2024-03-28 20:55:56, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_145185 3386 bp mRNA linear PRI 05-MAY-2013 DEFINITION Homo sapiens mitogen-activated protein kinase kinase 7 (MAP2K7), mRNA. ACCESSION NM_145185 NM_005043 NM_145329 VERSION NM_145185.2 GI:40806198 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3386) AUTHORS Cohen-Katsenelson,K., Wasserman,T., Darlyuk-Saadon,I., Rabner,A., Glaser,F. and Aronheim,A. TITLE Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins JOURNAL J. Biol. Chem. 288 (10), 7294-7304 (2013) PUBMED 23341463 REMARK GeneRIF: Data indicate that WDR62 dimerization is required for JNK2 and MKK7beta1 recruitment. REFERENCE 2 (bases 1 to 3386) AUTHORS Guo,Y., Wang,W., Wang,J., Feng,J., Wang,Q., Jin,J., Lv,M., Li,X., Li,Y., Ma,Y., Shen,B. and Zhang,J. TITLE Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity JOURNAL Hepatology 57 (1), 140-151 (2013) PUBMED 22903704 REMARK GeneRIF: Overexpressed RACK1 augments JNK activity and thereby promotes hepatocellular carcinoma growth through directly binding to MKK7 and enhancing MKK7 activity. REFERENCE 3 (bases 1 to 3386) AUTHORS Winchester,C.L., Ohzeki,H., Vouyiouklis,D.A., Thompson,R., Penninger,J.M., Yamagami,K., Norrie,J.D., Hunter,R., Pratt,J.A. and Morris,B.J. TITLE Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia JOURNAL Hum. Mol. Genet. 21 (22), 4910-4921 (2012) PUBMED 22899651 REMARK GeneRIF: the results imply that reduced function of the MAP2K7-c-Jun N-terminal kinase (JNK) signalling cascade may underlie some of the neurochemical changes and core symptoms in schizophrenia. REFERENCE 4 (bases 1 to 3386) AUTHORS Tang,R.X., Kong,F.Y., Fan,B.F., Liu,X.M., You,H.J., Zhang,P. and Zheng,K.Y. TITLE HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module JOURNAL World J. Gastroenterol. 18 (13), 1485-1495 (2012) PUBMED 22509080 REMARK GeneRIF: Data show that HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression. REFERENCE 5 (bases 1 to 3386) AUTHORS Uchida,Y., Osaki,T., Yamasaki,T., Shimomura,T., Hata,S., Horikawa,K., Shibata,S., Todo,T., Hirayama,J. and Nishina,H. TITLE Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock JOURNAL J. Biol. Chem. 287 (11), 8318-8326 (2012) PUBMED 22267733 REMARK GeneRIF: a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state. REFERENCE 6 (bases 1 to 3386) AUTHORS Foltz,I.N., Gerl,R.E., Wieler,J.S., Luckach,M., Salmon,R.A. and Schrader,J.W. TITLE Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli JOURNAL J. Biol. Chem. 273 (15), 9344-9351 (1998) PUBMED 9535930 REFERENCE 7 (bases 1 to 3386) AUTHORS Wang,Y., Su,B., Sah,V.P., Brown,J.H., Han,J. and Chien,K.R. TITLE Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells JOURNAL J. Biol. Chem. 273 (10), 5423-5426 (1998) PUBMED 9488659 REFERENCE 8 (bases 1 to 3386) AUTHORS Wu,Z., Wu,J., Jacinto,E. and Karin,M. TITLE Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase JOURNAL Mol. Cell. Biol. 17 (12), 7407-7416 (1997) PUBMED 9372971 REFERENCE 9 (bases 1 to 3386) AUTHORS Lu,X., Nemoto,S. and Lin,A. TITLE Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38 JOURNAL J. Biol. Chem. 272 (40), 24751-24754 (1997) PUBMED 9312068 REFERENCE 10 (bases 1 to 3386) AUTHORS Tournier,C., Whitmarsh,A.J., Cavanagh,J., Barrett,T. and Davis,R.J. TITLE Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (14), 7337-7342 (1997) PUBMED 9207092 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF013588.1, AF003199.1, BC038295.2 and AK098807.1. This sequence is a reference standard in the RefSeqGene project. On or before Jan 26, 2004 this sequence version replaced gi:21735541, gi:21735545, gi:21735543. Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF013588.1, AF022805.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-64 AF013588.1 3-66 65-847 AF003199.1 61-843 848-1001 BC038295.2 887-1040 1002-1459 AF013588.1 1004-1461 1460-2438 BC038295.2 1520-2498 2439-3370 AK098807.1 669-1600 3371-3386 BC038295.2 3431-3446 FEATURES Location/Qualifiers source 1..3386 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13.3-p13.2" gene 1..3386 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="mitogen-activated protein kinase kinase 7" /db_xref="GeneID:5609" /db_xref="HGNC:6847" /db_xref="MIM:603014" exon 1..189 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" misc_feature 21..23 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="upstream in-frame stop codon" CDS 66..1325 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /EC_number="2.7.12.2" /note="MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; MEK 7; JNKK 2; MAPKK 7; MAPK/ERK kinase 7; SAPK kinase 4; stress-activated protein kinase kinase 4" /codon_start=1 /product="dual specificity mitogen-activated protein kinase kinase 7" /protein_id="NP_660186.1" /db_xref="GI:21735544" /db_xref="CCDS:CCDS42491.1" /db_xref="GeneID:5609" /db_xref="HGNC:6847" /db_xref="MIM:603014" /translation="
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
