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2024-04-25 14:21:56, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_153001 1821 bp mRNA linear PRI 20-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4
(PSMC4), transcript variant 2, mRNA.
ACCESSION NM_153001
VERSION NM_153001.2 GI:394953929
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1821)
AUTHORS Amoroso,M.R., Matassa,D.S., Laudiero,G., Egorova,A.V.,
Polishchuk,R.S., Maddalena,F., Piscazzi,A., Paladino,S.,
Sarnataro,D., Garbi,C., Landriscina,M. and Esposito,F.
TITLE TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in
the endoplasmic reticulum and control cellular ubiquitination of
specific mitochondrial proteins
JOURNAL Cell Death Differ. 19 (4), 592-604 (2012)
PUBMED 21979464
REMARK GeneRIF: The proposed TRAP1 network has an impact in vivo, as it is
conserved in human colorectal cancers, is controlled by
ER-localized TRAP1 interacting with TBP7 and provides a novel model
of the ER-mitochondria crosstalk.
REFERENCE 2 (bases 1 to 1821)
AUTHORS Mojic,M., Mijatovic,S., Maksimovic-Ivanic,D., Dinic,S., Grdovic,N.,
Miljkovic,D., Stosic-Grujicic,S., Tumino,S., Fagone,P., Mangano,K.,
Zocca,M.B., Al-Abed,Y., McCubrey,J.A. and Nicoletti,F.
TITLE Saquinavir-NO-targeted S6 protein mediates sensitivity of
androgen-dependent prostate cancer cells to TRAIL
JOURNAL Cell Cycle 11 (6), 1174-1182 (2012)
PUBMED 22370480
REMARK GeneRIF: Saquinavir-NO inhibits activation of S6 protein in
androgen-dependent prostate cancer cells.
REFERENCE 3 (bases 1 to 1821)
AUTHORS Molochnikov,L., Rabey,J.M., Dobronevsky,E., Bonucelli,U.,
Ceravolo,R., Frosini,D., Grunblatt,E., Riederer,P., Jacob,C.,
Aharon-Peretz,J., Bashenko,Y., Youdim,M.B. and Mandel,S.A.
TITLE A molecular signature in blood identifies early Parkinson's disease
JOURNAL Mol Neurodegener 7, 26 (2012)
PUBMED 22651796
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 1821)
AUTHORS Marx,F.P., Soehn,A.S., Berg,D., Melle,C., Schiesling,C., Lang,M.,
Kautzmann,S., Strauss,K.M., Franck,T., Engelender,S., Pahnke,J.,
Dawson,S., von Eggeling,F., Schulz,J.B., Riess,O. and Kruger,R.
TITLE The proteasomal subunit S6 ATPase is a novel synphilin-1
interacting protein--implications for Parkinson's disease
JOURNAL FASEB J. 21 (8), 1759-1767 (2007)
PUBMED 17327361
REMARK GeneRIF: a novel specific interaction of synphilin-1 with the
regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like
intracytoplasmic inclusions
REFERENCE 5 (bases 1 to 1821)
AUTHORS Tanahashi,N., Suzuki,M., Fujiwara,T., Takahashi,E., Shimbara,N.,
Chung,C.H. and Tanaka,K.
TITLE Chromosomal localization and immunological analysis of a family of
human 26S proteasomal ATPases
JOURNAL Biochem. Biophys. Res. Commun. 243 (1), 229-232 (1998)
PUBMED 9473509
REFERENCE 6 (bases 1 to 1821)
AUTHORS Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
TITLE The addition of 5'-coding information to a 3'-directed cDNA library
improves analysis of gene expression
JOURNAL Gene 146 (2), 199-207 (1994)
PUBMED 8076819
REFERENCE 7 (bases 1 to 1821)
AUTHORS Dubiel,W., Ferrell,K. and Rechsteiner,M.
TITLE Tat-binding protein 7 is a subunit of the 26S protease
JOURNAL Biol. Chem. Hoppe-Seyler 375 (4), 237-240 (1994)
PUBMED 8060531
REFERENCE 8 (bases 1 to 1821)
AUTHORS Shaw,D.R. and Ennis,H.L.
TITLE Molecular cloning and developmental regulation of Dictyostelium
discoideum homologues of the human and yeast HIV1 Tat-binding
protein
JOURNAL Biochem. Biophys. Res. Commun. 193 (3), 1291-1296 (1993)
PUBMED 8323548
REFERENCE 9 (bases 1 to 1821)
AUTHORS Ohana,B., Moore,P.A., Ruben,S.M., Southgate,C.D., Green,M.R. and
Rosen,C.A.
