Home |
Help |
Advanced search
2024-04-25 11:09:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_139055 5676 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ADAM metallopeptidase with thrombospondin type 1
motif, 15 (ADAMTS15), mRNA.
ACCESSION NM_139055
VERSION NM_139055.2 GI:291045218
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5676)
AUTHORS Stupka,N., Kintakas,C., White,J.D., Fraser,F.W., Hanciu,M.,
Aramaki-Hattori,N., Martin,S., Coles,C., Collier,F., Ward,A.C.,
Apte,S.S. and McCulloch,D.R.
TITLE Versican processing by a disintegrin-like and metalloproteinase
domain with thrombospondin-1 repeats proteinases-5 and -15
facilitates myoblast fusion
JOURNAL J. Biol. Chem. 288 (3), 1907-1917 (2013)
PUBMED 23233679
REMARK GeneRIF: Versican processing by ADAMTS5 and ADAMTS15 contribute to
muscle fiber formation.
REFERENCE 2 (bases 1 to 5676)
AUTHORS Molokwu,C.N., Adeniji,O.O., Chandrasekharan,S., Hamdy,F.C. and
Buttle,D.J.
TITLE Androgen regulates ADAMTS15 gene expression in prostate cancer
cells
JOURNAL Cancer Invest. 28 (7), 698-710 (2010)
PUBMED 20590445
REMARK GeneRIF: ADAMTS-15 but not ADAMTS-1 expression was downregulated by
androgen in LNCaP prostate cancer cells, possibly through androgen
response elements associated with the gene
REFERENCE 3 (bases 1 to 5676)
AUTHORS Viloria,C.G., Obaya,A.J., Moncada-Pazos,A., Llamazares,M.,
Astudillo,A., Capella,G., Cal,S. and Lopez-Otin,C.
TITLE Genetic inactivation of ADAMTS15 metalloprotease in human
colorectal cancer
JOURNAL Cancer Res. 69 (11), 4926-4934 (2009)
PUBMED 19458070
REMARK GeneRIF: ADAMTS15 may be target of inactivating mutations in human
cancer.
REFERENCE 4 (bases 1 to 5676)
AUTHORS Porter,S., Span,P.N., Sweep,F.C., Tjan-Heijnen,V.C.,
Pennington,C.J., Pedersen,T.X., Johnsen,M., Lund,L.R., Romer,J. and
Edwards,D.R.
TITLE ADAMTS8 and ADAMTS15 expression predicts survival in human breast
carcinoma
JOURNAL Int. J. Cancer 118 (5), 1241-1247 (2006)
PUBMED 16152618
REMARK GeneRIF: ADAMTS8 and ADAMTS15 have emerged as novel predictors of
survival in patients with breast carcinoma
REFERENCE 5 (bases 1 to 5676)
AUTHORS Cross,N.A., Chandrasekharan,S., Jokonya,N., Fowles,A., Hamdy,F.C.,
Buttle,D.J. and Eaton,C.L.
TITLE The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and
TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation
of versican
JOURNAL Prostate 63 (3), 269-275 (2005)
PUBMED 15599946
REMARK GeneRIF: negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15
coupled with increases in their inhibitor, TIMP-3 may aid the
accumulation of versican in the stromal compartment of the prostate
in BPH and prostate cancer
REFERENCE 6 (bases 1 to 5676)
AUTHORS Cal,S., Obaya,A.J., Llamazares,M., Garabaya,C., Quesada,V. and
Lopez-Otin,C.
TITLE Cloning, expression analysis, and structural characterization of
seven novel human ADAMTSs, a family of metalloproteinases with
disintegrin and thrombospondin-1 domains
JOURNAL Gene 283 (1-2), 49-62 (2002)
PUBMED 11867212
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC109114.1 and AP003459.2.
On Mar 13, 2010 this sequence version replaced gi:21265057.
Summary: This gene encodes a member of the ADAMTS (a disintegrin
and metalloproteinase with thrombospondin motifs) protein family.
