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2024-03-28 17:31:24, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_139049               5671 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript
            variant JNK1-a2, mRNA.
ACCESSION   NM_139049
VERSION     NM_139049.2  GI:513788277
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5671)
  AUTHORS   Park,M.K., You,H.J., Lee,H.J., Kang,J.H., Oh,S.H., Kim,S.Y. and
            Lee,C.H.
  TITLE     Transglutaminase-2 induces N-cadherin expression in
            TGF-beta1-induced epithelial mesenchymal transition via
            c-Jun-N-terminal kinase activation by protein phosphatase 2A
            down-regulation
  JOURNAL   Eur. J. Cancer 49 (7), 1692-1705 (2013)
   PUBMED   23290789
  REMARK    GeneRIF: Results suggest that Tgase-2/PP2A/JNK might be a novel
            axis that affects N-cadherin switching in the
            epithelial-mesenchymal-transition (EMT) of A549 lung cancer cells.
REFERENCE   2  (bases 1 to 5671)
  AUTHORS   Takahashi,R., Hirata,Y., Sakitani,K., Nakata,W., Kinoshita,H.,
            Hayakawa,Y., Nakagawa,H., Sakamoto,K., Hikiba,Y., Ijichi,H.,
            Moses,H.L., Maeda,S. and Koike,K.
  TITLE     Therapeutic effect of c-Jun N-terminal kinase inhibition on
            pancreatic cancer
  JOURNAL   Cancer Sci. 104 (3), 337-344 (2013)
   PUBMED   23237571
  REMARK    GeneRIF: activation of JNK promotes development of pancreatic
            cancer
REFERENCE   3  (bases 1 to 5671)
  AUTHORS   An,J., Liu,H., Magyar,C.E., Guo,Y., Veena,M.S., Srivatsan,E.S.,
            Huang,J. and Rettig,M.B.
  TITLE     Hyperactivated JNK is a therapeutic target in pVHL-deficient renal
            cell carcinoma
  JOURNAL   Cancer Res. 73 (4), 1374-1385 (2013)
   PUBMED   23393199
  REMARK    GeneRIF: Data indicate that von Hippel-Lindau (VHL)-deficient clear
            cell renal cell carcinomas (RCC) are dependent upon
            c-Jun-NH(2)-kinase (JNK) activity for in vitro and in vivo growth.
REFERENCE   4  (bases 1 to 5671)
  AUTHORS   Li,M., Qiu,L., Lin,T., He,D., Hua,Y., Yuan,X., Liu,X. and Wei,G.
  TITLE     c-Jun N-terminal kinase is upregulated in patients with hypospadias
  JOURNAL   Urology 81 (1), 178-183 (2013)
   PUBMED   23273084
  REMARK    GeneRIF: We observed that the JNK1 gene and the phosphorylated
            expression of JNK1 and JNK2 were upregulated in the skin of
            patients with hypospadias compared with that in the normal prepuce
            in the levels of mRNA and protein, respectively.
REFERENCE   5  (bases 1 to 5671)
  AUTHORS   Kanaji,N., Nelson,A., Wang,X., Sato,T., Nakanishi,M., Gunji,Y.,
            Basma,H., Michalski,J., Farid,M., Rennard,S.I. and Liu,X.
  TITLE     Differential roles of JNK, ERK1/2, and p38 mitogen-activated
            protein kinases on endothelial cell tissue repair functions in
            response to tumor necrosis factor-alpha
  JOURNAL   J. Vasc. Res. 50 (2), 145-156 (2013)
   PUBMED   23258237
  REMARK    GeneRIF: TNF-alpha stimulates tissue repair functions of HPAECs.
            This may be mediated, at least in part, positively via JNK &
            ERK1/2. This may play a role in endothelial cell-mediated tissue
            repair, especially in an inflammatory milieu where TNF-alpha is
            present.
REFERENCE   6  (bases 1 to 5671)
  AUTHORS   Kharbanda,S., Saleem,A., Shafman,T., Emoto,Y., Taneja,N., Rubin,E.,
            Weichselbaum,R., Woodgett,J., Avruch,J., Kyriakis,J. et al.
