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2019-03-23 03:29:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_134442               9794 bp    mRNA    linear   PRI 26-MAY-2013
DEFINITION  Homo sapiens cAMP responsive element binding protein 1 (CREB1),
            transcript variant B, mRNA.
ACCESSION   NM_134442
VERSION     NM_134442.3  GI:215490110
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9794)
  AUTHORS   Hoang,T., Fenne,I.S., Madsen,A., Bozickovic,O., Johannessen,M.,
            Bergsvag,M., Lien,E.A., Stallcup,M.R., Sagen,J.V., Moens,U. and
            Mellgren,G.
  TITLE     cAMP response element-binding protein interacts with and stimulates
            the proteasomal degradation of the nuclear receptor coactivator
            GRIP1
  JOURNAL   Endocrinology 154 (4), 1513-1527 (2013)
   PUBMED   23462962
  REMARK    GeneRIF: cAMP response element-binding protein (CREB) downregulates
            GRIP1 and is necessary for the PKA-stimulated degradation of GRIP1,
            which leads to changes in the expression of a subset of genes
            regulated by estrogen receptor-alpha in MCF-7 breast cancer cells.
REFERENCE   2  (bases 1 to 9794)
  AUTHORS   Shimizu,A., Nakayama,H., Wang,P., Konig,C., Akino,T., Sandlund,J.,
            Coma,S., Italiano,J.E. Jr., Mammoto,A., Bielenberg,D.R. and
            Klagsbrun,M.
  TITLE     Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis
            by multiple pathways including activation of RhoA, cathepsin B, and
            cAMP-response element-binding protein
  JOURNAL   J. Biol. Chem. 288 (4), 2210-2222 (2013)
   PUBMED   23195957
  REMARK    GeneRIF: Netrin-1 promotes glioblastoma cell invasiveness and
            angiogenesis by multiple pathways including activation of RhoA,
            cathepsin B, and cAMP-response element-binding protein
REFERENCE   3  (bases 1 to 9794)
  AUTHORS   Luo,Q., Viste,K., Urday-Zaa,J.C., Senthil Kumar,G., Tsai,W.W.,
            Talai,A., Mayo,K.E., Montminy,M. and Radhakrishnan,I.
  TITLE     Mechanism of CREB recognition and coactivation by the
            CREB-regulated transcriptional coactivator CRTC2
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (51), 20865-20870 (2012)
   PUBMED   23213254
  REMARK    GeneRIF: Mechanism of CREB recognition and coactivation by the
            CREB-regulated transcriptional coactivator CRTC2
REFERENCE   4  (bases 1 to 9794)
  AUTHORS   Tan,X., Wang,S., Yang,B., Zhu,L., Yin,B., Chao,T., Zhao,J.,
            Yuan,J., Qiang,B. and Peng,X.
  TITLE     The CREB-miR-9 negative feedback minicircuitry coordinates the
            migration and proliferation of glioma cells
  JOURNAL   PLoS ONE 7 (11), E49570 (2012)
   PUBMED   23185366
  REMARK    GeneRIF: CREB-miR-9 negative feedback minicircuitry coordinates the
            migration and proliferation of glioma cells
REFERENCE   5  (bases 1 to 9794)
  AUTHORS   Li,Y., Shaw,C.A., Sheffer,I., Sule,N., Powell,S.Z., Dawson,B.,
            Zaidi,S.N., Bucasas,K.L., Lupski,J.R., Wilhelmsen,K.C., Doody,R.
            and Szigeti,K.
  TITLE     Integrated copy number and gene expression analysis detects a CREB1
            association with Alzheimer's disease
  JOURNAL   Transl Psychiatry 2, E192 (2012)
   PUBMED   23168992
  REMARK    GeneRIF: Copy number variation upstream of CREB1 was associated
            with Alzheimer disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9794)
  AUTHORS   Meyer,T.E. and Habener,J.F.
  TITLE     Cyclic AMP response element binding protein CREB and modulator
            protein CREM are products of distinct genes
  JOURNAL   Nucleic Acids Res. 20 (22), 6106 (1992)
   PUBMED   1461747
REFERENCE   7  (bases 1 to 9794)
  AUTHORS   Zhao,L.J. and Giam,C.Z.
