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2024-04-27 05:21:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138625 4952 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11),
transcript variant 5, mRNA.
ACCESSION NM_138625
VERSION NM_138625.3 GI:323362956
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4952)
AUTHORS Hara,H., Takeda,T., Yamamoto,N., Furuya,K., Hirose,K., Kamiya,T.
and Adachi,T.
TITLE Zinc-induced modulation of SRSF6 activity alters Bim splicing to
promote generation of the most potent apoptotic isoform BimS
JOURNAL FEBS J. 280 (14), 3313-3327 (2013)
PUBMED 23648111
REFERENCE 2 (bases 1 to 4952)
AUTHORS Ha Thi,H.T., Lim,H.S., Kim,J., Kim,Y.M., Kim,H.Y. and Hong,S.
TITLE Transcriptional and post-translational regulation of Bim is
essential for TGF-beta and TNF-alpha-induced apoptosis of gastric
cancer cell
JOURNAL Biochim. Biophys. Acta 1830 (6), 3584-3592 (2013)
PUBMED 23500081
REFERENCE 3 (bases 1 to 4952)
AUTHORS Piazza,R., Magistroni,V., Mogavero,A., Andreoni,F., Ambrogio,C.,
Chiarle,R., Mologni,L., Bachmann,P.S., Lock,R.B., Collini,P.,
Pelosi,G. and Gambacorti-Passerini,C.
TITLE Epigenetic silencing of the proapoptotic gene BIM in anaplastic
large cell lymphoma through an MeCP2/SIN3a deacetylating complex
JOURNAL Neoplasia 15 (5), 511-522 (2013)
PUBMED 23633923
REFERENCE 4 (bases 1 to 4952)
AUTHORS Bean,G.R., Ganesan,Y.T., Dong,Y., Takeda,S., Liu,H., Chan,P.M.,
Huang,Y., Chodosh,L.A., Zambetti,G.P., Hsieh,J.J. and Cheng,E.H.
TITLE PUMA and BIM are required for oncogene inactivation-induced
apoptosis
JOURNAL Sci Signal 6 (268), RA20 (2013)
PUBMED 23532334
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 4952)
AUTHORS Sharma,A., Singh,K., Mazumder,S., Hill,B.T., Kalaycio,M. and
Almasan,A.
TITLE BECN1 and BIM interactions with MCL-1 determine fludarabine
resistance in leukemic B cells
JOURNAL Cell Death Dis 4, E628 (2013)
PUBMED 23681223
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4952)
AUTHORS Ng,K.P., Hillmer,A.M., Chuah,C.T., Juan,W.C., Ko,T.K., Teo,A.S.,
Ariyaratne,P.N., Takahashi,N., Sawada,K., Fei,Y., Soh,S., Lee,W.H.,
Huang,J.W., Allen,J.C. Jr., Woo,X.Y., Nagarajan,N., Kumar,V.,
Thalamuthu,A., Poh,W.T., Ang,A.L., Mya,H.T., How,G.F., Yang,L.Y.,
Koh,L.P., Chowbay,B., Chang,C.T., Nadarajan,V.S., Chng,W.J.,
Than,H., Lim,L.C., Goh,Y.T., Zhang,S., Poh,D., Tan,P., Seet,J.E.,
Ang,M.K., Chau,N.M., Ng,Q.S., Tan,D.S., Soda,M., Isobe,K.,
Nothen,M.M., Wong,T.Y., Shahab,A., Ruan,X., Cacheux-Rataboul,V.,
Sung,W.K., Tan,E.H., Yatabe,Y., Mano,H., Soo,R.A., Chin,T.M.,
Lim,W.T., Ruan,Y. and Ong,S.T.
TITLE A common BIM deletion polymorphism mediates intrinsic resistance
and inferior responses to tyrosine kinase inhibitors in cancer
JOURNAL Nat. Med. 18 (4), 521-528 (2012)
PUBMED 22426421
REMARK GeneRIF: the heterogeneity of tyrosine kinase inhibitors responses
across individuals and suggest the possibility of personalizing
therapy with BH3 mimetics to overcome BIM-polymorphism-associated
tyrosine kinase inhibitors resistance.