ADAMTS family members share several distinct protein modules,
including a propeptide region, a metalloproteinase domain, a
disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
Individual members of this family differ in the number of
C-terminal TS motifs, and some have unique C-terminal domains. The
protein encoded by this gene has a high sequence similarity to the
proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul
2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC109114.1, AJ315733.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2853 BC109114.1 1-2853
2854-5676 AP003459.2 4248-7070
FEATURES Location/Qualifiers
source 1..5676
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q25"
gene 1..5676
/gene="ADAMTS15"
/note="ADAM metallopeptidase with thrombospondin type 1
motif, 15"
/db_xref="GeneID:170689"
/db_xref="HGNC:16305"
/db_xref="HPRD:06330"
/db_xref="MIM:607509"
CDS 1..2853
/gene="ADAMTS15"
/note="a disintegrin and metalloproteinase with
thrombospondin motifs 15; a disintegrin-like and
metalloprotease (reprolysin type) with thrombospondin type
1 motif, 15, preproprotein; ADAM-TS15; ADAMTS-15; ADAM-TS
15; metalloprotease disintegrin 15 with thrombospondin
domains"
/codon_start=1
/product="A disintegrin and metalloproteinase with
thrombospondin motifs 15 preproprotein"
/protein_id="NP_620686.1"
/db_xref="GI:21265058"
/db_xref="CCDS:CCDS8488.1"
/db_xref="GeneID:170689"
/db_xref="HGNC:16305"
/db_xref="HPRD:06330"
/db_xref="MIM:607509"
/translation="
MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC
"
sig_peptide 1..51
/gene="ADAMTS15"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
proprotein 52..2850
/gene="ADAMTS15"
/product="A disintegrin and metalloproteinase with
thrombospondin motifs 15 proprotein"
misc_feature 70..429
/gene="ADAMTS15"
/note="Reprolysin family propeptide; Region:
Pep_M12B_propep; pfam01562"
/db_xref="CDD:201861"
misc_feature 514..537
/gene="ADAMTS15"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1);
Region: Cysteine switch (By similarity)"
mat_peptide 637..2850
/gene="ADAMTS15"
/product="A disintegrin and metalloproteinase with
thrombospondin motifs 15"
misc_feature 652..1272
/gene="ADAMTS15"
/note="Zinc-dependent metalloprotease, ADAMTS_like
subgroup. ADAMs (A Disintegrin And Metalloprotease) are
glycoproteins, which play roles in cell signaling, cell
fusion, and cell-cell interactions. This particular
subfamily represents domain architectures that...; Region:
ZnMc_ADAMTS_like; cd04273"
/db_xref="CDD:58574"
misc_feature order(1081..1086,1093..1095,1111..1113)
/gene="ADAMTS15"
/note="active site"
/db_xref="CDD:58574"
misc_feature 1309..1518
/gene="ADAMTS15"
/note="ADAM cysteine-rich; Region: ADAM_CR; cl15456"
/db_xref="CDD:210111"
misc_feature 1555..1713
/gene="ADAMTS15"
/note="Thrombospondin type 1 repeats; Region: TSP1;
smart00209"
/db_xref="CDD:197574"
misc_feature 2047..2403
/gene="ADAMTS15"
/note="ADAM-TS Spacer 1; Region: ADAM_spacer1; pfam05986"
/db_xref="CDD:203365"
misc_feature 2101..2514
/gene="ADAMTS15"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TE58.1);
Region: Spacer"
misc_feature 2536..2685
/gene="ADAMTS15"
/note="Thrombospondin type 1 repeats; Region: TSP1;
smart00209"
/db_xref="CDD:197574"
misc_feature 2689..2850
/gene="ADAMTS15"
/note="Thrombospondin type 1 repeats; Region: TSP1;
smart00209"
/db_xref="CDD:197574"
exon 1..957
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 41
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:371076060"
variation 48
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:150283574"
variation 67
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:146878786"
variation 105
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:140642434"
variation 167
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:370618159"
variation 195
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:374330728"
variation 215
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:199831999"
variation 238
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:61733898"
variation 277
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:138290327"
variation 280
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:149595264"
variation 315
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:143228441"
variation 333
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:201987156"
variation 334
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:148309073"
variation 336
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:141417398"
variation 386
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:147421042"
variation 393
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:374081471"
variation 397
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:185269810"
variation 422
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:139785307"
variation 446
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:367974617"
variation 447
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:201226379"
variation 501
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:200818431"
variation 530
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:372042079"
variation 531
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:375154318"
variation 546
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:369900757"
variation 647
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:143601958"
variation 650
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:367694277"
variation 687
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:372642079"
variation 703
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:61753090"
variation 711
