2024-03-29 08:17:21, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_145725 7793 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 1, mRNA. ACCESSION NM_145725 VERSION NM_145725.2 GI:313661479 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7793) AUTHORS Cai,X., Du,J., Liu,Y., Xia,W., Liu,J., Zou,M., Wang,Y., Wang,M., Su,H. and Xu,D. TITLE Identification and characterization of receptor-interacting protein 2 as a TNFR-associated factor 3 binding partner JOURNAL Gene 517 (2), 205-211 (2013) PUBMED 23333941 REMARK GeneRIF: In an attempt to explore TRAF3 binding partners that may be involved in TRAF3-regulated signaling, a yeast two-hybrid screen of a human spleen cDNA library was undertaken. RIP2 was identified as a TRAF3 binding partner. REFERENCE 2 (bases 1 to 7793) AUTHORS Wolf,K. and Fields,K.A. TITLE Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3 JOURNAL J. Immunol. 190 (4), 1695-1701 (2013) PUBMED 23303668 REMARK GeneRIF: Levels of TRAF3 degradation correlate with number of cells infected with Chlamydia pneumoniae, because more TRAF3 is detected at a lower multiplicity of C. pneumoniae infection. REFERENCE 3 (bases 1 to 7793) AUTHORS Shen,J., Qiao,Y.Q., Ran,Z.H. and Wang,T.R. TITLE Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory bowel disease JOURNAL Int J Med Sci 10 (2), 156-163 (2013) PUBMED 23329887 REMARK GeneRIF: TRAF3 and TRAF5 are overexpressed in inflammatory bowel disease. Although the endoscopic appearance can be normal, TRAF3 and TRAF5 pre-activation can be detected in non-inflamed colonic segments REFERENCE 4 (bases 1 to 7793) AUTHORS Belgnaoui,S.M., Paz,S., Samuel,S., Goulet,M.L., Sun,Q., Kikkert,M., Iwai,K., Dikic,I., Hiscott,J. and Lin,R. TITLE Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex JOURNAL Cell Host Microbe 12 (2), 211-222 (2012) PUBMED 22901541 REMARK GeneRIF: Ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. REFERENCE 5 (bases 1 to 7793) AUTHORS van Zuylen,W.J., Doyon,P., Clement,J.F., Khan,K.A., D'Ambrosio,L.M., Do,F., St-Amant-Verret,M., Wissanji,T., Emery,G., Gingras,A.C., Meloche,S. and Servant,M.J. TITLE Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity JOURNAL PLoS Pathog. 8 (7), E1002747 (2012) PUBMED 22792062 REMARK GeneRIF: model proposed where dsDNA and dsRNA sensing induces the formation of membrane-bound compartments originating from the Golgi, which mediate the dynamic association of TRAF3 with MAVS leading to an optimal induction of innate immune responses REFERENCE 6 (bases 1 to 7793) AUTHORS Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V. TITLE TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways JOURNAL Cell 84 (2), 299-308 (1996) PUBMED 8565075 REFERENCE 7 (bases 1 to 7793) AUTHORS Cheng,G., Cleary,A.M., Ye,Z.S., Hong,D.I., Lederman,S. and Baltimore,D. TITLE Involvement of CRAF1, a relative of TRAF, in CD40 signaling JOURNAL Science 267 (5203), 1494-1498 (1995) PUBMED 7533327 REFERENCE 8 (bases 1 to 7793) AUTHORS Mosialos,G., Birkenbach,M., Yalamanchili,R., VanArsdale,T., Ware,C. and Kieff,E. TITLE The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family JOURNAL Cell 80 (3), 389-399 (1995) PUBMED 7859281 REFERENCE 9 (bases 1 to 7793) AUTHORS Sato,T., Irie,S. and Reed,J.C. TITLE A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40 JOURNAL FEBS Lett. 358 (2), 113-118 (1995) PUBMED 7530216 REFERENCE 10 (bases 1 to 7793) AUTHORS Hu,H.M., O'Rourke,K., Boguski,M.S. and Dixit,V.M. TITLE A novel RING finger protein interacts with the cytoplasmic domain of CD40 JOURNAL J. Biol. Chem. 269 (48), 30069-30072 (1994) PUBMED 7527023 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U21092.1, AL132801.5, BX247977.1, AL117209.7 and BQ000015.1. This sequence is a reference standard in the RefSeqGene project. On Dec 7, 2010 this sequence version replaced gi:22027617. Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX247977.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-81 U21092.1 4-84 82-106 AL132801.5 21810-21834 c 107-154 U21092.1 110-157 155-2537 BX247977.1 1-2383 2538-7771 AL117209.7 122476-127709 7772-7793 BQ000015.1 1-22 c FEATURES Location/Qualifiers source 1..7793 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="14" /map="14q32.32" gene 1..7793 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="TNF receptor-associated factor 3" /db_xref="GeneID:7187" /db_xref="HGNC:12033" /db_xref="HPRD:03539" /db_xref="MIM:601896" exon 1..197 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 131 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:1051750" exon 198..336 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 212 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:79869075" variation 242 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:140896812" misc_feature 