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2024-03-29 19:05:26, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_147187               4067 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens tumor necrosis factor receptor superfamily, member 10b
            (TNFRSF10B), transcript variant 2, mRNA.
ACCESSION   NM_147187
VERSION     NM_147187.2  GI:224494025
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4067)
  AUTHORS   Wang,G., Wang,X., Yu,H., Wei,S., Williams,N., Holmes,D.L.,
            Halfmann,R., Naidoo,J., Wang,L., Li,L., Chen,S., Harran,P., Lei,X.
            and Wang,X.
  TITLE     Small-molecule activation of the TRAIL receptor DR5 in human cancer
            cells
  JOURNAL   Nat. Chem. Biol. 9 (2), 84-89 (2013)
   PUBMED   23292651
  REMARK    GeneRIF: analysis of small-molecule activation of the TRAIL
            receptor DR5 in human cancer cells
REFERENCE   2  (bases 1 to 4067)
  AUTHORS   Silke,J. and Strasser,A.
  TITLE     The FLIP Side of Life
  JOURNAL   Sci Signal 6 (258), PE2 (2013)
   PUBMED   23322903
  REMARK    GeneRIF: Studies indicate that the anti-apoptotic protein c-FLIP is
            an important regulator of death receptor signaling, including
            TNFR1, Fas, DR4, and DR5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4067)
  AUTHORS   Peppa,D., Gill,U.S., Reynolds,G., Easom,N.J., Pallett,L.J.,
            Schurich,A., Micco,L., Nebbia,G., Singh,H.D., Adams,D.H.,
            Kennedy,P.T. and Maini,M.K.
  TITLE     Up-regulation of a death receptor renders antiviral T cells
            susceptible to NK cell-mediated deletion
  JOURNAL   J. Exp. Med. 210 (1), 99-114 (2013)
   PUBMED   23254287
  REMARK    GeneRIF: Increased TRAIL-R2 expression on T cells in chronic
            hepatitis B.
REFERENCE   4  (bases 1 to 4067)
  AUTHORS   Benedict,C.A. and Ware,C.F.
  TITLE     TRAIL: not just for tumors anymore?
  JOURNAL   J. Exp. Med. 209 (11), 1903-1906 (2012)
   PUBMED   23091198
  REMARK    GeneRIF: Studies suggest that TNF-related apoptosis-inducing ligand
            (TRAIL) plays broader roles in regulating immune processes.
            Review article
REFERENCE   5  (bases 1 to 4067)
  AUTHORS   Kriegl,L., Jung,A., Horst,D., Rizzani,A., Jackstadt,R.,
            Hermeking,H., Gallmeier,E., Gerbes,A.L., Kirchner,T., Goke,B. and
            De Toni,E.N.
  TITLE     Microsatellite instability, KRAS mutations and cellular
            distribution of TRAIL-receptors in early stage colorectal cancer
  JOURNAL   PLoS ONE 7 (12), E51654 (2012)
   PUBMED   23284732
  REMARK    GeneRIF: Loss of membrane TRAIL-R2 expression is associated with
            early stage colorectal cancer.
REFERENCE   6  (bases 1 to 4067)
  AUTHORS   Walczak,H., Degli-Esposti,M.A., Johnson,R.S., Smolak,P.J.,
            Waugh,J.Y., Boiani,N., Timour,M.S., Gerhart,M.J., Schooley,K.A.,
            Smith,C.A., Goodwin,R.G. and Rauch,C.T.
  TITLE     TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
  JOURNAL   EMBO J. 16 (17), 5386-5397 (1997)
   PUBMED   9311998
REFERENCE   7  (bases 1 to 4067)
  AUTHORS   Screaton,G.R., Mongkolsapaya,J., Xu,X.N., Cowper,A.E.,
            McMichael,A.J. and Bell,J.I.
  TITLE     TRICK2, a new alternatively spliced receptor that transduces the
            cytotoxic signal from TRAIL
  JOURNAL   Curr. Biol. 7 (9), 693-696 (1997)
   PUBMED   9285725
REFERENCE   8  (bases 1 to 4067)
  AUTHORS   Sheridan,J.P., Marsters,S.A., Pitti,R.M., Gurney,A., Skubatch,M.,
            Baldwin,D., Ramakrishnan,L., Gray,C.L., Baker,K., Wood,W.I.,
            Goddard,A.D., Godowski,P. and Ashkenazi,A.
