GGRNA Home | Help | Advanced search

2024-03-28 20:55:56, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_145185               3386 bp    mRNA    linear   PRI 05-MAY-2013
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase 7 (MAP2K7),
            mRNA.
ACCESSION   NM_145185 NM_005043 NM_145329
VERSION     NM_145185.2  GI:40806198
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Cohen-Katsenelson,K., Wasserman,T., Darlyuk-Saadon,I., Rabner,A.,
            Glaser,F. and Aronheim,A.
  TITLE     Identification and analysis of a novel dimerization domain shared
            by various members of c-Jun N-terminal kinase (JNK) scaffold
            proteins
  JOURNAL   J. Biol. Chem. 288 (10), 7294-7304 (2013)
   PUBMED   23341463
  REMARK    GeneRIF: Data indicate that WDR62 dimerization is required for JNK2
            and MKK7beta1 recruitment.
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Guo,Y., Wang,W., Wang,J., Feng,J., Wang,Q., Jin,J., Lv,M., Li,X.,
            Li,Y., Ma,Y., Shen,B. and Zhang,J.
  TITLE     Receptor for activated C kinase 1 promotes hepatocellular carcinoma
            growth by enhancing mitogen-activated protein kinase kinase 7
            activity
  JOURNAL   Hepatology 57 (1), 140-151 (2013)
   PUBMED   22903704
  REMARK    GeneRIF: Overexpressed RACK1 augments JNK activity and thereby
            promotes hepatocellular carcinoma growth through directly binding
            to MKK7 and enhancing MKK7 activity.
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Winchester,C.L., Ohzeki,H., Vouyiouklis,D.A., Thompson,R.,
            Penninger,J.M., Yamagami,K., Norrie,J.D., Hunter,R., Pratt,J.A. and
            Morris,B.J.
  TITLE     Converging evidence that sequence variations in the novel candidate
            gene MAP2K7 (MKK7) are functionally associated with schizophrenia
  JOURNAL   Hum. Mol. Genet. 21 (22), 4910-4921 (2012)
   PUBMED   22899651
  REMARK    GeneRIF: the results imply that reduced function of the
            MAP2K7-c-Jun N-terminal kinase (JNK) signalling cascade may
            underlie some of the neurochemical changes and core symptoms in
            schizophrenia.
REFERENCE   4  (bases 1 to 3386)
  AUTHORS   Tang,R.X., Kong,F.Y., Fan,B.F., Liu,X.M., You,H.J., Zhang,P. and
            Zheng,K.Y.
  TITLE     HBx activates FasL and mediates HepG2 cell apoptosis through
            MLK3-MKK7-JNKs signal module
  JOURNAL   World J. Gastroenterol. 18 (13), 1485-1495 (2012)
   PUBMED   22509080
  REMARK    GeneRIF: Data show that HBx can induce HepG2 cell apoptosis via a
            novel active MLK3-MKK7-JNKs signaling module to upregulate FasL
            protein expression.
REFERENCE   5  (bases 1 to 3386)
  AUTHORS   Uchida,Y., Osaki,T., Yamasaki,T., Shimomura,T., Hata,S.,
            Horikawa,K., Shibata,S., Todo,T., Hirayama,J. and Nishina,H.
  TITLE     Involvement of stress kinase mitogen-activated protein kinase
            kinase 7 in regulation of mammalian circadian clock
  JOURNAL   J. Biol. Chem. 287 (11), 8318-8326 (2012)
   PUBMED   22267733
  REMARK    GeneRIF: a novel function for the stress kinase MKK7 as a regulator
            of the circadian clock in mammalian cells at steady state.
REFERENCE   6  (bases 1 to 3386)
  AUTHORS   Foltz,I.N., Gerl,R.E., Wieler,J.S., Luckach,M., Salmon,R.A. and
            Schrader,J.W.