267..269 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="upstream in-frame stop codon" variation 327 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:186237761" exon 337..598 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 346 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:370752725" variation 348 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:190521973" CDS 354..2060 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="isoform 1 is encoded by transcript variant 1; CD40 binding protein; CD40 receptor associated factor 1; CD40 associated protein 1; LMP1-associated protein 1" /codon_start=1 /product="TNF receptor-associated factor 3 isoform 1" /protein_id="NP_663777.1" /db_xref="GI:22027618" /db_xref="CCDS:CCDS9975.1" /db_xref="GeneID:7187" /db_xref="HGNC:12033" /db_xref="HPRD:03539" /db_xref="MIM:601896" /translation="
MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
" misc_feature 507..638 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cd00162" /db_xref="CDD:29102" misc_feature order(510..512,519..521,555..557,561..563,570..572, 579..581,615..617,624..626) /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="cross-brace motif; other site" /db_xref="CDD:29102" misc_feature 759..929 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176" /db_xref="CDD:190233" misc_feature 942..1106 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176" /db_xref="CDD:190233" misc_feature 1485..2042 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the...; Region: MATH_TRAF3; cd03777" /db_xref="CDD:58108" misc_feature order(1548..1550,1557..1559,1581..1583,1587..1589, 1608..1610,1614..1616,1698..1703,1794..1796,1803..1805, 1854..1856) /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="trimer interface [polypeptide binding]; other site" /db_xref="CDD:58108" misc_feature order(1722..1724,1728..1730,1740..1742,1746..1748, 1773..1775,1887..1889,1896..1898,1911..1913,1941..1952) /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /note="TNFR binding site; other site" /db_xref="CDD:58108" variation 362 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:377427517" variation 387 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:139127242" variation 389 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:199639339" variation 400..401 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="c" /db_xref="dbSNP:376342002" variation 406 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:145456077" variation 427 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:370955205" variation 428 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:1051749" variation 429 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:375545964" variation 469 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:147686384" variation 491 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:201415483" variation 538 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:183443558" variation 542 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:142350527" exon 599..650 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 599 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:146435455" variation 620 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:147871145" variation 623 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:149018928" exon 651..755 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 694 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:12896018" variation 700 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:372370114" variation 705 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:143813189" variation 730 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="t" /db_xref="dbSNP:377142394" variation 739 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:1131877" exon 756..923 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 802 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:141920055" variation 836 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:374166578" variation 860 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:145367471" variation 915 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:137916856" exon 924..1004 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 935 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:368161114" variation 938 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:186117694" variation 939 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:142439625" variation 979 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:199989168" variation 981 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:145947234" variation 1000 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:139458877" exon 1005..1079 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 