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2024-04-18 15:24:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_145331 5172 bp mRNA linear PRI 20-APR-2013
DEFINITION Homo sapiens mitogen-activated protein kinase kinase kinase 7
(MAP3K7), transcript variant B, mRNA.
ACCESSION NM_145331
VERSION NM_145331.2 GI:395132443
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5172)
AUTHORS Zheng,H., Li,Q., Chen,R., Zhang,J., Ran,Y., He,X., Li,S. and
Shu,H.B.
TITLE The dual-specificity phosphatase DUSP14 negatively regulates tumor
necrosis factor- and interleukin-1-induced nuclear factor-kappaB
activation by dephosphorylating the protein kinase TAK1
JOURNAL J. Biol. Chem. 288 (2), 819-825 (2013)
PUBMED 23229544
REMARK GeneRIF: findings suggest that DUSP14 negatively regulates TNF- or
IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at
Thr-187
REFERENCE 2 (bases 1 to 5172)
AUTHORS Wen,J., Hu,Y., Luo,K.J., Yang,H., Zhang,S.S. and Fu,J.H.
TITLE Positive transforming growth factor-beta activated kinase-1
expression has an unfavorable impact on survival in T3N1-3M0
esophageal squamous cell carcinomas
JOURNAL Ann. Thorac. Surg. 95 (1), 285-290 (2013)
PUBMED 23272845
REMARK GeneRIF: TAK1 expression correlates with lymph node metastasis and
is a negative, independent prognostic factor in resected T3N1-3M0
ESCCs.
REFERENCE 3 (bases 1 to 5172)
AUTHORS Morioka,S., Inagaki,M., Komatsu,Y., Mishina,Y., Matsumoto,K. and
Ninomiya-Tsuji,J.
TITLE TAK1 kinase signaling regulates embryonic angiogenesis by
modulating endothelial cell survival and migration
JOURNAL Blood 120 (18), 3846-3857 (2012)
PUBMED 22972987
REMARK GeneRIF: We found that endothelial TAK1 and TAB2, but not TAB1,
were critically involved in vascular formation
REFERENCE 4 (bases 1 to 5172)
AUTHORS Gaudreault,E., Paquet-Bouchard,C., Fiola,S., Le Bel,M., Lacerte,P.,
Shio,M.T., Olivier,M. and Gosselin,J.
TITLE TAK1 contributes to the enhanced responsiveness of LTB(4)-treated
neutrophils to Toll-like receptor ligands
JOURNAL Int. Immunol. 24 (11), 693-704 (2012)
PUBMED 22843747
REMARK GeneRIF: Results indicate that TAK1 and p38 kinases appear to be
central in the 'priming effect' of LTB(4) on neutrophils to enhance
response to Toll-like receptor ligands.
REFERENCE 5 (bases 1 to 5172)
AUTHORS Dai,L., Aye Thu,C., Liu,X.Y., Xi,J. and Cheung,P.C.
TITLE TAK1, more than just innate immunity
JOURNAL IUBMB Life 64 (10), 825-834 (2012)
PUBMED 22941947
REMARK GeneRIF: TAK1 plays central role in both innate and adaptive
immunity as well as in DNA damage, osmotic stress, and hypoxia.
(Review)
Review article
REFERENCE 6 (bases 1 to 5172)
AUTHORS Moriguchi,T., Kuroyanagi,N., Yamaguchi,K., Gotoh,Y., Irie,K.,
Kano,T., Shirakabe,K., Muro,Y., Shibuya,H., Matsumoto,K.,
Nishida,E. and Hagiwara,M.
TITLE A novel kinase cascade mediated by mitogen-activated protein kinase
kinase 6 and MKK3
JOURNAL J. Biol. Chem. 271 (23), 13675-13679 (1996)
PUBMED 8663074
REFERENCE 7 (bases 1 to 5172)
AUTHORS Shibuya,H., Yamaguchi,K., Shirakabe,K., Tonegawa,A., Gotoh,Y.,
Ueno,N., Irie,K., Nishida,E. and Matsumoto,K.
