2024-03-29 19:05:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_147187 4067 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 2, mRNA. ACCESSION NM_147187 VERSION NM_147187.2 GI:224494025 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4067) AUTHORS Wang,G., Wang,X., Yu,H., Wei,S., Williams,N., Holmes,D.L., Halfmann,R., Naidoo,J., Wang,L., Li,L., Chen,S., Harran,P., Lei,X. and Wang,X. TITLE Small-molecule activation of the TRAIL receptor DR5 in human cancer cells JOURNAL Nat. Chem. Biol. 9 (2), 84-89 (2013) PUBMED 23292651 REMARK GeneRIF: analysis of small-molecule activation of the TRAIL receptor DR5 in human cancer cells REFERENCE 2 (bases 1 to 4067) AUTHORS Silke,J. and Strasser,A. TITLE The FLIP Side of Life JOURNAL Sci Signal 6 (258), PE2 (2013) PUBMED 23322903 REMARK GeneRIF: Studies indicate that the anti-apoptotic protein c-FLIP is an important regulator of death receptor signaling, including TNFR1, Fas, DR4, and DR5. Publication Status: Online-Only REFERENCE 3 (bases 1 to 4067) AUTHORS Peppa,D., Gill,U.S., Reynolds,G., Easom,N.J., Pallett,L.J., Schurich,A., Micco,L., Nebbia,G., Singh,H.D., Adams,D.H., Kennedy,P.T. and Maini,M.K. TITLE Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion JOURNAL J. Exp. Med. 210 (1), 99-114 (2013) PUBMED 23254287 REMARK GeneRIF: Increased TRAIL-R2 expression on T cells in chronic hepatitis B. REFERENCE 4 (bases 1 to 4067) AUTHORS Benedict,C.A. and Ware,C.F. TITLE TRAIL: not just for tumors anymore? JOURNAL J. Exp. Med. 209 (11), 1903-1906 (2012) PUBMED 23091198 REMARK GeneRIF: Studies suggest that TNF-related apoptosis-inducing ligand (TRAIL) plays broader roles in regulating immune processes. Review article REFERENCE 5 (bases 1 to 4067) AUTHORS Kriegl,L., Jung,A., Horst,D., Rizzani,A., Jackstadt,R., Hermeking,H., Gallmeier,E., Gerbes,A.L., Kirchner,T., Goke,B. and De Toni,E.N. TITLE Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer JOURNAL PLoS ONE 7 (12), E51654 (2012) PUBMED 23284732 REMARK GeneRIF: Loss of membrane TRAIL-R2 expression is associated with early stage colorectal cancer. REFERENCE 6 (bases 1 to 4067) AUTHORS Walczak,H., Degli-Esposti,M.A., Johnson,R.S., Smolak,P.J., Waugh,J.Y., Boiani,N., Timour,M.S., Gerhart,M.J., Schooley,K.A., Smith,C.A., Goodwin,R.G. and Rauch,C.T. TITLE TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL JOURNAL EMBO J. 16 (17), 5386-5397 (1997) PUBMED 9311998 REFERENCE 7 (bases 1 to 4067) AUTHORS Screaton,G.R., Mongkolsapaya,J., Xu,X.N., Cowper,A.E., McMichael,A.J. and Bell,J.I. TITLE TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL JOURNAL Curr. Biol. 7 (9), 693-696 (1997) PUBMED 9285725 REFERENCE 8 (bases 1 to 4067) AUTHORS Sheridan,J.P., Marsters,S.A., Pitti,R.M., Gurney,A., Skubatch,M., Baldwin,D., Ramakrishnan,L., Gray,C.L., Baker,K., Wood,W.I., Goddard,A.D., Godowski,P. and Ashkenazi,A. TITLE Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors JOURNAL Science 277 (5327), 818-821 (1997) PUBMED 9242611 REFERENCE 9 (bases 1 to 4067) AUTHORS Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M. TITLE An antagonist decoy receptor and a death domain-containing receptor for TRAIL JOURNAL Science 277 (5327), 815-818 (1997) PUBMED 9242610 REFERENCE 10 (bases 1 to 4067) AUTHORS Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P., Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et al. TITLE Identification and characterization of a new member of the TNF family that induces apoptosis JOURNAL Immunity 3 (6), 673-682 (1995) PUBMED 8777713 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA738472.1, DA889488.1, BC001281.1, AF192548.1 and AC107959.8. On Mar 4, 2009 this sequence version replaced gi:22547118. Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF012535.1, AY358277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-387 DA738472.1 1-387 388-718 DA889488.1 232-562 719-769 BC001281.1 573-623 770-1884 AF192548.1 577-1691 1885-4067 AC107959.8 82828-85010 c FEATURES Location/Qualifiers source 1..4067 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="8" /map="8p22-p21" gene 1..4067 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="tumor necrosis factor receptor superfamily, member 10b" /db_xref="GeneID:8795" /db_xref="HGNC:11905" /db_xref="MIM:603612" exon 1..437 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" variation 203 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:11135695" misc_feature 264..266 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="upstream in-frame stop codon" CDS 294..1529 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="isoform 2 precursor is encoded by transcript variant 2; death receptor 5; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; tumor necrosis factor receptor-like protein ZTNFR9; death domain containing receptor for TRAIL/Apo-2L; cytotoxic TRAIL receptor-2; p53-regulated DNA damage-inducible cell death receptor(killer); Fas-like protein; TNF-related apoptosis-inducing ligand receptor 2" /codon_start=1 /product="tumor necrosis factor receptor superfamily member 10B isoform 2 precursor" /protein_id="NP_671716.2" /db_xref="GI:224494026" /db_xref="CCDS:CCDS6036.1" /db_xref="GeneID:8795" /db_xref="HGNC:11905" /db_xref="MIM:603612" /translation="