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:199889124"
variation 747
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:139507757"
variation 769
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:149703887"
variation 775
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:371415392"
variation 779
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:368298830"
variation 858
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:199895882"
variation 864
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:191956913"
variation 876
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:145460271"
variation 937
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:372398084"
variation 951
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:148390136"
exon 958..1090
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 958
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:184041499"
variation 1021
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:187607006"
variation 1083
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:192559172"
exon 1091..1258
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 1096
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:372007830"
variation 1115
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:139285573"
variation 1176
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:375634484"
variation 1191
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:369731938"
variation 1196
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:200077954"
variation 1200
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:142515274"
variation 1236
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:146867800"
variation 1238
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:112912416"
variation 1249
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:373541711"
variation 1251
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:376439882"
variation 1252
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:144157651"
exon 1259..1542
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 1284
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:200860030"
variation 1303
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:376372695"
variation 1317
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:372542959"
variation 1324
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:116897071"
variation 1344
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:376836072"
variation 1359
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:146615969"
variation 1396
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:200241369"
variation 1414
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:201237546"
variation 1433
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:375482848"
variation 1444
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:200083994"
variation 1447
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:184661787"
variation 1448
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:189029139"
variation 1449
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:371157496"
variation 1464
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:200281061"
variation 1482
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:199807884"
variation 1491
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:140984314"
variation 1503
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:367635274"
variation 1507
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:201611580"
variation 1527
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:371809427"
variation 1532
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:77956639"
exon 1543..1720
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 1547
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:201255964"
variation 1560
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:141788719"
variation 1587
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:369902413"
variation 1593
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:138815910"
variation 1606
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:149341964"
variation 1630
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:147042663"
variation 1650
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:373357559"
variation 1687
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:201680830"
variation 1688
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:200435814"
variation 1698
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:731446"
variation 1705
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:143767322"
variation 1712
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:377651980"
exon 1721..1902
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 1723
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:79839754"
variation 1726
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:147190472"
variation 1745
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:148676964"
variation 1749
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:141261317"
variation 1751
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:369119460"
variation 1764
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:200393200"
variation 1786
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:373000118"
variation 1798
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:377184006"
variation 1807
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:370391190"
variation 1818
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:150734073"
variation 1824
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:375413440"
variation 1837
