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2020-10-24 07:15:01, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_144709               3820 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens pseudouridylate synthase 10 (PUS10), mRNA.
ACCESSION   NM_144709
VERSION     NM_144709.2  GI:207113129
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3820)
  AUTHORS   Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
            JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
            Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
            Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
            Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
            Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
            Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
            LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
            J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
            Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
            CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
            Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
            Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
            S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
            Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
            RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
            Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
            Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
            Cho JH.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   2  (bases 1 to 3820)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet. 8 (3), E1002559 (2012)
   PUBMED   22412388
REFERENCE   3  (bases 1 to 3820)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat. Genet. 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   4  (bases 1 to 3820)
  AUTHORS   Festen,E.A., Goyette,P., Green,T., Boucher,G., Beauchamp,C.,
            Trynka,G., Dubois,P.C., Lagace,C., Stokkers,P.C., Hommes,D.W.,
            Barisani,D., Palmieri,O., Annese,V., van Heel,D.A., Weersma,R.K.,
            Daly,M.J., Wijmenga,C. and Rioux,J.D.
  TITLE     A meta-analysis of genome-wide association scans identifies
            IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's
            disease and celiac disease
  JOURNAL   PLoS Genet. 7 (1), E1001283 (2011)
   PUBMED   21298027
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3820)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat. Genet. 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   6  (bases 1 to 3820)
  AUTHORS   Park,S.Y., Shin,J.N., Woo,H.N., Piya,S., Moon,A.R., Seo,Y.W.,
            Seol,D.W. and Kim,T.H.
  TITLE     DOBI is cleaved by caspases during TRAIL-induced apoptotic cell
            death
  JOURNAL   BMB Rep 42 (8), 511-515 (2009)
   PUBMED   19712588
  REMARK    GeneRIF: These data suggest that the cleaved DOBI may acquire a new
            function, possibly by cooperating with tBid in the mitochondrial
            event of cell death caused by TRAIL.
REFERENCE   7  (bases 1 to 3820)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3820)
  AUTHORS   Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M,
            Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW,
            Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D,
            Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D,
            McArdle W, Lewis CM, Lobo A, Sanderson J, Jewell DP, Deloukas P,
            Mansfield JC, Mathew CG, Satsangi J and Parkes M.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Investigation of Crohn's disease risk loci in ulcerative colitis
            further defines their molecular relationship
  JOURNAL   Gastroenterology 136 (2), 523-529 (2009)
   PUBMED   19068216
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3820)
  AUTHORS   McCleverty,C.J., Hornsby,M., Spraggon,G. and Kreusch,A.
  TITLE     Crystal structure of human Pus10, a novel pseudouridine synthase
  JOURNAL   J. Mol. Biol. 373 (5), 1243-1254 (2007)
   PUBMED   17900615
  REMARK    GeneRIF: crystal structure of Pus10 (previously denoted as
            FLJ32312) at 2.0 A resolution and modeling studies describe protein
            domains and active sites
REFERENCE   10 (bases 1 to 3820)
  AUTHORS   Aza-Blanc,P., Cooper,C.L., Wagner,K., Batalov,S., Deveraux,Q.L. and
            Cooke,M.P.
  TITLE     Identification of modulators of TRAIL-induced apoptosis via
            RNAi-based phenotypic screening
  JOURNAL   Mol. Cell 12 (3), 627-637 (2003)
   PUBMED   14527409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP354604.1, AK056874.1, BC101680.1, AC010733.8 and AA878516.1.
            On Sep 30, 2008 this sequence version replaced gi:21389306.
