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2024-04-20 00:54:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138690 3270 bp mRNA linear PRI 14-MAY-2013
DEFINITION Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate
3B (GRIN3B), mRNA.
ACCESSION NM_138690 XM_290850
VERSION NM_138690.1 GI:62988345
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3270)
AUTHORS Saus,E., Brunet,A., Armengol,L., Alonso,P., Crespo,J.M.,
Fernandez-Aranda,F., Guitart,M., Martin-Santos,R., Menchon,J.M.,
Navines,R., Soria,V., Torrens,M., Urretavizcaya,M., Valles,V.,
Gratacos,M. and Estivill,X.
TITLE Comprehensive copy number variant (CNV) analysis of neuronal
pathways genes in psychiatric disorders identifies rare variants
within patients
JOURNAL J Psychiatr Res 44 (14), 971-978 (2010)
PUBMED 20398908
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 3270)
AUTHORS Sedaghati,M., Vousooghi,N., Goodarzi,A., Yaghmaei,P., Mokri,A. and
Zarrindast,M.R.
TITLE Expression of NR3B but not NR2D subunit of NMDA receptor in human
blood lymphocytes can serve as a suitable peripheral marker for
opioid addiction studies
JOURNAL Eur. J. Pharmacol. 633 (1-3), 50-54 (2010)
PUBMED 20153313
REMARK GeneRIF: our findings suggest that the over-expression of NR3B
subunit of NMDA receptor is a long lasting result of chronic opioid
abuse.
REFERENCE 3 (bases 1 to 3270)
AUTHORS Liu,H.P., Lin,W.Y., Liu,S.H., Wang,W.F., Tsai,C.H., Wu,B.T.,
Wang,C.K. and Tsai,F.J.
TITLE Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but
not NR3B influences susceptibility to Alzheimer's disease
JOURNAL Dement Geriatr Cogn Disord 28 (6), 521-527 (2009)
PUBMED 20016182
REMARK GeneRIF: These observations suggest that the genetic variation of
the NR3B subunit of the NMDA receptor is not a risk factor for
Alzheimer's dis pathogenesis
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 3270)
AUTHORS Niemann,S., Landers,J.E., Churchill,M.J., Hosler,B., Sapp,P.,
Speed,W.C., Lahn,B.T., Kidd,K.K., Brown,R.H. Jr. and Hayashi,Y.
TITLE Motoneuron-specific NR3B gene: no association with ALS and evidence
for a common null allele
JOURNAL Neurology 70 (9), 666-676 (2008)
PUBMED 17687115
REMARK GeneRIF: We tested whether genetic dysfunction of GRIN3B is
implicated in the pathogenesis of amyotrophic lateral sclerosis
(ALS).
REFERENCE 5 (bases 1 to 3270)
AUTHORS Lammi,J., Rajalin,A.M., Huppunen,J. and Aarnisalo,P.
TITLE Cross-talk between the NR3B and NR4A families of orphan nuclear
receptors
JOURNAL Biochem. Biophys. Res. Commun. 359 (2), 391-397 (2007)
PUBMED 17543277
REMARK GeneRIF: cross-talk between NR3B and NR4A receptors is a mechanism
modulating the transcriptional activities of these orphan nuclear
receptors
REFERENCE 6 (bases 1 to 3270)
AUTHORS Bendel,O., Meijer,B., Hurd,Y. and von Euler,G.
TITLE Cloning and expression of the human NMDA receptor subunit NR3B in
the adult human hippocampus
JOURNAL Neurosci. Lett. 377 (1), 31-36 (2005)
PUBMED 15722182
REMARK GeneRIF: NR3B mRNA expression in the human hippocampal formation
(CA1-CA4 and dentate gyrus) and adjacent neocortex may have
implications for understanding the role of NMDA receptors for
physiological and pathological processes in these forebrain
regions.
REFERENCE 7 (bases 1 to 3270)
AUTHORS Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
Myers,R.M., Rubin,E.M. and Lucas,S.M.
TITLE The DNA sequence and biology of human chromosome 19
JOURNAL Nature 428 (6982), 529-535 (2004)
PUBMED 15057824
REFERENCE 8 (bases 1 to 3270)
AUTHORS Nishi,M., Hinds,H., Lu,H.P., Kawata,M. and Hayashi,Y.
TITLE Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate
receptor subunit that works in a dominant-negative manner
JOURNAL J. Neurosci. 21 (23), RC185 (2001)
PUBMED 11717388
REFERENCE 9 (bases 1 to 3270)
AUTHORS Andersson,O., Stenqvist,A., Attersand,A. and von Euler,G.
TITLE Nucleotide sequence, genomic organization, and chromosomal
localization of genes encoding the human NMDA receptor subunits
NR3A and NR3B
JOURNAL Genomics 78 (3), 178-184 (2001)
PUBMED 11735224
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BK000070.1 and
CB243197.1.
On May 1, 2005 this sequence version replaced gi:51474946.
