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2024-04-20 18:35:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138799 3804 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens membrane bound O-acyltransferase domain containing 2
(MBOAT2), mRNA.
ACCESSION NM_138799 XM_938724
VERSION NM_138799.2 GI:40548386
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3804)
AUTHORS Tamaki,H., Shimada,A., Ito,Y., Ohya,M., Takase,J., Miyashita,M.,
Miyagawa,H., Nozaki,H., Nakayama,R. and Kumagai,H.
TITLE LPT1 encodes a membrane-bound O-acyltransferase involved in the
acylation of lysophospholipids in the yeast Saccharomyces
cerevisiae
JOURNAL J. Biol. Chem. 282 (47), 34288-34298 (2007)
PUBMED 17890783
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC016005.1, AK027321.2 and AK074779.1.
On or before Mar 4, 2006 this sequence version replaced
gi:88954785, gi:20270350.
##Evidence-Data-START##
Transcript exon combination :: BC146871.1, AK027321.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-208 BC016005.1 5-212
209-1583 AK027321.2 172-1546
1584-1882 BC016005.1 1266-1564
1883-3804 AK074779.1 706-2627
FEATURES Location/Qualifiers
source 1..3804
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p25.1"
gene 1..3804
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/note="membrane bound O-acyltransferase domain containing
2"
/db_xref="GeneID:129642"
/db_xref="HGNC:25193"
/db_xref="HPRD:11410"
/db_xref="MIM:611949"
exon 1..208
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
CDS 134..1696
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/EC_number="2.3.1.51"
/EC_number="2.3.1.n7"
/note="O-acyltransferase (membrane bound) domain
containing 2; LPAAT; LPEAT; LPLAT 2; lyso-PA
acyltransferase; lyso-PE acyltransferase; lysophosphatidic
acid acyltransferase; 1-acylglycerophosphate
O-acyltransferase; lysophosphatidylethanolamine
acyltransferase; O-acyltransferase domain-containing
protein 2; 1-acylglycerophosphoethanolamine
O-acyltransferase; membrane-bound O-acyltransferase
domain-containing protein 2"
/codon_start=1
/product="lysophospholipid acyltransferase 2"
/protein_id="NP_620154.2"
/db_xref="GI:40548387"
/db_xref="CCDS:CCDS1660.1"
/db_xref="GeneID:129642"
/db_xref="HGNC:25193"
/db_xref="HPRD:11410"
/db_xref="MIM:611949"
/translation="
MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ
"
misc_feature 167..1483
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/note="MBOAT, membrane-bound O-acyltransferase family;
Region: MBOAT; cl00738"
/db_xref="CDD:207183"
misc_feature 197..259
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 314..376
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 395..457
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 683..745
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 842..904
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 923..985
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 1229..1291
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 1379..1441
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
misc_feature 1463..1525
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZWT7.2);
transmembrane region"
exon 209..354
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
STS 248..1250
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/standard_name="Mboat2"
/db_xref="UniSTS:498747"
exon 355..432
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 433..528
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 529..584
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 585..639
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 640..823
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 824..1016
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
variation 830
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34573615"
exon 1017..1120
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 1121..1185
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 1186..1318
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 1319..1470
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
exon 1471..3804
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/inference="alignment:Splign:1.39.8"
variation 1534
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/replace="a"
/replace="g"
/db_xref="dbSNP:35943010"
STS 1680..1808
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/standard_name="RH99216"
/db_xref="UniSTS:87148"
STS 1965..2203
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/standard_name="RH80026"
/db_xref="UniSTS:91030"
STS 2058..2200
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/standard_name="G29251"
/db_xref="UniSTS:75988"
variation 2212
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1128192"
STS 3073..3252
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/standard_name="RH92405"
/db_xref="UniSTS:92264"
variation 3647