TITLE TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal
transduction
JOURNAL Science 272 (5265), 1179-1182 (1996)
PUBMED 8638164
REFERENCE 8 (bases 1 to 5172)
AUTHORS Yamaguchi,K., Shirakabe,K., Shibuya,H., Irie,K., Oishi,I., Ueno,N.,
Taniguchi,T., Nishida,E. and Matsumoto,K.
TITLE Identification of a member of the MAPKKK family as a potential
mediator of TGF-beta signal transduction
JOURNAL Science 270 (5244), 2008-2011 (1995)
PUBMED 8533096
REFERENCE 9 (bases 1 to 5172)
AUTHORS Hirose,T., Fujimoto,W., Tamaai,T., Kim,K.H., Matsuura,H. and
Jetten,A.M.
TITLE TAK1: molecular cloning and characterization of a new member of the
nuclear receptor superfamily
JOURNAL Mol. Endocrinol. 8 (12), 1667-1680 (1994)
PUBMED 7708055
REFERENCE 10 (bases 1 to 5172)
AUTHORS DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
Calos,M.P.
TITLE Analysis of mutation in human cells by using an Epstein-Barr virus
shuttle system
JOURNAL Mol. Cell. Biol. 7 (1), 379-387 (1987)
PUBMED 3031469
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BM172351.1, AB009357.1,
AL121964.16 and AI147171.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 12, 2012 this sequence version replaced gi:21735561.
Summary: The protein encoded by this gene is a member of the
serine/threonine protein kinase family. This kinase mediates the
signaling transduction induced by TGF beta and morphogenetic
protein (BMP), and controls a variety of cell functions including
transcription regulation and apoptosis. In response to IL-1, this
protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and
MAP3K7P2/TAB2; this complex is required for the activation of
nuclear factor kappa B. This kinase can also activate MAPK8/JNK,
MAP2K4/MKK4, and thus plays a role in the cell response to
environmental stresses. Four alternatively spliced transcript
variants encoding distinct isoforms have been reported. [provided
by RefSeq, Jul 2008].
Transcript Variant: This variant (B) encodes the longest isoform
(B).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB009357.1, BT019655.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-256 BM172351.1 9-264
257-3106 AB009357.1 1-2850
3107-4838 AL121964.16 70207-71938
4839-5172 AI147171.1 1-334 c
FEATURES Location/Qualifiers
source 1..5172
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q15"
gene 1..5172
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="mitogen-activated protein kinase kinase kinase 7"
/db_xref="GeneID:6885"
/db_xref="HGNC:6859"
/db_xref="HPRD:04011"
/db_xref="MIM:602614"
exon 1..538
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
variation 211
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:34016005"
misc_feature 212..214
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="upstream in-frame stop codon"
CDS 419..2239
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/EC_number="2.7.11.25"
/note="isoform B is encoded by transcript variant B;
transforming growth factor-beta-activated kinase 1;
TGF-beta activated kinase 1; TGF-beta-activated kinase 1"
/codon_start=1
/product="mitogen-activated protein kinase kinase kinase 7
isoform B"
/protein_id="NP_663304.1"
/db_xref="GI:21735562"
/db_xref="CCDS:CCDS5028.1"
/db_xref="GeneID:6885"
/db_xref="HGNC:6859"
/db_xref="HPRD:04011"
/db_xref="MIM:602614"
/translation="
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
"
misc_feature 419..1318
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O43318.1);
Region: Interaction with MAPK8IP1 (By similarity)"
misc_feature 545..1273
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="Catalytic domain of Protein Tyrosine Kinases;
Region: PTKc; cd00192"
/db_xref="CDD:173624"
misc_feature 545..1270
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="Tyrosine kinase, catalytic domain; Region: TyrKc;
smart00219"
/db_xref="CDD:197581"
misc_feature order(545..556,566..568,599..601,605..607,728..739,
746..751,884..886,896..901,905..907,941..943,995..1000,
1019..1021,1124..1126)
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="active site"
/db_xref="CDD:173624"
misc_feature order(545..547,551..556,566..568,599..601,605..607,
728..739,746..751,896..901,905..907,941..943)
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173624"
misc_feature order(884..886,896..898,995..1000,1019..1021,1124..1126)
