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2024-04-16 13:34:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_139013 1431 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens mitogen-activated protein kinase 14 (MAPK14),
transcript variant 3, mRNA.
ACCESSION NM_139013
VERSION NM_139013.2 GI:194578904
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1431)
AUTHORS Kim,S.U., Park,Y.H., Min,J.S., Sun,H.N., Han,Y.H., Hua,J.M.,
Lee,T.H., Lee,S.R., Chang,K.T., Kang,S.W., Kim,J.M., Yu,D.Y.,
Lee,S.H. and Lee,D.S.
TITLE Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant
that regulates NF-kappaB-mediated iNOS induction and microglial
activation
JOURNAL J. Neuroimmunol. 259 (1-2), 26-36 (2013)
PUBMED 23602274
REMARK GeneRIF: Prx I is an antioxidant that is up-regulated in a reactive
oxygen species/p38 MAPK-dependent manner and governs the
progression of neuroinflammation by suppressing microglial
activation.
REFERENCE 2 (bases 1 to 1431)
AUTHORS Beaudoin,T., LaFayette,S., Roussel,L., Berube,J., Desrosiers,M.,
Nguyen,D. and Rousseau,S.
TITLE The level of p38alpha mitogen-activated protein kinase activation
in airway epithelial cells determines the onset of innate immune
responses to planktonic and biofilm Pseudomonas aeruginosa
JOURNAL J. Infect. Dis. 207 (10), 1544-1555 (2013)
PUBMED 23402824
REMARK GeneRIF: There exists a threshold of p38alpha MAPK activation
required to trigger host defense mechanisms against P. aeruginosa.
Planktonic PsaDM induces a stronger p38alpha MAPK activation as
compared to biofilm PsaDM.
REFERENCE 3 (bases 1 to 1431)
AUTHORS Jeong,M.J., Kim,E.J., Cho,E.A., Ye,S.K., Kang,G.H. and Juhnn,Y.S.
TITLE cAMP signalling decreases p300 protein levels by promoting its
ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in
lung cancer cells
JOURNAL FEBS Lett. 587 (9), 1373-1378 (2013)
PUBMED 23523631
REMARK GeneRIF: cAMP signalling decreases the level of the p300 protein by
promoting its ubiquitin-proteasome dependent degradation, which is
mediated by Epac and p38 MAPK
REFERENCE 4 (bases 1 to 1431)
AUTHORS Cannon,M.J., Goyne,H.E., Stone,P.J., Macdonald,L.J., James,L.E.,
Cobos,E. and Chiriva-Internati,M.
TITLE Modulation of p38 MAPK signaling enhances dendritic cell activation
of human CD4+ Th17 responses to ovarian tumor antigen
JOURNAL Cancer Immunol. Immunother. 62 (5), 839-849 (2013)
PUBMED 23354626
REMARK GeneRIF: p38 MAPK signaling modulation enhances dendritic cell
activation of human CD4+ Th17 responses to ovarian tumor antigen
REFERENCE 5 (bases 1 to 1431)
AUTHORS Ki,Y.W., Park,J.H., Lee,J.E., Shin,I.C. and Koh,H.C.
TITLE JNK and p38 MAPK regulate oxidative stress and the inflammatory
response in chlorpyrifos-induced apoptosis
JOURNAL Toxicol. Lett. 218 (3), 235-245 (2013)
PUBMED 23416140
REMARK GeneRIF: The JNK and p38 MAPK pathways might be critical mediators
in chlorpyrifos-induced neuronal apoptosis by both generating ROS
and up-regulating COX-2.
REFERENCE 6 (bases 1 to 1431)
AUTHORS Engel,K., Schultz,H., Martin,F., Kotlyarov,A., Plath,K., Hahn,M.,
Heinemann,U. and Gaestel,M.
TITLE Constitutive activation of mitogen-activated protein
kinase-activated protein kinase 2 by mutation of phosphorylation
sites and an A-helix motif
JOURNAL J. Biol. Chem. 270 (45), 27213-27221 (1995)
PUBMED 7592979
REFERENCE 7 (bases 1 to 1431)
AUTHORS Zervos,A.S., Faccio,L., Gatto,J.P., Kyriakis,J.M. and Brent,R.
TITLE Mxi2, a mitogen-activated protein kinase that recognizes and
phosphorylates Max protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (23), 10531-10534 (1995)
PUBMED 7479834
REFERENCE 8 (bases 1 to 1431)
AUTHORS Raingeaud,J., Gupta,S., Rogers,J.S., Dickens,M., Han,J.,
Ulevitch,R.J. and Davis,R.J.
TITLE Pro-inflammatory cytokines and environmental stress cause p38
mitogen-activated protein kinase activation by dual phosphorylation
on tyrosine and threonine
JOURNAL J. Biol. Chem. 270 (13), 7420-7426 (1995)
PUBMED 7535770
REFERENCE 9 (bases 1 to 1431)
AUTHORS Han,J., Richter,B., Li,Z., Kravchenko,V. and Ulevitch,R.J.
