2024-04-20 18:36:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138578 2575 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens BCL2-like 1 (BCL2L1), transcript variant 1, mRNA. ACCESSION NM_138578 VERSION NM_138578.1 GI:20336334 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2575) AUTHORS Casanelles,E., Gozzelino,R., Marques-Fernandez,F., Iglesias-Guimarais,V., Garcia-Belinchon,M., Sanchez-Osuna,M., Sole,C., Moubarak,R.S., Comella,J.X. and Yuste,V.J. TITLE NF-kappaB activation fails to protect cells to TNFalpha-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w JOURNAL Biochim. Biophys. Acta 1833 (5), 1085-1095 (2013) PUBMED 23369735 REMARK GeneRIF: This indicates that TNFalpha-induced apoptosis in SR-IkappaBalpha-overexpressing cells relies on the protein levels of Bcl-xL. REFERENCE 2 (bases 1 to 2575) AUTHORS Rahmani,M., Aust,M.M., Attkisson,E., Williams,D.C. Jr., Ferreira-Gonzalez,A. and Grant,S. TITLE Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism JOURNAL Cancer Res. 73 (4), 1340-1351 (2013) PUBMED 23243017 REMARK GeneRIF: Findings suggest that inhibiton of Bcl-2, Bcl-xL and PI3K, and release of Bim from Bcl-2/Bcl-xL and GSK3alpha/beta culminating in Bax/Bak activation and apoptosis. REFERENCE 3 (bases 1 to 2575) AUTHORS Todt,F., Cakir,Z., Reichenbach,F., Youle,R.J. and Edlich,F. TITLE The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria JOURNAL Cell Death Differ. 20 (2), 333-342 (2013) PUBMED 23079612 REMARK GeneRIF: the importance of the C-terminal membrane anchor of Bcl-xL for both Bax and Bcl-xL retrotranslocation. REFERENCE 4 (bases 1 to 2575) AUTHORS Geng,X., Huang,C., Qin,Y., McCombs,J.E., Yuan,Q., Harry,B.L., Palmer,A.E., Xia,N.S. and Xue,D. TITLE Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (45), 18471-18476 (2012) PUBMED 23091012 REMARK GeneRIF: HBx targets Bcl-2 proteins through its BH3-like motif to promote cytosolic calcium elevation, cell death, and viral replication. REFERENCE 5 (bases 1 to 2575) AUTHORS Zhan,Z., He,K., Zhu,D., Jiang,D., Huang,Y.H., Li,Y., Sun,C. and Jin,Y.H. TITLE Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xL JOURNAL PLoS ONE 7 (9), E44923 (2012) PUBMED 23028682 REMARK GeneRIF: cyclin A-Cdk2 regulates apoptosis through a mechanism that involves Rad9phosphorylation REFERENCE 6 (bases 1 to 2575) AUTHORS Broome,H.E., Dargan,C.M., Krajewski,S. and Reed,J.C. TITLE Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal JOURNAL J. Immunol. 155 (5), 2311-2317 (1995) PUBMED 7650367 REFERENCE 7 (bases 1 to 2575) AUTHORS Sedlak,T.W., Oltvai,Z.N., Yang,E., Wang,K., Boise,L.H., Thompson,C.B. and Korsmeyer,S.J. TITLE Multiple Bcl-2 family members demonstrate selective dimerizations with Bax JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7834-7838 (1995) PUBMED 7644501 REFERENCE 8 (bases 1 to 2575) AUTHORS Jaattela,M., Benedict,M., Tewari,M., Shayman,J.A. and Dixit,V.M. TITLE Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells JOURNAL Oncogene 10 (12), 2297-2305 (1995) PUBMED 7540278 REFERENCE 9 (bases 1 to 2575) AUTHORS Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and Korsmeyer,S.J. TITLE Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death JOURNAL Cell 80 (2), 285-291 (1995) PUBMED 7834748 REFERENCE 10 (bases 1 to 2575) AUTHORS Boise,L.H., Gonzalez-Garcia,M., Postema,C.E., Ding,L., Lindsten,T., Turka,L.A., Mao,X., Nunez,G. and Thompson,C.B. TITLE bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death JOURNAL Cell 74 (4), 597-608 (1993) PUBMED 8358789 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC019307.1. This sequence is a reference standard in the RefSeqGene project. Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) is also known as bcl-xL. It encodes a longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019307.1, BQ927754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. FEATURES Location/Qualifiers source 1..2575 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20q11.21" gene 1..2575 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="BCL2-like 1" /db_xref="GeneID:598" /db_xref="HGNC:992" /db_xref="HPRD:02497" /db_xref="MIM:600039" exon 1..236 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /inference="alignment:Splign:1.39.8" exon 237..930 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /inference="alignment:Splign:1.39.8" STS 246..764 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="BCL2L1" /db_xref="UniSTS:505873" STS 273..348 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC92563P3" /db_xref="UniSTS:273621" misc_feature 316..318 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="upstream in-frame stop codon" STS 328..1091 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="Bcl2l" /db_xref="UniSTS:141168" STS 364..1088 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC196230P1" /db_xref="UniSTS:271802" CDS 367..1068 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="isoform 1 is encoded by transcript variant 1; bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52" /codon_start=1 /product="bcl-2-like protein 1 isoform 1" /protein_id="NP_612815.1" /db_xref="GI:20336335" /db_xref="CCDS:CCDS13189.1" /db_xref="GeneID:598" /db_xref="HGNC:992" /db_xref="HPRD:02497" /db_xref="MIM:600039" /translation="
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
