2024-04-23 23:01:29, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138624 5139 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 4, mRNA. ACCESSION NM_138624 VERSION NM_138624.3 GI:323362955 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5139) AUTHORS Hara,H., Takeda,T., Yamamoto,N., Furuya,K., Hirose,K., Kamiya,T. and Adachi,T. TITLE Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS JOURNAL FEBS J. 280 (14), 3313-3327 (2013) PUBMED 23648111 REFERENCE 2 (bases 1 to 5139) AUTHORS Ha Thi,H.T., Lim,H.S., Kim,J., Kim,Y.M., Kim,H.Y. and Hong,S. TITLE Transcriptional and post-translational regulation of Bim is essential for TGF-beta and TNF-alpha-induced apoptosis of gastric cancer cell JOURNAL Biochim. Biophys. Acta 1830 (6), 3584-3592 (2013) PUBMED 23500081 REFERENCE 3 (bases 1 to 5139) AUTHORS Piazza,R., Magistroni,V., Mogavero,A., Andreoni,F., Ambrogio,C., Chiarle,R., Mologni,L., Bachmann,P.S., Lock,R.B., Collini,P., Pelosi,G. and Gambacorti-Passerini,C. TITLE Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex JOURNAL Neoplasia 15 (5), 511-522 (2013) PUBMED 23633923 REFERENCE 4 (bases 1 to 5139) AUTHORS Bean,G.R., Ganesan,Y.T., Dong,Y., Takeda,S., Liu,H., Chan,P.M., Huang,Y., Chodosh,L.A., Zambetti,G.P., Hsieh,J.J. and Cheng,E.H. TITLE PUMA and BIM are required for oncogene inactivation-induced apoptosis JOURNAL Sci Signal 6 (268), RA20 (2013) PUBMED 23532334 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 5139) AUTHORS Sharma,A., Singh,K., Mazumder,S., Hill,B.T., Kalaycio,M. and Almasan,A. TITLE BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells JOURNAL Cell Death Dis 4, E628 (2013) PUBMED 23681223 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 5139) AUTHORS Ng,K.P., Hillmer,A.M., Chuah,C.T., Juan,W.C., Ko,T.K., Teo,A.S., Ariyaratne,P.N., Takahashi,N., Sawada,K., Fei,Y., Soh,S., Lee,W.H., Huang,J.W., Allen,J.C. Jr., Woo,X.Y., Nagarajan,N., Kumar,V., Thalamuthu,A., Poh,W.T., Ang,A.L., Mya,H.T., How,G.F., Yang,L.Y., Koh,L.P., Chowbay,B., Chang,C.T., Nadarajan,V.S., Chng,W.J., Than,H., Lim,L.C., Goh,Y.T., Zhang,S., Poh,D., Tan,P., Seet,J.E., Ang,M.K., Chau,N.M., Ng,Q.S., Tan,D.S., Soda,M., Isobe,K., Nothen,M.M., Wong,T.Y., Shahab,A., Ruan,X., Cacheux-Rataboul,V., Sung,W.K., Tan,E.H., Yatabe,Y., Mano,H., Soo,R.A., Chin,T.M., Lim,W.T., Ruan,Y. and Ong,S.T. TITLE A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer JOURNAL Nat. Med. 18 (4), 521-528 (2012) PUBMED 22426421 REMARK GeneRIF: the heterogeneity of tyrosine kinase inhibitors responses across individuals and suggest the possibility of personalizing therapy with BH3 mimetics to overcome BIM-polymorphism-associated tyrosine kinase inhibitors resistance. Publication Status: Online-Only REFERENCE 7 (bases 1 to 5139) AUTHORS Huang,D.C., Adams,J.M. and Cory,S. TITLE The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4 JOURNAL EMBO J. 17 (4), 1029-1039 (1998) PUBMED 9463381 REFERENCE 8 (bases 1 to 5139) AUTHORS O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M., Cory,S. and Huang,D.C. TITLE Bim: a novel member of the Bcl-2 family that promotes apoptosis JOURNAL EMBO J. 17 (2), 384-395 (1998) PUBMED 9430630 REFERENCE 9 (bases 1 to 5139) AUTHORS Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J. TITLE Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) JOURNAL Cell 87 (4), 619-628 (1996) PUBMED 8929531 REFERENCE 10 (bases 1 to 5139) AUTHORS Wang,K., Yin,X.M., Chao,D.T., Milliman,C.L. and Korsmeyer,S.J. TITLE BID: a novel BH3 domain-only death agonist JOURNAL Genes Dev. 10 (22), 2859-2869 (1996) PUBMED 8918887 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096670.1, AK290377.1, AB071197.1 and AI268146.1. This sequence is a reference standard in the RefSeqGene project. On Feb 12, 2011 this sequence version replaced gi:46276875. Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]. Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AB071197.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support ERS025081, ERS025083 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 AC096670.1 78236-78307 c 73-288 AK290377.1 73-288 289-785 AB071197.1 1-497 786-786 AC096670.1 49107-49107 c 787-918 AB071197.1 499-630 919-5114 AC096670.1 30794-34989 c 5115-5139 AI268146.1 1-25 c FEATURES Location/Qualifiers source 1..5139 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q13" gene 1..5139 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="BCL2-like 11 (apoptosis facilitator)" /db_xref="GeneID:10018" /db_xref="HGNC:994" /db_xref="MIM:603827" exon 1..275 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 67..69 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="gcc" /db_xref="dbSNP:5833391" variation 72 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:1439286" variation 75 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:3929143" misc_feature 121..123 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="upstream in-frame stop codon" variation 196 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:368164757" variation 209 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:116907128" exon 276..682 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 285 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:189552070" CDS 289..696 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="isoform 4 is encoded by transcript variant 4; bcl-2 interacting protein Bim; bcl-2 interacting mediator of cell death; bcl-2-related ovarian death agonist" /codon_start=1 /product="bcl-2-like protein 11 isoform 4" /protein_id="NP_619530.1" /db_xref="GI:20336321" /db_xref="CCDS:CCDS56134.1" /db_xref="GeneID:10018" /db_xref="HGNC:994" /db_xref="MIM:603827" /translation="