" misc_feature 174..236 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (O14733.2); Region: D domain (By similarity)" misc_feature 195..200 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /experiment="experimental evidence, no additional details recorded" /note="Cleavage, by anthrax lethal factor; propagated from UniProtKB/Swiss-Prot (O14733.2); cleavage site" misc_feature 291..296 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /experiment="experimental evidence, no additional details recorded" /note="Cleavage, by anthrax lethal factor; propagated from UniProtKB/Swiss-Prot (O14733.2); cleavage site" misc_feature 375..1265 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="Catalytic domain of the dual-specificity Protein Kinase, MAP kinase kinase 7; Region: PKc_MKK7; cd06618" /db_xref="CDD:132949" misc_feature 426..1205 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(441..455,459..461,465..467,504..506,510..512, 603..605,651..662,666..671,675..680,792..794,798..809, 813..815,846..848,855..857,894..905,909..911,1005..1007, 1032..1034) /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="active site" /db_xref="CDD:132949" misc_feature order(441..455,459..461,465..467,504..506,510..512, 603..605,651..662,666..671,675..680,798..800,804..809, 813..815,846..848) /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:132949" misc_feature order(450..455,792..794,798..806,855..857,894..905, 909..911,1005..1007,1032..1034) /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:132949" misc_feature 843..911 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /note="activation loop (A-loop); other site" /db_xref="CDD:132949" misc_feature 1194..1265 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (O14733.2); Region: DVD domain" variation 101 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:371236199" variation 116 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:17853819" exon 190..331 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 288 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="c" /db_xref="dbSNP:138677713" variation 325 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="t" /db_xref="dbSNP:144581836" exon 332..398 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 338 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:367925050" exon 399..512 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 411 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:28395770" variation 418 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:56316660" variation 419 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:369656037" variation 432 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="t" /db_xref="dbSNP:372177955" variation 437 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:34562033" variation 440 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:28395771" variation 449 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:369896403" variation 458 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:28395773" variation 477 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:56106612" variation 487 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="c" /db_xref="dbSNP:376991761" variation 501 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:200200323" variation 503 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="t" /db_xref="dbSNP:373472944" variation 506 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:200460916" exon 513..632 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 527 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:373551377" variation 535 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:367833467" variation 590 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:370478429" variation 593 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:201775683" STS 599..768 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /standard_name="RH65754" /db_xref="UniSTS:33867" variation 602 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:55772368" variation 631 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:199553372" exon 633..740 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 634 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:377648179" variation 635 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:36024099" variation 638 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:2303701" variation 647 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:200708722" variation 648 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:55800262" variation 671 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:35139435" variation 677..678 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="t" /db_xref="dbSNP:35609416" variation 710 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="c" /db_xref="dbSNP:117765980" variation 727 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:372316207" variation 736 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="t" /db_xref="dbSNP:373789571" exon 741..920 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 791 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:376803808" variation 794 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:200791594" variation 836 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:202061567" variation 840 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:1053566" variation 851 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:376594925" variation 860 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:372642511" variation 890 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:373957718" variation 896 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:77549726" exon 921..1001 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 938 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:182111602" variation 974 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:372752473" variation 980 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:370603578" variation 987 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:56278855" variation 998 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:374835674" variation 999 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:1132882" exon 1002..1144 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 1061 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:372323735" variation 1071 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:375557842" variation 1088 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:370087443" variation 