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3206236"
variation 3777
/gene="MBOAT2"
/gene_synonym="LPCAT4; OACT2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1550254"
ORIGIN
ggccttccccgcgcagagctccgaccgcgggcggcccaggggcgggcgcgccgctgcatccccatcctcgtcgtcgcccggcacagcgcgagcgggcgagcggcgcgggcggccggagcgccgaggcccggccatggccaccaccagcaccacgggctccaccctgctgcagcccctcagcaacgccgtgcagctgcccatcgaccaggtcaactttgtagtgtgccaactctttgccttgctagcagccatttggtttcgaacttatctacattcaagcaaaactagctcttttataagacatgtagttgctacccttttgggcctttatcttgcacttttttgctttggatggtatgccttacactttcttgtacaaagtggaatttcctactgtatcatgatcatcataggagtggagaacatgcacaattactgctttgtgtttgctctgggatacctcacagtgtgccaagttactcgagtctatatctttgactatggacaatattctgctgatttttcaggcccaatgatgatcattactcagaagatcactagtttggcttgcgaaattcatgatgggatgtttcggaaggatgaagaactgacttcctcacagagggatttagctgtaaggcgcatgccaagcttactggagtatttgagttacaactgtaacttcatggggatcctggcaggcccactttgctcttacaaagactacattactttcattgaaggcagatcataccatatcacacaatctggtgaaaatggaaaagaagagacacagtatgaaagaacagagccatctccaaatactgcggttgttcagaagctcttagtttgtgggctgtccttgttatttcacttgaccatctgtacaacattacctgtggagtacaacattgatgagcattttcaagctacagcttcgtggccaacaaagattatctatctgtatatctctcttttggctgccagacccaaatactattttgcatggacgctagctgatgccattaataatgctgcaggctttggtttcagagggtatgacgaaaatggagcagctcgctgggacttaatttccaatttgagaattcaacaaatagagatgtcaacaagtttcaagatgtttcttgataattggaatattcagacagctctttggctcaaaagggtgtgttatgaacgaacctccttcagtccaactatccagacgttcattctctctgccatttggcacggggtatacccaggatattatctaacgtttctaacaggggtgttaatgacattagcagcaagagctatgagaaataactttagacattatttcattgaaccttcccaactgaaattattttatgatgttataacatggatagtaactcaagtagcaataagttacacagttgtgccatttgtgcttctttctataaaaccatcactcacgttttacagctcctggtattattgcctgcacattcttggtatcttagtattattgttgttgccagtgaaaaaaactcaaagaagaaagaatacacatgaaaacattcagctctcacaatccaaaaagtttgatgaaggagaaaattctttgggacagaacagtttttctacaacaaacaatgtttgcaatcagaatcaagaaatagcctcgagacattcatcactaaagcagtgatcgggaaggctctgagggctgttttttttttttgatgttaacagaaaccaatcttagcaccttttcaaggggtttgagtttgttggaaaagcagttaactggggggaaatggacagttatagataaggaatttcctgtacaccagattggaaatggagtgaaacaagccctcccatgccatgtccccgtgggccacgccttatgtaagaatatttccatatttcagtgggcactcccaacctcagcacttgtccgtagggtcacacgcgtgccctgttgctgaatgtatgttgcgtatcccaaggcactgaagaggtggaaaaataatcgtgtcaatctggatgatagagagaaattaacttttccaaatgaatgtcttgccttaaaccctctatttcctaaaatattgttcctaaatggtattttcaagtgtaatattgtgagaacgctactgcagtagttgatgttgtgtgctgtaaaggattttaggaggaatttgaaacaggatatttaagagtgtggatatttttaaaatgcaataaacatctcagtatttgaagggttttcttaaagtatgtcaaatgactacaatccatagtgaaactgtaaacagtaatggacgccaaattataggtagctgattttgctggagagtttaattaccttgtgcagtcaaagagcgcttccagaaggaatctcttaaaacataatgagaggtttggtaatgtgatattttaagcttattctttttcttaaaagagagaggtgacgaaggaaggcaggaatgaagaagcactgcgtggcctccggtggaatgcacggggcacagccgcgactctgcaggcagcttcccccccatgccagggctctgcgccgtcatgtgagacttaaaaaaaaagttgaatgacttcgtgatactttggacttctaaattaaatttatcaggcataaattatgtagaattagaggctttgaaaataatactggtaggttgctcaaaggttttgaaagagaaatcgctaggtaggttactatctggctaatccatttcttatccttgacaatttaattcatatttgggaaacttttagggaaatgaaaaataaaagtcactgagtctgggtgacattttttaagaataatataaattcagtttcaaactcttctcacattaaaattttgctgtgaactcttactaaaatgagttttaggttctgtaagtggaaaaatgtgcttttattttatgggccatttttaccacaactaatcttgccttggattactaagcatctcctgcgatcccacagaggactgtggtggccacaggagctgaaagcagaagagtgggatttgatgccaggcagtggagtggcctcagccccagattgtacctcctgccctgtaggaggggagggggcaaagccttctgacttcacctttgtttgacctatgtatggaacttacttttactttttgccttaaatttttaatgaaatgcaaattttctgtgatggggttctctctctctttttttcggggggtggagtcactaataaatttgcaaatgaagttaaagacaaggcaaccatctggcttatgctatataatacttcatttaaagaagaaaggaaaagcaaatgcacttgcagcttttgaggtctcagcaaaaatgggcatgtgtcttttttgaagtttagaaatatcctaatctatttttatttatctaaaagtaagtgttttccggctgataaggctaaccctacccaggaaaggattgataactaaataaatttcctctgttttcccatgcattgaaattatgttggctgagcatggtggctcacacctgtaatcctagcactttgggaggccgaggtgggcggatcacttgaggtcaggagttggagaccagcctggccaacgtggtgaatccccgtctctactgaaaacacaaaaattagacgggcatggtggcgcacacctgtaatcccagctacttgggaggctgaggcaggagaattgcttgaacctgggaggtggaggttgcagtgagctaaaattgtgccactgcactccagcctgggtgacagaggaagactccgtctcac
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:129642 -> Molecular function: GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] evidence: IEA
GeneID:129642 -> Biological process: GO:0006644 [phospholipid metabolic process] evidence: TAS
GeneID:129642 -> Biological process: GO:0036151 [phosphatidylcholine acyl-chain remodeling] evidence: TAS
GeneID:129642 -> Biological process: GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] evidence: TAS
GeneID:129642 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:129642 -> Biological process: GO:0046474 [glycerophospholipid biosynthetic process] evidence: TAS
GeneID:129642 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:129642 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_620154 -> EC 2.3.1.51
NP_620154 -> EC 2.3.1.n7
by
@meso_cacase at
DBCLS
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