  TITLE     Ionizing radiation stimulates a Grb2-mediated association of the
            stress-activated protein kinase with phosphatidylinositol 3-kinase
  JOURNAL   J. Biol. Chem. 270 (32), 18871-18874 (1995)
   PUBMED   7642542
REFERENCE   7  (bases 1 to 5671)
  AUTHORS   van Dam,H., Wilhelm,D., Herr,I., Steffen,A., Herrlich,P. and
            Angel,P.
  TITLE     ATF-2 is preferentially activated by stress-activated protein
            kinases to mediate c-jun induction in response to genotoxic agents
  JOURNAL   EMBO J. 14 (8), 1798-1811 (1995)
   PUBMED   7737130
REFERENCE   8  (bases 1 to 5671)
  AUTHORS   Livingstone,C., Patel,G. and Jones,N.
  TITLE     ATF-2 contains a phosphorylation-dependent transcriptional
            activation domain
  JOURNAL   EMBO J. 14 (8), 1785-1797 (1995)
   PUBMED   7737129
REFERENCE   9  (bases 1 to 5671)
  AUTHORS   Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J.,
            Ulevitch,R.J. and Davis,R.J.
  TITLE     Independent human MAP-kinase signal transduction pathways defined
            by MEK and MKK isoforms
  JOURNAL   Science 267 (5198), 682-685 (1995)
   PUBMED   7839144
  REMARK    Erratum:[Science 1995 Jul 7;269(5220):17]
REFERENCE   10 (bases 1 to 5671)
  AUTHORS   Seth,A., Alvarez,E., Gupta,S. and Davis,R.J.
  TITLE     A phosphorylation site located in the NH2-terminal domain of c-Myc
            increases transactivation of gene expression
  JOURNAL   J. Biol. Chem. 266 (35), 23521-23524 (1991)
   PUBMED   1748630
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292523.1, U34822.1,
            AC016397.6 and AA808177.1.
            On Jun 20, 2013 this sequence version replaced gi:20986522.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as an integration point for multiple
            biochemical signals, and are involved in a wide variety of cellular
            processes such as proliferation, differentiation, transcription
            regulation and development. This kinase is activated by various
            cell stimuli, and targets specific transcription factors, and thus
            mediates immediate-early gene expression in response to cell
            stimuli. The activation of this kinase by tumor-necrosis factor
            alpha (TNF-alpha) is found to be required for TNF-alpha induced
            apoptosis. This kinase is also involved in UV radiation induced
            apoptosis, which is thought to be related to cytochrom c-mediated
            cell death pathway. Studies of the mouse counterpart of this gene
            suggested that this kinase play a key role in T cell proliferation,
            apoptosis and differentiation. Five alternatively spliced
            transcript variants encoding distinct isoforms have been reported.
            [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (JNK1-a2) encodes the longer of
            the two JNK1 alpha isoforms (JNK1 alpha2). The JNK1-a2 variant
            differs from the JNK1-b2 variant in the use of an alternate
            internal coding exon of the same length. Thus, JNK1 alpha2 isoform
            is the same length as JNK1 beta2 isoform, with a few aa difference
            in an internal protein segment.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AK292523.1         80-116
            38-1402             U34822.1           1-1365
            1403-5292           AC016397.6         82907-86796
            5293-5671           AA808177.1         1-379               c
FEATURES             Location/Qualifiers
     source          1..5671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..5671
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="mitogen-activated protein kinase 8"
                     /db_xref="GeneID:5599"
                     /db_xref="HGNC:6881"
                     /db_xref="HPRD:03100"
                     /db_xref="MIM:601158"
     exon            1..171
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    35..37
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="upstream in-frame stop codon"
     CDS             50..1333
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /EC_number="2.7.11.24"
                     /note="isoform alpha2 is encoded by transcript variant
                     JNK1-a2; JUN N-terminal kinase; c-Jun N-terminal kinase 1;
                     mitogen-activated protein kinase 8 isoform JNK1 alpha1;
                     mitogen-activated protein kinase 8 isoform JNK1 beta2; MAP
                     kinase 8; stress-activated protein kinase 1;
                     stress-activated protein kinase 1c"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 8 isoform
                     alpha2"
