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2024-04-26 00:54:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_144687 3880 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens NLR family, pyrin domain containing 12 (NLRP12),
transcript variant 2, mRNA.
ACCESSION NM_144687
VERSION NM_144687.3 GI:459683879
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3880)
AUTHORS Zambetti,L.P., Laudisi,F., Licandro,G., Ricciardi-Castagnoli,P. and
Mortellaro,A.
TITLE The rhapsody of NLRPs: master players of inflammation...and a lot
more
JOURNAL Immunol. Res. 53 (1-3), 78-90 (2012)
PUBMED 22427013
REMARK Review article
REFERENCE 2 (bases 1 to 3880)
AUTHORS Pinheiro,A.S., Eibl,C., Ekman-Vural,Z., Schwarzenbacher,R. and
Peti,W.
TITLE The NLRP12 pyrin domain: structure, dynamics, and functional
insights
JOURNAL J. Mol. Biol. 413 (4), 790-803 (2011)
PUBMED 21978668
REMARK GeneRIF: The authors report the first in vitro confirmed
non-homotypic interaction between NLRP12 pyrin domain and the
pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links
the innate immune system to apoptotic signaling.
REFERENCE 3 (bases 1 to 3880)
AUTHORS Jeru,I., Le Borgne,G., Cochet,E., Hayrapetyan,H., Duquesnoy,P.,
Grateau,G., Morali,A., Sarkisian,T. and Amselem,S.
TITLE Identification and functional consequences of a recurrent NLRP12
missense mutation in periodic fever syndromes
JOURNAL Arthritis Rheum. 63 (5), 1459-1464 (2011)
PUBMED 21538323
REMARK GeneRIF: NLRP12 missense mutation in periodic fever syndromes;
study provides evidence of deleterious effect of an NLRP12 missense
mutation; this newly identified molecular defect emphasizes the
crucial role played by NLRP12 in autoinflammation
REFERENCE 4 (bases 1 to 3880)
AUTHORS Borghini,S., Tassi,S., Chiesa,S., Caroli,F., Carta,S., Caorsi,R.,
Fiore,M., Delfino,L., Lasiglie,D., Ferraris,C., Traggiai,E., Di
Duca,M., Santamaria,G., D'Osualdo,A., Tosca,M., Martini,A.,
Ceccherini,I., Rubartelli,A. and Gattorno,M.
TITLE Clinical presentation and pathogenesis of cold-induced
autoinflammatory disease in a family with recurrence of an NLRP12
mutation
JOURNAL Arthritis Rheum. 63 (3), 830-839 (2011)
PUBMED 21360512
REMARK GeneRIF: Even with a variable range of associated manifestations,
the extreme sensitivity to cold represents the main clinical
hallmark in an individual carrying the p.D294E mutation of the
NLRP12 gene.
REFERENCE 5 (bases 1 to 3880)
AUTHORS Lich,J.D., Williams,K.L., Moore,C.B., Arthur,J.C., Davis,B.K.,
Taxman,D.J. and Ting,J.P.
TITLE Monarch-1 suppresses non-canonical NF-kappaB activation and
p52-dependent chemokine expression in monocytes
JOURNAL J. Immunol. 178 (3), 1256-1260 (2007)
PUBMED 17237370
REMARK GeneRIF: Monarch-1 inhibits CD40-mediated activation of NF-kappaB
via the non-canonical pathway in human monocytes. This inhibition
stems from the ability of Monarch-1 to associate with and induce
proteasome-mediated degradation of NF-kappaB inducing kinase
REFERENCE 6 (bases 1 to 3880)
AUTHORS Williams,K.L., Lich,J.D., Duncan,J.A., Reed,W., Rallabhandi,P.,
Moore,C., Kurtz,S., Coffield,V.M., Accavitti-Loper,M.A., Su,L.,
Vogel,S.N., Braunstein,M. and Ting,J.P.
TITLE The CATERPILLER protein monarch-1 is an antagonist of toll-like
receptor-, tumor necrosis factor alpha-, and Mycobacterium
tuberculosis-induced pro-inflammatory signals
JOURNAL J. Biol. Chem. 280 (48), 39914-39924 (2005)
PUBMED 16203735
REMARK GeneRIF: Monarch-1 associates with IRAK-1 but not MyD88, resulting
in the blockage of IRAK-1 hyperphosphorylation
REFERENCE 7 (bases 1 to 3880)
AUTHORS Williams,K.L., Taxman,D.J., Linhoff,M.W., Reed,W. and Ting,J.P.