" misc_feature 367..1065 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="apoptosis regulator; Region: bcl-2; TIGR00865" /db_xref="CDD:162075" misc_feature 367..447 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="Bcl-2 homology region 4; Region: BH4; pfam02180" /db_xref="CDD:145370" misc_feature 376..438 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q07817.1); Region: BH4" misc_feature 490..492 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:00253" misc_feature 511..513 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PLK3; propagated from UniProtKB/Swiss-Prot (Q07817.1); phosphorylation site" misc_feature 547..552 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="Cleavage, by caspase-1; propagated from UniProtKB/Swiss-Prot (Q07817.1); cleavage site" misc_feature 547..549 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:00977" misc_feature 550..552 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by CDK1; propagated from UniProtKB/Swiss-Prot (Q07817.1); phosphorylation site" misc_feature <607..948 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; Region: Bcl-2_like; cd06845" /db_xref="CDD:132900" misc_feature 622..666 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q07817.1); Region: BH3" misc_feature 634..660 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="BH3; other site" /db_xref="CDD:132900" misc_feature order(643..648,652..657,667..669,676..681,727..732, 739..744,751..756,772..774,778..783,787..792,802..804, 814..816,946..948) /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="BH3-homology region binding site; other site" /db_xref="CDD:132900" misc_feature 751..810 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q07817.1); Region: BH1" misc_feature order(751..759,769..807) /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="BH1; other site" /db_xref="CDD:132900" misc_feature 904..951 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q07817.1); Region: BH2" misc_feature 904..948 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /note="BH2; other site" /db_xref="CDD:132900" misc_feature 994..1044 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q07817.1); transmembrane region" variation 405 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="c" /replace="t" /db_xref="dbSNP:11550474" variation 495 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="g" /replace="t" /db_xref="dbSNP:11550476" variation 556 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="a" /replace="g" /db_xref="dbSNP:11550473" STS 612..868 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC20354P5" /db_xref="UniSTS:271938" STS 613..789 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC156147P6" /db_xref="UniSTS:271383" STS 652..1064 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC316415P1" /db_xref="UniSTS:272987" STS 672..884 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC300830P1" /db_xref="UniSTS:272474" STS 726..907 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="PMC262691P2" /db_xref="UniSTS:272324" exon 931..2559 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /inference="alignment:Splign:1.39.8" variation 1043 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="c" /replace="t" /db_xref="dbSNP:11550472" variation 1193 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="g" /replace="t" /db_xref="dbSNP:11550475" variation 1220 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="c" /replace="t" /db_xref="dbSNP:10861" variation 1982 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="a" /replace="c" /db_xref="dbSNP:3208680" variation 2001 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="c" /replace="t" /db_xref="dbSNP:3208681" variation 2002 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="c" /replace="g" /db_xref="dbSNP:3208682" variation 2006 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="c" /replace="g" /db_xref="dbSNP:3208683" variation 2015 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /replace="a" /replace="c" /db_xref="dbSNP:3208684" STS 2274..2558 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" /standard_name="RH25072" /db_xref="UniSTS:90736" polyA_signal 2536..2541 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" polyA_site 2559 /gene="BCL2L1" /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52" ORIGIN
ggaggaggaagcaagcgagggggctggttcctgagcttcgcaattcctgtgtcgccttctgggctcccagcctgccgggtcgcatgatccctccggccggagctggtttttttgccagccaccgcgaggccggctgagttaccggcatccccgcagccacctcctctcccgacctgtgatacaaaagatcttccgggggctgcacctgcctgcctttgcctaaggcggatttgaatctctttctctcccttcagaatcttatcttggctttggatcttagaagagaatcactaaccagagacgagactcagtgagtgagcaggtgttttggacaatggactggttgagcccatccctattataaaaatgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaaggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaagggactgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggcagacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtgatccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcggtaccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatatcagagctttgaacaggtagtgaatgaactcttccgggatggggtaaactggggtcgcattgtggcctttttctccttcggcggggcactgtgcgtggaaagcgtagacaaggagatgcaggtattggtgagtcggatcgcagcttggatggccacttacctgaatgaccacctagagccttggatccaggagaacggcggctgggatacttttgtggaactctatgggaacaatgcagcagccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtggccggcgtggttctgctgggctcactcttcagtcggaaatgaccagacactgaccatccactctaccctcccacccccttctctgctccaccacatcctccgtccagccgccattgccaccaggagaaccactacatgcagcccatgcccacctgcccatcacagggttgggcccagatctggtcccttgcagctagttttctagaatttatcacacttctgtgagacccccacacctcagttcccttggcctcagaattcacaaaatttccacaaaatctgtccaaaggaggctggcaggtatggaagggtttgtggctgggggcaggagggccctacctgattggtgcaacccttaccccttagcctccctgaaaatgtttttctgccagggagcttgaaagttttcagaacctcttccccagaaaggagactagattgcctttgttttgatgtttgtggcctcagaattgatcattttccccccactctccccacactaacctgggttccctttccttccatccctaccccctaagagccatttaggggccacttttgactagggattcaggctgcttgggataaagatgcaaggaccaggactccctcctcacctctggactggctagagtcctcactcccagtccaaatgtcctccagaagcctctggctagaggccagccccacccaggagggagggggctatagctacaggaagcaccccatgccaaagctagggtggcccttgcagttcagcaccaccctagtcccttcccctccctggctcccatgaccatactgagggaccaactgggcccaagacagatgccccagagctgtttatggcctcagctgcctcacttcctacaagagcagcctgtggcatctttgccttgggctgctcctcatggtgggttcaggggactcagccctgaggtgaaagggagctatcaggaacagctatgggagccccagggtcttccctacctcaggcaggaagggcaggaaggagagcctgctgcatggggtggggtagggctgactagaagggccagtcctgcctggccaggcagatctgtgccccatgcctgtccagcctgggcagccaggctgccaaggccagagtggcctggccaggagctcttcaggcctccctctctcttctgctccacccttggcctgtctcatccccaggggtcccagccaccccgggctctctgctgtacatatttgagactagtttttattccttgtgaagatgatatactatttttgttaagcgtgtctgtatttatgtgtgaggagctgctggcttgcagtgcgcgtgcacgtggagagctggtgcccggagattggacggcctgatgctccctcccctgccctggtccagggaagctggccgagggtcctggctcctgaggggcatctgcccctcccccaacccccaccccacacttgttccagctctttgaaatagtctgtgtgaaggtgaaagtgcagttcagtaataaactgtgtttactcagtgaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:598 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:598 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI GeneID:598 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:598 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA GeneID:598 -> Molecular function: GO:0051434 [BH3 domain binding] evidence: IPI GeneID:598 -> Biological process: GO:0000910 [cytokinesis] evidence: IMP GeneID:598 -> Biological process: GO:0001541 [ovarian follicle development] evidence: IEA GeneID:598 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA GeneID:598 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IDA GeneID:598 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:598 -> Biological process: GO:0007093 [mitotic cell cycle checkpoint] evidence: IMP GeneID:598 -> Biological process: GO:0007281 [germ cell development] evidence: IEA GeneID:598 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA GeneID:598 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA GeneID:598 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA GeneID:598 -> Biological process: GO:0008584 [male gonad development] evidence: IEA GeneID:598 -> Biological process: GO:0008637 [apoptotic mitochondrial changes] evidence: TAS GeneID:598 -> Biological process: GO:0009566 [fertilization] evidence: IEA GeneID:598 -> Biological process: GO:0010507 [negative regulation of autophagy] evidence: TAS GeneID:598 -> Biological process: GO:0019050 [suppression by virus of host apoptotic process] evidence: IDA GeneID:598 -> Biological process: GO:0034097 [response to cytokine stimulus] evidence: IDA GeneID:598 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS GeneID:598 -> Biological process: GO:0040007 [growth] evidence: IEA GeneID:598 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA GeneID:598 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA GeneID:598 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP GeneID:598 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IEA GeneID:598 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:598 -> Biological process: GO:0046898 [response to cycloheximide] evidence: IEA GeneID:598 -> Biological process: GO:0046902 [regulation of mitochondrial membrane permeability] evidence: IDA GeneID:598 -> Biological process: GO:0051881 [regulation of mitochondrial membrane potential] evidence: IDA GeneID:598 -> Biological process: GO:0060154 [cellular process regulating host cell cycle in response to virus] evidence: IEA GeneID:598 -> Biological process: GO:0071230 [cellular response to amino acid stimulus] evidence: IEA GeneID:598 -> Biological process: GO:0071312 [cellular response to alkaloid] evidence: IEA GeneID:598 -> Biological process: GO:0071480 [cellular response to gamma radiation] evidence: IEA GeneID:598 -> Biological process: GO:0090005 [negative regulation of establishment of protein localization to plasma membrane] evidence: IDA GeneID:598 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IC GeneID:598 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IDA GeneID:598 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:598 -> Biological process: GO:1900118 [negative regulation of execution phase of apoptosis] evidence: IDA GeneID:598 -> Biological process: GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA GeneID:598 -> Biological process: GO:2000811 [negative regulation of anoikis] evidence: IMP GeneID:598 -> Biological process: GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS GeneID:598 -> Biological process: GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] evidence: IDA GeneID:598 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: TAS GeneID:598 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:598 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:598 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: NAS GeneID:598 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS GeneID:598 -> Cellular component: GO:0005813 [centrosome] evidence: IDA GeneID:598 -> Cellular component: GO:0005829 [cytosol] evidence: IEA GeneID:598 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA GeneID:598 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IEA GeneID:598 -> Cellular component: GO:0097136 [Bcl-2 family protein complex] evidence: IDA
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