                     /protein_id="NP_620637.1"
                     /db_xref="GI:20986523"
                     /db_xref="CCDS:CCDS7224.1"
                     /db_xref="GeneID:5599"
                     /db_xref="HGNC:6881"
                     /db_xref="HPRD:03100"
                     /db_xref="MIM:601158"
                     /translation="
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
"
     misc_feature    74..1129
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; Region: STKc_JNK; cd07850"
                     /db_xref="CDD:173746"
     misc_feature    125..1012
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(143..163,167..169,206..208,212..214,263..265,
                     305..307,371..391,395..400,500..502,506..508,512..517,
                     521..523,551..556,563..565,596..598,602..613,617..619,
                     728..730)
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="active site"
                     /db_xref="CDD:173746"
     misc_feature    order(143..163,167..169,206..208,212..214,305..307,
                     371..391,521..523,551..553)
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173746"
     misc_feature    order(263..265,395..397,500..502,506..508,563..565,
                     596..598,602..613,617..619,728..730)
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173746"
     misc_feature    order(383..385,401..403,428..430,437..439,524..538,
                     1016..1021,1025..1027,1034..1036)
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="KIM docking site [polypeptide binding]; other site"
                     /db_xref="CDD:173746"
     misc_feature    order(551..583,596..619)
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173746"
     misc_feature    596..604
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P45983.2);
                     Region: TXY"
     misc_feature    596..598
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by MAP2K7; propagated from
                     UniProtKB/Swiss-Prot (P45983.2); phosphorylation site"
     misc_feature    596..598
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04309"
     misc_feature    602..604
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by MAP2K4; propagated from
                     UniProtKB/Swiss-Prot (P45983.2); phosphorylation site"
     misc_feature    602..604
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03213"
     misc_feature    602..604
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01266"
     misc_feature    1178..1180
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            172..301
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            302..360
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            361..499
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            500..665
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            666..737
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            738..920
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            921..1045
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     STS             979..1083
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="MARC_12374-12375:997362452:1"
                     /db_xref="UniSTS:267421"
     STS             985..1086
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="MARC_13424-13425:1002294866:1"
                     /db_xref="UniSTS:267492"
     exon            1046..1109
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            1110..1187
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     exon            1188..5664
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /inference="alignment:Splign:1.39.8"
     STS             1202..1338
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="STS-L26318"
                     /db_xref="UniSTS:6223"
     STS             1221..1344
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="D10S2185"
                     /db_xref="UniSTS:27764"
     STS             1924..2011
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="RH69616"
                     /db_xref="UniSTS:47949"
     STS             2000..2137
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="STS-T94087"
                     /db_xref="UniSTS:42388"
     polyA_signal    2160..2165
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
     polyA_site      2187
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
     STS             2422..2635
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="HSC1IF052"
                     /db_xref="UniSTS:25988"
     STS             2487..2692
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="A004M36"
