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2024-04-19 01:08:45, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_153216 1295 bp mRNA linear PRI 01-MAY-2013
DEFINITION Homo sapiens POU domain class 5, transcription factor 2 (POU5F2),
mRNA.
ACCESSION NM_153216
VERSION NM_153216.1 GI:23463325
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1295)
AUTHORS Wey,E., Lyons,G.E. and Schafer,B.W.
TITLE A human POU domain gene, mPOU, is expressed in developing brain and
specific adult tissues
JOURNAL Eur. J. Biochem. 220 (3), 753-762 (1994)
PUBMED 7908264
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AK098546.1.
##Evidence-Data-START##
Transcript exon combination :: AK098546.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1295
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q15"
gene 1..1295
/gene="POU5F2"
/gene_synonym="SPRM-1"
/note="POU domain class 5, transcription factor 2"
/db_xref="GeneID:134187"
/db_xref="HGNC:26367"
/db_xref="HPRD:08695"
exon 1..1295
/gene="POU5F2"
/gene_synonym="SPRM-1"
/inference="alignment:Splign:1.39.8"
variation complement(19)
/gene="POU5F2"
/gene_synonym="SPRM-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375465714"
variation complement(20)
/gene="POU5F2"
/gene_synonym="SPRM-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112317301"
CDS 41..1027
/gene="POU5F2"
/gene_synonym="SPRM-1"
/note="sperm 1 POU domain transcription factor"
/codon_start=1
/product="POU domain, class 5, transcription factor 2"
/protein_id="NP_694948.1"
/db_xref="GI:23463326"
/db_xref="CCDS:CCDS59489.1"
/db_xref="GeneID:134187"
/db_xref="HGNC:26367"
/db_xref="HPRD:08695"
/translation="
MAGHRPSNHFCPLPGSGGGGPRGPMPLRVDTLTWLSTQAAPGRVMVWPAVRPGICPGPDVWRIPLGPLPHEFRGWIAPCRPRLGASEAGDWLRRPSEGALPGPYIALRSIPKLPPPEDISGILKELQQLAKELRQKRLSLGYSQADVGIAVGALFGKVLSQTTICRFEAQQLSVANMWKLRPLLKKWLKEVEAENLLGLCKMEMILQQSGKWRRASRERRIGNSLEKFFQRCPKPTPQQISHIAGCLQLQKDVVRVWFYNRSKMGSRPTNDASPREIVGTAGPPCPGAPVCFHLGLGLPVDIPHYTRLYSAGVAHSSAPATTLGLLRF
" misc_feature 407..616 /gene="POU5F2" /gene_synonym="SPRM-1" /note="Pou domain - N-terminal to homeobox domain; Region: Pou; pfam00157" /db_xref="CDD:189427" misc_feature 671..823 /gene="POU5F2" /gene_synonym="SPRM-1" /note="Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cd00086" /db_xref="CDD:28970" misc_feature order(671..685,689..691,740..742,758..760,797..799, 803..808,815..820) /gene="POU5F2" /gene_synonym="SPRM-1" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:28970" misc_feature order(677..679,686..688,806..808,815..820) /gene="POU5F2" /gene_synonym="SPRM-1" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:28970" variation complement(43) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:370809672" variation complement(63) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:373831731" variation complement(76) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="g" /db_xref="dbSNP:372798416" variation complement(100) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:369781509" variation complement(148) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:376581154" variation complement(157) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:371634969" variation complement(168) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:181777565" variation complement(187) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="t" /db_xref="dbSNP:372897251" variation complement(194) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:368188217" variation complement(199) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="g" /replace="t" /db_xref="dbSNP:374687071" variation complement(209) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="g" /db_xref="dbSNP:372081385" variation complement(217) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:138308146" variation complement(295) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:111528856" variation complement(328) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:374189353" variation complement(334) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:190094264" variation complement(344) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:371062975" variation complement(385) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="g" /replace="t" /db_xref="dbSNP:376341807" variation complement(395) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:373841980" variation complement(400) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:147041924" variation complement(429) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:376579858" variation complement(461) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="g" /replace="t" /db_xref="dbSNP:373405434" variation complement(485) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:369187302" variation complement(517) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:142976192" variation complement(526) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:185367860" STS 545..723 /gene="POU5F2" /gene_synonym="SPRM-1" /standard_name="STS-Z21965" /db_xref="UniSTS:48660" variation complement(570) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="g" /replace="t" /db_xref="dbSNP:373989380" variation complement(578) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="g" /db_xref="dbSNP:200489758" variation complement(664) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="g" /replace="t" /db_xref="dbSNP:377225323" variation complement(703) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:199511635" variation complement(732) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:371786597" variation complement(781) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="t" /db_xref="dbSNP:369080417" variation complement(804) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:374849047" variation complement(840) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="g" /db_xref="dbSNP:372162822" variation complement(883) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="g" /db_xref="dbSNP:367941888" variation complement(948) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="c" /replace="g" /db_xref="dbSNP:374302489" variation complement(1098) /gene="POU5F2" /gene_synonym="SPRM-1" /replace="a" /replace="c" /db_xref="dbSNP:374928860" ORIGIN
atcagttcctaccagagccgctgcgggtgccattccacccatggccggacacaggccctcaaaccacttctgcccccttccaggcagtggtgggggcggccccagagggccgatgcccctgcgggttgacactctgacctggttgagcacccaggcggcccctggcagggtgatggtctggccggcagtcaggccagggatctgcccaggccctgacgtgtggaggattcccctgggtcccctgccacacgaattccggggctggatagcaccctgcaggccccgtcttggagctagtgaggcaggggactggttgcgacgcccctccgaaggcgccctcccggggccctacattgccctgcggagcattccgaagttgccgccgccagaggacatctcgggcatactgaaagagttgcagcaattggccaaggagttgaggcagaagaggttgagcctagggtactcgcaggccgatgtggggatcgctgtgggagctctgtttgggaaggtgcttagccagacgaccatctgccgcttcgaggcccagcagctaagcgtcgccaacatgtggaagctgcgaccactgctgaaaaagtggctgaaggaagtggaagcagagaaccttctgggcttatgcaaaatggagatgatcctgcaacagtctgggaagtggagacgggcaagcagagagcgacgaatcggaaacagcctggagaaattcttccagcggtgccctaagcccacaccccagcaaatcagccacattgctgggtgcctccagctgcagaaggatgtggttcgagtttggttctataaccgcagcaagatgggcagtcgaccaaccaatgatgcttccccacgggagattgtggggacagccgggcctccttgcccaggagcaccagtgtgctttcacctgggactggggctcccagtggatatcccccactatacacgtctctactctgcaggggtagcccactcctctgccccagccaccactctgggcctcctcagattttagggctgaggggcttgcccttcacggcacggttggagaggggagaagaagggaaaacccaggaaatgtccctagggttcatttgagggcttttagtattaatttctcattcactgtctaaagaagttaaggatacatagtagggaatgggggtgggaattgttcaagaaaaacctgggagagaagatgaagtttattgcagttttgtgttttccctttgtttttccctagcattggtttaaaggtacattacagtatatagatggtttcg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:134187 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:134187 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:134187 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:134187 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
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