1097 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:201502330" variation 1098 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:200517538" exon 1145..1190 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 1184 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:139511301" exon 1191..3372 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /inference="alignment:Splign:1.39.8" variation 1211 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:36016973" variation 1214 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:200201904" variation 1215 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:372974513" variation 1261 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:201368825" variation 1276 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:202245509" variation 1277 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="g" /replace="t" /db_xref="dbSNP:201101315" variation 1281 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="t" /db_xref="dbSNP:377699571" variation 1334 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:371283714" variation 1337 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:41285786" variation 1351 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="g" /replace="t" /db_xref="dbSNP:367868279" variation 1352 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="g" /db_xref="dbSNP:370693649" variation 1367 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="g" /replace="t" /db_xref="dbSNP:374068196" variation 1483 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="g" /db_xref="dbSNP:12461368" variation 1635 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:377058331" variation 1707 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:144003467" variation 1711 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:373766038" variation 1730 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="g" /replace="t" /db_xref="dbSNP:377433579" variation 1879 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:3745386" variation 1937..1938 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="ct" /db_xref="dbSNP:143071290" variation 1938..1941 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="ctct" /db_xref="dbSNP:373407605" variation 1938 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="c" /replace="ctc" /db_xref="dbSNP:60437175" variation 1938 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:7247283" variation 1942 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="c" /replace="ctc" /db_xref="dbSNP:61676760" variation 1952..1953 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="tc" /db_xref="dbSNP:5826990" variation 1953..1954 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="tc" /db_xref="dbSNP:36012622" variation 1963..1964 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="ct" /db_xref="dbSNP:3066695" variation 2205 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:11558677" variation 2225 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:187462044" variation 2303 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:72997866" variation 2310 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:192966939" STS 2379..2506 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /standard_name="G43572" /db_xref="UniSTS:95019" variation 2416 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:4804835" variation 2435 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:142209587" variation 2439 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:3679" variation 2489 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:78114760" variation 2500 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="g" /replace="t" /db_xref="dbSNP:151231797" variation 2538 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:372134723" variation 2646 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="t" /db_xref="dbSNP:1053579" variation 2649 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="c" /db_xref="dbSNP:1053580" variation 2654 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="c" /db_xref="dbSNP:1053581" variation 2661 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="c" /db_xref="dbSNP:1063858" variation 2664..2665 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="a" /db_xref="dbSNP:369538864" variation 2664 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:1063859" variation 2694 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:140502873" variation 2703..2704 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="a" /db_xref="dbSNP:34473118" variation 2727 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:184711481" variation 2749 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:188052407" variation 2750 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:192332147" variation 2782 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="g" /db_xref="dbSNP:202049550" variation 2795..2797 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="tta" /db_xref="dbSNP:144185410" variation 2985 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:144233609" variation 3019 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:183484324" variation 3086 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:113957491" variation 3131 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="g" /db_xref="dbSNP:368777564" variation 3164 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:141275903" variation 3254 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:41285788" variation 3324 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="a" /replace="g" /db_xref="dbSNP:371727420" variation 3335 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="c" /db_xref="dbSNP:34759683" variation 3335 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:200206210" variation 3339..3340 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="" /replace="c" /db_xref="dbSNP:34038379" variation 3343 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" /replace="c" /replace="t" /db_xref="dbSNP:189380399" polyA_signal 3349..3354 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" polyA_site 3372 /gene="MAP2K7" /gene_synonym="Jnkk2; MAPKK7; MKK7; PRKMK7; SAPKK-4; SAPKK4" ORIGIN
