2024-04-20 05:26:54, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_145341 3728 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 2, mRNA. ACCESSION NM_145341 VERSION NM_145341.3 GI:313760535 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3728) AUTHORS Kolpa,H.J., Peal,D.S., Lynch,S.N., Giokas,A.C., Ghatak,S., Misra,S., Norris,R.A., Macrae,C.A., Markwald,R.R., Ellinor,P., Bischoff,J. and Milan,D.J. TITLE miR-21 represses Pdcd4 during cardiac valvulogenesis JOURNAL Development 140 (10), 2172-2180 (2013) PUBMED 23578931 REMARK GeneRIF: miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4 REFERENCE 2 (bases 1 to 3728) AUTHORS Wang,Q., Zhu,J., Zhang,Y., Sun,Z., Guo,X., Wang,X., Lee,E., Bakthavatchalu,V., Yang,Q. and Yang,H.S. TITLE Down-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice JOURNAL Eur. J. Cancer 49 (7), 1761-1770 (2013) PUBMED 23312883 REMARK GeneRIF: Data indicate that programmed cell death 4 (Pdcd4) knockdown altered the adhesion capacity of colon carcinoma GEO cells. REFERENCE 3 (bases 1 to 3728) AUTHORS Paik,W.H., Kim,H.R., Park,J.K., Song,B.J., Lee,S.H. and Hwang,J.H. TITLE Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol JOURNAL Anticancer Res. 33 (4), 1473-1481 (2013) PUBMED 23564788 REMARK GeneRIF: Loss of PDCD4 indicates chemoresistance in pancreatic cancer. REFERENCE 4 (bases 1 to 3728) AUTHORS Li,C.R., Su,J.J., Wang,W.Y., Lee,M.T., Wang,T.Y., Jiang,K.Y., Li,C.F., Hsu,J.M., Chen,C.K., Chen,M., Jiang,S.S., Weaver,V.M. and Tsai,K.K. TITLE Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer JOURNAL Am. J. Pathol. 182 (2), 363-374 (2013) PUBMED 23219426 REMARK GeneRIF: Programmed cell death protein 4 (PDCD4) and Kruppel-like factor 6 (KLF6) were identified as critical regulators and surrogate markers of prostatic tissue architectures. REFERENCE 5 (bases 1 to 3728) AUTHORS Ludwig,K., Fassan,M., Mescoli,C., Pizzi,M., Balistreri,M., Albertoni,L., Pucciarelli,S., Scarpa,M., Sturniolo,G.C., Angriman,I. and Rugge,M. TITLE PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis JOURNAL Virchows Arch. 462 (1), 57-63 (2013) PUBMED 23224068 REMARK GeneRIF: PDCD4 nuclear down-regulation (which parallels miR-21 up-regulation) is involved in the molecular pathway of inflammatory bowel disease-associated carcinogenesis. REFERENCE 6 (bases 1 to 3728) AUTHORS Chen,Y., Knosel,T., Kristiansen,G., Pietas,A., Garber,M.E., Matsuhashi,S., Ozaki,I. and Petersen,I. TITLE Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis JOURNAL J. Pathol. 200 (5), 640-646 (2003) PUBMED 12898601 REFERENCE 7 (bases 1 to 3728) AUTHORS Kang,M.J., Ahn,H.S., Lee,J.Y., Matsuhashi,S. and Park,W.Y. TITLE Up-regulation of PDCD4 in senescent human diploid fibroblasts JOURNAL Biochem. Biophys. Res. Commun. 293 (1), 617-621 (2002) PUBMED 12054647 REMARK GeneRIF: up-regulated in senescent diploid fibroblasts REFERENCE 8 (bases 1 to 3728) AUTHORS Yoshinaga,H., Matsuhashi,S., Fujiyama,C. and Masaki,Z. TITLE Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody JOURNAL Pathol. Int. 49 (12), 1067-1077 (1999) PUBMED 10632927 REFERENCE 9 (bases 1 to 3728) AUTHORS Soejima,H., Miyoshi,O., Yoshinaga,H., Masaki,Z., Ozaki,I., Kajiwara,S., Niikawa,N., Matsuhashi,S. and Mukai,T. TITLE Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization JOURNAL Cytogenet. Cell Genet. 