TITLE The type 1 human immunodeficiency virus Tat binding protein is a
transcriptional activator belonging to an additional family of
evolutionarily conserved genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (1), 138-142 (1993)
PUBMED 8419915
REFERENCE 10 (bases 1 to 1821)
AUTHORS Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A.
TITLE A cDNA for a protein that interacts with the human immunodeficiency
virus Tat transactivator
JOURNAL Science 248 (4963), 1650-1653 (1990)
PUBMED 2194290
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI828251.1, BC010396.1 and
AC007842.1.
On Jul 11, 2012 this sequence version replaced gi:24430154.
Summary: The 26S proteasome is a multicatalytic proteinase complex
with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28
non-identical subunits; 2 rings are composed of 7 alpha subunits
and 2 rings are composed of 7 beta subunits. The 19S regulator is
composed of a base, which contains 6 ATPase subunits and 2
non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. This
gene encodes a member of the triple-A family of ATPases that is a
component of the 19S regulatory subunit and plays a role in 26S
proteasome assembly. The encoded protein interacts with gankyrin, a
liver oncoprotein, and may also play a role in Parkinson's disease
through interactions with synphilin-1. Alternatively spliced
transcript variants encoding multiple isoforms have been observed
for this gene. [provided by RefSeq, Jul 2012].
Transcript Variant: This variant (2) uses an alternate splice site
in the 5' coding region, but maintains the reading frame, compared
to variant 1. The encoded isoform (2) is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC010396.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-165 BI828251.1 1-165
166-1495 BC010396.1 5-1334
1496-1821 AC007842.1 99681-100006
FEATURES Location/Qualifiers
source 1..1821
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.11-q13.13"
gene 1..1821
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="proteasome (prosome, macropain) 26S subunit,
ATPase, 4"
/db_xref="GeneID:5704"
/db_xref="HGNC:9551"
/db_xref="HPRD:04085"
/db_xref="MIM:602707"
exon 1..234
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 51
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:74704415"
variation 79
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:113047034"
variation 146
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:369037676"
misc_feature 157..159
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="upstream in-frame stop codon"
variation 192
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="g"
/db_xref="dbSNP:377120872"
CDS 199..1362
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="isoform 2 is encoded by transcript variant 2;
protease 26S subunit 6; Tat-binding protein 7; 26S
protease regulatory subunit 6B; MB67-interacting protein;
26S proteasome AAA-ATPase subunit RPT3"
/codon_start=1
/product="26S protease regulatory subunit 6B isoform 2"
/protein_id="NP_694546.1"
/db_xref="GI:24430155"
/db_xref="CCDS:CCDS46076.1"
/db_xref="GeneID:5704"
/db_xref="HGNC:9551"
/db_xref="HPRD:04085"
/db_xref="MIM:602707"
/translation="
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
"
misc_feature 283..1326
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="26S proteasome subunit P45 family; Region: 26Sp45;
TIGR01242"
/db_xref="CDD:130309"
misc_feature 607..1110
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 721..744
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(724..747,907..909,1039..1041)
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature order(895..909,931..933)
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature 1081..1083
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/note="arginine finger; other site"
/db_xref="CDD:99707"
variation 220
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:202032108"
exon 235..333
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 259
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="g"
/replace="t"
/db_xref="dbSNP:149889186"
variation 274
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:368678447"
variation 281
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:143871854"
variation 283
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542842"
variation 300
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:140248429"
exon 334..427
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 342
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542841"
variation 372
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:142604125"
variation 411
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542838"
variation 417
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:151282645"
variation 422
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:140491901"
exon 428..574
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 441
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:150414570"
variation 462
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:138214626"
variation 497
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542836"
variation 520
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061961"
variation 560
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:369260443"
variation 570
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="c"
/db_xref="dbSNP:192678537"
exon 575..684
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 582
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:141185060"
variation 600
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:34344223"
variation 606
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:139005066"
variation 619
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:373413671"
variation 645
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542840"
variation 669
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:201936053"
exon 685..778
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 687
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:200412097"
variation 693
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:368343641"
variation 701