1059 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:368804411" variation 1071 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:200118821" exon 1080..1172 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 1083 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="t" /db_xref="dbSNP:149327017" variation 1127 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:144578195" variation 1159 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:369640883" variation 1160 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:201211273" exon 1173..1313 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 1191..1192 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="a" /db_xref="dbSNP:35228820" variation 1307 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:182757817" exon 1314..1488 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 1315 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:148461790" variation 1322 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:1131876" variation 1340 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:372134660" variation 1376 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:145200267" variation 1413 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:369697250" variation 1445 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:201374351" variation 1452 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:147610812" variation 1463 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:1051743" variation 1465 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:144719184" exon 1489..7776 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /inference="alignment:Splign:1.39.8" variation 1538 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:376141594" variation 1547 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:151258452" variation 1553 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:370697221" variation 1577 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:140423891" variation 1580 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:150483724" variation 1592 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:111762207" variation 1607 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:201486992" variation 1622 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:377168511" variation 1649 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:145391228" variation 1667 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:3742448" STS 1697..2587 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /standard_name="TRAF3_v555" /db_xref="UniSTS:277842" variation 1706 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:1051742" variation 1736 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:141356642" variation 1760 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:200974693" variation 1769 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:150561735" variation 1838 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:199868254" variation 1841 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:145126372" variation 1862 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:138943371" variation 1867 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:186844617" variation 1880 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:202084269" variation 1895 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:374255469" variation 1931 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:142501447" variation 1980 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:372089179" variation 1987 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:144637377" variation 1997 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:370725073" variation 2042 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:148195281" variation 2051 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:377148855" variation 2077 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:369453811" STS 2098..2229 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /standard_name="RH69049" /db_xref="UniSTS:33196" variation 2116 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:373244439" variation 2165 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:191258518" variation 2178 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:377143104" variation 2190 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:139584485" STS 2214..2451 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /standard_name="G15867" /db_xref="UniSTS:12048" variation 2410..2411 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="ac" /db_xref="dbSNP:371921986" variation 2411..2412 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="ac" /db_xref="dbSNP:142806500" variation 2411 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:201568881" variation 