  TITLE     Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly
            conserved c-Jun N-terminal kinase/stress-activated protein kinase
            (JNK/SAPK) activated by environmental stresses and physiological
            stimuli
  JOURNAL   J. Biol. Chem. 273 (15), 9344-9351 (1998)
   PUBMED   9535930
REFERENCE   7  (bases 1 to 3386)
  AUTHORS   Wang,Y., Su,B., Sah,V.P., Brown,J.H., Han,J. and Chien,K.R.
  TITLE     Cardiac hypertrophy induced by mitogen-activated protein kinase
            kinase 7, a specific activator for c-Jun NH2-terminal kinase in
            ventricular muscle cells
  JOURNAL   J. Biol. Chem. 273 (10), 5423-5426 (1998)
   PUBMED   9488659
REFERENCE   8  (bases 1 to 3386)
  AUTHORS   Wu,Z., Wu,J., Jacinto,E. and Karin,M.
  TITLE     Molecular cloning and characterization of human JNKK2, a novel Jun
            NH2-terminal kinase-specific kinase
  JOURNAL   Mol. Cell. Biol. 17 (12), 7407-7416 (1997)
   PUBMED   9372971
REFERENCE   9  (bases 1 to 3386)
  AUTHORS   Lu,X., Nemoto,S. and Lin,A.
  TITLE     Identification of c-Jun NH2-terminal protein kinase
            (JNK)-activating kinase 2 as an activator of JNK but not p38
  JOURNAL   J. Biol. Chem. 272 (40), 24751-24754 (1997)
   PUBMED   9312068
REFERENCE   10 (bases 1 to 3386)
  AUTHORS   Tournier,C., Whitmarsh,A.J., Cavanagh,J., Barrett,T. and Davis,R.J.
  TITLE     Mitogen-activated protein kinase kinase 7 is an activator of the
            c-Jun NH2-terminal kinase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (14), 7337-7342 (1997)
   PUBMED   9207092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF013588.1, AF003199.1,
            BC038295.2 and AK098807.1.
            This sequence is a reference standard in the RefSeqGene project.
            On or before Jan 26, 2004 this sequence version replaced
            gi:21735541, gi:21735545, gi:21735543.
            
            Summary: The protein encoded by this gene is a dual specificity
            protein kinase that belongs to the MAP kinase kinase family. This
            kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this
            kinase itself is phosphorylated and activated by MAP kinase kinase
            kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and
            MAP4K2/GCK. This kinase is involved in the signal transduction
            mediating the cell responses to proinflammatory cytokines, and
            environmental stresses. Multiple alternatively spliced transcript
            variants encoding distinct isoforms have been found, but only one
            transcript variant has been supported and defined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013588.1, AF022805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AF013588.1         3-66
            65-847              AF003199.1         61-843
            848-1001            BC038295.2         887-1040
            1002-1459           AF013588.1         1004-1461
            1460-2438           BC038295.2         1520-2498
            2439-3370           AK098807.1         669-1600
            3371-3386           BC038295.2         3431-3446
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3-p13.2"
     gene            1..3386
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="mitogen-activated protein kinase kinase 7"
                     /db_xref="GeneID:5609"
                     /db_xref="HGNC:6847"
                     /db_xref="MIM:603014"
     exon            1..189
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    21..23
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="upstream in-frame stop codon"
     CDS             66..1325
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /EC_number="2.7.12.2"
                     /note="MAP kinase kinase 7; JNK-activating kinase 2; c-Jun
                     N-terminal kinase kinase 2; MEK 7; JNKK 2; MAPKK 7;
                     MAPK/ERK kinase 7; SAPK kinase 4; stress-activated protein
                     kinase kinase 4"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 7"
                     /protein_id="NP_660186.1"
                     /db_xref="GI:21735544"
                     /db_xref="CCDS:CCDS42491.1"
                     /db_xref="GeneID:5609"
                     /db_xref="HGNC:6847"
                     /db_xref="MIM:603014"
                     /translation="
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
"
     misc_feature    174..236
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14733.2);
                     Region: D domain (By similarity)"
     misc_feature    195..200
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by anthrax lethal factor; propagated from
                     UniProtKB/Swiss-Prot (O14733.2); cleavage site"
     misc_feature    291..296
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by anthrax lethal factor; propagated from
                     UniProtKB/Swiss-Prot (O14733.2); cleavage site"
     misc_feature    375..1265
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="Catalytic domain of the dual-specificity Protein
                     Kinase, MAP kinase kinase 7; Region: PKc_MKK7; cd06618"
                     /db_xref="CDD:132949"
     misc_feature    426..1205
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(441..455,459..461,465..467,504..506,510..512,
                     603..605,651..662,666..671,675..680,792..794,798..809,
                     813..815,846..848,855..857,894..905,909..911,1005..1007,
                     1032..1034)
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="active site"
                     /db_xref="CDD:132949"
     misc_feature    order(441..455,459..461,465..467,504..506,510..512,
                     603..605,651..662,666..671,675..680,798..800,804..809,
                     813..815,846..848)
