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2024-04-26 04:02:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_138458 2280 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens WD repeat domain 92 (WDR92), transcript variant 1,
mRNA.
ACCESSION NM_138458
VERSION NM_138458.3 GI:374429543
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2280)
AUTHORS Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
Vierkant,R.A. and Poland,G.A.
TITLE Genome-wide analysis of polymorphisms associated with cytokine
responses in smallpox vaccine recipients
JOURNAL Hum. Genet. 131 (9), 1403-1421 (2012)
PUBMED 22610502
REFERENCE 2 (bases 1 to 2280)
AUTHORS Cloutier,P., Al-Khoury,R., Lavallee-Adam,M., Faubert,D., Jiang,H.,
Poitras,C., Bouchard,A., Forget,D., Blanchette,M. and Coulombe,B.
TITLE High-resolution mapping of the protein interaction network for the
human transcription machinery and affinity purification of RNA
polymerase II-associated complexes
JOURNAL Methods 48 (4), 381-386 (2009)
PUBMED 19450687
REMARK GeneRIF: Is part of an RNA polymerase II-associated complex with
possible chaperone activity.
REFERENCE 3 (bases 1 to 2280)
AUTHORS Han,Z., Guo,L., Wang,H., Shen,Y., Deng,X.W. and Chai,J.
TITLE Structural basis for the specific recognition of methylated histone
H3 lysine 4 by the WD-40 protein WDR5
JOURNAL Mol. Cell 22 (1), 137-144 (2006)
PUBMED 16600877
REFERENCE 4 (bases 1 to 2280)
AUTHORS Saeki,M., Irie,Y., Ni,L., Yoshida,M., Itsuki,Y. and Kamisaki,Y.
TITLE Monad, a WD40 repeat protein, promotes apoptosis induced by
TNF-alpha
JOURNAL Biochem. Biophys. Res. Commun. 342 (2), 568-572 (2006)
PUBMED 16487927
REMARK GeneRIF: Monad may function as a novel modulator of apoptosis
pathway.
GeneRIF: Monad could be involved in apoptosis induced by TNF-alpha
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP271204.1 and AK056303.1.
On Feb 2, 2012 this sequence version replaced gi:89242164.
Summary: This gene encodes a protein with two WD40 repeat domains
thought to be involved in an apoptosis via activation of caspase-3.
Multiple transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq, Feb 2012].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longer protein (isoform 1).
##Evidence-Data-START##
Transcript exon combination :: AK056303.1, BC020271.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-36 BP271204.1 1-36
37-1514 AK056303.1 1-1478
1515-2280 AK056303.1 1482-2247
FEATURES Location/Qualifiers
source 1..2280
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p14"
gene 1..2280
/gene="WDR92"
/note="WD repeat domain 92"
/db_xref="GeneID:116143"
/db_xref="HGNC:25176"
/db_xref="HPRD:14012"
/db_xref="MIM:610729"
exon 1..300
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
CDS 118..1191
/gene="WDR92"
/note="isoform 1 is encoded by transcript variant 1;
monad; WD repeat-containing protein 92; WD
repeat-containing protein Monad"
/codon_start=1
/product="WD repeat-containing protein 92 isoform 1"
/protein_id="NP_612467.1"
/db_xref="GI:24308444"
/db_xref="CCDS:CCDS1884.1"
/db_xref="GeneID:116143"
/db_xref="HGNC:25176"
/db_xref="HPRD:14012"
/db_xref="MIM:610729"
/translation="
MSAFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNKI
"
misc_feature 127..>1161
/gene="WDR92"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature 160..1161
/gene="WDR92"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cl02567"
/db_xref="CDD:207648"
misc_feature order(166..168,220..222,244..246,262..267,301..306,
370..372,382..384,400..405,442..447,514..516,529..531,
547..552,604..606,667..669,682..684,700..705,736..741,
802..804,814..816,832..837,886..891,943..945,958..960,
976..981,1072..1077,1129..1131,1144..1146)
/gene="WDR92"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
misc_feature 304..432
/gene="WDR92"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96MX6.1);
Region: WD 1"
misc_feature 460..579
/gene="WDR92"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96MX6.1);
Region: WD 2"
misc_feature 601..732
/gene="WDR92"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96MX6.1);
Region: WD 3"