            
            Summary: Pseudouridination, the isomerization of uridine to
            pseudouridine, is the most common posttranscriptional nucleotide
            modification found in RNA and is essential for biologic functions
            such as spliceosome biogenesis. Pseudouridylate synthases, such as
            PUS10, catalyze pseudouridination of structural RNAs, including
            transfer, ribosomal, and splicing RNAs. These enzymes also act as
            RNA chaperones, facilitating the correct folding and assembly of
            tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by
            OMIM, May 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056874.1, BC101680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               BP354604.1         10-166
            158-859             AK056874.1         1-702
            860-1905            BC101680.1         681-1726
            1906-3597           AC010733.8         94081-95772         c
            3598-3820           AA878516.1         1-223               c
FEATURES             Location/Qualifiers
     source          1..3820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..3820
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="pseudouridylate synthase 10"
                     /db_xref="GeneID:150962"
                     /db_xref="HGNC:26505"
                     /db_xref="MIM:612787"
     exon            1..223
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    224..646
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST H17239 (NID:g883479) ym42f05.r1"
     misc_feature    <224..480
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST AA878516 (NID:g2987481) oj19b08.s1"
     exon            224..364
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    <224..360
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST AA813267 (NID:g2883252) aj44g04.s1"
     misc_feature    <224..252
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST BE883758 (NID:g10332534)"
     misc_feature    227..229
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="upstream in-frame stop codon"
     CDS             239..1828
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="pseudouridine synthase 10; coiled-coil domain
                     containing 139; psi55 synthase; tRNA-uridine isomerase;
                     tRNA pseudouridylate synthase; tRNA pseudouridine 55
                     synthase; coiled-coil domain-containing protein 139"
                     /codon_start=1
                     /product="putative tRNA pseudouridine synthase Pus10"
                     /protein_id="NP_653310.2"
                     /db_xref="GI:207113130"
                     /db_xref="CCDS:CCDS1865.1"
                     /db_xref="GeneID:150962"
                     /db_xref="HGNC:26505"
                     /db_xref="MIM:612787"
                     /translation="
MFPLTEENKHVAQLLLNTGTCPRCIFRFCGVDFHAPYKLPYKELLNELQKFLETEKDELILEVMNPPPKKIRLQELEDSIDNLSQNGEGRISVSHVGSTASKNSNLNVCNVCLGILQEFCEKDFIKKVCQKVEASGFEFTSLVFSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRDDIVQLKEAYKWITHPLFSEELGVPIDGKSLFEVSVVFAHPETVEDCHFLAAICPDCFKPAKNKQSVFTRMAVMKALNKIKEEDFLKQFPCPPNSPKAVCAVLEIECAHGAVFVAGRYNKYSRNLPQTPWIIDGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKINNSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQKKDIEFLNDIKDLKIDQKTPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDVESVDVDWPPALDD
"
     misc_feature    473..475
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q3MIT2.1); phosphorylation site"
     misc_feature    488..490
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q3MIT2.1); phosphorylation site"
     misc_feature    <1100..1807
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="putative pseudouridylate synthase; Provisional;
                     Region: PRK14554"
                     /db_xref="CDD:184741"
     misc_feature    1148..1189
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3MIT2.1);
                     Region: RNA binding forefinger loop (Potential)"
     misc_feature    1562..1609
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3MIT2.1);
                     Region: RNA binding thumb loop (Potential)"
     misc_feature    244..443
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST BF986046 (NID:g12392366)"
     exon            365..619
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    397..605
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST BG111144 (NID:g12604650)"
     misc_feature    537..1354
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST BG567982 (NID:g13575635)"
     exon            620..706
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            707..741
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            742..853
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            854..915
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    866..1319
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST BG433736 (NID:g13340242)"
     exon            916..961
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            962..1026
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1027..1112
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1113..1238
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1213..>1915
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST BG546841 (NID:g13545506)"
     exon            1239..1295
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1296..1372
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1373..1428
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1429..1546