  TITLE     Human T-cell lymphotropic virus type I (HTLV-I) transcriptional
            activator, Tax, enhances CREB binding to HTLV-I 21-base-pair
            repeats by protein-protein interaction
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (15), 7070-7074 (1992)
   PUBMED   1386673
REFERENCE   8  (bases 1 to 9794)
  AUTHORS   Rehfuss,R.P., Walton,K.M., Loriaux,M.M. and Goodman,R.H.
  TITLE     The cAMP-regulated enhancer-binding protein ATF-1 activates
            transcription in response to cAMP-dependent protein kinase A
  JOURNAL   J. Biol. Chem. 266 (28), 18431-18434 (1991)
   PUBMED   1655749
REFERENCE   9  (bases 1 to 9794)
  AUTHORS   Short,M.L., Manohar,C.F., Furtado,M.R., Ghadge,G.D., Wolinsky,S.M.,
            Thimmapaya,B. and Jungmann,R.A.
  TITLE     Nucleotide and derived amino-acid sequences of the CRE-binding
            proteins from rat C6 glioma and HeLa cells
  JOURNAL   Nucleic Acids Res. 19 (15), 4290 (1991)
   PUBMED   1831258
REFERENCE   10 (bases 1 to 9794)
  AUTHORS   Waeber,G., Meyer,T.E., Hoeffler,J.P. and Habener,J.F.
  TITLE     Diversification of cyclic AMP-responsive enhancer binding
            proteins-generated by alternative exon splicing
  JOURNAL   Trans. Assoc. Am. Physicians 103, 28-37 (1990)
   PUBMED   1966745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC366797.1, BC010636.1,
            AC079767.7 and AW205606.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Dec 3, 2008 this sequence version replaced gi:22219460.
            
            Summary: This gene encodes a transcription factor that is a member
            of the leucine zipper family of DNA binding proteins. This protein
            binds as a homodimer to the cAMP-responsive element, an octameric
            palindrome. The protein is phosphorylated by several protein
            kinases, and induces transcription of genes in response to hormonal
            stimulation of the cAMP pathway. Alternate splicing of this gene
            results in two transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (B) encodes the longer isoform (B)
            of this protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010636.1, X55545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               DC366797.1         1-157
            158-2719            BC010636.1         1-2562
            2720-9298           AC079767.7         8455-15033
            9299-9794           AW205606.1         1-496               c
FEATURES             Location/Qualifiers
     source          1..9794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34"
     gene            1..9794
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /note="cAMP responsive element binding protein 1"
                     /db_xref="GeneID:1385"
                     /db_xref="HGNC:2345"
                     /db_xref="HPRD:00442"
                     /db_xref="MIM:123810"
     exon            1..243
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     STS             166..940
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /standard_name="Creb1"
                     /db_xref="UniSTS:527295"
     variation       181
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050641"
     exon            244..365
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    249..251
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /note="upstream in-frame stop codon"
     CDS             252..1277
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /note="isoform B is encoded by transcript variant B;
                     cAMP-response element-binding protein-1; active
                     transcription factor CREB; transactivator protein; cyclic
                     AMP-responsive element-binding protein 1; CREB-1;
                     cAMP-responsive element-binding protein 1"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 1
                     isoform B"
                     /protein_id="NP_604391.1"
                     /db_xref="GI:19745184"
                     /db_xref="CCDS:CCDS2375.1"
                     /db_xref="GeneID:1385"
                     /db_xref="HGNC:2345"
                     /db_xref="HPRD:00442"
                     /db_xref="MIM:123810"
                     /translation="
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
"
     misc_feature    549..551
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    582..584
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    606..608
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    612..614
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06347"
     misc_feature    <618..704
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /note="pKID domain; Region: pKID; pfam02173"
                     /db_xref="CDD:145367"
     misc_feature    636..638
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05418"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CaMK1, CaMK2, CaMK4, PKB/AKT1 or
                     PKB/AKT2, RPS6KA3, RPS6KA4, RPS6KA5 and SGK1; propagated
                     from UniProtKB/Swiss-Prot (P16220.2); phosphorylation
