctgccctcgtggcttcggagagcagaggggtcaggcccaggggaacgagctggccttgccaaccctctgcttgactccgcactgccacttgtccccccacacccgtccacctgcccagagctcagagctaaccaccatccatggtcaagacctctcctagctccacacaagcagtagagtctcagctccacagctttacccagaagccctgtaagcctggcccctggcccctccccatgtccctccaggcctcagccacctgcccgccacatcctctgcctgctgtccccttcccaccctcatccctgaccgactccacttaacccccaaacccagccccccttccaggggtccagggccagcctgagatgcccgtgaaactcctacccacagttacagccacaagcctgcctcctcccaccctgccagcctatgagttcccagagggttggggcagtcccatgaccccatgtcccagctccccacacagcgctgggccagagaggcattggtgcgagggattgaataaagaaacaaatgaatggctgcccaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:116085 -> Molecular function: GO:0015143 [urate transmembrane transporter activity] evidence: IDA
            GeneID:116085 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IPI
            GeneID:116085 -> Biological process: GO:0015747 [urate transport] evidence: IDA
            GeneID:116085 -> Biological process: GO:0019725 [cellular homeostasis] evidence: NAS
            GeneID:116085 -> Biological process: GO:0042493 [response to drug] evidence: IDA
            GeneID:116085 -> Biological process: GO:0046415 [urate metabolic process] evidence: IMP
            GeneID:116085 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
            GeneID:116085 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:116085 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:116085 -> Cellular component: GO:0016021 [integral to membrane] evidence: IDA
            GeneID:116085 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
            GeneID:116085 -> Cellular component: GO:0031526 [brush border membrane] evidence: ISS
            GeneID:116085 -> Cellular component: GO:0031526 [brush border membrane] evidence: NAS

by @meso_cacase at DBCLS
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