2514 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:184183944" variation 2943 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:188857207" variation 2970..2971 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="a" /db_xref="dbSNP:57120368" variation 3004 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:142745057" variation 3016 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:192894065" variation 3037 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:147370186" variation 3041 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:185305434" variation 3084 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:139583976" variation 3127 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:144980713" variation 3129 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:80216614" variation 3172 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:190155467" variation 3290 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:374592471" variation 3341 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:75249707" variation 3358..3359 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="atct" /db_xref="dbSNP:375424663" variation 3373 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:72704737" variation 3572 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:373295670" variation 3577 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:372051148" variation 3634 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:112261683" variation 3672 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:376429109" variation 3679..3680 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="ca" /db_xref="dbSNP:201700309" variation 3813 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:182212093" variation 3846 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:148584503" variation 3914 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:367719643" variation 3984 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:142988351" variation 3997..3998 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="a" /db_xref="dbSNP:34474027" variation 4013 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:151084914" variation 4016 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:186127559" variation 4065 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:141331668" variation 4099 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:117897999" variation 4106 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:117475076" variation 4165 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:188198787" variation 4259 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:114392221" variation 4322 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:376100146" variation 4339 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:145120246" variation 4381 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:117653635" variation 4382 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:117106738" variation 4408 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:7152158" variation 4502 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="" /replace="c" /db_xref="dbSNP:34578787" variation 4560 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:116178840" variation 4610 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:374825187" variation 4616 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:180688846" variation 4649 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:11160707" variation 4823 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:11552465" variation 5000 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:185075993" variation 5026 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:146802843" variation 5039 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:191356380" variation 5076 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:372945156" variation 5101 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:183222973" variation 5133 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:45517731" variation 5206 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:376995306" variation 5269 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="g" /db_xref="dbSNP:45585743" variation 5333 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:78630751" variation 5366 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:201281332" variation 5385 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:186841343" variation 5413 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:80197834" variation 5445 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:191683954" variation 5453 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:183394545" variation 5479 