                     site"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01261"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02092"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03402"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03403"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04677"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06789"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:08910"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:11882"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04264"
     misc_feature    648..650
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:12642"
     misc_feature    1062..1064
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by HIPK2; propagated from
                     UniProtKB/Swiss-Prot (P16220.2); phosphorylation site"
     misc_feature    1092..1274
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /note="bZIP transcription factor; Region: bZIP_1;
                     pfam00170"
                     /db_xref="CDD:201054"
     misc_feature    1101..1178
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P16220.2);
                     Region: Basic motif (By similarity)"
     misc_feature    1182..1247
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P16220.2);
                     Region: Leucine-zipper (By similarity)"
     misc_feature    1191..1193
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Required for binding TORCs; propagated from
                     UniProtKB/Swiss-Prot (P16220.2); other site"
     variation       259..260
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35318842"
     variation       273
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367727829"
     variation       318
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:56292136"
     variation       326
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370037055"
     variation       354
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114514847"
     exon            366..512
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     variation       388
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143117860"
     variation       407
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140357947"
     variation       430
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374575266"
     variation       434
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35349697"
     variation       467
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78701038"
     variation       475
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376460743"
     exon            513..554
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     exon            555..655
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     variation       598
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:387906617"
     exon            656..798
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     variation       758
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201642429"
     exon            799..981
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     variation       845
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376739437"
     variation       866
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111280106"
     variation       875
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:56020464"
     variation       972
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147363050"
     exon            982..1132
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     variation       1001
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74338269"
     variation       1031
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370046152"
     variation       1058
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373274620"
     exon            1133..9779
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /inference="alignment:Splign:1.39.8"
     variation       1154
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145164313"
     variation       1169
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140407055"
     variation       1199
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113621918"
     variation       1201
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76312267"
     variation       1236
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113145794"
     variation       1321
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372883715"
     variation       1322
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375322973"
     polyA_signal    1345..1350
                     /gene="CREB1"
                     /gene_synonym="CREB"
     STS             1364..1465
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /standard_name="D2S2634"
                     /db_xref="UniSTS:947"
     polyA_site      1366
                     /gene="CREB1"
                     /gene_synonym="CREB"
     variation       1494
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192082921"
     variation       1540
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56267720"
     STS             1558..2432
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /standard_name="CREB1_v456"
                     /db_xref="UniSTS:277126"
     variation       1616
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:182906174"
     variation       1668
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143587811"
     variation       1717