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 4952)
AUTHORS Huang,D.C., Adams,J.M. and Cory,S.
TITLE The conserved N-terminal BH4 domain of Bcl-2 homologues is
essential for inhibition of apoptosis and interaction with CED-4
JOURNAL EMBO J. 17 (4), 1029-1039 (1998)
PUBMED 9463381
REFERENCE 8 (bases 1 to 4952)
AUTHORS O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M.,
Cory,S. and Huang,D.C.
TITLE Bim: a novel member of the Bcl-2 family that promotes apoptosis
JOURNAL EMBO J. 17 (2), 384-395 (1998)
PUBMED 9430630
REFERENCE 9 (bases 1 to 4952)
AUTHORS Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J.
TITLE Serine phosphorylation of death agonist BAD in response to survival
factor results in binding to 14-3-3 not BCL-X(L)
JOURNAL Cell 87 (4), 619-628 (1996)
PUBMED 8929531
REFERENCE 10 (bases 1 to 4952)
AUTHORS Wang,K., Yin,X.M., Chao,D.T., Milliman,C.L. and Korsmeyer,S.J.
TITLE BID: a novel BH3 domain-only death agonist
JOURNAL Genes Dev. 10 (22), 2859-2869 (1996)
PUBMED 8918887
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC096670.1, AK290377.1,
AB071199.1 and AI268146.1.
This sequence is a reference standard in the RefSeqGene project.
On Feb 12, 2011 this sequence version replaced gi:46276876.
Summary: The protein encoded by this gene belongs to the BCL-2
protein family. BCL-2 family members form hetero- or homodimers and
act as anti- or pro-apoptotic regulators that are involved in a
wide variety of cellular activities. The protein encoded by this
gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to
interact with other members of the BCL-2 protein family and to act
as an apoptotic activator. The expression of this gene can be
induced by nerve growth factor (NGF), as well as by the forkhead
transcription factor FKHR-L1, which suggests a role of this gene in
neuronal and lymphocyte apoptosis. Transgenic studies of the mouse
counterpart suggested that this gene functions as an essential
initiator of apoptosis in thymocyte-negative selection. Several
alternatively spliced transcript variants of this gene have been
identified. [provided by RefSeq, Jun 2013].
Transcript Variant: This variant (5, also known as Bim-beta3) uses
an alternate splice site in the 5' coding region, contains an
alternate internal exon, and differs in the 3' coding region and
UTR, compared to variant 1. The resulting isoform (5) is shorter
and has a distinct C-terminus, compared to isoform 1. This record
was created to support clinical studies, but the encoded isoform
currently lacks experimental evidence.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AB071199.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025083 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
NMD candidate :: translation inferred
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-72 AC096670.1 78236-78307 c
73-288 AK290377.1 73-288
289-731 AB071199.1 1-443
732-4927 AC096670.1 30794-34989 c
4928-4952 AI268146.1 1-25 c
FEATURES Location/Qualifiers
source 1..4952
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q13"
gene 1..4952
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/note="BCL2-like 11 (apoptosis facilitator)"
/db_xref="GeneID:10018"
/db_xref="HGNC:994"
/db_xref="MIM:603827"
exon 1..275
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/inference="alignment:Splign:1.39.8"
variation 67..69
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="gcc"
/db_xref="dbSNP:5833391"
variation 72
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:1439286"
variation 75
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:3929143"
misc_feature 121..123
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/note="upstream in-frame stop codon"
variation 196
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:368164757"
variation 209
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:116907128"
exon 276..412
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/inference="alignment:Splign:1.39.8"
variation 285
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:189552070"
CDS 289..516
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/note="isoform 5 is encoded by transcript variant 5; bcl-2
interacting protein Bim; bcl-2 interacting mediator of
cell death; bcl-2-related ovarian death agonist"
/codon_start=1
/product="bcl-2-like protein 11 isoform 5"
/protein_id="NP_619531.1"
/db_xref="GI:20336323"
/db_xref="GeneID:10018"
/db_xref="HGNC:994"
/db_xref="MIM:603827"
/translation="
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQVSLCHPGWSALVRSWLTATSNSQVQAVLLPQPPK
"
misc_feature 298..408
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/note="Bim protein N-terminus; Region: Bim_N; pfam06773"
/db_xref="CDD:115431"
variation 327
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:112446582"
variation 342
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:140468882"