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173624"
misc_feature order(938..961,995..1000)
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173624"
misc_feature 968..970
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04011"
misc_feature 977..979
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O43318.1); phosphorylation site"
misc_feature 977..979
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04011"
misc_feature 992..994
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O43318.1); phosphorylation site"
misc_feature 992..994
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04011"
misc_feature 1583..1585
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43318.1); phosphorylation site"
misc_feature 1583..1585
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1733..1735
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43318.1); phosphorylation site"
misc_feature 1733..1735
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 539..649
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 650..715
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 716..761
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 762..900
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
variation 835
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:34261934"
exon 901..1025
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
variation 922
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:35084747"
exon 1026..1154
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1155..1285
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1286..1367
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1368..1498
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1499..1628
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1629..1709
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1710..1774
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1775..1880
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1881..1942
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 1943..2058
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
exon 2059..5167
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/inference="alignment:Splign:1.39.8"
variation 2173
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:34631230"
variation 2251
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:3734657"
variation 2417
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:2131906"
variation 2583
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:35335029"
variation 2722
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:2172710"
STS 2756..3043
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/standard_name="WI-19992"
/db_xref="UniSTS:75830"
STS 2830..2924
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/standard_name="SHGC-24062"
/db_xref="UniSTS:45135"
STS 2852..3043
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/standard_name="SHGC-132368"
/db_xref="UniSTS:184321"
STS 2853..3087
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/standard_name="STS-N93759"
/db_xref="UniSTS:65830"
variation 2948
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:9396"
polyA_signal 3025..3030
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
polyA_site 3046
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
variation 3239
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:157704"
variation 3324
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:157705"
variation 3340
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:34087194"
variation 3542
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:157706"
variation 4187..4188
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace=""
/replace="a"
/db_xref="dbSNP:34973388"
variation 4188
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:199552422"
variation 4430
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:34651140"
variation 4839
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:10894"
STS 4999..5100
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/standard_name="SHGC-34216"
/db_xref="UniSTS:61151"
variation 5017
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:2180736"
polyA_signal 5136..5141
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
polyA_site 5167
/gene="MAP3K7"