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75550279"
     variation       1773
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188411162"
     variation       1815
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191157228"
     variation       1916
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371836046"
     STS             1927..2023
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /standard_name="RH67919"
                     /db_xref="UniSTS:28279"
     variation       2084
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:56390214"
     variation       2086
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55879019"
     variation       2105
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182205610"
     variation       2107
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372808746"
     polyA_signal    2147..2152
                     /gene="CREB1"
                     /gene_synonym="CREB"
     polyA_site      2176
                     /gene="CREB1"
                     /gene_synonym="CREB"
     variation       2199
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79271892"
     variation       2222
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187559873"
     variation       2389
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368510478"
     variation       2399
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192450396"
     variation       2427
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185867924"
     variation       2437
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56291091"
     variation       2474
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56299306"
     variation       2568..2569
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ta"
                     /db_xref="dbSNP:374093740"
     variation       2578
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375850822"
     variation       2706..2708
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="aaa"
                     /db_xref="dbSNP:200878580"
     variation       2706..2707
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:143222694"
     variation       2706
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:10568689"
     variation       2765
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184610034"
     variation       2788
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73056958"
     variation       2836
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150397030"
     variation       2948
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138437655"
     variation       3015
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143910207"
     variation       3039
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146786929"
     variation       3069
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201051271"
     variation       3070
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11319861"
     variation       3070
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199698025"
     variation       3119
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79736988"
     variation       3155
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76511710"
     variation       3171
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139198232"
     variation       3214
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56325368"
     variation       3287
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12998128"
     variation       3373
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:188764041"
     variation       3419
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374925108"
     variation       3434
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143340162"
     variation       3560
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377363594"
     variation       3746
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:180685015"
     variation       3766
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372887564"
     variation       3786
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78823096"
     variation       3799
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369543832"
     variation       3909
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35836086"
     variation       4081
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188447438"
     variation       4366
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371052022"
     variation       4457..4458
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="atat"
                     /db_xref="dbSNP:71412422"
     variation       4457
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375493613"
     variation       4458..4461
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="atat"
                     /db_xref="dbSNP:72442628"
     variation       4458..4459
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="at"
                     /replace="atat"
                     /db_xref="dbSNP:71786143"
     variation       4468..4469
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:72062178"
     variation       4482..4483
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="tata"
                     /db_xref="dbSNP:71036937"
     variation       4497