TITLE Molecular cloning of human p38 MAP kinase
JOURNAL Biochim. Biophys. Acta 1265 (2-3), 224-227 (1995)
PUBMED 7696354
REFERENCE 10 (bases 1 to 1431)
AUTHORS Zhukov-Verezhnikov,N.N., Anisimov,P.I., Goncharova,N.S.,
Bochko,G.M. and Karaseva,Z.N.
TITLE [Study of the heterogenetic antigens in vaccinal preparations of V.
cholerae]
JOURNAL Biull Eksp Biol Med 82 (8), 961-962 (1976)
PUBMED 1088347
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA438432.1 and U19775.1.
On Jul 29, 2008 this sequence version replaced gi:20986513.
Summary: The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases act as an integration point for multiple
biochemical signals, and are involved in a wide variety of cellular
processes such as proliferation, differentiation, transcription
regulation and development. This kinase is activated by various
environmental stresses and proinflammatory cytokines. The
activation requires its phosphorylation by MAP kinase kinases
(MKKs), or its autophosphorylation triggered by the interaction of
MAP3K7IP1/TAB1 protein with this kinase. The substrates of this
kinase include transcription regulator ATF2, MEF2C, and MAX, cell
cycle regulator CDC25B, and tumor suppressor p53, which suggest the
roles of this kinase in stress related transcription and cell cycle
regulation, as well as in genotoxic stress response. Four
alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (3) contains a different internal
segment within the coding region, and a different 3' coding region
as well as a different 3' UTR, when compared to variant 1. It thus
encodes an isoform that has a different internal segment, and a
distinct C-terminus, as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025081,
ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-475 DA438432.1 1-475
476-1431 U19775.1 38-993
FEATURES Location/Qualifiers
source 1..1431
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3-p21.2"
gene 1..1431
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="mitogen-activated protein kinase 14"
/db_xref="GeneID:1432"
/db_xref="HGNC:6876"
/db_xref="HPRD:02619"
/db_xref="MIM:600289"
exon 1..597
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 47
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:367598559"
variation 70
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201196027"
variation 74
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:611846"
variation 103
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:61763096"
variation 105
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:70965452"
variation 124
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:201107265"
variation 132
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201749429"
variation 138
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:200279778"
variation 164
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:201059311"
variation 180
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:56156688"
variation 185
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200461047"
variation 196
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:185564627"
variation 202
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:199518270"
variation 210
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:200943566"
variation 227
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201395168"
variation 247
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:199753014"
variation 268
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:190620906"
variation 280
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:200631642"
variation 281
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:201656447"
variation 282
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:200192591"
variation 342
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:61763098"
variation 345..346
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace=""
/replace="c"
/db_xref="dbSNP:199581601"
variation 434
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:112052460"
variation 439
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:377357612"
variation 466
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:201937823"
variation 468
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:373094210"
CDS 482..1375
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/EC_number="2.7.11.24"
/note="isoform 3 is encoded by transcript variant 3; MAP
kinase Mxi2; p38 mitogen activated protein kinase; p38 MAP
kinase; p38alpha Exip; stress-activated protein kinase 2A;
MAX-interacting protein 2; Csaids binding protein;
cytokine suppressive anti-inflammatory drug binding
protein; MAP kinase 14; MAP kinase p38 alpha;
CSAID-binding protein; mitogen-activated protein kinase
p38 alpha; cytokine suppressive anti-inflammatory
drug-binding protein"
/codon_start=1
/product="mitogen-activated protein kinase 14 isoform 3"
/protein_id="NP_620582.1"
/db_xref="GI:20986514"
/db_xref="GeneID:1432"
/db_xref="HGNC:6876"
/db_xref="HPRD:02619"
/db_xref="MIM:600289"
/translation="
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLGKLTIYPHLMDIELVMI
"
misc_feature 485..487
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (Q16539.3); acetylation site"
misc_feature 485..487
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q16539.3); phosphorylation site"
misc_feature 503..>1321
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="Catalytic domain of the Serine/Threonine Kinase,
p38 Mitogen-Activated Protein Kinase; Region: STKc_p38;
cd07851"
/db_xref="CDD:143356"
misc_feature 527..529
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q16539.3); phosphorylation site"
misc_feature 551..1267
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(569..580,584..586,590..595,632..634,638..640,
689..691,704..706,731..733,737..739,791..793,797..808,
815..817,821..826,929..931,935..937,941..946,950..952,
980..985,989..994,1019..1021,1025..1036,1040..1042,
1154..1156)
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="active site"
/db_xref="CDD:143356"
misc_feature order(569..574,584..586,590..595,632..634,638..640,
704..706,731..733,737..739,791..793,797..808,815..817,
929..931,935..937,941..946,980..985,989..991)
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:143356"
misc_feature 638..640
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q16539.3); acetylation site"
misc_feature order(689..691,821..823,929..931,935..937,992..994,
1019..1021,1025..1036,1040..1042,1154..1156)
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:143356"
misc_feature 689..694
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16539.3);
Region: Inhibitor-binding"
misc_feature 797..811
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16539.3);