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:74082969" variation 5528 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:187691773" variation 5533 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="t" /db_xref="dbSNP:4906271" variation 5642 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:375292813" variation 5755 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:35360806" variation 5857 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:368940960" variation 5970 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:4906272" variation 6024 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:375381789" variation 6068 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:138179996" variation 6091 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:117406867" variation 6096 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:149530934" variation 6128 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:143203754" variation 6133 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:191019034" variation 6178 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:369985542" variation 6197 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:11620870" variation 6221 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:182443319" variation 6234 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:186731083" variation 6264 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:192760623" variation 6325 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:117597898" variation 6333 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:138947290" variation 6346 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:142791534" variation 6419 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:147406100" variation 6423 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:4906273" variation 6463 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="t" /db_xref="dbSNP:373563762" variation 6499 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:138001318" variation 6517 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:376776135" variation 6540 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:370848396" variation 6571 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:45478597" variation 6577 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="c" /db_xref="dbSNP:188439936" variation 6713 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:374197709" variation 6726 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:193031191" variation 6729 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:369332741" variation 6767 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:4900558" variation 6807 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:377603736" variation 6838 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:184726526" variation 6971 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:370260743" variation 7005 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:143573604" variation 7006 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:374968722" variation 7071 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:377708288" variation 7195 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:150503115" variation 7260 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:10133111" variation 7264 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:1046299" variation 7288 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:45528941" variation 7293 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="g" /replace="t" /db_xref="dbSNP:11552464" variation 7401 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:79926472" variation 7410 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:368377660" variation 7416 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="g" /db_xref="dbSNP:117858701" STS 7638..7746 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /standard_name="WI-13969" /db_xref="UniSTS:60858" variation 7659 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="c" /replace="t" /db_xref="dbSNP:115804335" variation 7681 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" /replace="a" /replace="t" /db_xref="dbSNP:78211216" polyA_signal 7753..7758 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" polyA_site 7776 /gene="TRAF3" /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1" ORIGIN