/gene_synonym="MEKK7; TAK1; TGF1a"
ORIGIN
gtcctctctcgcggtatcatccggttgctgaggccctgtaataaaggtctcgcgaaatttgttctagaggtccaagtttgcttcttagcttactccaccccacccccaacctgtccctccttttctttccaagtcacaaaattctcccctcccctaccccggagtttacggccctcctcctgtttccgatttcagcccggaaccggaagtgtagtgggcggggcccgtcggcggaaaacgcagcggagccagagccggacacggctgtggccgctgcctctacccccgccacggatcgccgggtagtaggactgcgcggctccaggctgagggtcggtccggaggcgggtgggcgcgggtctcacccggattgtccgggtggcaccgttcccggccccaccgggcgccgcgagggatcatgtctacagcctctgccgcctcctcctcctcctcgtcttcggccggtgagatgatcgaagccccttcccaggtcctcaactttgaagagatcgactacaaggagatcgaggtggaagaggttgttggaagaggagcctttggagttgtttgcaaagctaagtggagagcaaaagatgttgctattaaacaaatagaaagtgaatctgagaggaaagcgtttattgtagagcttcggcagttatcccgtgtgaaccatcctaatattgtaaagctttatggagcctgcttgaatccagtgtgtcttgtgatggaatatgctgaagggggctctttatataatgtgctgcatggtgctgaaccattgccatattatactgctgcccacgcaatgagttggtgtttacagtgttcccaaggagtggcttatcttcacagcatgcaacccaaagcgctaattcacagggacctgaaaccaccaaacttactgctggttgcaggggggacagttctaaaaatttgtgattttggtacagcctgtgacattcagacacacatgaccaataacaaggggagtgctgcttggatggcacctgaagtttttgaaggtagtaattacagtgaaaaatgtgacgtcttcagctggggtattattctttgggaagtgataacgcgtcggaaaccctttgatgagattggtggcccagctttccgaatcatgtgggctgttcataatggtactcgaccaccactgataaaaaatttacctaagcccattgagagcctgatgactcgttgttggtctaaagatccttcccagcgcccttcaatggaggaaattgtgaaaataatgactcacttgatgcggtactttccaggagcagatgagccattacagtatccttgtcagtattcagatgaaggacagagcaactctgccaccagtacaggctcattcatggacattgcttctacaaatacgagtaacaaaagtgacactaatatggagcaagttcctgccacaaatgatactattaagcgcttagaatcaaaattgttgaaaaatcaggcaaagcaacagagtgaatctggacgtttaagcttgggagcctcccgtgggagcagtgtggagagcttgcccccaacctctgagggcaagaggatgagtgctgacatgtctgaaatagaagctaggatcgccgcaaccacagcctattccaagcctaaacggggccaccgtaaaactgcttcatttggcaacattctggatgtccctgagatcgtcatatcaggcaacggacagccaagacgtagatccatccaagacttgactgtaactggaacagaacctggtcaggtgagcagtaggtcatccagtcccagtgtcagaatgattactacctcaggaccaacctcagaaaagccaactcgaagtcatccatggacccctgatgattccacagataccaatggatcagataactccatcccaatggcttatcttacactggatcaccaactacagcctctagcaccgtgcccaaactccaaagaatctatggcagtgtttgaacagcattgtaaaatggcacaagaatatatgaaagttcaaacagaaattgcattgttattacagagaaagcaagaactagttgcagaactggaccaggatgaaaaggaccagcaaaatacatctcgcctggtacaggaacataaaaagcttttagatgaaaacaaaagcctttctacttactaccagcaatgcaaaaaacaactagaggtcatcagaagtcagcagcagaaacgacaaggcacttcatgattctctgggaccgttacattttgaaatatgcaaagaaagactttttttttaaggaaaggaaaaccttataatgacgattcatgagtgttagctttttggcgtgttctgaatgccaactgcctatatttgctgcatttttttcattgtttattttccttttctcatggtggacatacaattttactgtttcattgcataacatggtagcatctgtgacttgaatgagcagcactttgcaacttcaaaacagatgcagtgaactgtggctgtatatgcatgctcattgtgtgaaggctagcctaacagaacaggaggtatcaaactagctgctatgtgcaaacagcgtccattttttcatattagaggtggaacctcaagaatgactttattcttgtatctcatctcaaaatattaataatttttttcccaaaagatggtatataccaagttaaagacagggtattataaatttagagtgattggtggtatattacggaaatacggaacctttagggatagttccgtgtaagggctttgatgccagcatccttggatcagtactgaactcagttccatccgtaaaatatgtaaaggtaagtggcagctgctctatttaatgaaagcagttttaccggattttgttagactaaaatttgattgtgatacattgaacaaaatggaactcatttttttttaaggagtaaagatttttaattctgtgattgtgtgtatgtgtgttgaaactgtaaagcttttatgactctaatattaatctcttaaatgaaattaaaaggcaaaagaacatgattgagcttaaatgatcatttcttcctgcagtgattcttggattgttttctcatgtatttgaaaaaaaaaaaatgaagaaaaataatggaaaatggaagtaattactccagctaaaaaaagcttggacttagatttctttttatgataccaaatgagaaataaaccaggcaaatcagaaggaagttaaagaagcaaatataaattcaacaagtgtcctaattatcctggatattggaatatttgattttccttacaatcccgttctagaatgcctgccgcctttcaacactttcaagagaatttcaacacttacagagtatttatattgttaacagtaattttgctaccaaaaccttcagaataactttaataataaaatgacactgaaataatagactatacaaactctatattttttcagttggtgttaaaataagtcacattttgataccagtacaagatgtcttttaaataaggatgtcatcagtctgatttttatagcattaatgttttatgaagaaaaagttcaaaatgaaagcattaattgctgtgattattagaattctatcatgactgtattgtagtttttgctctatttcagataagcaagatctaagaagttatcaaaactattctttaaaatgctaaagcaggtaactttttcttccattattttttcctcctaccactgagttttgtaatgaattccttgtgtatacaagcaatacaggtgaatactaaactgttatttttagcttcttcaaaagctattttagaaagcttcctggaaataaatgtcttctgtcatttaatttaaataaaaggagtgttaattgttcccaaatttgattacctagctgaaacagatattggattcagcatagtaatagtaaaataaaattggcagagaaaataactgtagactaggataaagcatgactcctccatagcattgttgcttgtatgtacatctgtcactccactgaaagggacctagtcactttaaagaggccttttatctcagcacgagatatccaagcgtgaatgctaaggcttgatgtttccattaggatttagcattcgagatttcagattttatttatagtcattgatgtgttttgctgtattataacacatttaagggaaattttattatggtttttacatgtagtcatttcataaaaatatccagataggtaaatggaagaaaatagtagattttagtcatggtaccaaatgcaagaggctgttgaacagttgcttgtttgtttacagtaagttccttgagattttcagtactgtagttgccctggacattgagtacagttcagccttactctgtttttaagtagttgtgttgtcaatttcatgcttttaagtcctgatgatccttggagatgggagaaaaagataccagggataattaaaatccacagccagtttcatcagtttcctcatccatcctgcaaataaaaatgttaacaaggagccaaacttattcgttctggttttacaatttattttgaccgttttttgggtgaaaattgcaaacagccaagcaagtggctggaatgccccagtctaagaaattcaaaaacaatcactgagtaagccctaattacattaattacattttactcttgactccaggaaaagaaagcaagcttttatctaatctagagggaagtattcgtgagcaataaaaatcacttttttgagttgaataataatcagttaagaatatttaccgcatagcaacacaacatataaagatttgttacaagttgtttacggatgtttgactatttttgctgaagtattttagagtattgaatgtcttctctcttcaagtttctttcatgttcctaatttcagctcctgtagccagagatcacaggtcttccctgtgaaactttggtttctttctataaatgtgtgtggttttcagcgctcaactcctgtcttcaaatggtagtaagttctacttctacttctgtcattcagaacattttatgtcaaatgatgtaatgcagaaattcttgtgcatatttgtaactgaaggaagctttttagatttatttttgtttttaataaaattcagattcctattctaaactggtaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6885 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IEA
GeneID:6885 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:6885 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: EXP
GeneID:6885 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:6885 -> Molecular function: GO:0004708 [MAP kinase kinase activity] evidence: IEA
GeneID:6885 -> Molecular function: GO:0004709 [MAP kinase kinase kinase activity] evidence: IDA
GeneID:6885 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6885 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6885 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: IDA
GeneID:6885 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: IDA
GeneID:6885 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
GeneID:6885 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:6885 -> Biological process: GO:0001841 [neural tube formation] evidence: IEA
GeneID:6885 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0002726 [positive regulation of T cell cytokine production] evidence: IMP
GeneID:6885 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:6885 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6885 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: IEA
GeneID:6885 -> Biological process: GO:0007249 [I-kappaB kinase/NF-kappaB cascade] evidence: TAS
GeneID:6885 -> Biological process: GO:0007250 [activation of NF-kappaB-inducing kinase activity] evidence: IMP
GeneID:6885 -> Biological process: GO:0007252 [I-kappaB phosphorylation] evidence: IDA
GeneID:6885 -> Biological process: GO:0007254 [JNK cascade] evidence: IDA
GeneID:6885 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
GeneID:6885 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IMP
GeneID:6885 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:6885 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
GeneID:6885 -> Biological process: GO:0043507 [positive regulation of JUN kinase activity] evidence: IDA
GeneID:6885 -> Biological process: GO:0043507 [positive regulation of JUN kinase activity] evidence: IMP
GeneID:6885 -> Biological process: GO:0043966 [histone H3 acetylation] evidence: IDA
GeneID:6885 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:6885 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IEA
GeneID:6885 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: NAS
GeneID:6885 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
GeneID:6885 -> Biological process: GO:0050870 [positive regulation of T cell activation] evidence: IC
GeneID:6885 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: TAS
GeneID:6885 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: IDA
GeneID:6885 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:6885 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS
GeneID:6885 -> Cellular component: GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] evidence: IDA
GeneID:6885 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6885 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:6885 -> Cellular component: GO:0008385 [IkappaB kinase complex] evidence: IPI
GeneID:6885 -> Cellular component: GO:0010008 [endosome membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_663304 -> EC 2.7.11.25
by
@meso_cacase at
DBCLS
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