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
" sig_peptide 294..458 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" mat_peptide 459..1526 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /product="tumor necrosis factor receptor superfamily member 10B isoform 2" misc_feature 507..764 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; Region: TNFR; cd00185" /db_xref="CDD:29147" misc_feature order(528..557,567..581,681..689) /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="protein binding site [polypeptide binding]; other site" /db_xref="CDD:29147" misc_feature order(528..530,540..542,546..548,570..572,579..581, 612..614) /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="parallel homodimerization interface [polypeptide binding]; other site" /db_xref="CDD:29147" misc_feature order(600..602,633..635,660..662,726..728,750..752) /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="antiparallel homodimerization interface [polypeptide binding]; other site" /db_xref="CDD:29147" misc_feature order(609..614,630..638) /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="50's loop TNF binding site; other site" /db_xref="CDD:29147" misc_feature 708..827 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="Tumor necrosis factor receptor / nerve growth factor receptor repeats; Region: TNFR; smart00208" /db_xref="CDD:128504" misc_feature order(726..728,750..764) /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="90's loop TNF binding site; other site" /db_xref="CDD:29147" misc_feature 1203..1490 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /note="Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors; Region: Death_TRAILR_DR4_DR5; cd08315" /db_xref="CDD:176730" variation 388 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:1129424" exon 438..543 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" variation 493 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:1047266" exon 544..657 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" exon 658..769 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" exon 770..843 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" exon 844..954 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" variation 868 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:61761317" exon 955..986 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" exon 987..1142 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" variation 1031 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:141284481" exon 1143..1215 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" exon 1216..4067 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /inference="alignment:Splign:1.39.8" variation 1551 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="g" /db_xref="dbSNP:1047275" polyA_site 1764 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" variation 3340 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="g" /db_xref="dbSNP:1047305" STS 3583..3701 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /standard_name="D11S2560" /db_xref="UniSTS:37928" STS 3594..3682 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /standard_name="D8S2279" /db_xref="UniSTS:473907" STS 3777..3877 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /standard_name="WI-15306" /db_xref="UniSTS:13264" STS 3815..3924 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /standard_name="D8S2055" /db_xref="UniSTS:24780" variation 3845 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:141093234" variation 3945 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" /replace="c" /replace="t" /db_xref="dbSNP:3187321" polyA_signal 4042..4047 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" polyA_site 4067 /gene="TNFRSF10B" /gene_synonym="CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9" ORIGIN