gcggtgtttgtctgccggactgacgggcggccgggcggtgcgcggcggcggtggcggcggggaagatggcggcgtcctccctggaacagaagctgtcccgcctggaagcaaagctgaagcaggagaaccgggaggcccggcggaggatcgacctcaacctggatatcagcccccagcggcccaggcccaccctgcagctcccgctggccaacgatgggggcagccgctcgccatcctcagagagctccccgcagcaccccacgccccccgcccggccccgccacatgctggggctcccgtcaaccctgttcacaccccgcagcatggagagcattgagattgaccagaagctgcaggagatcatgaagcagacgggctacctgaccatcgggggccagcgctaccaggcagaaatcaacgacctggagaacttgggcgagatgggcagcggcacctgcggccaggtgtggaagatgcgcttccggaagaccggccacgtcattgccgttaagcaaatgcggcgctccgggaacaaggaggagaacaagcgcatcctcatggacctggatgtggtgctgaagagccacgactgcccctacatcgtgcagtgctttgggacgttcatcaccaacacggacgtcttcatcgccatggagctcatgggcacctgcgctgagaagctcaagaagcggatgcagggccccatccccgagcgcattctgggcaagatgacagtggcgattgtgaaggcgctgtactacctgaaggagaagcacggtgtcatccaccgcgacgtcaagccctccaacatcctgctggacgagcggggccagatcaagctctgcgacttcggcatcagcggccgcctggtggactccaaagccaagacgcggagcgccggctgtgccgcctacatggcacccgagcgcattgaccccccagaccccaccaagccggactatgacatccgggccgacgtatggagcctgggcatctcgttggtggagctggcaacaggacagtttccctacaagaactgcaagacggactttgaggtcctcaccaaagtcctacaggaagagcccccgcttctgcccggacacatgggcttctcgggggacttccagtccttcgtcaaagactgccttactaaagatcacaggaagagaccaaagtataataagctacttgaacacagcttcatcaagcgctacgagacgctggaggtggacgtggcgtcctggttcaaggatgtcatggcgaagactgagtcaccgcggactagcggcgtcctgagccagccccacctgcccttcttcaggtagctgcttggcggcggccagccccacagggggccaggggcatggccacaggcccccctccccacttggccacccagctgcctgccaggggagacctgggacctggacggccacctaggactgaggacagagagtggggggtgcccacccaccccccccgccccgggcctaccaagcccccgcccttcccaccccggggtcagccggccgtgtgcgtcccccgacagacactgtgaacggaagacagcaggccgcgatcagagtcgctgttcattcagccgcagcctctgggccggggcggcccccaggggccaggagagagccctggagtcccgcagccaccatgcacgctcccagcgtgctgtgtccttcgccactcccacgcgcccgttcctcttccgtcgccctctgtcccctgctctacctctctgtccttgtctggctctcccgtcaccctccctgcctctgtctctcttctggcctgagcctgggcccagccacctcctgacgggtcccctgggtctgcataggtctcccatggcgcaatgagtcagtggcccccagccaggcagtgtgggcattgccactgcggctggacggggctgcgcgctcgcgctctctctctctctctctctctctctttgatctcagggggtcctttttggagtttattgtattttattgtacttggtggggtgtttggggtgggggcggaggagagcttgttctcgtggggttgtcggtaccttcagaaacttttaccaaagtcacgattagctgcttgtggtggggccccaaccgccctcgggcactggggagctgggctggggctgctgctctggggtctccgggggccacagcttggggtgagttgaagacctcaggggatgtggaggggtctgcggggccctggccgcacaggatggccttcagggaaggtggtcttggggcatggtgcagagcaggtgaccggagggaatcggtgacggagcggggccaagggaggggtccggagggagtcagggatggagggcagagggagtggatgtgggggtttgaggacgtgtgacaagctccagcaggggtgggggccgggctgagggtgggggtgcgaggtggtcactcccatcgtgcccctggccgtccctccactcacccacacctggcccagtccacgttgaggtccaggactgggaaggaccgggtgagtgcaccggggacccaggccaggtgccccccggagcctgctggggtggccagagcaggagggggtgtgtttcctttttgtgggtgttgcatgcaaatcaagtggacaagaaaaaataacaaaacaaaaaacaagaaaaaaaaaacacaaaaccccgtaaaatcacaaagaaaatccaacaccaaaggcgcagaagccggctggccgtggtgggggcagcgtaggcgtagcatccctctcctctcacttagcctgttgactcttgttattatcatgatattcacaaaacgccgcatgtttaaaaagtcatagatgtcatcttctctctgcccccagggaggaaagccaccttctcttgccccttggcccctttgtcaggggccaggggtctgccgggtgggggtgccaacaggcctggccctttcctcccctgcatccagccatgggggcctctgcgattgccggaaggttgcatggctggtcccagggccagcacaggcccgaggccgggctgcctggttttatttttatttaactttattttctgttttatgagtgtgtgtccgcccacccccacccccttcagtgttaagtggggagccctgggggagtctctcctgcctcccagcctctcccaagacctcccccctcgtcaccagccatccctctggaccaggcagagggcggaccgggtgggcaggggcctgagggtggctcgggccagcccaccagccaatggacccctcctcaggccgccagtgtcgccctgcccctttttaaaacaaaatgccctcgtttgtaaacccttagacgcttgagaataaaccccttccttttcttccaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5609 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA GeneID:5609 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:5609 -> Molecular function: GO:0004708 [MAP kinase kinase activity] evidence: IDA GeneID:5609 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: IEA GeneID:5609 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5609 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:5609 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IEA GeneID:5609 -> Molecular function: GO:0008545 [JUN kinase kinase activity] evidence: IEA GeneID:5609 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI GeneID:5609 -> Molecular function: GO:0019903 [protein phosphatase binding] evidence: ISS GeneID:5609 -> Molecular function: GO:0031435 [mitogen-activated protein kinase kinase kinase binding] evidence: IEA GeneID:5609 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:5609 -> Biological process: GO:0006950 [response to stress] evidence: IDA GeneID:5609 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:5609 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS GeneID:5609 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: ISS GeneID:5609 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS GeneID:5609 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA GeneID:5609 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:5609 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: IDA GeneID:5609 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS GeneID:5609 -> Cellular component: GO:0005634 [nucleus] evidence: ISS GeneID:5609 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS GeneID:5609 -> Cellular component: GO:0005829 [cytosol] evidence: TAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_660186 -> EC 2.7.12.2
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