LOCUS       NM_152353                990 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens claudin domain containing 2 (CLDND2), mRNA.
ACCESSION   NM_152353
VERSION     NM_152353.2  GI:160420329
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 990)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res. 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008750.9 and BC029518.1.
            On Nov 17, 2007 this sequence version replaced gi:22748764.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029518.1, CV024668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AC008750.9         41606-41953         c
            349-990             BC029518.1         349-990
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..990
                     /gene="CLDND2"
                     /note="claudin domain containing 2"
                     /db_xref="GeneID:125875"
                     /db_xref="HGNC:28511"
                     /db_xref="HPRD:14574"
     exon            1..595
                     /gene="CLDND2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    172..174
                     /gene="CLDND2"
                     /note="upstream in-frame stop codon"
     CDS             427..930
                     /gene="CLDND2"
                     /codon_start=1
                     /product="claudin domain-containing protein 2"
                     /protein_id="NP_689566.1"
                     /db_xref="GI:22748765"
                     /db_xref="CCDS:CCDS12829.1"
                     /db_xref="GeneID:125875"
                     /db_xref="HGNC:28511"
                     /db_xref="HPRD:14574"
                     /translation="

MGVKRSLQSGGILLSLVANVLMVLSTATNYWTRQQEGHSGLWQECNHGICSSIPCQTTLAVTVACMVLAVGVGVVGMVMGLRIRCDEGESLRGQTTSAFLFLGGLLLLTALIGYTVKNAWKNNVFFSWSYFSGWLALPFSILAGFCFLLADMIMQSTDAISGFPVCL

"
     misc_feature    445..507
                     /gene="CLDND2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NHS1.1);
                     transmembrane region"
     misc_feature    601..663
                     /gene="CLDND2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NHS1.1);
                     transmembrane region"
     misc_feature    712..774
                     /gene="CLDND2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NHS1.1);
                     transmembrane region"
     misc_feature    826..888
                     /gene="CLDND2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NHS1.1);
                     transmembrane region"
     exon            596..736
                     /gene="CLDND2"
                     /inference="alignment:Splign:1.39.8"
     variation       681
                     /gene="CLDND2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3745403"
     exon            737..856
                     /gene="CLDND2"
                     /inference="alignment:Splign:1.39.8"
     exon            857..974
                     /gene="CLDND2"
                     /inference="alignment:Splign:1.39.8"
     variation       897
                     /gene="CLDND2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1059344"
ORIGIN      

gtctctctgggctctgtgtctaaggagccctagggcactgggtgtgagtcacttaggtgggcctgtgtggaggggtgtctggggaggacattgaacaggctgggctgaaagggcgttcggctgtcgggggaggtctctgggaagacaggttcctcacagcaaagcctgtggtgaaggtctcagaggcctctcaggggaagtctcaaggtctccagtaaggggaacgaggtctggagggaggaggttgtggatcctcaggcagggttgttgagggaggggggtctccaggtccccagaagcagggacctcaggcaggagtaccaggggaggagtgtggaggaagcgggctcctcagctgggggcctcggggtaggaaaggcctgggcccatcctgcccttgtggcccccggctgcagcctcagtggcatgggggtgaagcggagcctccagagtgggggcattctgctcagcctcgtggccaacgtcctcatggtgctctccacggccaccaactactggacccgccaacaagagggccacagtggcctgtggcaggaatgcaaccacggcatctgctccagcatcccctgccagaccacgctggcggtgactgtggcgtgcatggtgctggcggtgggtgtcggcgtggtgggcatggtgatgggactgcggattcggtgcgacgagggcgagtcgctgcggggccagaccacgagcgccttcctcttcctcggcggactgctgctgctgaccgccttgataggctacaccgtgaagaatgcgtggaagaacaacgtcttcttctcttggtcctatttttctgggtggctggccttacccttctcaattctcgcgggcttctgctttctgctggcagacatgatcatgcagagcaccgacgccatcagtggattccccgtgtgtctgtgactgcagcctgcctggggcagaataaaggaacggctttttttagcaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:125875 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA