LOCUS       NM_144569               3888 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens SPOC domain containing 1 (SPOCD1), mRNA.
ACCESSION   NM_144569
VERSION     NM_144569.4  GI:142366582
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3888)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem. Biol. 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK131447.1.
            On Apr 6, 2007 this sequence version replaced gi:47271474.
            
            Sequence Note: removed 1 base from the 5' end that did not align to
            the reference genome assembly.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131447.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3888              AK131447.1         2-3889
FEATURES             Location/Qualifiers
     source          1..3888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..3888
                     /gene="SPOCD1"
                     /note="SPOC domain containing 1"
                     /db_xref="GeneID:90853"
                     /db_xref="HGNC:26338"
     exon            1..19
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            20..1441
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     CDS             59..3709
                     /gene="SPOCD1"
                     /codon_start=1
                     /product="SPOC domain-containing protein 1"
                     /protein_id="NP_653170.3"
                     /db_xref="GI:47271475"
                     /db_xref="CCDS:CCDS347.1"
                     /db_xref="GeneID:90853"
                     /db_xref="HGNC:26338"
                     /translation="

MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQHDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGLPDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAPRGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFHRDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSLGPTDEAGSECPFPRKA

"
     misc_feature    1880..2209
                     /gene="SPOCD1"
                     /note="Transcription factor S-II (TFIIS), central domain;
                     Region: TFIIS_M; pfam07500"
                     /db_xref="CDD:203654"
     misc_feature    2657..2953
                     /gene="SPOCD1"
                     /note="SPOC domain; Region: SPOC; pfam07744"
                     /db_xref="CDD:203754"
     variation       206
                     /gene="SPOCD1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34615674"
     variation       624
                     /gene="SPOCD1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35533335"
     exon            1442..1483
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            1484..1660
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            1661..1786
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            1787..1841
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            1842..1926
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     variation       1874
                     /gene="SPOCD1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35893741"
     exon            1927..2086
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            2087..2203
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            2204..2329
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            2330..2441
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     variation       2375
                     /gene="SPOCD1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34341430"
     exon            2442..2592
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            2593..2743
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            2744..2833
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            2834..3020
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     exon            3021..3888
                     /gene="SPOCD1"
                     /inference="alignment:Splign:1.39.8"
     variation       3584
                     /gene="SPOCD1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:36047547"
     variation       3747
                     /gene="SPOCD1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12384"
     variation       3827
                     /gene="SPOCD1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13426"
ORIGIN      

aaaactcagggaagcccagggcccgtgttgtgcttttggcccaggtaggtggacagacatgtcccaggcgggggacgtagaaggccccagcacaggagaccctgtgctcagtccccaacacaactgtgagcttttacagaacatggaaggagccagctccatgccaggcctgtcaccagatgggccgggagcaagctctgggcccggagtcagggctggcagcagaaggaagatccccaggaaggaggcccttcgaggtggcagctcccgggctgcaggtgctgctgaggtccggccaggggtcttggagctgctagctgtggtacagagccggggctcgatgctggctcctgggctccacatgcagctgccctcggtgcctactcaggggagagctctgacctccaagaggctccaggtttctctgtgtgacatcttagatgacagttgccccaggaaactttgtagcaggtctgctggcctcccagagagagctctggcctgcagggagaggcttgcaggagtggaggaggtgagctgcctcaggcccagggaggccagagacggtggaatgagttctccagggtgtgacagaagaagccccacactcagcaaagaggagccccctggaaggcccctgacatcctcaccagacccagtccctgtgagggtaagaaagaaatggaggaggcaaggggctcattcagagtgtgaggaaggggctggtgacttcctgtggcttgatcagagccctcgtggggacaacctcctgtctgtgggagaccctccccaagttgctgacctggagtccttgggaggcccttgcagacctccctctccaaaagacactgggtctgggcctggagagccaggtggaagtggggcaggatgtgcctcagggactgagaaatttggatatttgcccgctacaggggatgggccccagccaggcagcccctgtggccctgtcgggttcccagtgcccagtggaggggagtccctcagttcagctgcacaggctcctccacagagcgcagcactgtgcctgggggcgtcagcacaggcctctgcagagcagcaagaagctgtgtgtgtcgtgcggactggcagcgatgaaggccaggctccagcacaggaccaggaggagctggaggccaaggctcagccagcttccaggggaaggctggagcaaggactcgctgcccccgctgacacctgtgccagctcccgggagcccttgggcggcctcagctcctccctggatactgaagccagcagggcctgctcaggcccattcatggagcagagaagatccaagggcactaagaacctgaagaaaggtccagtgccctgtgcccaagaccggggcacagacagaagctcagacaactcccaccaggacaggccagaggaacccagcccaggaggctgccccagactggaggaagtgaaaataccccatggagtgaagcttgtgtgctacctgggttccgggccagtgatccagctcctgggggccatcagccacggccaggcaggggggcagctgccaccaaagctggaggttctagaggacttgatggaggtcagctcaccctcacctgcccagaggctcagaaggaagaaaaggcccatggtgcagggccctgctgggtgccaggttttccagccttctccttcaggaggcacagcaggggaccctggtggcctctctgaccccttctaccctccaagaagcggttccctggcccttggcgaccccagctcggaccctgcatgttcccagagtggcccaatggaggctgaagaggattctcttccggagcagccagaggactcagctcagctccaacaggagaagccatccctgtatattggggtgcggggcactgttgtccgttccatgcaggaggtactatggactcgccttcgggagctcccagacccagtgctgagtgaggaggtggtggagggcattgctgctggcattgaggcagccctctgggacctgacacaaggcaccaatggccggtacaagaccaagtatcgcagcctgctgttcaacctgcgggaccccaggaacctggacttgtttctcaaagtggttcatggagatgtcaccccctacgacctggtgcggatgagctcgatgcagctggccccccaggagctggcccgctggcgggaccaggaggagaaaaggggcctgaatatcattgagcagcaacagaaggagccgtgcagacttccagcctccaaaatgacccacaagggcgaagtggagattcagcgggacatggaccagacactgaccctggaggatctggtgggaccgcagatgttcatggactgcagcccacaggccctgcccatcgcatcagaggacaccacggggcagcatgaccaccacttcttagaccccaactgccacatctgcaaggactgggagccctcgaatgagctgctaggctccttcgaagccgccaagagctgcggggacaatatcttccagaaagccctaagccaaactcctatgcctgctccagagatgcccaaaaccagggagttgtctcccacggaaccacaggacagggtccctccatctgggctccatgtgcctgctgcacccacaaaggccctgccctgcctgccaccctgggaaggtgttctggacatgttctccatcaagcggttccgggccagggcccagctggtctcgggacacagctgtcggcttgtccaggctctgcccaccgtgatccgctcggcaggctgcatcccctccaacattgtctgggaccttctggccagcatctgcccagccaaggccaaggacgtctgcgtggtcagactgtgcccacatggggcccgggacacccagaactgccgcctgctctactcatacctcaatgataggcagcgccacgggctggcctctgtggagcacatggggatggtcctgctgcccctgcctgccttccagcccctgcccaccaggctgcgccctttggggggcccaggcctttgggctcttcctgtctcccctctcctttccccaggtctggaggtcactcactcaagtctgttgctggctgtgctgctccccaaggaagggcttccagacacagcagggtccagcccctggttggggaaggttcaaaagatggtctccttcaacagtaaggtggagaagagatactatcagccagatgacaggaggccgaatgtgcccctgaagggcacccctcccccaggaggtgcctggcagcagagccagggcaggggcagtatagctccaaggggaatctctgcttggcagaggccccccagaggcagggggaggctctggccagagcctgaaaactggcagcatcctgggcgagggcagtggcccccagagccaggcttgcgccagtcccagcatccctattcagtagcaccagctggtcatggctttggccgtggccagcacttccacagggactcctgtccccaccaagccctgctccggcacctcgaatccctggcgaccatgagtcaccagctccaagccttactgtgcccccagaccaagagctccatcccccgccctctgcagcgtttgtctagcgcccttgcagctccagagccccctggcccagcccgtgactcctctttggggcctacagatgaagctggctctgagtgtcccttccctagaaaggcctgaccctccttacccaccagaacaggggttttgatgccctcactagtgttgaagcctgttccagagagaggtgggactgcaaggagaggatggtcagccctacccacctgccctgtttgagcttcctgtttgacaatgtttgctgttgattttttgttcaataaagaatttggtaaaattgg

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:90853 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:90853 -> Biological process: GO:0010923 [negative regulation of phosphatase activity] evidence: IDA