TITLE Cutting edge: Monarch-1: a pyrin/nucleotide-binding
domain/leucine-rich repeat protein that controls classical and
nonclassical MHC class I genes
JOURNAL J. Immunol. 170 (11), 5354-5358 (2003)
PUBMED 12759408
REMARK GeneRIF: Monarch-1 enhances nonclassical and classical major
histocompatibility complex class I expression at the level of the
promoter, RNA, and protein expression.
REFERENCE 8 (bases 1 to 3880)
AUTHORS Tschopp,J., Martinon,F. and Burns,K.
TITLE NALPs: a novel protein family involved in inflammation
JOURNAL Nat. Rev. Mol. Cell Biol. 4 (2), 95-104 (2003)
PUBMED 12563287
REMARK Review article
REFERENCE 9 (bases 1 to 3880)
AUTHORS Wang,L., Manji,G.A., Grenier,J.M., Al-Garawi,A., Merriam,S.,
Lora,J.M., Geddes,B.J., Briskin,M., DiStefano,P.S. and Bertin,J.
TITLE PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates
activation of NF-kappa B and caspase-1-dependent cytokine
processing
JOURNAL J. Biol. Chem. 277 (33), 29874-29880 (2002)
PUBMED 12019269
REMARK GeneRIF: regulates activation of NF-kappa B and caspase-1-dependent
cytokine processing
REFERENCE 10 (bases 1 to 3880)
AUTHORS Shami,P.J., Kanai,N., Wang,L.Y., Vreeke,T.M. and Parker,C.H.
TITLE Identification and characterization of a novel gene that is
upregulated in leukaemia cells by nitric oxide
JOURNAL Br. J. Haematol. 112 (1), 138-147 (2001)
PUBMED 11167794
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA619102.1, AY154467.1 and
BC028069.1.
On Mar 9, 2013 this sequence version replaced gi:188497620.
Summary: This gene encodes a member of the CATERPILLER family of
cytoplasmic proteins. The encoded protein, which contains an
N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain,
and a C-terminus leucine-rich repeat region, functions as an
attenuating factor of inflammation by suppressing inflammatory
responses in activated monocytes. Mutations in this gene cause
familial cold autoinflammatory syndrome type 2. Alternative
splicing results in multiple transcript variants. [provided by
RefSeq, Mar 2013].
Transcript Variant: This variant (2) uses an alternate splice site
in the central coding region, compared to variant 3, resulting in
an isoform (2) that is 1 aa shorter than isoform 3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY095146.1, BC028069.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025089 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-65 DA619102.1 1-65
66-2697 AY154467.1 13-2644
2698-3580 BC028069.1 2588-3470
3581-3880 AY154467.1 3528-3827
FEATURES Location/Qualifiers
source 1..3880
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.42"
gene 1..3880
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="NLR family, pyrin domain containing 12"
/db_xref="GeneID:91662"
/db_xref="HGNC:22938"
/db_xref="HPRD:14803"
/db_xref="MIM:609648"
exon 1..518
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
misc_feature 179..181
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="upstream in-frame stop codon"
CDS 230..3415
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="isoform 2 is encoded by transcript variant 2;
nucleotide-binding oligomerization domain, leucine rich
repeat and pyrin domain containing 12; NACHT, LRR and PYD
domains-containing protein 12; PYRIN-containing APAF1-like
protein 7; monarch 1; regulated by nitric oxide"
/codon_start=1
/product="NACHT, LRR and PYD domains-containing protein 12
isoform 2"
/protein_id="NP_653288.1"
/db_xref="GI:21955154"
/db_xref="CCDS:CCDS12864.1"
/db_xref="GeneID:91662"
/db_xref="HGNC:22938"
/db_xref="HPRD:14803"
/db_xref="MIM:609648"
/translation="
MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
"
misc_feature 260..505
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Pyrin death domain found in NALP proteins; Region:
Pyrin_NALPs; cd08320"
/db_xref="CDD:176735"
misc_feature 863..1372
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="NACHT domain; Region: NACHT; pfam05729"
/db_xref="CDD:191357"
misc_feature 1910..2827
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
(RI)-like subfamily. LRRs are 20-29 residue sequence
motifs present in many proteins that participate in
protein-protein interactions and have different functions
and cellular locations. LRRs correspond...; Region:
LRR_RI; cl15309"
/db_xref="CDD:199167"
misc_feature order(1913..1915,1922..1924,1928..1930,1970..1972,
1982..1984,1988..1990,1997..1999,2003..2005,2057..2059,
2066..2068,2072..2074,2081..2083,2087..2089,2144..2146,