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1547..1689
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1571..>1915
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST AW295480 (NID:g6702116)"
     misc_feature    1579..>1915
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST AV700540 (NID:g10302511)"
     exon            1690..1789
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     exon            1790..3810
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1877..>1915
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /note="match to EST AA213749 (NID:g1812367) zr93c02.r1"
     STS             3230..3441
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /standard_name="WIAF-2118"
                     /db_xref="UniSTS:25257"
     STS             3262..3397
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /standard_name="SHGC-56768"
                     /db_xref="UniSTS:7343"
     variation       3358
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1206"
     variation       3597
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1053862"
     STS             3669..3796
                     /gene="PUS10"
                     /gene_synonym="CCDC139; DOBI"
                     /standard_name="WI-15536"
                     /db_xref="UniSTS:82826"
ORIGIN      
gtggctggacaaatgccgctctcaactgctacagaccaaagtctacgctttaaagatagagaagccattctgtcaaagtgaaaacagaagcggtaggtaggaagccgcccccctttctttcaagcacagagacccagagagacgcccaggagctcccgaaaaaaacgttgctgattagagctgccgggtcagaaacagctgtgagacactaaagtccccactgttataattattcaatatgttcccactgactgaggaaaacaagcatgtggcccagttgttgctcaatactggtacttgtccaagatgtatcttcagattctgtggtgtggattttcatgcaccttacaaacttccatacaaggagttgctcaatgaactacagaaatttctggaaactgaaaaagatgaattaattttggaagttatgaacccacctcccaagaaaattcgactgcaagaactggaagatagtattgataatctaagtcaaaatggagagggaaggatctctgttagtcatgttggaagcactgcttccaagaactcaaatttaaatgtatgtaatgtatgcctaggaattcttcaagaattctgtgagaaagatttcattaaaaaggtgtgccaaaaggttgaggcctctgggtttgaattcaccagcttggtattttcagtctccttcccaccacaactatctgtaagagagcatgctgcatggttgctggtaaaacaggaaatgggaaagcagagtctgtcgctgggaagagatgatatagttcagctaaaagaagcctacaaatggataactcaccccctgttttcagaggaactgggtgttcccattgatggaaagagcttgtttgaagtgagtgtggtctttgctcacccagaaacagttgaggattgccacttcctagctgcgatatgcccagattgttttaagccagccaaaaacaaacagtctgtattcactagaatggcagttatgaaagccttgaataagataaaggaagaggatttccttaagcagtttccttgtcctccaaactcaccaaaggctgtatgcgctgttcttgaaattgaatgtgctcatggtgctgtttttgtggctgggagatataataaatactccaggaatctaccacaaactccttggataattgatggagaaaggaagctggaatcttcagtggaagaattaatttcagatcatctgttggcagtatttaaagcagagagttttaatttttcatcctctggaagagaagatgtagatgtgagaacattaggaaatggaaggccctttgcaattgagctggtgaatcctcatagagtacatttcacttcacaagaaattaaggaacttcagcagaaaattaataactcatctaacaaaatccaagtacgtgacttgcagcttgtcacaagagaggcaataggacatatgaaagaaggtgaagaagaaaagacaaagacctacagtgccttaatttggacaaataaagcgatacagaagaaagacattgaattcctaaatgacataaaggacttaaaaatcgaccagaaaacacctttgcgcgtccttcaccgaaggcccctggctgtgcgagctcgcgtcattcacttcatggagacacagtacgtggatgagcaccacttccgcctccacttgaaaactcaggctggcacctacattaaagagtttgtacatggagacttcgggagaaccaagccaaacattgggtccctgatgaatgtgactgcagacattctggagctggatgttgagtctgtagatgttgactggccacctgctctggatgactagctttcaaatttggagacaaagagtatggttttcctggcatgatgtggacatccatggagcacatgccgtaaaatggctgtttacccaccataacggtgtcttgaaaactatttggatcatgttgatctatataattgttaatttgttgtaacatctcaggatctatatatgtgtatattttgtgttaaattgttccaaggatgtcttaggatttttctcattccctctttcacccccacaaaccaaactatgaataatgaaataattctccttaattctttcatttagagaggtgcacaaacaggacacattctctgttaacctaagaagctgtaatttcagcaagatttccctccacaagagatataccacctttaaaatcatgttctaatttttgtaaattatctgaataaaagttatatctagatttatgcagcataatatcctataatagtctaagattgcaaatgcaaatctgacatcattattttccccaggaagcctcaaacaagctattaccaatgaagttcttttggctgtgatttgtcataaatcttaaccaaactatgaataatgaaataattctcattaatactttcattaagaaagaattttgacaatctaaaattgtcaatataggtttcctgtggagggaaagtaaaaccgtaggagccaaggcatgccatggtaggagcctttcataaatcttttaaataaggagaaacaagtgcctttaataacttcaatcccagggttaagaatttgaaaaattgagattgctaaacaaagacgaactggtattatttcagaatgcttcaatatattatccaattataaacattttaataataccttattaaagtagataggatattgtctccattttataaatatggaaaccaaagactagaagttaaatgacttatccaaaattgttagctacttctatattgaggactagaactgaagtttcttggtttctagggtctttctaataagccctattactgagcacctgtttgtgtgaaggggcagctatggatgccatttaaactcatgtaactgataattaacttttggaatgtagttaccaaatcaaagagcttaccaaaaaatagcccaagactatttaatacaatcttatatagttaccatttgttattaagttaaacctcagttggtattatgaagaggaaaaacattaagctaaacctaaaaaaaatgaatgggtcatttaagtttcagaaaggagcctcattacaatttcagatttgagtataatttccatcaccctaattcaactatttgagctttttttaagaatacatgtgacttgactagtattagattactaaccatttcccatctctatattaaacataaatcacagataccaagattcactttagatatgaggaaaatggttttaatggacacaaaggagtcagccacgttggaaccaacatagtttcataccacgttgaaaccatgtgtttgatatgcaaataacagcaaataattttttcactcttgtcaatgccaatgcattgaaaggcccagaaaatgagaaaaggataacaaacttttgataaaaaggtaagaatttctgtgtggatgttcctcagtttctgggaaaattttgctacaaaagagatttaaataatttaggaggcagtcttttgcatggtatttttggcttacctttgaatctagtggacctgtaatatgtaagaatgaagaatgtgcttagcaaactgaaatgagaagatttctatttcttaaatttctattcctgagattatataaaatttcacgcaaagagtaagcattagctttaaatacttcttccaaatgttcctagaattttgagacaaagattgttaaaaattaatgtatgtctttgttttaggcagaactggaaatattaagtagtgagagtactatagtttcccttttgcctacataaaagcattttaaaattaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:150962 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
            GeneID:150962 -> Molecular function: GO:0009982 [pseudouridine synthase activity] evidence: IEA
            GeneID:150962 -> Biological process: GO:0001522 [pseudouridine synthesis] evidence: IEA
            GeneID:150962 -> Biological process: GO:0008033 [tRNA processing] evidence: IEA

by @meso_cacase at DBCLS
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