Region: Inhibitor-binding"
misc_feature order(812..814,827..829,854..859,866..868,953..967)
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="KIM docking site [polypeptide binding]; other site"
/db_xref="CDD:143356"
misc_feature 935..937
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q16539.3); acetylation site"
misc_feature 980..1042
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="activation loop (A-loop); other site"
/db_xref="CDD:143356"
misc_feature 983..988
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16539.3);
Region: Inhibitor-binding"
misc_feature 1019..1027
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q16539.3);
Region: TXY"
misc_feature 1019..1021
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAP2K3, MAP2K4, MAP2K6 and
autocatalysis; propagated from UniProtKB/Swiss-Prot
(Q16539.3); phosphorylation site"
misc_feature 1019..1021
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1019..1021
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1025..1027
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by MAP2K3, MAP2K4, MAP2K6 and
autocatalysis; propagated from UniProtKB/Swiss-Prot
(Q16539.3); phosphorylation site"
misc_feature 1025..1027
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1025..1027
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01266"
misc_feature 1025..1027
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03155"
misc_feature order(1052..1057,1064..1066,1070..1072,1076..1084,
1187..1189,1205..1207,1217..1219,1226..1228,1256..1258)
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/note="lipid binding site [chemical binding];
lipid-binding site"
/db_xref="CDD:143356"
misc_feature 1268..1270
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q16539.3); phosphorylation site"
misc_feature 1268..1270
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 497
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:200659578"
variation 501
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:199820420"
variation 507
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201314635"
variation 516
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201909878"
variation 546
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:200060741"
variation 559
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:200859008"
exon 598..727
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 619
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:368105032"
variation 620
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:368785448"
variation 621
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:202184006"
variation 622
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200421328"
variation 648
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:201290273"
variation 676
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:185580358"
variation 697
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:372488284"
variation 700
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:141509171"
exon 728..786
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 760
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:368125769"
variation 780
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200810274"
exon 787..898
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 797
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:199803489"
variation 837
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:373974101"
variation 853
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:201131979"
variation 859
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:202167664"
variation 880
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200498429"
variation 895
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:145610257"
exon 899..928
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
STS 911..1070
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/standard_name="fd03e12.y1"
/db_xref="UniSTS:194881"
exon 929..976
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 962..963
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace=""
/replace="c"
/db_xref="dbSNP:34387346"
variation 962
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201771693"
exon 977..1091
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 1024
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:138119801"
variation 1027
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:141740563"
variation 1061
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:202156045"
exon 1092..1163
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 1117
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:200577487"
variation 1123
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:201451587"
variation 1127
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:375208032"
variation 1163
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:150550578"
exon 1164..1243
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 1169
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131205"
variation 1171
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:1131206"
variation 1177
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:1131207"
variation 1183
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:1131208"
variation 1187
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:1131209"
variation 1189
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131210"
variation 1190
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:1050576"
variation 1192
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:1050577"
variation 1193
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:139802452"
variation 1195
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:115856784"
variation 1196
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200081934"
variation 1208
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:1050578"
variation 1211
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:376583872"
variation 1213
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:201065328"
variation 1214
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:1050579"
variation 1216
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:1050580"
variation 1226
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace=""
/replace="a"
/db_xref="dbSNP:150174370"
variation 1227
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131211"
exon 1244..1431
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/inference="alignment:Splign:1.39.8"
variation 1285
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:201624180"
variation 1287
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:200108942"
variation 1294
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:145344045"