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:132949"
     misc_feature    order(450..455,792..794,798..806,855..857,894..905,
                     909..911,1005..1007,1032..1034)
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:132949"
     misc_feature    843..911
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:132949"
     misc_feature    1194..1265
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14733.2);
                     Region: DVD domain"
     variation       101
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371236199"
     variation       116
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17853819"
     exon            190..331
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       288
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138677713"
     variation       325
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:144581836"
     exon            332..398
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       338
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367925050"
     exon            399..512
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       411
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28395770"
     variation       418
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56316660"
     variation       419
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369656037"
     variation       432
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372177955"
     variation       437
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34562033"
     variation       440
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28395771"
     variation       449
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369896403"
     variation       458
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28395773"
     variation       477
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56106612"
     variation       487
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376991761"
     variation       501
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200200323"
     variation       503
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373472944"
     variation       506
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200460916"
     exon            513..632
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       527
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373551377"
     variation       535
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367833467"
     variation       590
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370478429"
     variation       593
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201775683"
     STS             599..768
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /standard_name="RH65754"
                     /db_xref="UniSTS:33867"
     variation       602
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55772368"
     variation       631
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199553372"
     exon            633..740
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       634
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377648179"
     variation       635
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:36024099"
     variation       638
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2303701"
     variation       647
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200708722"
     variation       648
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55800262"
     variation       671
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35139435"
     variation       677..678
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35609416"
     variation       710
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:117765980"
     variation       727
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372316207"
     variation       736
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373789571"
     exon            741..920
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       791
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376803808"
     variation       794
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200791594"
     variation       836
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202061567"
     variation       840
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1053566"
     variation       851
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376594925"
     variation       860
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372642511"
     variation       890
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373957718"
     variation       896
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77549726"
     exon            921..1001
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       938
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182111602"
     variation       974
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372752473"
     variation       980
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370603578"
     variation       987
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56278855"
     variation       998
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374835674"
     variation       999
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1132882"
     exon            1002..1144
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1061
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372323735"
     variation       1071
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375557842"
     variation       1088
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370087443"
     variation       1097
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201502330"
     variation       1098
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200517538"