variation 365
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:375839187"
variation 382
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:200974474"
variation 386
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:370683853"
variation 388
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:151214891"
variation 390
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:150345581"
exon 413..528
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/inference="alignment:Splign:1.39.8"
variation 413
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:112161660"
variation 436
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:184006090"
variation 458
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:113135335"
variation 521
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:141009683"
exon 529..632
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/inference="alignment:Splign:1.39.8"
variation 559
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:114585494"
variation 562
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:141962978"
variation 578
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:143377281"
variation 590..591
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="c"
/db_xref="dbSNP:35807932"
variation 591
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:146318804"
variation 594
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:370016302"
variation 595
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:373945451"
variation 599
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:724710"
variation 614
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:142641143"
variation 622
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:376024148"
exon 633..4945
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/inference="alignment:Splign:1.39.8"
variation 635
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:142125092"
variation 659
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:193171782"
variation 666
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:374405413"
variation 673
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:185078669"
variation 687
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:138706378"
variation 697
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:150291943"
variation 719
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:372164447"
variation 723
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:375598912"
STS 729..871
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/standard_name="RH99076"
/db_xref="UniSTS:90012"
variation 743
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:200016050"
variation 744
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:202136894"
variation 749
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:376786434"
variation 758
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:73954977"
variation 763
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:10199276"
variation 799
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:111743396"
variation 810
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:7595612"
variation 818
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:12996100"
variation 839
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:73954978"
variation 858
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:12989846"
variation 863
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:114776970"
variation 956
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:115158848"
variation 1027
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:367628733"
variation 1030
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:116174114"
variation 1067
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:149549441"
variation 1110
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:115106683"
polyA_signal 1112..1117
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
polyA_site 1125
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
variation 1138
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:371903732"
variation 1242
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:72948380"
variation 1268
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="t"
/db_xref="dbSNP:143188267"
variation 1360
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:148236299"
variation 1374
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:141765222"
variation 1399
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:189977826"
variation 1480
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:73954981"
variation 1834
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:77565616"
variation 1971
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:146204948"
variation 1981
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="c"
/db_xref="dbSNP:181241895"