87 (1-2), 113-114 (1999) PUBMED 10640828 REFERENCE 10 (bases 1 to 3728) AUTHORS Azzoni,L., Zatsepina,O., Abebe,B., Bennett,I.M., Kanakaraj,P. and Perussia,B. TITLE Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells JOURNAL J. Immunol. 161 (7), 3493-3500 (1998) PUBMED 9759869 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB241608.1, AL136368.24, AK315295.1, AL158163.11 and BX647834.1. On Dec 9, 2010 this sequence version replaced gi:34304341. Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]. Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region and utilizes a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025083 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-59 DB241608.1 1-59 60-60 AL136368.24 125230-125230 61-123 DB241608.1 61-123 124-475 AK315295.1 2-353 476-476 AL136368.24 134671-134671 477-1295 AK315295.1 355-1173 1296-1311 AL158163.11 8134-8149 1312-1780 AK315295.1 1190-1658 1781-1869 BX647834.1 1539-1627 1870-1962 AL158163.11 15706-15798 1963-3448 BX647834.1 1719-3204 3449-3449 AL158163.11 17285-17285 3450-3728 BX647834.1 3206-3484 FEATURES Location/Qualifiers source 1..3728 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q24" gene 1..3728 /gene="PDCD4" /gene_synonym="H731" /note="programmed cell death 4 (neoplastic transformation inhibitor)" /db_xref="GeneID:27250" /db_xref="HGNC:8763" /db_xref="HPRD:10549" /db_xref="MIM:608610" exon 1..224 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 225..329 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 330..413 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" misc_feature 401..403 /gene="PDCD4" /gene_synonym="H731" /note="upstream in-frame stop codon" CDS 404..1780 /gene="PDCD4" /gene_synonym="H731" /note="isoform 2 is encoded by transcript variant 2; nuclear antigen H731; programmed cell death protein 4; protein 197/15a; neoplastic transformation inhibitor protein" /codon_start=1 /product="programmed cell death protein 4 isoform 2" /protein_id="NP_663314.1" /db_xref="GI:21735598" /db_xref="CCDS:CCDS44478.1" /db_xref="GeneID:27250" /db_xref="HGNC:8763" /db_xref="HPRD:10549" /db_xref="MIM:608610" /translation="
MTKYPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
" misc_feature 581..583 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 596..598 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 602..604 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 608..610 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 647..649 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 650..652 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 824..826 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 860..1195 /gene="PDCD4" /gene_synonym="H731" /note="Domain in DAP-5, eIF4G, MA-3 and other proteins; Region: MA3; smart00544" /db_xref="CDD:128817" misc_feature 1349..1690 /gene="PDCD4" /gene_synonym="H731" /note="Domain in DAP-5, eIF4G, MA-3 and other proteins; Region: MA3; smart00544" /db_xref="CDD:128817" misc_feature 1739..1741 /gene="PDCD4" /gene_synonym="H731" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 414..716 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" STS 