                     /db_xref="UniSTS:62067"
     polyA_site      2731
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
     STS             5471..5590
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
                     /standard_name="D10S1856"
                     /db_xref="UniSTS:81152"
     polyA_signal    5629..5634
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
     polyA_site      5664
                     /gene="MAPK8"
                     /gene_synonym="JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2;
                     PRKM8; SAPK1; SAPK1c"
ORIGIN      
cttcttggtgaatttttggatgaagccattaaattaattgcttgccatcatgagcagaagcaagcgtgacaacaatttttatagtgtagagattggagattctacattcacagtcctgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagtatgcgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccgaccatttcagaatcagactcatgccaagcgggcctacagagagctagttcttatgaaatgtgttaatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaatttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcagatggagctagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaagcaccttcattctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaatctgattgcactttgaagattcttgacttcggtctggccaggactgcaggaacgagttttatgatgacgccttatgtagtgactcgctactacagagcacccgaggtcatccttggcatgggctacaaggaaaacgtggatttatggtctgtggggtgcattatgggagaaatggtttgccacaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacagcttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttacgttgaaaacagacctaaatatgctggatatagctttgagaaactcttccctgatgtccttttcccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaaatgctggtaatagatgcatctaaaaggatctctgtagatgaagctctccaacacccgtacatcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatccctgacaagcagttagatgaaagggaacacacaatagaagagtggaaagaattgatatataaggaagttatggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggtgcagcagtgatcaatggctctcagcatccatcatcatcgtcgtctgtcaatgatgtgtcttcaatgtcaacagatccgactttggcctctgatacagacagcagtctagaagcagcagctgggcctctgggctgctgtagatgactacttgggccatcggggggtgggagggatggggagtcggttagtcattgatagaactactttgaaaacaattcagtggtcttatttttgggtgatttttcaaaaaatgtagaattcattttgtagtaaagtagtttattttttttaatttcaagtgatgtaatttaaaacctaagttgtgtttcaaaacagcaacaaaactgtattgtattttttttgctgtaattaactgtataatgtaaacctaattattttatcatggtttaaattttttgcatatttgctttatcttatgctgctgatttttttaactgaatttgtaagattttgtttatcaaagcaactattatgtggtgacttgcctatatcatgaattatttaagatttttatagttttttttaattagaatttatttcagatgttttgttcatgatactatccttcagggttatgtgcttatcaatgaaataaccccagaggagtgagggaaaataacttgtagccagttatattcaggaataactactgtaaatgatgaacgtgttaggagacctccaatatttgctacttgccaatcctaatttagttacaagaattggtaggcaatcctacttaattttggcaaaagccccgtcatctaaatggcagaataactcagagcatgtctttgaagatgctgggcgtctaccaccaccttatgtccccaccctacccaacaaaaataagtaaaaagaatatggtgtattctacaaatttgtggcatgctcaaagtttatgatcacataaaggcaagaggatacttcatgaataatacatttcaatgcaaataaacagatggttcacttctactagctatgagcctgtttttgtatacactgagttaatctactcaggctgtaggtcccagcaatgttctagagtctggtctttccctttcctgcagcttcgggtccttggacctttcctgtttcctattacttggagtgtctgtcagttgagcaccagttgttctggtgtttcatttgattctacttgtagcataatcatttatacgagctattgggaggttccaaaccctacctagatttgtgtaggtgatgtatcaaatgagcaatataccgttcatctgaaaatagtagcacacagccatatataggatatcattttctaaggactgtttcttcacattgagcagagcaggcataaatggtggttatttagtctaagtcttttatttttttatacctgattttcaacataacacgcaatgtggatgtcgagtagtgttaagaatggtgctgctcctgacaagtgtatgttaactgtttacattttctatctgtagaattatttctctattactgaacttttcctaagtaaaatgtctttgaagtctcgttatttctgaaatacgttgtctgtaatagacccaggcaccttttaaattatctctggaacaagagggatttcatgtaatgaactaggaaatgcatactcacataagcaacaaggttctaggcagaaagccccttggaatttgtgaccaacaggagcaagaacaggtgcggctcaacatgcaatgtctgaaaatttgcttggcattttattcatatatttagtgcaaaattatttttgagtgagatattttacatcactgttaatgtgcaatatttaagattaaaatacattagcttttttatatactttgaagtagcaagtttgttttcgatggcttagagtcatgatttccagcttcccagcctttttatcagtcccttttctaatacaacaaggtgcattaatttgattaggcaaattagagttctaagacacttcttgaattgtagacagaaaatattggattcacaatttcagcagaaatttgagaatgagtgtgtttatattaatttcacaattagctgtattttctgtagcatagattatgtcactgttgcactttcacagcagacatgctttcagaaggttctcatattttatgtttgattgctgataagccatctctattgatacagattttggttaagtaaggaaaaccaggtgtgtgtctgtatcatttattgtaaatgccagctgccacttgccaaccatcatgttcagttcaattcaaagaaaacaaactctcattacttagtgtaaactaaaatacttaacaaattatatcctaaaaacaaggtctctttgttaaatgttgcatgccctaggttttaaattactacatccaaatacagttttcgtcttaaatttgttaagctaaatatatgttggttctttttattttggaatcctttaagcatcttaaacattttttttttgaagagaagttacaaataacatttctatcaggtagtacttgtatgaaaccacctttcttattctataattttgatttttcaattttatatacttaatatactcactgtcttactatcagaaagttattttgaccaagatttttattatcttcatagattcagaaagagatgctaattctgtaccaatgtcttcctggttactattctcttccctctaatatatactggccatttgtaaaaccattgtgttgttgggatcacttagttatactatacgcagatagagcatctcaactctgtcatagtgtttgctgaacagttttcagtgtcatgcacctttggctgctaattgttcctgacgtgcactcttccgagttggtaaaggcacagtgtgttcatgccagacttctaagagaaacaccagcctcttaaatcagaagcctacacacaacccccttaacaatccaaagaagcttgatggtgtgcaaagaagcatcctgccagccttgtcattgttctgttctatgctaatcctgctgtgttgtctaaaagatggagggaagaggacatcagtgtctgatagtgaaatcatcagcaggaaagtgaagctctttccttggttacagataagacttggtttacactattggccagtatctgctaaacatatgaagacttaactattcagtgttgcctaggcattcgcctgcacaacattttgaggttagaacatagaatattttcagaaatactgttgtagtttgtgagtgttgttcattagttacacattagctatagagtggatgcatgaagccccatgacaccagtaaacttctcttaccagtaggtaaaccaaacaccattctgtcattagcagccctcttaaatgttgcctctccgtatcctgttgcatttttgtgtgcattgtgtttctactgatctctcttaggtttttacggaatcaaaggaaactaatttttccttaatagcaagaaagatgaagaggtaaagggcattgaagcagaaatgtatagtttggggtacgattagaaaactcgtaaggaaaacagaagtcctaatttcaaactgactgctcttcgttaagtgctcttaaggagagtctagtaacagtaacactttctggccatttctagtttagattctcttcgttactgaaacttttgagaaatattacctgtggattaattttgcacaatgttctattctcataatgacttacaaattaaactaggtttttattgaactacctcacactaattttctatgctttcccaagtaagctgttgccctgttagatctttactgagtgaattataaatgtgtgttaaatactttctagccaatgttgacacaataccagtaagtatgtaaagtatataccttacatcagtaagagacacgtgtaaaatctttgactgtatgtcttgcaaaattgtgctcgttgacattattactgtttttgtaagtagaaacctgctcgtgatatcggtccatttacattttacaaaaggagtaaatcttagtaaaaattttacgaagaaataaattacttttgtaggcccaatatttggtatatttttgagaagctgttaatcttttagctgaataatgaagttagactgaattacgtgtctccctggactgtgacatctattttctcattacagtttatcctggtcagcagggtgtcacacctggaaacctgagtatgatagctgacatttgcttttctccctctgcgatgtcattcctcctccattcctctccttccctgtgttccgttccctctcctttcctctagacaaaacaaaatggggcactttttagggaatgctgagatcattattgtggtttttcatcattcatgccctagtcattaaacatgcaccactggaatgtaaacaatgttatctagtatgtcaattggttataatattttaaataaaaaagaaaaaagtggtatgaaaattatgaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5599 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:5599 -> Molecular function: GO:0004705 [JUN kinase activity] evidence: IDA
            GeneID:5599 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5599 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5599 -> Molecular function: GO:0035033 [histone deacetylase regulator activity] evidence: IMP
            GeneID:5599 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IPI
            GeneID:5599 -> Biological process: GO:0001503 [ossification] evidence: IEA
            GeneID:5599 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5599 -> Biological process: GO:0006950 [response to stress] evidence: TAS
            GeneID:5599 -> Biological process: GO:0007254 [JNK cascade] evidence: IDA
            GeneID:5599 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
            GeneID:5599 -> Biological process: GO:0007258 [JUN phosphorylation] evidence: IDA
            GeneID:5599 -> Biological process: GO:0009411 [response to UV] evidence: IDA
            GeneID:5599 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
            GeneID:5599 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
            GeneID:5599 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
            GeneID:5599 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IMP
            GeneID:5599 -> Biological process: GO:0031063 [regulation of histone deacetylation] evidence: IMP
            GeneID:5599 -> Biological process: GO:0032091 [negative regulation of protein binding] evidence: IDA
            GeneID:5599 -> Biological process: GO:0032880 [regulation of protein localization] evidence: IDA
            GeneID:5599 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS
            GeneID:5599 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
            GeneID:5599 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5599 -> Biological process: GO:0046686 [response to cadmium ion] evidence: IEA
            GeneID:5599 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: TAS
            GeneID:5599 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:5599 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
            GeneID:5599 -> Biological process: GO:0090045 [positive regulation of deacetylase activity] evidence: IMP
            GeneID:5599 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS
            GeneID:5599 -> Biological process: GO:2000017 [positive regulation of determination of dorsal identity] evidence: IEA
            GeneID:5599 -> Biological process: GO:2001235 [positive regulation of apoptotic signaling pathway] evidence: IEA
            GeneID:5599 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5599 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5599 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
            GeneID:5599 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_620637 -> EC 2.7.11.24

by @meso_cacase at DBCLS
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