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:139100319"
variation 1868
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:11222114"
variation 1890
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:374196474"
variation 1898
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:146430548"
exon 1903..2078
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 1912
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:370406941"
variation 1955
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:373574001"
variation 1963
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:368055583"
variation 1968
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:199956158"
variation 1970
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:199538468"
variation 2007
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:139750111"
variation 2069
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:191557934"
exon 2079..5676
/gene="ADAMTS15"
/inference="alignment:Splign:1.39.8"
variation 2101
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:375221444"
variation 2109
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:368293044"
variation 2115
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:372344949"
variation 2127
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:376722887"
variation 2130
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:80249996"
variation 2142
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:375820237"
variation 2160
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:61746092"
variation 2164
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:200637449"
variation 2166
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:149181155"
variation 2190
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:373104610"
variation 2213
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:191591899"
variation 2214
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:374831999"
variation 2231
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:199699144"
variation 2235
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:142412900"
variation 2241
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:369271185"
variation 2250
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:199730195"
variation 2272
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:200840813"
variation 2277
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:74487200"
variation 2280
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:61753091"
variation 2286
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:61739946"
variation 2287
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:78506847"
variation 2294
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:369552843"
variation 2315
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:148493027"
variation 2355
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:373985098"
variation 2365
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:182995457"
variation 2396
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:377766675"
variation 2405
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:142273348"
variation 2406
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:146069494"
variation 2413
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:370956319"
variation 2428
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:112935567"
variation 2443
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:147148311"
variation 2453
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:201623542"
variation 2494
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:144558172"
variation 2501
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:374363479"
variation 2504
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:200241034"
variation 2505
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:61757474"
variation 2516
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:367588540"
variation 2550
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:145936737"
variation 2557
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:139836940"
variation 2559
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:372169283"
variation 2588
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:199748492"
variation 2622
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:367980831"
variation 2631
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:372046155"
variation 2652
/gene="ADAMTS15"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:143168028"
variation 2653
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:150684307"
variation 2661
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:140009739"
variation 2670
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:149819360"
variation 2671
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:192825124"
variation 2685
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:145831913"
variation 2695
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:375061494"
variation 2702
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:141639972"
variation 2703
/gene="ADAMTS15"
/replace="a"
/replace="c"
/db_xref="dbSNP:111287791"
variation 2718
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:201275670"
variation 2776
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:61743322"
variation 2777
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:61743323"
variation 2839
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:61744317"
variation 2905
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:372201358"
variation 2972
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:79754628"
variation 3001
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:111559963"
variation 3046
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:183332648"
variation 3081
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:112348720"
variation 3110
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:187639825"
variation 3124
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:78272889"
variation 3147
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:139882544"
variation 3161
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:113413820"
variation 3200
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:73044885"
variation 3299
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:78409191"
variation 3305
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:75350986"
variation 3337
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:373624315"
variation 3361
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:114428943"
variation 3374
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:149018798"
variation 3377..3378
/gene="ADAMTS15"
/replace=""
/replace="g"
/db_xref="dbSNP:35116561"
variation 3396
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:144482969"
variation 3397
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:146557511"
variation 3434
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:141191413"
variation 3471
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:373934584"
variation 3598
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:77835179"
variation 3611
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:145056543"
variation 3619
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:111259608"
variation 3632
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:7120312"
variation 3719
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:148314803"
variation 3811
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:183743370"
variation 3830
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:373085029"
variation 3848
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:11222116"
variation 3850
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:372962242"
variation 3856
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:114557185"
variation 3894..3895
/gene="ADAMTS15"
/replace=""
/replace="c"
/db_xref="dbSNP:11403571"
variation 3958
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:189129069"
variation 3998
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:376181336"
variation 4003
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:371420512"
variation 4004
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:113582757"
variation 4070
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:193003693"
variation 4144
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:79112658"
variation 4161
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:184554372"
variation 4203
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:150362847"
variation 4265
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:115441025"
variation 4411
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:74551189"
variation 4482
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:138023787"
variation 4534
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:190268624"
variation 4560
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:143769532"
variation 4598
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:181483591"
variation 4601
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:3816894"
variation 4685
/gene="ADAMTS15"
/replace="c"
/replace="g"
/db_xref="dbSNP:368660386"
variation 4686
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:112966623"
variation 4769
/gene="ADAMTS15"
/replace="a"
/replace="t"
/db_xref="dbSNP:117104167"
variation 4787
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:186497959"
variation 4931
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:111641734"
variation 4991
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:189611570"
variation 5055
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:181904660"
variation 5078..5079
/gene="ADAMTS15"
/replace=""
/replace="g"
/db_xref="dbSNP:142813339"
variation 5223
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:116597263"
variation 5224
/gene="ADAMTS15"
/replace="g"
/replace="t"
/db_xref="dbSNP:79991456"
variation 5239
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:147210598"
variation 5352
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:186285421"
variation 5359
/gene="ADAMTS15"
/replace="a"
/replace="g"
/db_xref="dbSNP:367898982"
variation 5386..5398
/gene="ADAMTS15"
/replace=""
/replace="ctctcatatgaac"
/db_xref="dbSNP:146904164"
STS 5391..5640
/gene="ADAMTS15"
/standard_name="RH81015"
/db_xref="UniSTS:92052"
variation 5398..5399
/gene="ADAMTS15"
/replace=""
/replace="a"
/db_xref="dbSNP:201649144"
STS 5419..5544
/gene="ADAMTS15"
/standard_name="RH47034"
/db_xref="UniSTS:1200"
variation 5529
/gene="ADAMTS15"
/replace="c"
/replace="t"
/db_xref="dbSNP:138679768"
variation 5636
/gene="ADAMTS15"
/replace=""
/replace="c"
/db_xref="dbSNP:368987997"
polyA_signal 5651..5656
/gene="ADAMTS15"
polyA_site 5676
/gene="ADAMTS15"
ORIGIN