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMANWD
" misc_feature 298..408 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /note="Bim protein N-terminus; Region: Bim_N; pfam06773" /db_xref="CDD:115431" misc_feature 493..495 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by MAPK; propagated from UniProtKB/Swiss-Prot (O43521.1); phosphorylation site" variation 327 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:112446582" variation 342 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:140468882" variation 365 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:375839187" variation 382 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:200974474" variation 386 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:370683853" variation 388 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:151214891" variation 390 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:150345581" variation 428 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:199602272" variation 453 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:368816038" variation 476 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:376019476" variation 478 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:116642497" variation 497 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:142060590" variation 521 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:142670904" variation 542 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:372180669" variation 572 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375532454" exon 683..715 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 712 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:73954956" exon 716..819 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 746 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:114585494" variation 749 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:141962978" variation 765 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:143377281" variation 777..778 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="c" /db_xref="dbSNP:35807932" variation 778 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:146318804" variation 781 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:370016302" variation 782 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:373945451" variation 786 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:724710" variation 801 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:142641143" variation 809 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:376024148" exon 820..5132 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /inference="alignment:Splign:1.39.8" variation 822 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142125092" variation 846 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:193171782" variation 853 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:374405413" variation 860 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:185078669" variation 874 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:138706378" variation 884 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:150291943" variation 906 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:372164447" variation 910 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375598912" STS 916..1058 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="RH99076" /db_xref="UniSTS:90012" variation 930 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:200016050" variation 931 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:202136894" variation 936 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:376786434" variation 945 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:73954977" variation 950 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:10199276" variation 986 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:111743396" variation 997 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:7595612" variation 1005 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:12996100" variation 1026 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:73954978" variation 1045 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:12989846" variation 1050 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:114776970" variation 1143 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115158848" variation 1214 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:367628733" variation 1217 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:116174114" variation 1254 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:149549441" variation 1297 