##Evidence-Data-START##
Transcript exon combination :: BK004079.1, AY507106.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2670 BK000070.1 1-2670
2671-3270 CB243197.1 1-600 c
FEATURES Location/Qualifiers
source 1..3270
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.3"
gene 1..3270
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="glutamate receptor, ionotropic,
N-methyl-D-aspartate 3B"
/db_xref="GeneID:116444"
/db_xref="HGNC:16768"
/db_xref="MIM:606651"
CDS 1..3132
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="glutamate [NMDA] receptor subunit 3B; NMDA type
glutamate receptor subunit NR3B; NMDA receptor subunit 3B;
NMDAR3B; glutamate receptor ionotropic, NMDA 3B;
N-methyl-D-aspartate receptor subtype 3B"
/codon_start=1
/product="glutamate receptor ionotropic, NMDA 3B
precursor"
/protein_id="NP_619635.1"
/db_xref="GI:62988346"
/db_xref="CCDS:CCDS32861.1"
/db_xref="GeneID:116444"
/db_xref="HGNC:16768"
/db_xref="MIM:606651"
/translation="
MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARAALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGCDIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPRRLLQARAAPAEAPPHSGRPGSQE
"
sig_peptide 1..66
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 67..3129
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/product="Glutamate receptor ionotropic, NMDA 3B"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O60391.2)"
misc_feature 67..1215
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="N-terminal leucine/isoleucine/valine-binding
protein (LIVBP)-like domain of the NR3 subunit of NMDA
receptor family; Region: PBP1_iGluR_NMDA_NR3; cd06377"
/db_xref="CDD:107372"
misc_feature order(253..255,259..264,271..276,367..369,562..564,
571..573,607..609,613..615)
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="putative dimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:107372"
misc_feature 1432..>1674
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="Bacterial periplasmic transport systems use
membrane-bound complexes and substrate-bound,
membrane-associated, periplasmic binding proteins (PBPs)
to transport a wide variety of substrates, such as, amino
acids, peptides, sugars, vitamins and inorganic...;
Region: PBPb; cd00134"
/db_xref="CDD:29040"
misc_feature 1693..1755
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O60391.2);
transmembrane region"
misc_feature 1726..2496
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="Ligand-gated ion channel; Region: Lig_chan;
pfam00060"
/db_xref="CDD:189368"
misc_feature 1945..2007
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O60391.2);
transmembrane region"
misc_feature 2026..2430
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/note="Eukaryotic homologues of bacterial periplasmic
substrate binding proteins; Region: PBPe; smart00079"
/db_xref="CDD:197504"
misc_feature 2491..2553
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O60391.2);
transmembrane region"
exon 1..426
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 427..1019
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 1020..2052
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 2053..2198
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 2199..2314
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 2315..2466
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 2467..2631
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 2632..2702
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
exon 2703..3254
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/inference="alignment:Splign:1.39.8"
variation complement(3243)
/gene="GRIN3B"
/gene_synonym="GluN3B; NR3B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058618"
ORIGIN