variation 1982
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:139230805"
variation 1987
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:373964210"
variation 1993
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:200499684"
variation 2009..2010
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="t"
/db_xref="dbSNP:68021656"
variation 2035..2036
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="aat"
/db_xref="dbSNP:375483724"
variation 2043
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:142335632"
variation 2061
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:112485457"
variation 2077
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:150522049"
variation 2123
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:74787552"
variation 2201
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:183793167"
variation 2233
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:368175038"
variation 2271
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:13422314"
variation 2307
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:72837819"
variation 2321..2322
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="ta"
/db_xref="dbSNP:113512595"
variation 2411
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="t"
/db_xref="dbSNP:1051222"
variation 2418
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:375194820"
variation 2439
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:149840577"
variation 2466
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="t"
/db_xref="dbSNP:10201912"
variation 2514
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:369746614"
variation 2552
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="t"
/db_xref="dbSNP:6750142"
variation 2553
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:6753785"
variation 2621
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:180695314"
variation 2660
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:144847549"
variation 2709
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:375517063"
variation 2736
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:112845179"
variation 2738
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:111569632"
variation 2791
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:118047556"
variation 2915..2916
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="g"
/db_xref="dbSNP:35247728"
variation 3038
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:148552232"
variation 3039
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:186316334"
variation 3064
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="t"
/db_xref="dbSNP:73954982"
STS 3082..3191
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/standard_name="WI-11737"
/db_xref="UniSTS:72182"
variation 3171
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:145582217"
variation 3176
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:191863875"
variation 3203
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:147688758"
variation 3312..3313
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="a"
/db_xref="dbSNP:377590041"
variation 3369
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:371870358"
variation 3476..3477
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="a"
/db_xref="dbSNP:370249195"
variation 3482
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:182097802"
variation 3487..3488
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="ct"
/db_xref="dbSNP:139489747"
variation 3618
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:186695504"
variation 3752
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:13421457"
variation 3798
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:113315090"
variation 3947
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:142474437"
variation 3967..3968
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="a"
/db_xref="dbSNP:372197396"
variation 4099
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:191596895"
variation 4128
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:76256675"
variation 4184..4185
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="t"
/db_xref="dbSNP:113356382"
variation 4254
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:369475391"
variation 4287
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="g"
/db_xref="dbSNP:151236568"
variation 4294
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:114720778"
variation 4333
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:377665630"
variation 4350
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="t"
/db_xref="dbSNP:73954983"
variation 4375
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:140452150"
variation 4572
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:371052885"
variation 4592
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="g"