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115106683" polyA_signal 1299..1304 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" polyA_site 1318 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" variation 1325 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371903732" variation 1429 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:72948380" variation 1455 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:143188267" variation 1547 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:148236299" variation 1561 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:141765222" variation 1586 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:189977826" variation 1667 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:73954981" variation 2021 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:77565616" variation 2158 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:146204948" variation 2168 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="c" /db_xref="dbSNP:181241895" variation 2169 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:139230805" variation 2174 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:373964210" variation 2180 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:200499684" variation 2196..2197 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="t" /db_xref="dbSNP:68021656" variation 2222..2223 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="aat" /db_xref="dbSNP:375483724" variation 2230 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142335632" variation 2248 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:112485457" variation 2264 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:150522049" variation 2310 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:74787552" variation 2388 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:183793167" variation 2420 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:368175038" variation 2458 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:13422314" variation 2494 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:72837819" variation 2508..2509 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="ta" /db_xref="dbSNP:113512595" variation 2598 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:1051222" variation 2605 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:375194820" variation 2626 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:149840577" variation 2653 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:10201912" variation 2701 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:369746614" variation 2739 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:6750142" variation 2740 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:6753785" variation 2808 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:180695314" variation 2847 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:144847549" variation 2896 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:375517063" variation 2923 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:112845179" variation 2925 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:111569632" variation 2978 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:118047556" variation 3102..3103 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="g" /db_xref="dbSNP:35247728" variation 3225 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:148552232" variation 3226 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:186316334" variation 3251 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:73954982" STS 3269..3378 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="WI-11737" /db_xref="UniSTS:72182" variation 3358 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:145582217" variation 3363 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:191863875" variation 3390 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:147688758" variation 3499..3500 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:377590041" variation 3556 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371870358" variation 3663..3664 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:370249195" variation 3669 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:182097802" variation 3674..3675 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="ct" /db_xref="dbSNP:139489747" variation 3805 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:186695504" variation 3939 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:13421457" variation 3985 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:113315090" variation 4134 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:142474437" variation 4154..4155 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="a" /db_xref="dbSNP:372197396" variation 4286 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:191596895" variation 4315 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:76256675" variation 4371..4372 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="t" /db_xref="dbSNP:113356382" variation 4441 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:369475391" variation 4474 