566..722 /gene="PDCD4" /gene_synonym="H731" /standard_name="RH93337" /db_xref="UniSTS:83971" exon 717..811 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 812..925 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 926..1147 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 1148..1245 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" STS 1166..1303 /gene="PDCD4" /gene_synonym="H731" /standard_name="MARC_26204-26205:1030736270:1" /db_xref="UniSTS:268985" exon 1246..1360 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 1361..1468 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 1469..1579 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 1580..1719 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" exon 1720..3698 /gene="PDCD4" /gene_synonym="H731" /inference="alignment:Splign:1.39.8" STS 2154..2369 /gene="PDCD4" /gene_synonym="H731" /standard_name="SHGC-35716" /db_xref="UniSTS:82555" polyA_signal 2411..2416 /gene="PDCD4" /gene_synonym="H731" polyA_site 2428 /gene="PDCD4" /gene_synonym="H731" polyA_site 2431 /gene="PDCD4" /gene_synonym="H731" polyA_site 2442 /gene="PDCD4" /gene_synonym="H731" polyA_signal 2816..2821 /gene="PDCD4" /gene_synonym="H731" polyA_site 2839 /gene="PDCD4" /gene_synonym="H731" variation complement(3443) /gene="PDCD4" /gene_synonym="H731" /replace="c" /replace="g" /db_xref="dbSNP:11548763" STS 3521..3645 /gene="PDCD4" /gene_synonym="H731" /standard_name="RH44657" /db_xref="UniSTS:40387" polyA_signal 3674..3679 /gene="PDCD4" /gene_synonym="H731" polyA_site 3698 /gene="PDCD4" /gene_synonym="H731" ORIGIN
cttttcctcctcagctccggctccgccgccacgattggccagccgaccacccggcctcggccaataagcgccgccctctcgcccccgtgttactgggtagaagaaaacaaaaacaaacagagcgagaagggccagagactctccgaggcggcggcagagacagaagagcggggtcggggccggctgaccaggaacctgggcgagcagcggcgggggcccgagggattctgaaggaagatttccattaggtaatttgtttaatcagtgcaagcgaaattaagggaaaatggatgtagaaaatgagcagatactgaatgtaaaccctgcagggtattttccctaattctccatggtgcttcaatagcatgttattatcataaaaatgaacagttttgtggaatagatgaccaaatatcctgataacttaagtgactctctcttttccggtgatgaagaaaatgctgggactgaggaaataaagaatgaaataaatggaaattggatttcagcatcctccattaacgaagctagaattaatgccaaggcaaaaaggcgactaaggaaaaactcatcccgggactctggcagaggcgattcggtcagcgacagtgggagtgacgcccttagaagtggattaactgtgccaaccagtccaaagggaaggttgctggataggcgatccagatctgggaaaggaaggggactaccaaagaaaggtggtgcaggaggcaaaggtgtctggggtacacctggacaggtgtatgatgtggaggaggtggatgtgaaagatcctaactatgatgatgaccaggagaactgtgtttatgaaactgtagttttgcctttggatgaaagggcatttgagaagactttaacaccaatcatacaggaatattttgagcatggagatactaatgaagttgcggaaatgttaagagatttaaatcttggtgaaatgaaaagtggagtaccagtgttggcagtatccttagcattggaggggaaggctagtcatagagagatgacatctaagcttctttctgacctttgtgggacagtaatgagcacaactgatgtggaaaaatcatttgataaattgttgaaagatctacctgaattagcactggatactcctagagcaccacagttggtgggccagtttattgctagagctgttggagatggaattttatgtaatacctatattgatagttacaaaggaactgtagattgtgtgcaggctagagctgctctggataaggctaccgtgcttctgagtatgtctaaaggtggaaagcgtaaagatagtgtgtggggctctggaggtgggcagcaatctgtcaatcaccttgttaaagagattgatatgctgctgaaagaatatttactctctggagacatatctgaagctgaacattgccttaaggaactggaagtacctcattttcaccatgagcttgtatatgaagctattataatggttttagagtcaactggagaaagtacatttaagatgattttggatttattaaagtccctttggaagtcttctaccattactgtagaccaaatgaaaagaggttatgagagaatttacaatgaaattccggacattaatctggatgtcccacattcatactctgtgctggagcggtttgtagaagaatgttttcaggctggaataatttccaaacaactcagagatctttgtccttcaaggggcagaaagcgttttgtaagcgaaggagatggaggtcgtcttaaaccagagagctactgaatataagaactcttgcagtcttagatgttataaaaatatatatctgaattgtaagagttgttagcacaagttttttttttttttttttttaagcacttgttttgggtacaaggcatttctgacattttataaacctacatttaaggggaatttttaaaggaaatgttttttcttttttttttgtttttcgagggggcaaggagggacagaaaagtaacctcttcttaagtggaatattctaataagctaccttttgtaagtgccatgtttattatctaatcattccaagttttgcattgatgtctgactgccactcctttctttcaaggacagtgttttttgtagtaaaatcactggtttatacaaagctttatttagggggtaaagttaagctgctaaaaccccatgttggctgctgctgttgagatactgtgctttgggagtaaaaaaagaaagttatttctttgtcttaaagaatttttaaaaaattagtcatgagacttattcatctttccagggaacatactgattggtcttaaaagactagacagttaagtaaaaggtggctggaacatctatttttctacaaaactggaaaaatgaacctggttctagaagaatgtacaccaaaataaaacatgtgaagcagtattgattctttattgggagtacatttttttaggtctcttaaactttaatttcacacagtaaattttgaatctcataaggaagcatatttgaacctagtcaatttaatcttagtgttcccttgaaaactttttttccctacaaaattttaagtgaaaaatacaatagtaaattaagattacactggggaaaaaaatgcaggtatcactttactccattgttatctgacctagagcttaattaagttttagaaatatgtaataccttccatcattccatcatccttaaattctgttaccaaataatggctaatgttacaaaaagttatactccagagacccaaagcttgacatttacctaatgtatgagaaaatattaccaattaacaataaagaatgatcatatttttaacctcttttacatagcctaataactcagcaaggcctcaacgtctgtgctaatttaaactgccaaatattgactgcagcaaacaagaattatattcagaatttatgagggtactgttaggagtatactgcttacaggtttagatatagtctgttagaattaaaaccaagtttagtgttcatatttacctcatgggctttatcaagcccatattacctcagcttatatatagttaccatttttaggtttttaattgtttgacacttggatgataaatgcagtcattttattctcaagtgcttaaaattaatgtaattaaaagcttagctgactacagaataggtgagggtttcttaaaaatgagatttaagggctgggcacggtggctcatgcctgtaatcccagcactttgggaggccgaggtgggcggatcacttgaggttgggagttcatgaccagcttgaccaacatgaagaaaccctgtctctattaaaaatacaaaagtagccaggcatggtggcgcatgcgtgtaatcccagctacttgggaggctgaggcaggagaattgcttgaacctgggaggcagaggttgcagtgagtcgagatggtgccattgctctcgtttgggcaacaagagtgaaactcttgtctcaaaaaaaaaaaaaaatgaggtttaagacagttttgtcattactggtgggatctggtcacacaagatagcattaaacgtgacatggcacataaaattggttaaaaaattttgttttttaattacgtaatgtaaaagcccaacaaacactttatgcaagattggaatgtatcttcaaattcagatttaataaacatgtaaagatcctctgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:27250 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA GeneID:27250 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:27250 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS GeneID:27250 -> Biological process: GO:0007569 [cell aging] evidence: IDA GeneID:27250 -> Biological process: GO:0016070 [RNA metabolic process] evidence: IEA GeneID:27250 -> Biological process: GO:0043508 [negative regulation of JUN kinase activity] evidence: ISS GeneID:27250 -> Biological process: GO:0045786 [negative regulation of cell cycle] evidence: NAS GeneID:27250 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA GeneID:27250 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS GeneID:27250 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:27250 -> Cellular component: GO:0005634 [nucleus] evidence: IMP GeneID:27250 -> Cellular component: GO:0005634 [nucleus] evidence: ISS GeneID:27250 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:27250 -> Cellular component: GO:0005737 [cytoplasm] evidence: IMP GeneID:27250 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
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