misc_feature 736..864
/gene="WDR92"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96MX6.1);
Region: WD 4"
misc_feature 886..1008
/gene="WDR92"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96MX6.1);
Region: WD 5"
misc_feature 1072..1188
/gene="WDR92"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96MX6.1);
Region: WD 6"
exon 301..401
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
variation 304
/gene="WDR92"
/replace="a"
/replace="g"
/db_xref="dbSNP:11537860"
exon 402..532
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
exon 533..634
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
exon 635..750
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
variation 724
/gene="WDR92"
/replace="c"
/replace="t"
/db_xref="dbSNP:35021866"
exon 751..885
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
exon 886..983
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
exon 984..2280
/gene="WDR92"
/inference="alignment:Splign:1.39.8"
STS 1234..2125
/gene="WDR92"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 1234..1336
/gene="WDR92"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 1313..1418
/gene="WDR92"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
STS 1318..2195
/gene="WDR92"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 1318..1410
/gene="WDR92"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2106..2195
/gene="WDR92"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
ORIGIN
ggggcagaatacggaaagcgggagggacaaattgccaatgtttggagtctggtttccaggttgccgtttttgggggctctgggtgtggcggttgccgtagctgaaattggctgcaccatgtcggccttcgagaagcctcagatcatcgcccatatccagaagggcttcaactacacggtgtttgactgtaagtgggtgccctgcagcgccaaatttgtgaccatgggcaacttcgcacggggcaccggcgtcattcagctgtacgagatccagcacggggacctgaagctgcttcgggagattgaaaaggccaaacctattaaatgtggaacatttggtgcaacatctttacagcagagatatttagctactggagattttggtggaaaccttcatatatggaatttagaagctccagagatgccagtatattctgtaaagggccataaagaaattataaatgccatagatggcataggtggactaggaattggagaaggagcacctgaaattgtgactggcagccgagatggaactgtgaaggtgtgggacccaaggcaaaaagatgatcctgttgctaatatggaacctgtacaaggagaaaacaagagagactgttggactgtggcatttggcaatgcttataatcaagaagaacgtgttgtttgtgctggctatgacaatggggatatcaaactatttgatctcagaaatatggcattacggtgggagacaaacatcaaaaatggggtgtgtagcttggagtttgacagaaaagacataagtatgaataagttagtagccacatctctggaaggaaagttccatgtttttgacatgagaacacagcatccaaccaaaggttttgcctctgtttcagaaaaggctcataaatctactgtgtggcaggtccgacacctgccgcagaacagggagctctttctgacagctggaggcgccggcggccttcacctctggaagtatgaataccctattcagcggtcaaagaaagattctgagggaatagaaatgggagtcgcaggttctgtaagccttctgcagaatgttacgttgtccacccagcccatttcaagtttggattggagtccagataaaaggggtctctgcgtctgtagttcatttgaccaaacggtgagagtactgatcgttacaaagctcaataaaatttgacttcaagactttggacttgaggctgggcacggtggctcactcctgtaatcccagcactttgggaggccgaggcgggtggatcagaaggtcaggagatcgagaccatcctggctaacatggtgaaaccccgtctctactaaaaatataaaaaaaaatttgctgggtgtcatggcgggcatctgtagtcctagctacttgggaggctgaggcaggagaatggcgtgaacccgggaggcggaggttgcagtgagccgagattgtgccactgcactccagcctgggcaactgagcaagactgtctcaaaaaaaaaaaaaaaaaaaaagactttggacttgaaaccttccagaggaacactcacacaatttaagataggttctggagtcctctgaccctcattgaacaaagctggatttggctgatgataaaagaccccagccacaagcctctgggccagcctccagcctctctcggggcttgtttgctgacttgctgctgcacgtgggtatcagaagcaccaagtaaactatctccagggccagttcttttctctcccttccatttctaagtcaatagttgtctataattaaacatatttcagatttgttctgtgtccctgaagttccatattttatctttatgcttgtgttatgttttagtgtctataatgttgtggtgggaatcatttcatttggtttaaaagagtttgccttggaaaaactgaattaaccttcataaatacattttgagagatttcagtgtgagtaattttctggacataatattattgtataaaatatcaaaatggtgggccaggcgtggtagctcacgcctgtaattccagcactttgggaggctgaggcgggtgaatcacgaggtcaggaattcgagaccagcctggccaacatggtcaaaacccgtctctactaaaaatacaaaaaattagctgggcttagtggcgggcgcctgtaatcacagctacttgggaggctgaggcaggagaatcacttgaacccaggaggtggagattgcagtgagctgagattgcgccactgcactccagccctggcgacagagtgagactccgtctc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:116143 -> Molecular function: GO:0035064 [methylated histone residue binding] evidence: IDA
GeneID:116143 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:116143 -> Biological process: GO:0034968 [histone lysine methylation] evidence: IDA
by
@meso_cacase at
DBCLS
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