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="g" /db_xref="dbSNP:151236568" variation 4481 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:114720778" variation 4520 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:377665630" variation 4537 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="t" /db_xref="dbSNP:73954983" variation 4562 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:140452150" variation 4759 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:371052885" variation 4779 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="g" /replace="t" /db_xref="dbSNP:376059878" variation 4842..4848 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="aacataa" /db_xref="dbSNP:3833441" variation 4848..4854 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="" /replace="tttatgt" /db_xref="dbSNP:71801447" variation 4848 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:200735948" STS 4882..5004 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /standard_name="RH91369" /db_xref="UniSTS:85445" variation 5006 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="a" /replace="g" /db_xref="dbSNP:115389757" variation 5042 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" /replace="c" /replace="t" /db_xref="dbSNP:73954984" polyA_signal 5113..5118 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" polyA_site 5132 /gene="BCL2L11" /gene_synonym="BAM; BIM; BOD" ORIGIN
acttcgctccgcgcagccgcctggtctgcagtttgttggagctctgcgtccagcgccgctgccgctgccgccgccgccgccgccgccgccgccgccgccgccgccgccactaccaccacttgattcttgcagccaccctgcgaaccctgccacactgcgatcgcatcatcgcggtattcggttcgctgcgttcccgccgccaccgcctcggcgccctttcttggcccttgttcccccaaatgtctgactctgactctcggactgagaaacgcaagaaaaaaagaccaaatggcaaagcaaccttctgatgtaagttctgagtgtgaccgagaaggtagacaattgcagcctgcggagaggcctccccagctcagacctggggcccctacctccctacagacagagccacaaggtaatcctgaaggcaatcacggaggtgaaggggacagctgcccccacggcagccctcagggcccgctggccccacctgccagccctggcccttttgctaccagatccccgcttttcatctttatgagaagatcctccctgctgtctcgatcctccagtgggtatttctcttttgacacagacaggagcccagcacccatgagttgtgacaaatcaacacaaaccccaagtcctccttgccaggccttcaaccactatctcagtgcaatggctaactgggactagaaacagctccatcacccagcttccatgaggcaggctgaacctgcagatatgcgcccagagatatggatcgcccaagagttgcggcgtattggagacgagtttaacgcttactatgcaaggagggtatttttgaataattaccaagcagccgaagaccacccacgaatggttatcttacgactgttacgttacattgtccgcctggtgtggagaatgcattgacaggttctttgcggagccgagataccatgcagacattttgcttgttcaaaccaacaagacccagcaccgcggtctcctggtgccattattatgcagccagcggttctcttgtggagggggcaggtgacgtttcagaagacaccgagctggatgggactacctttctgttcatcaccacacagcagaatttctaatggaagtttgttgtgaatgtaaaggagggagcattctttgctttttaatatacaaaccatggttttttggagcaggattttgtgtaagaatggtgtttacatgcagtgtgttttccccctcaccttcaataaggtttttcaaaaaggaaatggaaactttttaaccaatttgtgaataacttttgtattaaaattttaagaacctacggcctattctcagaggattatgtaacccctgcagtggaaactgagccagctaacttaaaaagctgccttagtttatttttagagattacagaatttttaaacagggagacgtgtgatatactccctcccttccctactattgcctctctgacctttttaaattatttttaataccaaaagagttcttttgaaatggaactgattaaaagggcagagggtctgttgccagcctgcattgatataccagtcccatttgtaaatatttacgtacctttataaattcagttgcatctgtggcaaaatttcagactatttttgcgtctttcctcatcactttttgtgatgcaactccagtctggactcagatgcatagatttggtccagtgtattttcatgataaagtgaaattgagtcagaacaagagttaatatctgcctgtatcttgcacagttcgagcgatctgttattaactgggaagcatttggtgttggttttcattccatttcgacgagcatgttattgggaagtattctgaagaggcaatagcagtaataacaacagacttaagtgctacgcccctttgtgctgctggcttttctggttgcaggctttcccatggtcacaggatgcactgtcagcatcaggtcccagagggccaccgtgtccattacagcagagtccagctgcagcatccagctcacgccctcatgggaattggcacaggcctggggcagggcttctgatggccatttgcttggcctcctgcattttagtccaactcacagtccactagcttcactcctttaaattcactttgaaacaggcctcatcccacttccaccagcaccatagaagaataattctgggcagaagtctgttttttttcatttttccaggacagttggatattgtcaggccacttgtgaccccagccatgtagtgagggtgctctttctctgtgcctgctccttatgagtgcagtggaaggaagccacacactggtcagtcatttcagaggcagcagatgcccagggagacccaagaaagagtcaggttagggagcagtgaaagtgaggagggaagacaattctgtgaactctgtaactcttaaaatttttgaaaactccatcgttaaacaacttttaaaagaaataactaaattttcaaatgagtaagcagtgccaccaactagtgttttgcccgatagaagagccagcatgttcacgttatttaaattaggtggaaaaatctaaacatttttatcttcataatttaaaaaatatatatgtatatattgcatattcactttttcctttaggtagagatgatttcaatccaaatactcttactttaaaaaatttcctttccccaagaatctccttgggactttgacttatttttaaagctgtgttggagctcatcttgttccctgatgtgtctcgagcccattggtagggtcatacaaagcccacggttacaagcagtggtaggattgcagccgtgggcctgctggacacacacatacaccaaagatgtatttggatctgggcaccccctcccaggatccctgtactcacgtgccagtctcctgactagagcactttactctgtttcctcagccctgcagcccctgggagcacacactgggtgcagccctgggccaggcacgggaggccctgccctgtgctgcccaggggctgtgtgcaccacatgagcacatttccctctggcctggcggcctccaggctggctgtggaaacagttcctgaggaaattagagattctatgaattgtaggagtattaaagaccaggctgttggcaccagaacttaaagcgatgactggatgtctctgtactgtatgtatctggttatcaagatgcctctgtgcagaaagtatgcctcccgtgggtatacgtttttaccttttttaaaaaacatttttgtagaaaaaataattaaatcccctttttggaaacttactgcaggttttgtgccttgacaacctctccctatgtgaggtttgtaaaaagtgtcctgtgacttaacacagaaacgcaataaacacacacaaaatagtttcatgagtgattcttcagatgcccttcccaactggttagttgatcaagaattttgggggtgggggttgcggagaaatcaagtttaaaattccttctgattaaaaaaatatagtggaatacaattgtctgccgtttccccttcttaatgtatatattgtgagtatttattagattcgtaggtcatattacttatcaactgagccaaatgtctgtgtgcaattgtgtttcctttaccttgtaaaattttgtacagcataaataagtaaaaaaatcactgtttttctcaactttttcaaaatcaaggattgtaaatattgtagattctttttctgtgtgatgtgtcctactgtttcataatgctgtaacttgtagaaatattgtatatttattttctgcttatttaatgtcttaatttctgaaaagtattaacatccctgtctcccactcccctgccgtcccatgaagttaactcctgagagttgtcgggggtgactggagagctcattgcagaccacgtggtcctccagggtggctctccaccttcgggtcctggtatttccagtcaagtgggtttcaattcttgggctttgccgcccttatgatgaagtgtgtgtttgatgccagtgagaaactcagtctggcaggctacaaaattctactccaagaaatacccagcaaccttctgtttgttccaaagcaactagcttatcatgcaagcaaattttgctgactccaggctttatctttaggaaaacaaaaaaaccaaagtattatcagcaggtgggaaagatttttctattgaaaatttatccctgacaactcagcgtttagaaaagaaataaaatgtgccacttccagaggtgctgcattgcagttgttcagggctagggccaggcaggacaagtgaatgggtgggacaggtggctcctgcctaaggaccacctcaggccactaaccccttgtggacaactgtgagtagctgggttttcccccacctgctgtgcaacttcctgtgctttgaggttggactaacttgtcttcaggagctaattaactgtacagccctccccacgccccacccatacggtcactgcatttggtcagcctgcttcttcaggtcgatgccctccttctgatactccatctccttcaggggaggttggggccccactggactgggtgtcaagatgtgaaagcttatgggagctttaaggagacttcatggtggttccatgcaggtggttctgccatccctgctgatttagcctggtgcctgtgtgtgtccactcacgtacacgtggggtgggggaaacgtgtctacagatgacgctaaatcagttggggtctactctaaacagcattgtgtgtaagaagcatcctcaagctcccagttaagtaacttgactacttttatttgggaatttcagactatagaagctctcttatgttttatgtccagattctgtgaccactagttactgtatcagaactcatcaggtacccacttataaatagcactgatctggctgtatactgatccatcactaacctgttttctaggacccagcgtatgtagcatttgtattgcagtttccctggcttacttgtgttttgcactgatgaattttgacagggtaattgccactttacttgtgcaatactgctgtaaataactgcagatttttaaacaatcttttatgttaattttataaaaataaaactttcaactagttaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:10018 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IDA GeneID:10018 -> Molecular function: GO:0008017 [microtubule binding] evidence: IEA GeneID:10018 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA GeneID:10018 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA GeneID:10018 -> Biological process: GO:0001782 [B cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0001783 [B cell apoptotic process] evidence: IEA GeneID:10018 -> Biological process: GO:0001822 [kidney development] evidence: IEA GeneID:10018 -> Biological process: GO:0002262 [myeloid cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:10018 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS GeneID:10018 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA GeneID:10018 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IEA GeneID:10018 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA GeneID:10018 -> Biological process: GO:0007420 [brain development] evidence: IEA GeneID:10018 -> Biological process: GO:0008584 [male gonad development] evidence: IEA GeneID:10018 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA GeneID:10018 -> Biological process: GO:0030879 [mammary gland development] evidence: IEA GeneID:10018 -> Biological process: GO:0032464 [positive regulation of protein homooligomerization] evidence: IDA GeneID:10018 -> Biological process: GO:0034976 [response to endoplasmic reticulum stress] evidence: IDA GeneID:10018 -> Biological process: GO:0035148 [tube formation] evidence: IEA GeneID:10018 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA GeneID:10018 -> Biological process: GO:0043029 [T cell homeostasis] evidence: IEA GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP GeneID:10018 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS GeneID:10018 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA GeneID:10018 -> Biological process: GO:0043583 [ear development] evidence: IEA GeneID:10018 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: IEA GeneID:10018 -> Biological process: GO:0046620 [regulation of organ growth] evidence: IEA GeneID:10018 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:0048066 [developmental pigmentation] evidence: IEA GeneID:10018 -> Biological process: GO:0048070 [regulation of developmental pigmentation] evidence: IEA GeneID:10018 -> Biological process: GO:0048536 [spleen development] evidence: IEA GeneID:10018 -> Biological process: GO:0048538 [thymus development] evidence: IEA GeneID:10018 -> Biological process: GO:0048563 [post-embryonic organ morphogenesis] evidence: IEA GeneID:10018 -> Biological process: GO:0060154 [cellular process regulating host cell cycle in response to virus] evidence: IEA GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IGI GeneID:10018 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IMP GeneID:10018 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Biological process: GO:2000271 [positive regulation of fibroblast apoptotic process] evidence: IDA GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IMP GeneID:10018 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: TAS GeneID:10018 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:10018 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:10018 -> Cellular component: GO:0005874 [microtubule] evidence: IDA GeneID:10018 -> Cellular component: GO:0012505 [endomembrane system] evidence: IEA GeneID:10018 -> Cellular component: GO:0019898 [extrinsic to membrane] evidence: IEA GeneID:10018 -> Cellular component: GO:0097140 [BIM-BCL-xl complex] evidence: IDA GeneID:10018 -> Cellular component: GO:0097141 [BIM-BCL-2 complex] evidence: IDA
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