variation 1309
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:185588333"
variation 1318
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="g"
/db_xref="dbSNP:201665523"
variation 1332
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:369030062"
variation 1333
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:199841727"
variation 1334
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200999556"
variation 1349
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:201491038"
variation 1355
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201606518"
variation 1361
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:368212855"
polyA_signal 1412..1417
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
variation 1418
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:369906363"
polyA_site 1431
/gene="MAPK14"
/gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
ORIGIN
ttctctcacgaagccccgcccgcggagaggttccatattgggtaaaatctcggctctcggagagtcccgggagctgttctcgcgagagtactgcgggaggctcccgtttgctggctcttggaaccgcgaccactggagccttagcgggcgcagcagctggaacgggagtactgcgacgcagcccggagtcggccttgtaggggcgaaggtgcagggagatcgcggcgggcgcagtcttgagcgccggagcgcgtccctgcccttagcggggcttgccccagtcgcaggggcacatccagccgctgcggctgacagcagccgcgcgcgcgggagtctgcggggtcgcggcagccgcacctgcgcgggcgaccagcgcaaggtccccgcccggctgggcgggcagcaagggccggggagagggtgcgggtgcaggcgggggccccacagggccaccttcttgcccggcggctgccgctggaaaatgtctcaggagaggcccacgttctaccggcaggagctgaacaagacaatctgggaggtgcccgagcgttaccagaacctgtctccagtgggctctggcgcctatggctctgtgtgtgctgcttttgacacaaaaacggggttacgtgtggcagtgaagaagctctccagaccatttcagtccatcattcatgcgaaaagaacctacagagaactgcggttacttaaacatatgaaacatgaaaatgtgattggtctgttggacgtttttacacctgcaaggtctctggaggaattcaatgatgtgtatctggtgacccatctcatgggggcagatctgaacaacattgtgaaatgtcagaagcttacagatgaccatgttcagttccttatctaccaaattctccgaggtctaaagtatatacattcagctgacataattcacagggacctaaaacctagtaatctagctgtgaatgaagactgtgagctgaagattctggattttggactggctcggcacacagatgatgaaatgacaggctacgtggccactaggtggtacagggctcctgagatcatgctgaactggatgcattacaaccagacagttgatatttggtcagtgggatgcataatggccgagctgttgactggaagaacattgtttcctggtacagaccatattgatcagttgaagctcattttaagactcgttggaaccccaggggctgagcttttgaagaaaatctcctcagagtctgcaagaaactatattcagtctttgactcagatgccgaagatgaactttgcgaatgtatttattggtgccaatcccctgggtaagttgaccatatatcctcacctcatggatattgaattggttatgatataaattggggatttgaagaagagtttctccttttgaccaaataaagtaccattagttga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1432 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
GeneID:1432 -> Molecular function: GO:0004707 [MAP kinase activity] evidence: IDA
GeneID:1432 -> Molecular function: GO:0004708 [MAP kinase kinase activity] evidence: TAS
GeneID:1432 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1432 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1432 -> Molecular function: GO:0051525 [NFAT protein binding] evidence: ISS
GeneID:1432 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IEA
GeneID:1432 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
GeneID:1432 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IEA
GeneID:1432 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:1432 -> Biological process: GO:0002062 [chondrocyte differentiation] evidence: IEA
GeneID:1432 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA
GeneID:1432 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:1432 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:1432 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
GeneID:1432 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
GeneID:1432 -> Biological process: GO:0006950 [response to stress] evidence: IDA
GeneID:1432 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:1432 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
GeneID:1432 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: TAS
GeneID:1432 -> Biological process: GO:0007519 [skeletal muscle tissue development] evidence: IEA
GeneID:1432 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:1432 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:1432 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:1432 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:1432 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: ISS
GeneID:1432 -> Biological process: GO:0019395 [fatty acid oxidation] evidence: IEA
GeneID:1432 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:1432 -> Biological process: GO:0030316 [osteoclast differentiation] evidence: ISS
GeneID:1432 -> Biological process: GO:0031663 [lipopolysaccharide-mediated signaling pathway] evidence: IEA
GeneID:1432 -> Biological process: GO:0032495 [response to muramyl dipeptide] evidence: IEA
GeneID:1432 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0035924 [cellular response to vascular endothelial growth factor stimulus] evidence: IMP
GeneID:1432 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0042307 [positive regulation of protein import into nucleus] evidence: IEA
GeneID:1432 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
GeneID:1432 -> Biological process: GO:0042770 [signal transduction in response to DNA damage] evidence: IMP
GeneID:1432 -> Biological process: GO:0043536 [positive regulation of blood vessel endothelial cell migration] evidence: IMP
GeneID:1432 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:1432 -> Biological process: GO:0045648 [positive regulation of erythrocyte differentiation] evidence: IEA
GeneID:1432 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:1432 -> Biological process: GO:0048010 [vascular endothelial growth factor receptor signaling pathway] evidence: IMP
GeneID:1432 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:1432 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:1432 -> Biological process: GO:0051146 [striated muscle cell differentiation] evidence: IEA
GeneID:1432 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
GeneID:1432 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:1432 -> Biological process: GO:0070935 [3'-UTR-mediated mRNA stabilization] evidence: TAS
GeneID:1432 -> Biological process: GO:0071479 [cellular response to ionizing radiation] evidence: IMP
GeneID:1432 -> Biological process: GO:0090400 [stress-induced premature senescence] evidence: IMP
GeneID:1432 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IMP
GeneID:1432 -> Cellular component: GO:0000922 [spindle pole] evidence: IEA
GeneID:1432 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:1432 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1432 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:1432 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:1432 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_620582 -> EC 2.7.11.24
by
@meso_cacase at
DBCLS
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