     exon            1145..1190
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1184
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139511301"
     exon            1191..3372
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /inference="alignment:Splign:1.39.8"
     variation       1211
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36016973"
     variation       1214
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200201904"
     variation       1215
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372974513"
     variation       1261
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201368825"
     variation       1276
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202245509"
     variation       1277
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201101315"
     variation       1281
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377699571"
     variation       1334
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371283714"
     variation       1337
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41285786"
     variation       1351
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367868279"
     variation       1352
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370693649"
     variation       1367
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374068196"
     variation       1483
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12461368"
     variation       1635
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377058331"
     variation       1707
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144003467"
     variation       1711
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373766038"
     variation       1730
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377433579"
     variation       1879
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3745386"
     variation       1937..1938
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:143071290"
     variation       1938..1941
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="ctct"
                     /db_xref="dbSNP:373407605"
     variation       1938
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="c"
                     /replace="ctc"
                     /db_xref="dbSNP:60437175"
     variation       1938
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7247283"
     variation       1942
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="c"
                     /replace="ctc"
                     /db_xref="dbSNP:61676760"
     variation       1952..1953
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:5826990"
     variation       1953..1954
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:36012622"
     variation       1963..1964
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:3066695"
     variation       2205
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11558677"
     variation       2225
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187462044"
     variation       2303
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72997866"
     variation       2310
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192966939"
     STS             2379..2506
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /standard_name="G43572"
                     /db_xref="UniSTS:95019"
     variation       2416
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4804835"
     variation       2435
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142209587"
     variation       2439
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3679"
     variation       2489
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78114760"
     variation       2500
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151231797"
     variation       2538
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372134723"
     variation       2646
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1053579"
     variation       2649
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1053580"
     variation       2654
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1053581"
     variation       2661
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1063858"
     variation       2664..2665
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:369538864"
     variation       2664
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1063859"
     variation       2694
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140502873"
     variation       2703..2704
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34473118"
     variation       2727
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184711481"
     variation       2749
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188052407"
     variation       2750
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192332147"
     variation       2782
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202049550"
     variation       2795..2797
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="tta"
                     /db_xref="dbSNP:144185410"
     variation       2985
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144233609"
     variation       3019
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183484324"
     variation       3086
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113957491"
     variation       3131
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368777564"
     variation       3164
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141275903"
     variation       3254
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41285788"
     variation       3324
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371727420"
     variation       3335
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34759683"
     variation       3335