2162..2164,2168..2170,2177..2179,2183..2185,2216..2218,
2225..2227,2231..2233,2240..2242,2246..2248,2288..2290,
2297..2299,2303..2305,2312..2314,2318..2320,2372..2374,
2381..2383,2387..2389,2396..2398,2402..2404,2459..2461,
2468..2470,2474..2476,2483..2485,2489..2491,2543..2545,
2552..2554,2558..2560,2567..2569,2573..2575,2630..2632,
2639..2641,2645..2647,2654..2656,2660..2662,2714..2716,
2723..2725,2729..2731,2738..2740,2744..2746,2801..2803,
2810..2812,2816..2818,2825..2827)
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Leucine-rich repeats; other site"
/db_xref="CDD:29015"
misc_feature order(1991..1996,2174..2176,2309..2311,2393..2395,
2564..2566,2642..2644,2648..2650,2726..2728,2813..2815)
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Substrate binding site [chemical binding]; other
site"
/db_xref="CDD:29015"
misc_feature 2378..3334
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
(RI)-like subfamily. LRRs are 20-29 residue sequence
motifs present in many proteins that participate in
protein-protein interactions and have different functions
and cellular locations. LRRs correspond...; Region:
LRR_RI; cd00116"
/db_xref="CDD:29015"
misc_feature order(2381..2383,2387..2389,2396..2398,2402..2404,
2459..2461,2468..2470,2474..2476,2483..2485,2489..2491,
2543..2545,2552..2554,2558..2560,2567..2569,2630..2632,
2639..2641,2645..2647,2654..2656,2660..2662,2714..2716,
2723..2725,2729..2731,2738..2740,2744..2746,2801..2803,
2810..2812,2816..2818,2825..2827,2831..2833,2885..2887,
2894..2896,2900..2902,2909..2911,2915..2917,2972..2974,
2981..2983,2987..2989,2996..2998,3002..3004,3056..3058,
3065..3067,3071..3073,3080..3082,3086..3088,3143..3145,
3152..3154,3158..3160,3167..3169,3173..3175,3227..3229,
3236..3238,3242..3244,3251..3253,3257..3259,3314..3316,
3323..3325,3329..3331)
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Leucine-rich repeats; other site"
/db_xref="CDD:29015"
misc_feature order(2477..2482,2651..2653,2822..2824,2906..2908,
3077..3079,3155..3157,3161..3163,3239..3241,3326..3328)
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="Substrate binding site [chemical binding]; other
site"
/db_xref="CDD:29015"
misc_feature 2711..2773
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 1"
misc_feature 2798..2863
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 2"
misc_feature 2882..2947
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 3"
misc_feature 2969..3034
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 4"
misc_feature 3053..3115
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 5"
misc_feature 3140..3205
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 6"
misc_feature 3224..3289
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 7"
misc_feature 3311..3376
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59046.2);
Region: LRR 8"
exon 519..599
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
exon 600..2301
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
variation 1581
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76085152"
exon 2302..2472
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
variation 2394
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199475868"
variation 2467
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="a"
/replace="c"
/db_xref="dbSNP:199475869"
exon 2473..2643
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
variation 2623
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="a"
/replace="g"
/db_xref="dbSNP:4806773"
exon 2644..2814
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
variation 2668
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199475870"
exon 2815..2985
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
exon 2986..3156
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
exon 3157..3327
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
exon 3328..3880
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/inference="alignment:Splign:1.39.8"
variation 3380
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199475871"
variation 3541
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/replace="c"
/replace="g"
/db_xref="dbSNP:199475872"
polyA_signal 3701..3706
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
polyA_site 3721
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/note="This is an internal polyA site. The 3'-most polyA
site has not yet been determined."