atgcttctgctgggcatcctaaccctggctttcgccgggcgaaccgctggaggctctgagccagagcgggaggtagtcgttcccatccgactggacccggacattaacggccgccgctactactggcggggtcccgaggactccggggatcagggactcatttttcagatcacagcatttcaggaggacttttacctacacctgacgccggatgctcagttcttggctcccgccttctccactgagcatctgggcgtccccctccaggggctcaccgggggctcttcagacctgcgacgctgcttctattctggggacgtgaacgccgagccggactcgttcgctgctgtgagcctgtgcggggggctccgcggagcctttggctaccgaggcgccgagtatgtcattagcccgctgcccaatgctagcgcgccggcggcgcagcgcaacagccagggcgcacaccttctccagcgccggggtgttccgggcgggccttccggagaccccacctctcgctgcggggtggcctcgggctggaaccccgccatcctacgggccctggacccttacaagccgcggcgggcgggcttcggggagagtcgtagccggcgcaggtctgggcgcgccaagcgtttcgtgtctatcccgcggtacgtggagacgctggtggtcgcggacgagtcaatggtcaagttccacggcgcggacctggaacattatctgctgacgctgctggcaacggcggcgcgactctaccgccatcccagcatcctcaaccccatcaacatcgttgtggtcaaggtgctgcttcttagagatcgtgactccgggcccaaggtcaccggcaatgcggccctgacgctgcgcaacttctgtgcctggcagaagaagctgaacaaagtgagtgacaagcaccccgagtactgggacactgccatcctcttcaccaggcaggacctgtgtggagccaccacctgtgacaccctgggcatggctgatgtgggtaccatgtgtgaccccaagagaagctgctctgtcattgaggacgatgggcttccatcagccttcaccactgcccacgagctgggccacgtgttcaacatgccccatgacaatgtgaaagtctgtgaggaggtgtttgggaagctccgagccaaccacatgatgtccccgaccctcatccagatcgaccgtgccaacccctggtcagcctgcagtgctgccatcatcaccgacttcctggacagcgggcacggtgactgcctcctggaccaacccagcaagcccatctccctgcccgaggatctgccgggcgccagctacaccctgagccagcagtgcgagctggcttttggcgtgggctccaagccctgtccttacatgcagtactgcaccaagctgtggtgcaccgggaaggccaagggacagatggtgtgccagacccgccacttcccctgggccgatggcaccagctgtggcgagggcaagctctgcctcaaaggggcctgcgtggagagacacaacctcaacaagcacagggtggatggttcctgggccaaatgggatccctatggcccctgctcgcgcacatgtggtgggggcgtgcagctggccaggaggcagtgcaccaaccccacccctgccaacgggggcaagtactgcgagggagtgagggtgaaataccgatcctgcaatctggagccctgccccagctcagcctccggaaagagcttccgggaggagcagtgtgaggctttcaacggctacaaccacagcaccaaccggctcactctcgccgtggcatgggtgcccaagtactccggcgtgtctccccgggacaagtgcaagctcatctgccgagccaatggcactggctacttctatgtgctggcacccaaggtggtggacggcacgctgtgctctcctgactccacctccgtctgtgtccaaggcaagtgcatcaaggctggctgtgatgggaacctgggctccaagaagagattcgacaagtgtggggtgtgtgggggagacaataagagctgcaagaaggtgactggactcttcaccaagcccatgcatggctacaatttcgtggtggccatccccgcaggcgcctcaagcatcgacatccgccagcgcggttacaaagggctgatcggggatgacaactacctggctctgaagaacagccaaggcaagtacctgctcaacgggcatttcgtggtgtcggcggtggagcgggacctggtggtgaagggcagtctgctgcggtacagcggcacgggcacagcggtggagagcctgcaggcttcccggcccatcctggagccgctgaccgtggaggtcctctccgtggggaagatgacaccgccccgggtccgctactccttctatctgcccaaagagcctcgggaggacaagtcctctcatcccaaggacccccggggaccctctgtcttgcacaacagcgtcctcagcctctccaaccaggtggagcagccggacgacaggccccctgcacgctgggtggctggcagctgggggccgtgctccgcgagctgcggcagtggcctgcagaagcgggcggtggactgccggggctccgccgggcagcgcacggtccctgcctgtgatgcagcccatcggcccgtggagacacaagcctgcggggagccctgccccacctgggagctcagcgcctggtcaccctgctccaagagctgcggccggggatttcagaggcgctcactcaagtgtgtgggccacggaggccggctgctggcccgggaccagtgcaacttgcaccgcaagccccaggagctggacttctgcgtcctgaggccgtgctgagtggggtcatcgctttctccccctcactctccaccccactgatatgccagcgttctgccagctggagtagcgggcagaggacggtggccaggggctcacgccacgatgtcacccacatccggggacaaggaccatgggctggggcgagaggttccctcctcctccctggactgggcagagggaagcccaggaactcccgcacagtctacctcaggccccgctcctcgggccggttgcggggagaggctttgaggtgcagggcagaaggtgctgaggcccagtttccaaggaacttggaggatgggcaccttccaggcagaacttcagggaccccggcccccagaacggaggccacaggctgctggaagagccatgtcccagcagcttggcaccctcaggtggccccatgggctctgagccgtgtctgaacgaggcagggttttcacggtgcttttagcccactttcctttttgaactgacatggactaagcaataaaagctggctggggctgggcagaagccacggggagagtgagattagggcccctggagcctggcactccaccttggaagacgtggacgtgcacagggagtcccgaggtttctcatcctgcactcttggccctcctataaagaagcagcctctccttcctctgatgtgcagggtgtaggactagtggtagggctgccacggaagtgtcctctgaggctctgcaggtagcggggaaagccagtagggagtctgctgtcttcttcaagatggagccggccattacagaaagatgttgacatttgctaggggctatgcagtctgtggctgatgcagggagttttcagaaagttctggagggttctgctgtcactggactggggttggtgctgagctctgggcctggctttgggagatgtcaccctgggatagggaggaggaagctgcatttctaatggcttcctcctccagagaggcacgtatatgcaggctgacatccgagggtctgtgtcgcctcagacagccctgacagtggccacagtcccgtacccattgtgaggggctggggcatgcctaggagggctaggtgctgaacatctatgtgcctataaactcgtcttcgttccaaacagctactgctgtctgccctgggcacgtcacgttgcatcctaggccttagcttctccactgtttgctacctcagattatgccctctgggaacccagccgtatccctcccctaggacagtggtgacctggtccttccaccacactcagtctttggagagcgagctgtccagccacagaaatgagggtgtggtgcgtggcttcctgctccccacagcccagccccctgttggggctccaaagccgaagacagggcctcttcagactccttgggagtaggtttcaggaggcaccaagaatcaatgactgacccagggggcctggcagccactagtatgaactgctggagacctgtctgtcttatagacatgtcaggaaaatagaaacaggcattttctctagctccaagtggggagatattttggggtcacagcttctttggctaagcagggtgtttcttgaaggttcagatgccccactgtgtacatgggatattctgcttctgagtgtaggtgatgaatccaggtcctcagtggagaattttctggagctaagatcaaagcatgtgtcttcctgggagagaagagttccgttcttttatgtgggtttccctaatagtcagaatccacaaaccagccagccagccagccaagcctctgcgatgatgttctcatccggtctaacgctgggctggaaaccttggacagagttcatgcgggggcagagggggtgccagtctctgaggcagggctgcagtcacccctgaagaactaagtgaacaggaacccctctgtgccagtgaccactgtggggctaaagggacaaaaaggaccagggtaccaggcagaagcagatccttgatagctgacgacagcactgcgccctgtgcttggtgcactccctccttcaggaggagagggtggcatggggtctgtgcgggatggcagggggattgggtgggtgggaagagaggtgccatcggtaggaggctggcctccagtagaggagagcagcttttgccatcagtcactttacaaaccatttcaaggaaggacaacctctctggctcctgacacaagccaggcctcggtgcttttatctgttgtggtggtttttcttctttccctttttaaaagacgcatgaccaagacaacctagggagtttgtcttgcttgcctttgactatttccttaatccaaccatgctctcgagggctgagcagagactagactcaaggcacaggtttctggtgatggagtaaagttacagcggtatctcatgtctacacaagaagaggaacgttctgaaagctccaacaacttcttgagggggatggaccaatacagctttgggctcaggattccctagcctcctctgcccatcgcgtgcactgattggaggagtctggcccaaacactctcatatgaacctcgacatgctggagtggggtctggcaggagctgatgacagtttgagggacttgagtgtccctagcctggcagttggctcccggaagcactagacactgacactcattggtagaccctccctccccgccgttgtgtttggttcttttgcactccatgtactgcagaaggatggaaggacctgggtgctggctgggctgtgtatactgtgtatacaagggagctggctgctgaggtgaccacagccttctcctaataaagctgtaagtatttaaaacct
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:170689 -> Molecular function: GO:0004222 [metalloendopeptidase activity] evidence: IEA
GeneID:170689 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:170689 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:170689 -> Cellular component: GO:0005578 [proteinaceous extracellular matrix] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.