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200206210"
     variation       3339..3340
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34038379"
     variation       3343
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189380399"
     polyA_signal    3349..3354
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
     polyA_site      3372
                     /gene="MAP2K7"
                     /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4;
                     SAPKK4"
ORIGIN      
gcggtgtttgtctgccggactgacgggcggccgggcggtgcgcggcggcggtggcggcggggaagatggcggcgtcctccctggaacagaagctgtcccgcctggaagcaaagctgaagcaggagaaccgggaggcccggcggaggatcgacctcaacctggatatcagcccccagcggcccaggcccaccctgcagctcccgctggccaacgatgggggcagccgctcgccatcctcagagagctccccgcagcaccccacgccccccgcccggccccgccacatgctggggctcccgtcaaccctgttcacaccccgcagcatggagagcattgagattgaccagaagctgcaggagatcatgaagcagacgggctacctgaccatcgggggccagcgctaccaggcagaaatcaacgacctggagaacttgggcgagatgggcagcggcacctgcggccaggtgtggaagatgcgcttccggaagaccggccacgtcattgccgttaagcaaatgcggcgctccgggaacaaggaggagaacaagcgcatcctcatggacctggatgtggtgctgaagagccacgactgcccctacatcgtgcagtgctttgggacgttcatcaccaacacggacgtcttcatcgccatggagctcatgggcacctgcgctgagaagctcaagaagcggatgcagggccccatccccgagcgcattctgggcaagatgacagtggcgattgtgaaggcgctgtactacctgaaggagaagcacggtgtcatccaccgcgacgtcaagccctccaacatcctgctggacgagcggggccagatcaagctctgcgacttcggcatcagcggccgcctggtggactccaaagccaagacgcggagcgccggctgtgccgcctacatggcacccgagcgcattgaccccccagaccccaccaagccggactatgacatccgggccgacgtatggagcctgggcatctcgttggtggagctggcaacaggacagtttccctacaagaactgcaagacggactttgaggtcctcaccaaagtcctacaggaagagcccccgcttctgcccggacacatgggcttctcgggggacttccagtccttcgtcaaagactgccttactaaagatcacaggaagagaccaaagtataataagctacttgaacacagcttcatcaagcgctacgagacgctggaggtggacgtggcgtcctggttcaaggatgtcatggcgaagactgagtcaccgcggactagcggcgtcctgagccagccccacctgcccttcttcaggtagctgcttggcggcggccagccccacagggggccaggggcatggccacaggcccccctccccacttggccacccagctgcctgccaggggagacctgggacctggacggccacctaggactgaggacagagagtggggggtgcccacccaccccccccgccccgggcctaccaagcccccgcccttcccaccccggggtcagccggccgtgtgcgtcccccgacagacactgtgaacggaagacagcaggccgcgatcagagtcgctgttcattcagccgcagcctctgggccggggcggcccccaggggccaggagagagccctggagtcccgcagccaccatgcacgctcccagcgtgctgtgtccttcgccactcccacgcgcccgttcctcttccgtcgccctctgtcccctgctctacctctctgtccttgtctggctctcccgtcaccctccctgcctctgtctctcttctggcctgagcctgggcccagccacctcctgacgggtcccctgggtctgcataggtctcccatggcgcaatgagtcagtggcccccagccaggcagtgtgggcattgccactgcggctggacggggctgcgcgctcgcgctctctctctctctctctctctctctttgatctcagggggtcctttttggagtttattgtattttattgtacttggtggggtgtttggggtgggggcggaggagagcttgttctcgtggggttgtcggtaccttcagaaacttttaccaaagtcacgattagctgcttgtggtggggccccaaccgccctcgggcactggggagctgggctggggctgctgctctggggtctccgggggccacagcttggggtgagttgaagacctcaggggatgtggaggggtctgcggggccctggccgcacaggatggccttcagggaaggtggtcttggggcatggtgcagagcaggtgaccggagggaatcggtgacggagcggggccaagggaggggtccggagggagtcagggatggagggcagagggagtggatgtgggggtttgaggacgtgtgacaagctccagcaggggtgggggccgggctgagggtgggggtgcgaggtggtcactcccatcgtgcccctggccgtccctccactcacccacacctggcccagtccacgttgaggtccaggactgggaaggaccgggtgagtgcaccggggacccaggccaggtgccccccggagcctgctggggtggccagagcaggagggggtgtgtttcctttttgtgggtgttgcatgcaaatcaagtggacaagaaaaaataacaaaacaaaaaacaagaaaaaaaaaacacaaaaccccgtaaaatcacaaagaaaatccaacaccaaaggcgcagaagccggctggccgtggtgggggcagcgtaggcgtagcatccctctcctctcacttagcctgttgactcttgttattatcatgatattcacaaaacgccgcatgtttaaaaagtcatagatgtcatcttctctctgcccccagggaggaaagccaccttctcttgccccttggcccctttgtcaggggccaggggtctgccgggtgggggtgccaacaggcctggccctttcctcccctgcatccagccatgggggcctctgcgattgccggaaggttgcatggctggtcccagggccagcacaggcccgaggccgggctgcctggttttatttttatttaactttattttctgttttatgagtgtgtgtccgcccacccccacccccttcagtgttaagtggggagccctgggggagtctctcctgcctcccagcctctcccaagacctcccccctcgtcaccagccatccctctggaccaggcagagggcggaccgggtgggcaggggcctgagggtggctcgggccagcccaccagccaatggacccctcctcaggccgccagtgtcgccctgcccctttttaaaacaaaatgccctcgtttgtaaacccttagacgcttgagaataaaccccttccttttcttccaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5609 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
            GeneID:5609 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
            GeneID:5609 -> Molecular function: GO:0004708 [MAP kinase kinase activity] evidence: IDA
            GeneID:5609 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IEA
            GeneID:5609 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5609 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5609 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IEA
            GeneID:5609 -> Molecular function: GO:0008545 [JUN kinase kinase activity] evidence: IEA
            GeneID:5609 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:5609 -> Molecular function: GO:0019903 [protein phosphatase binding] evidence: ISS
            GeneID:5609 -> Molecular function: GO:0031435 [mitogen-activated protein kinase kinase kinase binding] evidence: IEA
            GeneID:5609 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:5609 -> Biological process: GO:0006950 [response to stress] evidence: IDA
            GeneID:5609 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:5609 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
            GeneID:5609 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: ISS
            GeneID:5609 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:5609 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA
            GeneID:5609 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5609 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: IDA
            GeneID:5609 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:5609 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
            GeneID:5609 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
            GeneID:5609 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_660186 -> EC 2.7.12.2

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.