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148160448"
     variation       4887
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182101766"
     variation       5039
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13029936"
     variation       5041
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114892556"
     variation       5144
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116076718"
     variation       5207..5208
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:34171849"
     variation       5208..5209
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:10559988"
     variation       5209..5214
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="tctgtt"
                     /db_xref="dbSNP:199601798"
     variation       5209..5210
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:72544077"
     variation       5209
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201988867"
     variation       5210
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201754017"
     variation       5230
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141652982"
     variation       5265
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150506251"
     variation       5267
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139870509"
     variation       5273
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2551928"
     variation       5344..5347
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ttta"
                     /db_xref="dbSNP:139164200"
     variation       5344
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ttta"
                     /db_xref="dbSNP:5838080"
     variation       5347..5350
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="attt"
                     /db_xref="dbSNP:376057671"
     variation       5347
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200703008"
     variation       5347
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="attt"
                     /db_xref="dbSNP:10559989"
     variation       5349
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200838888"
     variation       5434
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111992031"
     variation       5440
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187594841"
     variation       5660
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:191527208"
     variation       5701
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181966687"
     variation       5756..5760
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ctcaa"
                     /db_xref="dbSNP:375357358"
     variation       5765
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1806584"
     variation       5861
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1806585"
     variation       5935
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185366371"
     variation       5948
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:56129159"
     variation       6059
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143220643"
     variation       6072..6073
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35856558"
     variation       6108
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190175450"
     variation       6128
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146249401"
     variation       6134
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ttaag"
                     /db_xref="dbSNP:112958608"
     variation       6151..6152
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:200579743"
     variation       6204
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139271055"
     variation       6222
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149927228"
     variation       6299
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111842669"
     variation       6323
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:182658728"
     variation       6523
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377737239"
     variation       6645
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1045780"
     variation       6715
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149111106"
     variation       6768
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13386109"
     variation       6924
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186586133"
     polyA_signal    6958..6963
                     /gene="CREB1"
                     /gene_synonym="CREB"
     polyA_site      6987
                     /gene="CREB1"
                     /gene_synonym="CREB"
     variation       7025
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189904488"
     variation       7073
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183832672"
     variation       7196
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373213291"
     variation       7254
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12999688"
     variation       7292
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1045790"
     variation       7307
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115526431"
     variation       7492
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6785"
     variation       7495
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189094154"
     variation       7580
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192810631"
     variation       7684
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147657658"
     variation       7967
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2551929"
     variation       7994
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142438869"
     variation       8058..8059
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:376856014"
     variation       8106
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146501770"
     variation       8120
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139123873"
     variation       8238..8240
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="caa"
                     /db_xref="dbSNP:371137073"
     variation       8259
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374059381"
     variation       8290
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140564236"
     variation       8306
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35371479"
     variation       8359
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185369978"
     variation       8387
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187039760"
     variation       8409
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370775575"
     variation       8460
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191720781"
     variation       8540
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:55694411"
     variation       8553..8557
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="aactt"
                     /db_xref="dbSNP:138273242"
     variation       8620
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61058659"
     variation       8633
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150454556"
     variation       8639
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184271497"
     STS             8657..8787
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /standard_name="SGC35219"
                     /db_xref="UniSTS:61462"
     variation       8679
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2256941"
     variation       8683
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138348185"
     variation       8709..8712
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="aaga"
                     /db_xref="dbSNP:4025849"
     variation       8713
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:75167578"
     variation       8714..8715
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="ag"
                     /db_xref="dbSNP:4025848"
     variation       8753
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116590105"
     variation       8798
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149629990"
     variation       8825
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369869267"
     variation       8890..8892
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="acc"
                     /db_xref="dbSNP:147476972"
     variation       8892..8894
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="cac"
                     /db_xref="dbSNP:368442759"
     variation       8894
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188266883"
     variation       8970
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181042336"
     variation       8972
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78913180"
     variation       8978
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:185392351"
     variation       8997
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:58914399"
     variation       9024
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368788833"
     variation       9080
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2551930"
     variation       9139
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190734638"
     variation       9152
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374469647"
     variation       9241
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181529395"
     variation       9336
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185814853"
     variation       9491..9492
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:142169610"
     variation       9502
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145940427"
     variation       9669
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190615978"
     variation       9676
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367769465"
     variation       9745..9746
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:374747042"
     variation       9754
                     /gene="CREB1"
                     /gene_synonym="CREB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369125242"
ORIGIN      