STS 3736..3838
/gene="NLRP12"
/gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO;
RNO2"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
ORIGIN
agaacagccattggtgagtggggcagggcaggagggaactgaagagtgagaaagcattatttcagcaaaaggtctttcctcccttgctctctcctccaaccactggctcagcctctccgcccgctgcctgtgaatgatgcaatggaaggtgtgctggggtcgccctgtgtcccgtgcataggagcatctcagcctccaggtcctctcctttggggctcacggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggaagcatggagaaggccggtcccctggaaatggcccagctgctcatcacccacttcgggccagaggaggcctggaggttggctctcagcacctttgagcggataaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggataccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaagaaaagatccccaggaaacctacagggactatgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggtccagcagcagcttctggacacaggccggggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagacgaggagcgccccgagccaccgcgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatcttcagctgctggcctgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatcctcagggaccctggtgcctctgctgggaggagaaacggcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcaccatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagacgtccaggaccaccactgcagtgtacatgctctacctgctgagtctgatgcaacccaagccgggggccccgcgcctccagcccccacccaaccagagagggttgtgctccttggcggcagatgggctctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagacggggaagacgtctctgccttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccacttgagtttccaggaattctttgcagctatgtactatatcctggacgagggggagggcggggcaggcccagaccaggacgtgaccaggctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctggaaggtctcgccgcacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctgcagcagggctccttggagttcttcagctgcttgtacgagatccaggaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctccaagatggagcacatggtctcctcgttctgtctgaagcgctgcaggagcgcccaggtgctgcacttgtatggcgccacctacagcgcggacggggaagaccgcgcgaggtgctccgcaggagcgcacacgctgttggtgcagctaccagagaggaccgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaggtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttgacaaggatggatctcagtggcaacggcgttggattcccaggcatgatgctgctttgcgagggcctgcggcatccccaatgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggagatggcttctgtgctcggcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactatgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccgcctcactgctgctgcctgtgacgagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctgaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctgcggttgggcatctgccggctgggctctgccgcctgtgagggtctttctgtggtgctccaggccaaccacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttgctggctgaggggctgcaacatcccgcctgcagactccagaaactgtggctggatagctgtggcctcacagccaaggcttgtgagaatctttacttcaccctggggatcaaccagaccttgaccgacctttacctgaccaacaacgccctaggggacacaggtgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatggtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccccccagcataatgatcagcctccttcctagagacagactcatgcagattgagatcaaaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcgtggtggctcatgtatgtaatcctagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagattagcctggccaagatggtgaaaccctgtctctactaaaaataaaaaaaaattagccaggcatggtggcgggcacctgtagtcccagctactcaggaggctgaggcaggagaatcgcttgaacccgggaggtggaggttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagtgggactccatctcaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:91662 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:91662 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:91662 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: NAS
GeneID:91662 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: NAS
GeneID:91662 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:91662 -> Biological process: GO:0008588 [release of cytoplasmic sequestered NF-kappaB] evidence: IDA
GeneID:91662 -> Biological process: GO:0009968 [negative regulation of signal transduction] evidence: IDA
GeneID:91662 -> Biological process: GO:0031953 [negative regulation of protein autophosphorylation] evidence: IDA
GeneID:91662 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:91662 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IDA
GeneID:91662 -> Biological process: GO:0045381 [regulation of interleukin-18 biosynthetic process] evidence: NAS
GeneID:91662 -> Biological process: GO:0045409 [negative regulation of interleukin-6 biosynthetic process] evidence: IDA
GeneID:91662 -> Biological process: GO:0045751 [negative regulation of Toll signaling pathway] evidence: IDA
GeneID:91662 -> Biological process: GO:0050710 [negative regulation of cytokine secretion] evidence: IDA
GeneID:91662 -> Biological process: GO:0050711 [negative regulation of interleukin-1 secretion] evidence: IDA
GeneID:91662 -> Biological process: GO:0050718 [positive regulation of interleukin-1 beta secretion] evidence: NAS
GeneID:91662 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: IMP
GeneID:91662 -> Biological process: GO:0050729 [positive regulation of inflammatory response] evidence: NAS
GeneID:91662 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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