atggagtttgtgcgggcgctgtggctgggcctggcgctggcgctggggccggggtccgcggggggccaccctcagccgtgcggcgtcctggcgcgcctcgggggctccgtgcgcctgggcgccctcctgccccgcgcgcctctcgcccgcgcccgcgcccgcgccgccctggcccgggccgccctggcgccgcggctgccgcacaacctgagcttggagctggtggtcgccgcgccccccgcccgcgaccccgcctcgctgacccgcggcctgtgccaggcgctggtgcctccgggcgtggcggccctgctcgcctttcccgaggctcggcccgagctgctgcagctgcacttcctggcggcggccaccgagacccccgtgctcagcctgctgcggcgggaggcgcgcgcgcccctcggagccccgaacccattccacctgcagctgcactgggccagccccctggagacgctgctggatgtgctggtggcggtgctgcaggcgcacgcctgggaagacgtcggcctggccctgtgccgcactcaggaccccggcggcctggtggccctctggacaagccgggctggccggcccccacagctggtcctggacctaagccggcgggacacgggagatgcaggactgcgggcacgcctggccccgatggcggcgccagtggggggtgaagcaccggtacccgcggcggtcctcctcggctgtgacatcgcccgtgcccgtcgggtgctggaggccgtacctcccggcccccactggctgttggggacaccactgccgcccaaggccctgcccaccgcggggctgccaccagggctgctggcgctgggcgaggtggcacgacccccgctggaggccgccatccatgacattgtgcaactggtggcccgggcgctgggcagtgcggcccaggtgcagccgaagcgagccctcctccccgccccggtcaactgcggggacctgcagccggccgggcccgagtccccggggcgcttcttggcacggttcctggccaacacgtccttccagggccgcacgggccccgtgtgggtgacaggcagctcccaggtacacatgtctcggcactttaaggtgtggagccttcgccgggacccacggggcgccccggcctgggccacggtgggcagctggcgggacggccagctggacttggaaccgggaggtgcctctgcacggcccccgcccccacagggtgcccaggtctggcccaagctgcgtgtggtaacgctgttggaacacccatttgtgtttgcccgtgatccagacgaagacgggcagtgcccagcggggcagctgtgcctggaccctggcaccaacgactcggccaccctggacgcactgttcgccgcgctggccaacggctcagcgccccgtgccctgcgcaagtgctgctacggctactgcattgacctgctggagcggctggcggaggacacgcccttcgacttcgagctgtacctcgtgggtgacggcaagtacggcgccctgcgggacggccgctggaccggcctggtcggggacctgctggccggccgggcccacatggcggtcaccagcttcagtatcaactccgcccgctcacaggtggtggacttcaccagccccttcttctccaccagcctgggcatcatggtgcgggcacgggacacggcctcacccatcggtgcctttatgtggcccctgcactggtccacgtggctgggcgtctttgcggccctgcacctcaccgcgctcttcctcaccgtgtacgagtggcgtagcccctacggcctcacgccacgtggccgcaaccgcagcaccgtcttctcctactcctcagccctcaacctgtgctacgccatcctcttcagacgcaccgtgtccagcaagacgcccaagtgccccacgggccgcctgctcatgaacctctgggccatcttctgcctgctggtgctgtccagctacacggccaacctggctgccgtcatggtcggggacaagaccttcgaggagctgtcggggatccacgaccccaagctgcaccacccggcgcagggcttccgcttcggcaccgtgtgggagagcagcgccgaggcgtacatcaagaagagcttccccgacatgcacgcacacatgcggcgccacagcgcgcccaccacgccccgcggcgtcgccatgctcacgagcgacccccccaagctcaacgccttcatcatggacaagtcgctcctggactacgaggtctccatcgacgccgactgcaaactgctgaccgtgggaaagcccttcgccattgagggctatgggatcggactgccccagaactcgccgctcacctccaacctgtccgagttcatcagccgctacaagtcctccggcttcatcgacctgctccacgacaagtggtacaagatggtgccttgcggcaagcgggtctttgcggttacagagaccctgcagatgagcatctaccacttcgcgggcctcttcgtgttgctgtgcctgggcctgggcagcgctctgctcagctcgctgggcgagcacgccttcttccgcctggcgctgccgcgcatccgcaaggggagcaggctgcagtactggctgcacaccagccagaaaatccaccgcgccctcaacacggagccaccagaggggtcgaaggaggagacggcagaggcggagcccagcggccccgaggtggagcagcagcagcagcagcaggaccagccaacggctccggagggctggaaacgggcgcgccgggccgtggacaaggagcgccgcgtgcgcttcctgctggagcccgccgtggttgtggcacccgaagcggacgcggaggcggaggctgcgccgcgagagggccccgtctggctgtgctcctacggccgcccgcccgccgcaaggcccacgggggccccccagcccggggagctgcaggagctggagcgccgcatcgaagtcgcgcgtgagcggctccgccaggccctggtgcggcgcggccagctcctggcacagctcggggacagcgcacgtcaccggcctcggcgcttgcttcaggccagagcggcccccgcggaggccccaccacactctggccgaccggggagccaggaatgaggcggcagccgggccgtttgggctcaagacacacacacagcgcagtgagccgctgtcaacagacagtttattctatatacaaacacaattttgtacactgcaattaaatagaatggaatgagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:116444 -> Molecular function: GO:0004970 [ionotropic glutamate receptor activity] evidence: IEA
GeneID:116444 -> Molecular function: GO:0005234 [extracellular-glutamate-gated ion channel activity] evidence: IEA
GeneID:116444 -> Molecular function: GO:0005261 [cation channel activity] evidence: ISS
GeneID:116444 -> Molecular function: GO:0005262 [calcium channel activity] evidence: ISS
GeneID:116444 -> Molecular function: GO:0016594 [glycine binding] evidence: ISS
GeneID:116444 -> Molecular function: GO:0030594 [neurotransmitter receptor activity] evidence: ISS
GeneID:116444 -> Molecular function: GO:0042165 [neurotransmitter binding] evidence: ISS
GeneID:116444 -> Biological process: GO:0007268 [synaptic transmission] evidence: ISS
GeneID:116444 -> Biological process: GO:0035235 [ionotropic glutamate receptor signaling pathway] evidence: ISS
GeneID:116444 -> Biological process: GO:0051205 [protein insertion into membrane] evidence: ISS
GeneID:116444 -> Biological process: GO:0051924 [regulation of calcium ion transport] evidence: ISS
GeneID:116444 -> Cellular component: GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex] evidence: ISS
GeneID:116444 -> Cellular component: GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex] evidence: NAS
GeneID:116444 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:116444 -> Cellular component: GO:0043025 [neuronal cell body] evidence: ISS
GeneID:116444 -> Cellular component: GO:0045211 [postsynaptic membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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