gggagcgcggcgcggccgccgcgtgcgcgagccggggttgcagcccagccgggactttccagccggcggcagccgcggcggccgccggctcttccccgccccccgccatggggcagcccggggagcagaacgctgcggaccgcggcggaggacgcgcccggcgcccctgagccggccgagcggcgacggaccgcgagatgaggaaaatgaggcccaaagaagtgatgccacttggttaaggtcccagagcaggtcagaatcagacctaggatcagaaacctggctcctggctcctggctccctactcttctaaggatcgctgtcctgacagaagagaactcctctttcctaaaatggagtcgagtaaaaagatggactctcctggcgcgctgcagactaacccgccgctaaagctgcacactgaccgcagtgctgggacgccagtttttgtccctgaacaaggaggttacaaggaaaagtttgtgaagaccgtggaggacaagtacaagtgtgagaagtgccacctggtgctgtgcagcccgaagcagaccgagtgtgggcaccgcttctgcgagagctgcatggcggccctgctgagctcttcaagtccaaaatgtacagcgtgtcaagagagcatcgttaaagataaggtgtttaaggataattgctgcaagagagaaattctggctcttcagatctattgtcggaatgaaagcagaggttgtgcagagcagttaatgctgggacatctgctggtgcatttaaaaaatgattgccattttgaagaacttccatgtgtgcgtcctgactgcaaagaaaaggtcttgaggaaagacctgcgagaccacgtggagaaggcgtgtaaataccgggaagccacatgcagccactgcaagagtcaggttccgatgatcgcgctgcagaaacacgaagacaccgactgtccctgcgtggtggtgtcctgccctcacaagtgcagcgtccagactctcctgaggagcgagttgagtgcacacttgtcagagtgtgtcaatgcccccagcacctgtagttttaagcgctatggctgcgtttttcaggggacaaaccagcagatcaaggcccacgaggccagctccgccgtgcagcacgtcaacctgctgaaggagtggagcaactcgctcgaaaagaaggtttccttgttgcagaatgaaagtgtagaaaaaaacaagagcatacaaagtttgcacaatcagatatgtagctttgaaattgaaattgagagacaaaaggaaatgcttcgaaataatgaatccaaaatccttcatttacagcgagtgatagacagccaagcagagaaactgaaggagcttgacaaggagatccggcccttccggcagaactgggaggaagcagacagcatgaagagcagcgtggagtccctccagaaccgcgtgaccgagctggagagcgtggacaagagcgcggggcaagtggctcggaacacaggcctgctggagtcccagctgagccggcatgaccagatgctgagtgtgcacgacatccgcctagccgacatggacctgcgcttccaggtcctggagaccgccagctacaatggagtgctcatctggaagattcgcgactacaagcggcggaagcaggaggccgtcatggggaagaccctgtccctttacagccagcctttctacactggttactttggctataagatgtgtgccagggtctacctgaacggggacgggatggggaaggggacgcacttgtcgctgttttttgtcatcatgcgtggagaatatgatgccctgcttccttggccgtttaagcagaaagtgacactcatgctgatggatcaggggtcctctcgacgtcatttgggagatgcattcaagcccgaccccaacagcagcagcttcaagaagcccactggagagatgaatatcgcctctggctgcccagtctttgtggcccaaactgttctagaaaatgggacatatattaaagatgatacaatttttattaaagtcatagtggatacttcggatctgcccgatccctgataagtagctggggaggtggatttagcagaaggcaactcctctgggggatttgaaccggtctgtcttcactgaggtcctcgcgctcagaaaaggaccttgtgagacggaggaagcggcagaaggcggacgcgtgccggcgggaggagccacgcgtgagcacacctgacacgttttataatagactagccacacttcactctgaagaattatttatccttcaacaagataaatattgctgtcagagaaggttttcattttcatttttaaagatctagttaattaaggtggaaaacatatatgctaaacaaaagaaacatgatttttcttccttaaacttgaacaccaaaaaaacacacacacacacacacgtggggatagctggacatgtcagcatgttaagtaaaaggagaatttatgaaatagtaatgcaattctgatatcttctttctaaaattcaagagtgcaattttgtttcaaatacagtatattgtctatttttaaggcctcatctggtctctgttttaataatttgtttgtcagaagaccctgaagtatatacctaggtcttttttttgaaagtctctaaattcagaatcattttttaatttaaagttctacaaataattgttactgcaaacattttattttaaaacgttgatagactgatatttcttggaagaaaatataaaatatcaaacactggttatcacttgtgataggaaagagaatattcaacctgttgttatttctcgttagaaatgtaaaccttcaaatatctgtcgtagttaatgacacgacttcacaattctgaacggagcctcgctcatggatgctgtgcatcattttcagatttataattgttttcaccctaaaatagggcatccgttgaactttggagttctaaacaaaatcctgtaggtgtttggattctgccccatgtgttcggacgagctctctgttgctgacagcaccggccttcggtctccatgtcaggggtgggcgggtgactgctgagggaggcccgcaggtgtgtttctccatcccgtcatcttgctgcatgccgtcaacggtctccgaaagcaacgttgtgcgtagagctggtggcatacggcccacgtgccttagatgggacatgctgcttctccaccctgggtttgcattgagcatcattctagaaagtgctagtttaaccagacttttctctccaccactagatctttgtctctacaagggccctcagacacctctgcacctgctgaggggaagccaggctccaccgtcggcttctggagcctccgctgcttaattaccacagattccaaatctctaggccccacgagtgagccgcctggtccaagtacggcctggtcccaccctgagggaggcaggtgtggaacagaagccgagcctctccgtgtccccaccggggccgtgggcacccccacagcccgaagcagaaccctctgagcattccagagaccgctgctcgggggcctgcccaggctgaccaacgggcgctcctgaccaccaccctggcgggaagggtggccacggggcccgtcgtcccagcctgtgcctgcccagatggcattttctcaactcactgtttactgtctctcagtgtccaactgtgattagaagcctggagcctgccccctgcaccccttttgctatgcaccacgcttcatggtgctcttaccactgatgggtgctacacgcgacgggtgcttcttaggcaaaaccaatgtgtgcgaactgtcacacctgtgccactcgcccacaagccgcgcccacaattggccagctgggccgtgcacgtcagactgcctgcctcggctctccccgtggccgcgcggggacagcttggtgggtgcccggtggcccacctgtctctggtgctgccatctgtcctgggtgtgccttcgccccagtgcctgctggaagtgccctccgtcgcacccctgtgccctgagctcccgtgaggggcccgccgcgccctttcgcggtcgaagcgttccgttgttcttatctgcctttcctttccccgctctcctgggattactttgggggaatgagtatccttggttctgccctgtgagggagtcgtgtgtccctgctcataaaggaaggacttcctgcagaagctgcggaaaactactgttccctcgaaggtgtcccccacctgaggcctgtcccctacctgccctcaggtagttttcctgaggccaggggttaacaacagggacatccctgcaacttccccttcacaaaatgtataatattagatgaaggatatgcaacatcttggtctagtaagaaccgtttcctcccctctgggttgaagtcctggtgtggcccccagaagcagcagtgcgtgtcactgggacgtctccagtagcccttcccaggcagacgctcctggcgggacgccatggggcccacctgagggtcccacagacgtaacctgagtgacaggagtccttgaggatgggatggcctatgtcacacactttgtccttgaacctgagtgatgggggtccttgaggatgggatggcctgtgtcacgcgctttgtctttgtgtttggttgtatcggggtctctgttctgagtgtgtcttcctctcatgtactcaacacagtgggcagcagcctgggacggcgtcccctctcccggcggcgggcaagccttgcgctgctccaccctcggcctgggcaccctcacttggcgctggccacctgggccagcctggggccatggtctctctgcagctgaggcccagtggccccttgggcagtgatcggccctccccgcatcacagggccctggcagcaagcgggaaatgggggcgcacactgtgtgcttgggggtgctgcttgtttaccacacatgaccagactcccagcaggacagagctgctcagtactttacagaaaccaactgagtcgtttgtgcatgaattaagccggtctgcttccccgtcaccttcgtaacaaaacaacgtcccctctcccctcgcctcgagcagtttcttcaggacaccgtggctcgggctgctccctgctgccaggcacgctggttggctggcctgggcccggctcacgtgaagggcactggctcttgtgaccacactgagccacgtgcaagccgcagccgggcctggaagcctgaccctctggttctagggcttgtcccgcggagcctgcagagctagacgttggggtgtgtccgtgatgatatgggggccaggctgggagtagggcctttctagcagggttgggtggctcagtgagggtgtggaagtgggggacccacggggcctggctttgggactagacatgccagccccagctgggctggagggagcctgagtgagccccgacatacgctgggcctttcagctcgccgtgctctggtgacacacaggcggccaggttgggatttgtgtcaattctaggagccatcaagcatgaatgtggttctgtctcctgagcgcaagcctcgccggacccctgggcgaaggcctggacttgcagatgtgtgttccctgtgcgggtggacagagggggcccttatgacccacattgcagccccattccaccaccccttcctccccagagcagtctctgccgagggacagcacctgtgtcccttcgatgccacaacagccagttgaacaggggagccctttgctcaggcagcttctcctgcctctccctcctttctccttccctgccccatccccgtgcccttcttggcctgtggcgctggggagccatggtgtggcatactggggctcctgctccttgggccacttcctcagcccgggccccacaggcccaccacctgccagggctcccactgcactggctgtggcaggaggcttccccatgaccccgtgtggcccagctcggtgaggatgcagttctaggcacagcccctgggacagccagctgcctcccagaccacgtcagcctgctccagggtcctcagtcaccctgggccaggggccacgtgtcccatggatgtcgaccatgccaacgtcacattccagcaccccttttgcttgatggcgtctggtggtagtcagcatggtggacccacatcctacagccagaggtgatgttggacaaaggaaggggagtctggatgggtccttaaacgaccattctgtccgcagcggggtcattccttgtcagcccaagggagggccggggagtacactgatcccaacagctgggctgacacctcctttctcccctgcacggggaggattggcctgaggaccgtcaccctgtgcacagccccagtagggtggcagtgccactgtctccttgggccgttgcaggattgggcgggtgcagactccccttgcgggccccttgctcaatccccggccctcccagactcctccctctactgggggtaatttgtgtgtcagaagggctctggcagagctgtaaaatactgttttttaaaaattttagtccagatctttacttattagactgcagaaggagagctagggagagtgggggaagcccccttgcttttgtatctgtgaggtgaatgagggtctgtcacccaaatctacttctcagcccatgaccatagttctgttttccgtttgcaaatctcagtagctctgttttctccaaagtagaatgtgcgcaccggggtcctagccaggcgaggtcagtgtcggcaggctacctggtcattattgctgcctcgtccaggctgatgctgatggtcacaggcacggtggcatcagggagccgggccagcaggcggcgtgaggcggggccagcagctcactgcaagggcattttccacctgatcctggtgtgccccacatgcggtggcagggcagacgtgtgaagcctcggccgtctcggggctggcaggtgtgcgggtgaggaggccccggtggccaagcagagcctgcgtttcatttctcctgctgcactgtgtctagtctgtcttgtgaactctcaccgtgaaaagaggctagaagtccaggatcgctgtaccgctcctgtaattaggtgatgactggatttgacaacttagtcccctcagacaagtaagataccctccaacagcaaattcaatgacttaattggaaaacacacaagctggcatgatgtccggtgatttctgtaagaaatgcctgtaggagaaggtctgtgaagtgtggagggcagtgtcgacgctgcacagcatctgcagattcgcagcctcttctctgccggtgcctctgttcggttctgttacccaaaaacaaagaccaaagaaggccaatctctcatttgaccctgtctttttaatctgcctgttttaaaagttgcgtctgtagtagccgcttgctgtgaagacacatcttgacagtccaagtgattttgtgaccagtgatttgggtcctgttttccgctcttctaagaaaaaacaaaaagaccgtgagttattgcccagcaataatcatgttgttactgtgagttagcaacatgcctgacttcctgatagcattactgttttctagttttgtttattgtatattatgtgtggttttatttggtatttatttgtgttttgaggtcttgcaatgtttttgtgtttctgatgctaataactaaagtttgtaagactgtagaatgcaaaactcggagatgctaaactgtcttattagaggaaaataaatctgattatggagtctcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:7187 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS GeneID:7187 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS GeneID:7187 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:7187 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:7187 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA GeneID:7187 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI GeneID:7187 -> Molecular function: GO:0031996 [thioesterase binding] evidence: IPI GeneID:7187 -> Biological process: GO:0001817 [regulation of cytokine production] evidence: ISS GeneID:7187 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: ISS GeneID:7187 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:7187 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS GeneID:7187 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:7187 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS GeneID:7187 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:7187 -> Biological process: GO:0008063 [Toll signaling pathway] evidence: IEA GeneID:7187 -> Biological process: GO:0030162 [regulation of proteolysis] evidence: IMP GeneID:7187 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IMP GeneID:7187 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS GeneID:7187 -> Biological process: GO:0032648 [regulation of interferon-beta production] evidence: ISS GeneID:7187 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IMP GeneID:7187 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS GeneID:7187 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS GeneID:7187 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:7187 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:7187 -> Biological process: GO:0050688 [regulation of defense response to virus] evidence: ISS GeneID:7187 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA GeneID:7187 -> Cellular component: GO:0005768 [endosome] evidence: IEA GeneID:7187 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:7187 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: ISS GeneID:7187 -> Cellular component: GO:0035631 [CD40 receptor complex] evidence: ISS
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