  TITLE     Control of TRAIL-induced apoptosis by a family of signaling and
            decoy receptors
  JOURNAL   Science 277 (5327), 818-821 (1997)
   PUBMED   9242611
REFERENCE   9  (bases 1 to 4067)
  AUTHORS   Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
  TITLE     An antagonist decoy receptor and a death domain-containing receptor
            for TRAIL
  JOURNAL   Science 277 (5327), 815-818 (1997)
   PUBMED   9242610
REFERENCE   10 (bases 1 to 4067)
  AUTHORS   Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
            Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
            al.
  TITLE     Identification and characterization of a new member of the TNF
            family that induces apoptosis
  JOURNAL   Immunity 3 (6), 673-682 (1995)
   PUBMED   8777713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA738472.1, DA889488.1,
            BC001281.1, AF192548.1 and AC107959.8.
            On Mar 4, 2009 this sequence version replaced gi:22547118.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily, and contains an intracellular death
            domain. This receptor can be activated by tumor necrosis
            factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L),
            and transduces an apoptosis signal. Studies with FADD-deficient
            mice suggested that FADD, a death domain containing adaptor
            protein, is required for the apoptosis mediated by this protein.
            Two transcript variants encoding different isoforms and one
            non-coding transcript have been found for this gene. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) lacks an in-frame coding
            segment compared to variant 1. The resulting isoform (2) lacks an
            internal region, as compared to isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF012535.1, AY358277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               DA738472.1         1-387
            388-718             DA889488.1         232-562
            719-769             BC001281.1         573-623
            770-1884            AF192548.1         577-1691
            1885-4067           AC107959.8         82828-85010         c
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22-p21"
     gene            1..4067
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="tumor necrosis factor receptor superfamily, member
                     10b"
                     /db_xref="GeneID:8795"
                     /db_xref="HGNC:11905"
                     /db_xref="MIM:603612"
     exon            1..437
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     variation       203
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11135695"
     misc_feature    264..266
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="upstream in-frame stop codon"
     CDS             294..1529
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; death receptor 5; apoptosis inducing receptor
                     TRAIL-R2; apoptosis inducing protein TRICK2A/2B; tumor
                     necrosis factor receptor-like protein ZTNFR9; death domain
                     containing receptor for TRAIL/Apo-2L; cytotoxic TRAIL
                     receptor-2; p53-regulated DNA damage-inducible cell death
                     receptor(killer); Fas-like protein; TNF-related
                     apoptosis-inducing ligand receptor 2"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 10B isoform 2 precursor"
                     /protein_id="NP_671716.2"
                     /db_xref="GI:224494026"
                     /db_xref="CCDS:CCDS6036.1"
                     /db_xref="GeneID:8795"
                     /db_xref="HGNC:11905"
                     /db_xref="MIM:603612"
                     /translation="
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
"
     sig_peptide     294..458
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
     mat_peptide     459..1526
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /product="tumor necrosis factor receptor superfamily
                     member 10B isoform 2"
     misc_feature    507..764
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="Tumor necrosis factor receptor (TNFR) domain;
                     superfamily of TNF-like receptor domains. When bound to
                     TNF-like cytokines, TNFRs trigger multiple signal
                     transduction pathways, they are involved in inflammation
                     response, apoptosis, autoimmunity and...; Region: TNFR;
                     cd00185"
                     /db_xref="CDD:29147"
     misc_feature    order(528..557,567..581,681..689)
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="protein binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:29147"