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="c"
/db_xref="dbSNP:372675589"
variation 759
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:188483172"
exon 779..946
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 804
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542837"
variation 915
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:369564944"
variation 945
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:371930483"
exon 947..1023
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 948
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:201080278"
variation 963
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:376439285"
variation 966
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:368985128"
variation 1002
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:200850108"
exon 1024..1192
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 1057
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="g"
/replace="t"
/db_xref="dbSNP:28366821"
variation 1061
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:370184381"
variation 1062
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:372534701"
variation 1132
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:143383599"
variation 1168
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:376905637"
exon 1193..1248
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
variation 1230
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:1127090"
exon 1249..1821
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/inference="alignment:Splign:1.39.8"
STS 1262..1475
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/standard_name="STS-T26522"
/db_xref="UniSTS:69583"
variation 1275
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:147156023"
variation 1282
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="c"
/db_xref="dbSNP:374359098"
variation 1284
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:140312524"
STS 1319..1476
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/standard_name="RH98237"
/db_xref="UniSTS:92540"
variation 1335
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:142681478"
variation 1390
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="c"
/replace="t"
/db_xref="dbSNP:368335326"
polyA_signal 1475..1480
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
polyA_site 1498
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
variation 1701
/gene="PSMC4"
/gene_synonym="MIP224; RPT3; S6; TBP-7; TBP7"
/replace="a"
/replace="g"
/db_xref="dbSNP:111897642"
ORIGIN
tgcgggtacggacagcgcatgagcttatgttgagggcggagcccagaccagcccttcgtcctatcctgcccttccagcacctctcagccgtaacttaaactacacttcccagaagcctcctcagccagggacttccgttgtcgtcagcggaagcggtgacagatcatcccaggccacacagaggccggcttggtcactatggaggagataggcatcttggtggagaaggctcaggatgagatcccagcactgtccgtgtcccggccccagaccggcctgtccttcctgggccctgagcctgaggacctggaggacctgtacagccgctacaaggaggaggtgaagcgaatccaaagcatcccgctggtcatcggacaatttctggaggctgtggatcagaatacagccatcgtgggctctaccacaggctccaactattatgtgcgcatcctgagcaccatcgatcgggagctgctcaagcccaacgcctcagtggccctccacaagcacagcaatgcactggtggacgtgctgccccccgaagccgacagcagcatcatgatgctcacctcagaccagaagccagatgtgatgtacgcggacatcggaggcatggacatccagaagcaggaggtgcgggaggccgtggagctcccgctcacgcatttcgagctctacaagcagatcggcatcgatcccccccgaggcgtcctcatgtatggcccacctggctgtgggaagaccatgttggcaaaggcggtggcacatcacacaacagctgcattcatccgggtcgtgggctcggagtttgtacagaagtatctgggtgagggcccccgcatggtccgggatgtgttccgcctggccaaggagaatgcacctgccatcatcttcatagacgagattgatgccatcgccaccaagagattcgatgctcagacaggggccgacagggaggttcagaggatcctgctggagctgctgaatcagatggatggatttgatcagaatgtcaatgtcaaggtaatcatggccacaaacagagcagacaccctggatccggccctgctacggccaggacggctggaccgtaaaattgaatttccacttcctgaccgccgccagaagagattgattttctccactatcactagcaagatgaacctctctgaggaggttgacttggaagactatgtggcccggccagataagatttcaggagctgatattaactccatctgtcaggagagtggaatgttggctgtccgtgaaaaccgctacattgtcctggccaaggacttcgagaaagcatacaagactgtcatcaagaaggacgagcaggagcatgagttttacaagtgacccttcccttccctccaccacaccactcaggggctggggcttctctcgcacccccagcacctctgtcccaaaacctcattcccttttttctttacccaggattggtttcttcaataaatagataagatcgaatccatttaatttcttcttagaagtttaactcctttggagaatgtgggccttgaataggatcctctgggtccctcttaatctgacagatgagcagacgaggtgcatggcctgggttgcagcttgagagaaccaaaatattcaaaccagatgacttccaaaatgtggggaaagggatggaaaatgaacctgagatggagtccttaatcacgggataaagccctgtgcatctccctcatttcctacaggtaaaagacagtaaagaaattcaggtcacaggccttgggagttcataggaaggagatgtccagtgctgtccagtagaacttt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5704 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5704 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5704 -> Molecular function: GO:0016887 [ATPase activity] evidence: TAS
GeneID:5704 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5704 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5704 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5704 -> Biological process: GO:0001824 [blastocyst development] evidence: IEA
GeneID:5704 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5704 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5704 -> Biological process: GO:0006200 [ATP catabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0006508 [proteolysis] evidence: TAS
GeneID:5704 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5704 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5704 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5704 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5704 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5704 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5704 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5704 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5704 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5704 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5704 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5704 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:5704 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5704 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:5704 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5704 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
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