acttggacgcgcttgcggaggattgcgttgacgagactcttatttattgtcaccaacctgtggtggaatttgcagttgcacattggatctgattcgccccgccccgaatgacgcctgcccggaggcagtgaaagtacagccgcgccgccccaagtcagcctggacacataaatcagcacgcggccggagaaccccgcaatctctgcgcccacaaaatacaccgacgatgcccgatctactttaagggctgaaacccacgggcctgagagactataagagcgttccctaccgccatggaacaacggggacagaacgccccggccgcttcgggggcccggaaaaggcacggcccaggacccagggaggcgcggggagccaggcctgggccccgggtccccaagacccttgtgctcgttgtcgccgcggtcctgctgttggtctcagctgagtctgctctgatcacccaacaagacctagctccccagcagagagcggccccacaacaaaagaggtccagcccctcagagggattgtgtccacctggacaccatatctcagaagacggtagagattgcatctcctgcaaatatggacaggactatagcactcactggaatgacctccttttctgcttgcgctgcaccaggtgtgattcaggtgaagtggagctaagtccctgcaccacgaccagaaacacagtgtgtcagtgcgaagaaggcaccttccgggaagaagattctcctgagatgtgccggaagtgccgcacagggtgtcccagagggatggtcaaggtcggtgattgtacaccctggagtgacatcgaatgtgtccacaaagaatcaggcatcatcataggagtcacagttgcagccgtagtcttgattgtggctgtgtttgtttgcaagtctttactgtggaagaaagtccttccttacctgaaaggcatctgctcaggtggtggtggggaccctgagcgtgtggacagaagctcacaacgacctggggctgaggacaatgtcctcaatgagatcgtgagtatcttgcagcccacccaggtccctgagcaggaaatggaagtccaggagccagcagagccaacaggtgtcaacatgttgtcccccggggagtcagagcatctgctggaaccggcagaagctgaaaggtctcagaggaggaggctgctggttccagcaaatgaaggtgatcccactgagactctgagacagtgcttcgatgactttgcagacttggtgccctttgactcctgggagccgctcatgaggaagttgggcctcatggacaatgagataaaggtggctaaagctgaggcagcgggccacagggacaccttgtacacgatgctgataaagtgggtcaacaaaaccgggcgagatgcctctgtccacaccctgctggatgccttggagacgctgggagagagacttgccaagcagaagattgaggaccacttgttgagctctggaaagttcatgtatctagaaggtaatgcagactctgccatgtcctaagtgtgattctcttcaggaagtcagaccttccctggtttaccttttttctggaaaaagcccaactggactccagtcagtaggaaagtgccacaattgtcacatgaccggtactggaagaaactctcccatccaacatcacccagtggatggaacatcctgtaacttttcactgcacttggcattatttttataagctgaatgtgataataaggacactatggaaatgtctggatcattccgtttgtgcgtactttgagatttggtttgggatgtcattgttttcacagcacttttttatcctaatgtaaatgctttatttatttatttgggctacattgtaagatccatctacacagtcgttgtccgacttcacttgatactatatgatatgaaccttttttgggtggggggtgcggggcagttcactctgtctcccaggctggagtgcaatggtgcaatcttggctcactatagccttgacctctcaggctcaagcgattctcccacctcagccatccaaatagctgggaccacaggtgtgcaccaccacgcccggctaattttttgtattttgtctagatataggggctctctatgttgctcagggtggtctcgaattcctggactcaagcagtctgcccacctcagactcccaaagcggtggaattagaggcgtgagcccccatgcttggccttacctttctacttttataattctgtatgttattattttatgaacatgaagaaactttagtaaatgtacttgtttacatagttatgtgaatagattagataaacataaaaggaggagacatacaatgggggaagaagaagaagtcccctgtaagatgtcactgtctgggttccagccctccctcagatgtactttggcttcaatgattggcaacttctacaggggccagtcttttgaactggacaaccttacaagtatatgagtattatttataggtagttgtttacatatgagtcgggaccaaagagaactggatccacgtgaagtcctgtgtgtggctggtccctacctgggcagtctcatttgcacccatagcccccatctatggacaggctgggacagaggcagatgggttagatcacacataacaatagggtctatgtcatatcccaagtgaacttgagccctgtttgggctcaggagatagaagacaaaatctgtctcccacgtctgccatggcatcaagggggaagagtagatggtgcttgagaatggtgtgaaatggttgccatctcaggagtagatggcccggctcacttctggttatctgtcaccctgagcccatgagctgccttttagggtacagattgcctacttgaggaccttggccgctctgtaagcatctgactcatctcagaaatgtcaattcttaaacactgtggcaacaggacctagaatggctgacgcattaaggttttcttcttgtgtcctgttctattattgttttaagacctcagtaaccatttcagcctctttccagcaaacccttctccatagtatttcagtcatggaaggatcatttatgcaggtagtcattccaggagtttttggtcttttctgtctcaaggcattgtgtgttttgttccgggactggtttgggtgggacaaagttagaattgcctgaagatcacacattcagactgttgtgtctgtggagttttaggagtggggggtgacctttctggtctttgcacttccatcctctcccacttccatctggcatcccacgcgttgtcccctgcacttctggaaggcacagggtgctgctgcctcctggtctttgcctttgctgggccttctgtgcaggacgctcagcctcagggctcagaaggtgccagtccggtcccaggtcccttgtcccttccacagaggccttcctagaagatgcatctagagtgtcagccttatcagtgtttaagatttttcttttatttttaatttttttgagacagaatctcactctctcgcccaggctggagtgcaacggtacgatcttggctcagtgcaacctccgcctcctgggttcaagcgattctcgtgcctcagcctccggagtagctgggattgcaggcacccgccaccacgcctggctaatttttgtatttttagtagagacggggtttcaccatgttggtcaggctggtctcgaactcctgacctcaggtgatccaccttggcctccgaaagtgctgggattacaggcgtgagccaccagccaggccaagctattcttttaaagtaagcttcctgacgacatgaaataattgggggttttgttgtttagttacattaggctttgctatatccccaggccaaatagcatgtgacacaggacagccatagtatagtgtgtcactcgtggttggtgtcctttcatgcttctgccctgtcaaaggtccctatttgaaatgtgttataatacaaacaaggaagcacattgtgtacaaaatacttatgtatttatgaatccatgaccaaattaaatatgaaaccttatataaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:8795 -> Molecular function: GO:0004872 [receptor activity] evidence: NAS GeneID:8795 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:8795 -> Molecular function: GO:0045569 [TRAIL binding] evidence: NAS GeneID:8795 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS GeneID:8795 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:8795 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS GeneID:8795 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS GeneID:8795 -> Biological process: GO:0007250 [activation of NF-kappaB-inducing kinase activity] evidence: NAS GeneID:8795 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: NAS GeneID:8795 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IDA GeneID:8795 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: NAS GeneID:8795 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP GeneID:8795 -> Biological process: GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] evidence: IMP GeneID:8795 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP GeneID:8795 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:8795 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS GeneID:8795 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:8795 -> Cellular component: GO:0016021 [integral to membrane] evidence: IC
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