2024-03-29 01:42:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_153371 4804 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens ligand of numb-protein X 2 (LNX2), mRNA. ACCESSION NM_153371 VERSION NM_153371.3 GI:153791779 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4804) AUTHORS Mehraj,V., Boucherit,N., Ben Amara,A., Capo,C., Bonatti,S., Mege,J.L., Mottola,G. and Ghigo,E. TITLE The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever JOURNAL FEMS Immunol. Med. Microbiol. 64 (1), 98-100 (2012) PUBMED 22066909 REMARK GeneRIF: The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever. REFERENCE 2 (bases 1 to 4804) AUTHORS D'Agostino,M., Tornillo,G., Caporaso,M.G., Barone,M.V., Ghigo,E., Bonatti,S. and Mottola,G. TITLE Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8alpha and promote its ubiquitylation and endocytosis JOURNAL J. Cell. Sci. 124 (PT 21), 3545-3556 (2011) PUBMED 22045731 REMARK GeneRIF: LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis REFERENCE 3 (bases 1 to 4804) AUTHORS Kumar,V., Matsuo,K., Takahashi,A., Hosono,N., Tsunoda,T., Kamatani,N., Kong,S.Y., Nakagawa,H., Cui,R., Tanikawa,C., Seto,M., Morishima,Y., Kubo,M., Nakamura,Y. and Matsuda,K. TITLE Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility JOURNAL J. Hum. Genet. 56 (6), 436-439 (2011) PUBMED 21471979 REFERENCE 4 (bases 1 to 4804) AUTHORS Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L., Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E., Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E., Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T., Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R., Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P., Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J., Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E., Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J., French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J., Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E., Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J., Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M., Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S., Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E., Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J., McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A., Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M., Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D., Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W., Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W., Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S., Bentley,D.R., Rogers,J. and Ross,M.T. TITLE The DNA sequence and analysis of human chromosome 13 JOURNAL Nature 428 (6982), 522-528 (2004) PUBMED 15057823 REFERENCE 5 (bases 1 to 4804) AUTHORS Rice,D.S., Northcutt,G.M. and Kurschner,C. TITLE The Lnx family proteins function as molecular scaffolds for Numb family proteins JOURNAL Mol. Cell. Neurosci. 18 (5), 525-540 (2001) PUBMED 11922143 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB220129.1, BC036755.2, DN990012.1 and AK022995.1. On Jul 25, 2007 this sequence version replaced gi:34222215. ##Evidence-Data-START## Transcript exon combination :: BC036755.2, AK313394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025098 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-172 DB220129.1 1-172 173-175 BC036755.2 1-3 176-177 BC036755.2 5-6 178-708 DN990012.1 113-643 709-2870 BC036755.2 538-2699 2871-2991 AK022995.1 644-764 2992-3041 BC036755.2 2821-2870 3042-3565 AK022995.1 815-1338 3566-4804 BC036755.2 3395-4633 FEATURES Location/Qualifiers source 1..4804 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="13" /map="13q12.2" gene 1..4804 /gene="LNX2" /gene_synonym="PDZRN1" /note="ligand of numb-protein X 2" /db_xref="GeneID:222484" /db_xref="HGNC:20421" /db_xref="HPRD:10042" /db_xref="MIM:609733" exon 1..209 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" variation 151..157 /gene="LNX2" /gene_synonym="PDZRN1" /replace="" /replace="ctggtgc" /db_xref="dbSNP:71083680" exon 210..716 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" misc_feature 301..303 /gene="LNX2" /gene_synonym="PDZRN1" /note="upstream in-frame stop codon" CDS 310..2382 /gene="LNX2" /gene_synonym="PDZRN1" /note="PDZ domain containing ring finger 1; numb-binding protein 2; PDZ domain-containing RING finger protein 1" /codon_start=1 /product="ligand of Numb protein X 2" /protein_id="NP_699202.1" /db_xref="GI:24025688" /db_xref="CCDS:CCDS9323.1" /db_xref="GeneID:222484" /db_xref="HGNC:20421" /db_xref="HPRD:10042" /db_xref="MIM:609733" /translation="
MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV
" misc_feature 445..576 /gene="LNX2" /gene_synonym="PDZRN1" /note="Zinc finger, C3HC4 type (RING finger); Region: zf-C3HC4_2; pfam13923" /db_xref="CDD:206094" misc_feature 457..582 /gene="LNX2" /gene_synonym="PDZRN1" /note="RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cd00162" /db_xref="CDD:29102" misc_feature order(457..459,466..468,502..504,508..510,517..519, 526..528,559..561,568..570) /gene="LNX2" /gene_synonym="PDZRN1" /note="cross-brace motif; other site" /db_xref="CDD:29102" misc_feature 931..942 /gene="LNX2" /gene_synonym="PDZRN1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q8N448.1); Region: NPXY motif" misc_feature 1000..1254 /gene="LNX2" /gene_synonym="PDZRN1" /note="PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992" /db_xref="CDD:29049" misc_feature order(1039..1050,1054..1056,1204..1209,1216..1221) /gene="LNX2" /gene_synonym="PDZRN1" /note="protein binding site [polypeptide binding]; other site" /db_xref="CDD:29049" misc_feature 1318..1566 /gene="LNX2" /gene_synonym="PDZRN1" /note="PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992" /db_xref="CDD:29049" misc_feature order(1357..1368,1372..1374,1516..1521,1528..1533) /gene="LNX2" /gene_synonym="PDZRN1" /note="protein binding site [polypeptide binding]; other site" /db_xref="CDD:29049" misc_feature 1705..>1911 /gene="LNX2" /gene_synonym="PDZRN1" /note="PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992" /db_xref="CDD:29049" misc_feature order(1741..1752,1756..1758) /gene="LNX2" /gene_synonym="PDZRN1" /note="protein binding site [polypeptide binding]; other site" /db_xref="CDD:29049" misc_feature 2104..2358 /gene="LNX2" /gene_synonym="PDZRN1" /note="PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992" /db_xref="CDD:29049" misc_feature order(2137..2148,2152..2154,2308..2313,2320..2325) /gene="LNX2" /gene_synonym="PDZRN1" /note="protein binding site [polypeptide binding]; other site" /db_xref="CDD:29049" exon 717..964 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 965..1164 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 1165..1533 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 1534..1677 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 1678..1855 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 1856..2087 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 2088..2246 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" exon 2247..4804 /gene="LNX2" /gene_synonym="PDZRN1" /inference="alignment:Splign:1.39.8" STS 2885..2987 /gene="LNX2" /gene_synonym="PDZRN1" /standard_name="D11S2921" /db_xref="UniSTS:152074" variation 4526 /gene="LNX2" /gene_synonym="PDZRN1" /replace="c" /replace="t" /db_xref="dbSNP:11542454" variation 4684 /gene="LNX2" /gene_synonym="PDZRN1" /replace="c" /replace="t" /db_xref="dbSNP:1046524" STS 4701..4792 /gene="LNX2" /gene_synonym="PDZRN1" /standard_name="SHGC-24292" /db_xref="UniSTS:70184" STS 4701..4780 /gene="LNX2" /gene_synonym="PDZRN1" /standard_name="RH91737" /db_xref="UniSTS:87114" ORIGIN
aaggcagcaggggcggttgagaagtgaagtcttggccggagtttgctttttgccaggaaatccgcggcggcggcggcggcggcggcgattcctggcggagcggagccgggcaggctctccgctccctcagcgggccgcggagagcgggagctggtgccgagcagcggcgccaggagcccgtgcgcggcccgggcagccgcgctttcccaaaaaacacaccttgactttagtcagatacatcactgtctgttaaaggaaaccaagcgtgaagtggaagtctaacacatgaggatacagaattgattcaaaatgggaacaacaagtgatgagatggtgtctgtggaacagacctcctcctcttctctaaaccccctgtgttttgaatgtggccaacagcactggacaagagaaaaccatttgtacaattaccagaatgaagtggatgatgacctagtctgccatatttgccttcaacctctgctgcagccactagacacaccctgtggacatacattctgctacaagtgcctcagaaactttttacaagagaaagatttctgtccgttggaccggaaaagacttcattttaagttgtgcaagaagtctagtattctagttcataaactcctagacaaattattagttttatgtccattttcttcagtgtgcaaagatgtaatgcaacgttgtgatctggaggcacatctcaaaaacagatgtcctggagcttctcatcggagagttgccctggagagaaggaaaactagtagaactcaagcagagattgagaatgaaaatgggcccactctactagatcctgcaggtaccttatctccagaagcagactgtttggggacaggcgcagtgcctgtggagcggcacttgacatcagcgtctctttccacatggagtgaggagcctggccttgacaaccctgcctttgaggagagcgctggagctgacaccacacaacagccacttagtttaccagaaggagaaatcaccacgattgaaattcatcggtccaatccttacattcagttaggaatcagcattgtgggtggcaacgaaacacctttgattaacattgtcatccaggaggtctatcgggatggggtcattgccagagacgggagacttcttgctggagaccagattcttcaggtcaacaactacaatatcagcaatgtgtcccataactatgcccgagctgtcctttcccagccctgcaacacactgcatcttactgtgcttcgagagaggcgctttggcaaccgagcacacaaccattctgatagtaactctccacgagaagagattttccaagtggctcttcataaacgggactctggtgaacagcttggcattaaattggtgcgaaggacagatgagccaggggtttttattcttgacctgttggaaggggggttggctgcccaggacggcaggctaagcagcaatgaccgagtgctggccatcaatgggcacgacctgaagtatggaactccggagcttgctgcccagattattcaggccagtggagagagagtgaatttaacaattgctagaccagggaaaccccagcctggtaacaccattagagaagcaggaaatcatagcagcagcagccagcaccacacaccaccaccgtattatagcagaccaagctcacataaggatcttactcagtgtgttacatgccaagaaaaacacattactgtaaagaaggaaccacatgaatcccttggcatgaccgttgctgggggcaggggaagtaagagtggtgagctgcccatctttgtgaccagtgtgccaccccatggctgccttgcacgagatggcagaataaagagaggtgatgtgttgctaaatatcaacggcattgatttgaccaatttaagtcacagtgaggcagttgcaatgctgaaagccagtgccgcgtcccctgctgttgcccttaaagcacttgaggtccagattgttgaggaggcgactcagaacgcggaggagcagccgagtactttcagcgaaaatgagtatgatgccagttggtccccatcatgggtcatgtggcttgggcttcccagcacacttcatagctgccacgatatagttttacgaagaagttacttgggaagttggggctttagtatcgttggtggatatgaagagaaccacaccaatcagccttttttcattaaaactattgtcttgggaactcctgcttattatgatggaagattaaagtgtggtgacatgattgtggccgtaaatgggctgtcaaccgtgggcatgagccactctgcactagttcccatgttgaaggagcagaggaacaaagtcactctgaccgttatttgttggcctggcagccttgtatagattttggaaattggtttcaaatcttgcatcttccttttttagatttttgaaagaaaaccctttggtttcattgtgtttgtggtttaggagctgctgacactgctggtatacacagggccaaaacccactaagattgtccgtttatgtttatttaaatggtttcctaagttagttacatttcttttagcttggaaacagtcttccactaacctttgtgagtttatattttcagaattcagacttagttgttaaaatgttacctatggtaatgagcaaagctcacccaaactgtgccccagatggagtaaagaccttctggtgggtctttgttttcagtaactgaatcatagaacgagttctgtatccctcaggcctgatgtcagcaaagccagtaacaacagcgtgtactgccactgtcataaccaataccatgaatgaatatactttaaattttggtgataactgttccccatttttttttgaaccacagtctcactctcacccaggctggagtgcagtggcacaatctcagctcactgcaagctccgcctcctgggttcacgccattctcccacctcagcctcccgagtagctgggactacaggcgtgtgccaccatgcccagctaattttttgtacttttagtagagacggggtttcaccgtgttagccaggatggtctcgatctcctgaccttgtgatctgcccgcctcagcctcccaaagtgctgggattacaggtgtgagctgccgcacccggccgttcccattttttattggtgccaacatttcaaaacttcatactgtttataaactgattttctggtttatttctactgtaatctctcaatattcatagaagatgaagaaataagtctgacaacactaaagaaatttcttaatatactattattagaatagtagaggataaaagataatgttatccagttacaaaggaatttggatgataattataacttaatgttagagatggtaaagctgcacttacttgaacagcccaaaagcattaaaaatctatttccagaggaatgttttgctatgtagggaaattttgaagtagtttttgctaaaaaattatttctagagttgtgttattcttagcagtaatcttggctagaaatgtttttgtgatttatgcgattaaacgaaatgataaagataaaaccatattattaaatacctatatatcacagctaagtaggagaaagggagacctttttattttgttcaggtaggagtatttcttgtgtattttagaaacaattatttttcccattatttcttatgagattagttgtttcaagtaggagacagaaaagttctgttttgttggaaatgtaggttttagatgtatctttcagtcagctctcagtcactagactatttcatattttttgaaatgtttttgaaaattatgactagcccattttttgtcctttattcaacatacttatcctctgaacacataaataagtgaataagataaaaatatctttaccttattaatattatacatacttgaaaaaaatttcatttagaaacctagttcagaatctgagcaaatttacaagtgacctctgtaataaatggtattgataatcagagaatgtatttcagaatactacagtacaatatattatgaagcatgaccactttattttgaaacttagcaattgtattgctggggtttattgtatctgtagcatgtcactgattatttcagttagttttataatgatttttaaaaaacatatctatttggaataagatacagcaacaatcattgctactgacttgttcaaccccttagttacactgtatgatcaacatataacaagatacagtggaatggcccatacagtatattactgttgtgtgatgattggctttggaagcagtttgattttgaaatgctttgatattctaattgacatggaacaagttttttccctgctccccaaatagaattttgtaaccaactttgctatttttttaaagtttgtaagaatgtgtcatttcttggggagtagccatccatcaacaaatatcctgactgctactttgttatatacaaaatacttacattgaacctggtggcataatgagtattttgaaagaagaaatttcttcactctcatttttatagaaatcttggaatcagcttaagctgtagcttttatgacaaaagacagtcatttttggtcagagtgatatttggtgacggaaacttgttcataatttattgttactatagaactatttggattttctcatttttagttctgatagttaaatattttggtttgttctgtgccttcagtttaaattatttcaggatttttcagatgtttaaataatggtgtgaatcattcaggatggaaataaaagtcatcctttctgtaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:222484 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:222484 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:222484 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: IEA GeneID:222484 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA
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