     misc_feature    order(528..530,540..542,546..548,570..572,579..581,
                     612..614)
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="parallel homodimerization interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:29147"
     misc_feature    order(600..602,633..635,660..662,726..728,750..752)
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="antiparallel homodimerization interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:29147"
     misc_feature    order(609..614,630..638)
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="50's loop TNF binding site; other site"
                     /db_xref="CDD:29147"
     misc_feature    708..827
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="Tumor necrosis factor receptor / nerve growth
                     factor receptor repeats; Region: TNFR; smart00208"
                     /db_xref="CDD:128504"
     misc_feature    order(726..728,750..764)
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="90's loop TNF binding site; other site"
                     /db_xref="CDD:29147"
     misc_feature    1203..1490
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /note="Death domain of Tumor necrosis factor-Related
                     Apoptosis-Inducing Ligand Receptors; Region:
                     Death_TRAILR_DR4_DR5; cd08315"
                     /db_xref="CDD:176730"
     variation       388
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1129424"
     exon            438..543
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     variation       493
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1047266"
     exon            544..657
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     exon            658..769
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     exon            770..843
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     exon            844..954
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     variation       868
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61761317"
     exon            955..986
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     exon            987..1142
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     variation       1031
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141284481"
     exon            1143..1215
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     exon            1216..4067
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /inference="alignment:Splign:1.39.8"
     variation       1551
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1047275"
     polyA_site      1764
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
     variation       3340
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1047305"
     STS             3583..3701
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /standard_name="D11S2560"
                     /db_xref="UniSTS:37928"
     STS             3594..3682
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             3777..3877
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /standard_name="WI-15306"
                     /db_xref="UniSTS:13264"
     STS             3815..3924
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /standard_name="D8S2055"
                     /db_xref="UniSTS:24780"
     variation       3845
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141093234"
     variation       3945
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3187321"
     polyA_signal    4042..4047
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
     polyA_site      4067
                     /gene="TNFRSF10B"
                     /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2;
                     TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9"
ORIGIN      
acttggacgcgcttgcggaggattgcgttgacgagactcttatttattgtcaccaacctgtggtggaatttgcagttgcacattggatctgattcgccccgccccgaatgacgcctgcccggaggcagtgaaagtacagccgcgccgccccaagtcagcctggacacataaatcagcacgcggccggagaaccccgcaatctctgcgcccacaaaatacaccgacgatgcccgatctactttaagggctgaaacccacgggcctgagagactataagagcgttccctaccgccatggaacaacggggacagaacgccccggccgcttcgggggcccggaaaaggcacggcccaggacccagggaggcgcggggagccaggcctgggccccgggtccccaagacccttgtgctcgttgtcgccgcggtcctgctgttggtctcagctgagtctgctctgatcacccaacaagacctagctccccagcagagagcggccccacaacaaaagaggtccagcccctcagagggattgtgtccacctggacaccatatctcagaagacggtagagattgcatctcctgcaaatatggacaggactatagcactcactggaatgacctccttttctgcttgcgctgcaccaggtgtgattcaggtgaagtggagctaagtccctgcaccacgaccagaaacacagtgtgtcagtgcgaagaaggcaccttccgggaagaagattctcctgagatgtgccggaagtgccgcacagggtgtcccagagggatggtcaaggtcggtgattgtacaccctggagtgacatcgaatgtgtccacaaagaatcaggcatcatcataggagtcacagttgcagccgtagtcttgattgtggctgtgtttgtttgcaagtctttactgtggaagaaagtccttccttacctgaaaggcatctgctcaggtggtggtggggaccctgagcgtgtggacagaagctcacaacgacctggggctgaggacaatgtcctcaatgagatcgtgagtatcttgcagcccacccaggtccctgagcaggaaatggaagtccaggagccagcagagccaacaggtgtcaacatgttgtcccccggggagtcagagcatctgctggaaccggcagaagctgaaaggtctcagaggaggaggctgctggttccagcaaatgaaggtgatcccactgagactctgagacagtgcttcgatgactttgcagacttggtgccctttgactcctgggagccgctcatgaggaagttgggcctcatggacaatgagataaaggtggctaaagctgaggcagcgggccacagggacaccttgtacacgatgctgataaagtgggtcaacaaaaccgggcgagatgcctctgtccacaccctgctggatgccttggagacgctgggagagagacttgccaagcagaagattgaggaccacttgttgagctctggaaagttcatgtatctagaaggtaatgcagactctgccatgtcctaagtgtgattctcttcaggaagtcagaccttccctggtttaccttttttctggaaaaagcccaactggactccagtcagtaggaaagtgccacaattgtcacatgaccggtactggaagaaactctcccatccaacatcacccagtggatggaacatcctgtaacttttcactgcacttggcattatttttataagctgaatgtgataataaggacactatggaaatgtctggatcattccgtttgtgcgtactttgagatttggtttgggatgtcattgttttcacagcacttttttatcctaatgtaaatgctttatttatttatttgggctacattgtaagatccatctacacagtcgttgtccgacttcacttgatactatatgatatgaaccttttttgggtggggggtgcggggcagttcactctgtctcccaggctggagtgcaatggtgcaatcttggctcactatagccttgacctctcaggctcaagcgattctcccacctcagccatccaaatagctgggaccacaggtgtgcaccaccacgcccggctaattttttgtattttgtctagatataggggctctctatgttgctcagggtggtctcgaattcctggactcaagcagtctgcccacctcagactcccaaagcggtggaattagaggcgtgagcccccatgcttggccttacctttctacttttataattctgtatgttattattttatgaacatgaagaaactttagtaaatgtacttgtttacatagttatgtgaatagattagataaacataaaaggaggagacatacaatgggggaagaagaagaagtcccctgtaagatgtcactgtctgggttccagccctccctcagatgtactttggcttcaatgattggcaacttctacaggggccagtcttttgaactggacaaccttacaagtatatgagtattatttataggtagttgtttacatatgagtcgggaccaaagagaactggatccacgtgaagtcctgtgtgtggctggtccctacctgggcagtctcatttgcacccatagcccccatctatggacaggctgggacagaggcagatgggttagatcacacataacaatagggtctatgtcatatcccaagtgaacttgagccctgtttgggctcaggagatagaagacaaaatctgtctcccacgtctgccatggcatcaagggggaagagtagatggtgcttgagaatggtgtgaaatggttgccatctcaggagtagatggcccggctcacttctggttatctgtcaccctgagcccatgagctgccttttagggtacagattgcctacttgaggaccttggccgctctgtaagcatctgactcatctcagaaatgtcaattcttaaacactgtggcaacaggacctagaatggctgacgcattaaggttttcttcttgtgtcctgttctattattgttttaagacctcagtaaccatttcagcctctttccagcaaacccttctccatagtatttcagtcatggaaggatcatttatgcaggtagtcattccaggagtttttggtcttttctgtctcaaggcattgtgtgttttgttccgggactggtttgggtgggacaaagttagaattgcctgaagatcacacattcagactgttgtgtctgtggagttttaggagtggggggtgacctttctggtctttgcacttccatcctctcccacttccatctggcatcccacgcgttgtcccctgcacttctggaaggcacagggtgctgctgcctcctggtctttgcctttgctgggccttctgtgcaggacgctcagcctcagggctcagaaggtgccagtccggtcccaggtcccttgtcccttccacagaggccttcctagaagatgcatctagagtgtcagccttatcagtgtttaagatttttcttttatttttaatttttttgagacagaatctcactctctcgcccaggctggagtgcaacggtacgatcttggctcagtgcaacctccgcctcctgggttcaagcgattctcgtgcctcagcctccggagtagctgggattgcaggcacccgccaccacgcctggctaatttttgtatttttagtagagacggggtttcaccatgttggtcaggctggtctcgaactcctgacctcaggtgatccaccttggcctccgaaagtgctgggattacaggcgtgagccaccagccaggccaagctattcttttaaagtaagcttcctgacgacatgaaataattgggggttttgttgtttagttacattaggctttgctatatccccaggccaaatagcatgtgacacaggacagccatagtatagtgtgtcactcgtggttggtgtcctttcatgcttctgccctgtcaaaggtccctatttgaaatgtgttataatacaaacaaggaagcacattgtgtacaaaatacttatgtatttatgaatccatgaccaaattaaatatgaaaccttatataaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8795 -> Molecular function: GO:0004872 [receptor activity] evidence: NAS
            GeneID:8795 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8795 -> Molecular function: GO:0045569 [TRAIL binding] evidence: NAS
            GeneID:8795 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
            GeneID:8795 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:8795 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
            GeneID:8795 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
            GeneID:8795 -> Biological process: GO:0007250 [activation of NF-kappaB-inducing kinase activity] evidence: NAS
            GeneID:8795 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: NAS
            GeneID:8795 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IDA
            GeneID:8795 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: NAS
            GeneID:8795 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
            GeneID:8795 -> Biological process: GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] evidence: IMP
            GeneID:8795 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
            GeneID:8795 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:8795 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
            GeneID:8795 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:8795 -> Cellular component: GO:0016021 [integral to membrane] evidence: IC

by @meso_cacase at DBCLS
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