/replace="t"
/db_xref="dbSNP:376059878"
variation 4655..4661
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="aacataa"
/db_xref="dbSNP:3833441"
variation 4661..4667
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace=""
/replace="tttatgt"
/db_xref="dbSNP:71801447"
variation 4661
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:200735948"
STS 4695..4817
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/standard_name="RH91369"
/db_xref="UniSTS:85445"
variation 4819
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="a"
/replace="g"
/db_xref="dbSNP:115389757"
variation 4855
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
/replace="c"
/replace="t"
/db_xref="dbSNP:73954984"
polyA_signal 4926..4931
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
polyA_site 4945
/gene="BCL2L11"
/gene_synonym="BAM; BIM; BOD"
ORIGIN
acttcgctccgcgcagccgcctggtctgcagtttgttggagctctgcgtccagcgccgctgccgctgccgccgccgccgccgccgccgccgccgccgccgccgccgccactaccaccacttgattcttgcagccaccctgcgaaccctgccacactgcgatcgcatcatcgcggtattcggttcgctgcgttcccgccgccaccgcctcggcgccctttcttggcccttgttcccccaaatgtctgactctgactctcggactgagaaacgcaagaaaaaaagaccaaatggcaaagcaaccttctgatgtaagttctgagtgtgaccgagaaggtagacaattgcagcctgcggagaggcctccccagctcagacctggggcccctacctccctacagacagagccacaagtctcactctgtcacccaggctggagtgcactggtgcgatcttggctcactgcaacctccaactcccaagttcaagcggttctcctgcctcagcctcccaagtagctgggattacagcttccatgaggcaggctgaacctgcagatatgcgcccagagatatggatcgcccaagagttgcggcgtattggagacgagtttaacgcttactatgcaaggagggtatttttgaataattaccaagcagccgaagaccacccacgaatggttatcttacgactgttacgttacattgtccgcctggtgtggagaatgcattgacaggttctttgcggagccgagataccatgcagacattttgcttgttcaaaccaacaagacccagcaccgcggtctcctggtgccattattatgcagccagcggttctcttgtggagggggcaggtgacgtttcagaagacaccgagctggatgggactacctttctgttcatcaccacacagcagaatttctaatggaagtttgttgtgaatgtaaaggagggagcattctttgctttttaatatacaaaccatggttttttggagcaggattttgtgtaagaatggtgtttacatgcagtgtgttttccccctcaccttcaataaggtttttcaaaaaggaaatggaaactttttaaccaatttgtgaataacttttgtattaaaattttaagaacctacggcctattctcagaggattatgtaacccctgcagtggaaactgagccagctaacttaaaaagctgccttagtttatttttagagattacagaatttttaaacagggagacgtgtgatatactccctcccttccctactattgcctctctgacctttttaaattatttttaataccaaaagagttcttttgaaatggaactgattaaaagggcagagggtctgttgccagcctgcattgatataccagtcccatttgtaaatatttacgtacctttataaattcagttgcatctgtggcaaaatttcagactatttttgcgtctttcctcatcactttttgtgatgcaactccagtctggactcagatgcatagatttggtccagtgtattttcatgataaagtgaaattgagtcagaacaagagttaatatctgcctgtatcttgcacagttcgagcgatctgttattaactgggaagcatttggtgttggttttcattccatttcgacgagcatgttattgggaagtattctgaagaggcaatagcagtaataacaacagacttaagtgctacgcccctttgtgctgctggcttttctggttgcaggctttcccatggtcacaggatgcactgtcagcatcaggtcccagagggccaccgtgtccattacagcagagtccagctgcagcatccagctcacgccctcatgggaattggcacaggcctggggcagggcttctgatggccatttgcttggcctcctgcattttagtccaactcacagtccactagcttcactcctttaaattcactttgaaacaggcctcatcccacttccaccagcaccatagaagaataattctgggcagaagtctgttttttttcatttttccaggacagttggatattgtcaggccacttgtgaccccagccatgtagtgagggtgctctttctctgtgcctgctccttatgagtgcagtggaaggaagccacacactggtcagtcatttcagaggcagcagatgcccagggagacccaagaaagagtcaggttagggagcagtgaaagtgaggagggaagacaattctgtgaactctgtaactcttaaaatttttgaaaactccatcgttaaacaacttttaaaagaaataactaaattttcaaatgagtaagcagtgccaccaactagtgttttgcccgatagaagagccagcatgttcacgttatttaaattaggtggaaaaatctaaacatttttatcttcataatttaaaaaatatatatgtatatattgcatattcactttttcctttaggtagagatgatttcaatccaaatactcttactttaaaaaatttcctttccccaagaatctccttgggactttgacttatttttaaagctgtgttggagctcatcttgttccctgatgtgtctcgagcccattggtagggtcatacaaagcccacggttacaagcagtggtaggattgcagccgtgggcctgctggacacacacatacaccaaagatgtatttggatctgggcaccccctcccaggatccctgtactcacgtgccagtctcctgactagagcactttactctgtttcctcagccctgcagcccctgggagcacacactgggtgcagccctgggccaggcacgggaggccctgccctgtgctgcccaggggctgtgtgcaccacatgagcacatttccctctggcctggcggcctccaggctggctgtggaaacagttcctgaggaaattagagattctatgaattgtaggagtattaaagaccaggctgttggcaccagaacttaaagcgatgactggatgtctctgtactgtatgtatctggttatcaagatgcctctgtgcagaaagtatgcctcccgtgggtatacgtttttaccttttttaaaaaacatttttgtagaaaaaataattaaatcccctttttggaaacttactgcaggttttgtgccttgacaacctctccctatgtgaggtttgtaaaaagtgtcctgtgacttaacacagaaacgcaataaacacacacaaaatagtttcatgagtgattcttcagatgcccttcccaactggttagttgatcaagaattttgggggtgggggttgcggagaaatcaagtttaaaattccttctgattaaaaaaatatagtggaatacaattgtctgccgtttccccttcttaatgtatatattgtgagtatttattagattcgtaggtcatattacttatcaactgagccaaatgtctgtgtgcaattgtgtttcctttaccttgtaaaattttgtacagcataaataagtaaaaaaatcactgtttttctcaactttttcaaaatcaaggattgtaaatattgtagattctttttctgtgtgatgtgtcctactgtttcataatgctgtaacttgtagaaatattgtatatttattttctgcttatttaatgtcttaatttctgaaaagtattaacatccctgtctcccactcccctgccgtcccatgaagttaactcctgagagttgtcgggggtgactggagagctcattgcagaccacgtggtcctccagggtggctctccaccttcgggtcctggtatttccagtcaagtgggtttcaattcttgggctttgccgcccttatgatgaagtgtgtgtttgatgccagtgagaaactcagtctggcaggctacaaaattctactccaagaaatacccagcaaccttctgtttgttccaaagcaactagcttatcatgcaagcaaattttgctgactccaggctttatctttaggaaaacaaaaaaaccaaagtattatcagcaggtgggaaagatttttctattgaaaatttatccctgacaactcagcgtttagaaaagaaataaaatgtgccacttccagaggtgctgcattgcagttgttcagggctagggccaggcaggacaagtgaatgggtgggacaggtggctcctgcctaaggaccacctcaggccactaaccccttgtggacaactgtgagtagctgggttttcccccacctgctgtgcaacttcctgtgctttgaggttggactaacttgtcttcaggagctaattaactgtacagccctccccacgccccacccatacggtcactgcatttggtcagcctgcttcttcaggtcgatgccctccttctgatactccatctccttcaggggaggttggggccccactggactgggtgtcaagatgtgaaagcttatgggagctttaaggagacttcatggtggttccatgcaggtggttctgccatccctgctgatttagcctggtgcctgtgtgtgtccactcacgtacacgtggggtgggggaaacgtgtctacagatgacgctaaatcagttggggtctactctaaacagcattgtgtgtaagaagcatcctcaagctcccagttaagtaacttgactacttttatttgggaatttcagactatagaagctctcttatgttttatgtccagattctgtgaccactagttactgtatcagaactcatcaggtacccacttataaatagcactgatctggctgtatactgatccatcactaacctgttttctaggacccagcgtatgtagcatttgtattgcagtttccctggcttacttgtgttttgcactgatgaattttgacagggtaattgccactttacttgtgcaatactgctgtaaataactgcagatttttaaacaatcttttatgttaattttataaaaataaaactttcaactagttaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10018 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IDA
GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA
GeneID:10018 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:10018 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:10018 -> Biological process: GO:0001782 [B cell homeostasis] evidence: IEA
GeneID:10018 -> Biological process: GO:0001783 [B cell apoptotic process] evidence: IEA
GeneID:10018 -> Biological process: GO:0001822 [kidney development] evidence: IEA
GeneID:10018 -> Biological process: GO:0002262 [myeloid cell homeostasis] evidence: IEA
GeneID:10018 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:10018 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:10018 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
GeneID:10018 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA
GeneID:10018 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA
GeneID:10018 -> Biological process: GO:0007420 [brain development] evidence: IEA
GeneID:10018 -> Biological process: GO:0008584 [male gonad development] evidence: IEA
GeneID:10018 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
GeneID:10018 -> Biological process: GO:0030879 [mammary gland development] evidence: IEA
GeneID:10018 -> Biological process: GO:0032464 [positive regulation of protein homooligomerization] evidence: IDA
GeneID:10018 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IDA
GeneID:10018 -> Biological process: GO:0035148 [tube formation] evidence: IEA
GeneID:10018 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA
GeneID:10018 -> Biological process: GO:0043029 [T cell homeostasis] evidence: IEA
GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP
GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS
GeneID:10018 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA
GeneID:10018 -> Biological process: GO:0043583 [ear development] evidence: IEA
GeneID:10018 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: IEA
GeneID:10018 -> Biological process: GO:0046620 [regulation of organ growth] evidence: IEA
GeneID:10018 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:10018 -> Biological process: GO:0048066 [developmental pigmentation] evidence: IEA
GeneID:10018 -> Biological process: GO:0048070 [regulation of developmental pigmentation] evidence: IEA
GeneID:10018 -> Biological process: GO:0048536 [spleen development] evidence: IEA
GeneID:10018 -> Biological process: GO:0048538 [thymus development] evidence: IEA
GeneID:10018 -> Biological process: GO:0048563 [post-embryonic organ morphogenesis] evidence: IEA
GeneID:10018 -> Biological process: GO:0060154 [cellular process regulating host cell cycle in response to virus] evidence: IEA
GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IGI
GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IMP
GeneID:10018 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:10018 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:10018 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS
GeneID:10018 -> Biological process: GO:2000271 [positive regulation of fibroblast apoptotic process] evidence: IDA
GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP
GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:10018 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS
GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:10018 -> Cellular component: GO:0005874 [microtubule] evidence: IDA
GeneID:10018 -> Cellular component: GO:0012505 [endomembrane system] evidence: IEA
GeneID:10018 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: IEA
GeneID:10018 -> Cellular component: GO:0097140 [BIM-BCL-xl complex] evidence: IDA
GeneID:10018 -> Cellular component: GO:0097141 [BIM-BCL-2 complex] evidence: IDA
by
@meso_cacase at
DBCLS
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