tgtttccgtgcgcggccgctgcgcactcggcactgggcggcgctggctggctccctggctgcggctcctcagtcggcggcggctgctgctgcctgtggcccgggcggctgggagaagcggagtgttggtgagtgacgcggcggaggtgtagtttgacgcggtgtgttacgtgggggagagaataaaactccagcgagatccgggccgtgaacgaaagcagtgacggaggagcttgtaccaccggtaactaaatgaccatggaatctggagccgagaaccagcagagtggagatgcagctgtaacagaagctgaaaaccaacaaatgacagttcaagcccagccacagattgccacattagcccaggtatctatgccagcagctcatgcaacatcatctgctcccaccgtaactctagtacagctgcccaatgggcagacagttcaagtccatggagtcattcaggcggcccagccatcagttattcagtctccacaagtccaaacagttcagtcttcctgtaaggacttaaaaagacttttctccggaacacagatttcaactattgcagaaagtgaagattcacaggagtcagtggatagtgtaactgattcccaaaagcgaagggaaattctttcaaggaggccttcctacaggaaaattttgaatgacttatcttctgatgcaccaggagtgccaaggattgaagaagagaagtctgaagaggagacttcagcacctgccatcaccactgtaacggtgccaactccaatttaccaaactagcagtggacagtatattgccattacccagggaggagcaatacagctggctaacaatggtaccgatggggtacagggcctgcaaacattaaccatgaccaatgcagcagccactcagccgggtactaccattctacagtatgcacagaccactgatggacagcagatcttagtgcccagcaaccaagttgttgttcaagctgcctctggagacgtacaaacataccagattcgcacagcacccactagcactattgcccctggagttgttatggcatcctccccagcacttcctacacagcctgctgaagaagcagcacgaaagagagaggtccgtctaatgaagaacagggaagcagctcgagagtgtcgtagaaagaagaaagaatatgtgaaatgtttagaaaacagagtggcagtgcttgaaaatcaaaacaagacattgattgaggagctaaaagcacttaaggacctttactgccacaaatcagattaatttgggatttaaattttcacctgttaaggtggaaaatggactggcttggccacaacctgaaagacaaaataaacattttattttctaaacatttctttttttctatgcgcaaaactgcctgaaagcaactacagaatttcattcatttgtgcttttgcattaaactgtgaatgttccaacacctgcctccacttctcccctcaagaaattttcaacgccaggaatcatgaagagacttctgcttttcaacccccaccctcctcaagaagtaataatttgtttacttgtaaattgatgggagaaatgaggaaaagaaaatctttttaaaaatgatttcaaggtttgtgctgagctccttgattgccttagggacagaattaccccagcctcttgagctgaagtaatgtgtgggccgcatgcataaagtaagtaaggtgcaatgaagaagtgttgattgccaaattgacatgttgtcacattctcattgtgaattatgtaaagttgttaagagacataccctctaaaaaagaactttagcatggtattgaaggaattagaaatgaatttggagtgctttttatgtatgttgtcttcttcaatactgaaaatttgtccttggttcttaaaagcattctgtactaatacagctcttccatagggcagttgttgcttcttaattcagttctgtatgtgttcaacatttttgaatacattaaaagaagtaaccaactgaacgacaaagcatggtatttgaattttaaattaaagcaaagtaaataaaagtacaaagcatattttagttagtactaaattcttagtaaaatgctgatcagtaaaccaatcccttgagttatataacaagatttttaaataaatgttattgtcctcaccttcaaaaatatttatattgtcactcatttacgtaaaaagatatttctaatttactgttgcccattgcacttacataccaccaccaagaaagccttcaagatgtcaaataaagcaaagtgatatatatttgtttatgaaatgttacatgtagaaaaatactgattttaaatattttccatattaacaatttaacagagaatctctagtgaattttttaaatgaaagaagttgtaaggatataaaaagtacagtgttagatgtgcacaaggaaagttattttcagacatatttgaatgactgctgtactgcaatatttggattgtcattcttacaaaacatttttttgttctcttgtaaaaagagtagttattagttctgctttagctttccaatatgctgtatagcctttgtcattttataattttaattcctgattaaaacagtctgtatttgtgtatatcatacattgttttcaataccacttttaattgttactcattttattcactaagctcgataaatctaacagttactcttaaaaaaaaaaaaaaaagactaaggtggattttaaaaattggaaactgacataatgttaggttataatttctcatttggagccgggcgcagtggctcacgcctgtaatcccagcactttgggaggccaaggtgggtggatcacctgtggtcaagagttcaagaccagcctggccatcatggtgaaaccccatctctactaaaaatacaaaaattagccaggcgtggtggctggcgcctgtaatcccagctactcaggaggttgaggcagcagaattgcttgaacccaggaggcagagggttgcagtgagccgagatagcaccattgcactccagcctgggcgactccatctcaaaaaataaaaataaaaaaaatgtctcatttgggaaggaaattccttttaaaaaagagttgagacacttagaaaactaatgttttatatttagtcaagagttatttaagaaagtcaagcttgtttaacaacaaaatatgaagatttaagtgttaattgctggatccattttaaaataagattttaattaacatttgtaaatggtatattttcgtttgtaacaaaccattgtcttttttcaaggatgaacagagtttatgaaggagcatcattctaagaattaagtgatgtagtctttatgtttggacagttcaccagattctcaagaaggctttcaaacaactataaagtttgatgtttgtcctgctgagctaatggggaaagttatagcataaaaattgtgtaaccgcatagatatgtcatttttaaaaactggtttaacagaaatcaagcaaagtcacaaatatgttcacaagttggaattatttattgagtcaaaatgtcgaatcgaacattttgaatgaagtaagtgttataaatgaaaaattgcctgatgtttagcagtttgtattctctaaagctttttttcaaaagttcaggctttctacttactgggaagttggtggtcctcttagtccctgataaatcaaggcaatcacattcatgtgagctggatgaatttataagttataaagaccttatccttcataccttgaggatgattgcactggttttgaagtcagttgcttaatgatgaggtgagaaatgtatcctgttgctaaatctgtcttagacccttggtgaaacttgaagatttcagtttataaagataaaatcaagcatcttttgtgcagttttctttttttaatgcaagaatggtggggaggtttgtttgtaagcatgaaactttgagaatctttattaagaaaatgacataatttttaaaaaccttgtagccaagaacatatgtggccacattaccagtaataaatgtttttctctttatattggccaaaagggaataaaaatgtcatcataggaatttgtacatatgctactgatttgcctagaaaatagcaagtttgatattgctcactttgcaaatatagggccatgtggcacttttatctataggacagattaataaaaatgaagtggggaggggtttatttttgatatattactcttatgagttttcaagctttgataatgtttaactgaaaagtggcttagaaagggctagatccaatgtgttcattattaaataattgctatcagatacaattttaagttcattctttttcaaactcaagtaccatattggcaaccataatattgtcataggtgctctcttcatttagatattcttggggggggtggcatttgtataatatatgtgtacatatatatatatatatatatatatacatacagtatataatctaaagctctgagagctcttaagtcaggaatgctgagtattatagtatattgaggtcagatgaaattttacatttttgtgtgttctgttgcattccttctggtagtttctatgactgcattactccagcactcatgattgattttatcttctaattttcttccaagtattttattttttattagttttctttggcttgatacttttaaatatgttactagtcacttgaaagcctctcccccaaaagtatttggtttgtatgctttgtctgtggcagctataacagtggtaagaacattttgaagatagctttttaaaggaaccactgattttttcaaaaatcatcctgggggaggaattttggcatttcatttgagcagggattttgtcagaaaatgtgttttgatggtaggtcagcagcagtgctagtctctgaaagcacaataccagtcaggcagcctatcccatcagatgtcatctggctgaagtttatctctgtctctcaggataaatccctgtaggacaaatccctactatcatttctaccttttggggtgacatgtggaatcatacaaaggcttaggaagaaatacgtttgtttaaaccaggatgctttacttacttgaagtgacttcaatctagatttcttttaatatttaacaaatttttaattctatgatcagccacagtcagctattaccataaattggtctctgtttattttgaagatcacggctgcttcattttgcaggattaagtagggctaatgtatcttaaagttaagatcttgaattaaagtgagttttagaaatagtgttacataccttttcagttgttttcaagaggctttatttttgttgcctttgtagccctgaaagctgttggtatattttttccctcatggacccaatagaaaagttgtatatttatttggattatatttacattctgtcctttgtaaatgtttggtgtaacttgcacttttttaaatgacccagtttgggtattagcaacttaagaaattccctcatcaagtaattctcaactttttagtctttctcctctcttcaaatcatgtgactttttaaatggaagtttttcattgattaaaatattttagcacctaaaagctagccttaaaaacagctgtaaaagaaaaacatcaggaaattagatatgactagcccagttaattaaaagacgggctcaaaccttgttttattctttttcatcttggatgaagattgaagggaaaataactcaagtgcataatatttattttcaatttttaatgagactttatcctcatcacaacattaatactgtacatagtatgccaaaatatccattaatttgtctagaatagtacaagactttttaaagcaattgtcctcacagagaccacatgtaatatactgaaatatgttcatttttaatggctttgttaacatcaaagaaatgctgcctaaatttgatttcagatgaggaaggagaaagtaaagtgtgcatagtaaggctgtaggtgaagagttgtgagataaatagttcactcagttgtacaaagcacaactagaactttttgttgggaggcttacatacatcttgaatattcttaatgtaataatgttgactattaagttggctacacagtcactgtatgtactaggaactggtttccttgacattctagaatcaatggctaggagaggcattaatctttgaggggctgaacatatcatgaagctgagtcagtatggaaaattttcaaataaacagggtgctgaagttccatctgtctcatctgcttatgataagttcttattgattagtgaatgtagcttaagcctttgtatgtgtcctcagggggcagaccgactttaagagggaccagataacgtttgaatggagggattatatttcaggtgttttagcttgaaatttattttttaaaaaaagaaaaatttaaaaaatatataaataaaatagaacaaagccggtgatgcaagttgatattataaacaggcagttttagcacagaaagaaaatactgacctgtctgcattctggtacggtgggtgcaggtcccagctgggtatgacatgatacatttttaattattctcaccagcaagtaaaaggaaaatgaacaatcttttggaattgtctttgaaaaggatcaaagagtaggaaattcacatttgacctaacattacttgcctatagaagtatggcatttccaagcttttgtctgaggagcatctcagagaagtgagagtaaatctgagttagcttaaaaattggtagggaggaagaaaatctctgcaaataatgattttatgtttgttggccaagtgaaatgatctatcattgtgtttgggaggttttattttcttatgtttttaaaattggtaaatgctttatagatgtatttttatccaagtgccactccaatttgtgtatgtaataaaattatttatattaaaagtgggaaataattgtcaacattttttttgagtatagatttattaggggtggcaaagaagagtgctagttagcagttttccatgtaaagttgtccttgactgatttgtccacatgtcagttgtaactcccccactccctgcaaaaggaattatttctaacccagatgtatcacttgaaactttttagaagcaaaataatcagggaagttcctagaaaggtgtttggctttttggtttttgagggttggggtaaagaagacttcccccacaactgtcagcacaaaacagggtattgatttttaactctgatgtttctattggagttgaatactaaataaataactataatgagggaaatacatttctaataaaattccctacattctagaaacatccctgttttaatttttttatctaaatctttttgtgctttatgtgtaaagaaaaaaatgtactgagttacaatgcattttattaacactatgtacataatagctgctttgtgttcagaatagtagcagttgctttgtatattaaagtgatccttgtgaatttgtgaaatattgtcataaagtgctttttcttactgtaatctttgtggtatcaactgtcataatgctctttttacacaaacatttatgtgcagtcacataaacatgcttttaaaaactctgtaagtctcttttttggggatgggatctctatattttgttgggttttttttgctagtagtgtgaagccatgttttattggacttaaagttacaatatattacaagcttgtgttggaaggcagcaaaactaattcagacaacaacatgtcttcagttactggatccctaattttcaggacaaaacctgtttttcaataagattgaacagtgcctatttgtggatttggagatgttactgtcaagatgactaatggagacatacgaccagctgtgtctgatgtcataaaacacgtgttcactgaaaggacaataagactatataccttctcaggtccccttgcaattctaaaactctgtgatcatataaattggaaggaaaggggaggggatatggttaatctttgcttaagctgtaagaataaaaaagttatctcctatactattaacttctgaaataagttctgagacgagacatctgaaaataagcagctgcattatttgtatgtttcttcactgccaagatgtgttcaagcctgctatacctgccattgtattggaaggcttaatgaatttcatttattttctgcaacaacgattacagaatttattgcacaaaatgagacattttgagagtgatattaattacatgagggacaataggcatgaactaggattgttctaagcaaatcggaatcgggtcaccctgccacgttcaggtgcttggaccttcaggaaaagattgcccatcttgtcatttgaccaggcactgaagtgacaagaccatccttgagaagtcacatccaaagataaaattctgatccatttctagttttagtgtttcgccactgaagacttaacatatgtcttttacactcaggttgcaaaacacaggcccaagacaaacttaacttctcccccaaatcttccttccgctggtttttccatctcgtaagtggtgccactatccatctgttaaattgtttaggggaaacctagaaaagcactaccttaatcagtgttatccttcttcttaactgtgcgtcctaatttctccacatctttcttaagtgcagtgaccaaaccggatgagaattctaacacgggcctgacatcaaatggaaaggaaggataatgtccaggagttggaatgttatccttgtttttaattaagatgcaattcacataaattaactttttaagtgaacaattaagtggtagtacatccacaatggtgtacaaccaccacttctatctagctccaaaacattctcatcactccaaaagtaaagtcccgttactctccattttctcctcccaccgcccttgtccctggcaaccaccaatctgcttcctgtttctttggatttacatccgggtatttcatgtgagactcatacactgtgtattacttctttcgtctagctttaatgtgttgttgaggttgatccattgtaacatgttatcactacttcattcctttttatagctaagtatactttttatagtaagtatgccattgtagatatataccacaagtttatcgattcatccagttgagttgtttctactgtttggctaatgttcatagtgctgttatgaatgttcgtgtacaagtatttgagtccgtgttttcaattatttggggtatatgcctgggagtggagttgctgggtcatgttgaaatcgcacatttaactttttgaggaactgtcaaactttccctcagcagctgtaccgttttaccttccaccattgatgtatgagggttccaatttctccacaccttcaccaacacttattttgccattttaaaaattatagccatcctcatgggtgtggtctctcattgtggttttgatttgcatttccctgattactaatgatgtggagcatcttttgttgtctttggccatctgcgtatcttctttgaagaaatgtctgttgaggtcctttgttcattgaaattttgttgttgggttctgagttccttatatattctgggtactaggcccttataatattttcgcctataagtttttgctttataatgtcctcattgttttcaaacttactttatgtaatatgtacacttctaaaaaaaagaaacatggaaaagggcaaactgtaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1385 -> Molecular function: GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] evidence: IDA
            GeneID:1385 -> Molecular function: GO:0001102 [RNA polymerase II activating transcription factor binding] evidence: IPI
            GeneID:1385 -> Molecular function: GO:0001190 [RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
            GeneID:1385 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:1385 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:1385 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: TAS
            GeneID:1385 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1385 -> Molecular function: GO:0035497 [cAMP response element binding] evidence: IDA
            GeneID:1385 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:1385 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:1385 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0007202 [activation of phospholipase C activity] evidence: TAS
            GeneID:1385 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
            GeneID:1385 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
            GeneID:1385 -> Biological process: GO:0007595 [lactation] evidence: IEA
            GeneID:1385 -> Biological process: GO:0008361 [regulation of cell size] evidence: IEA
            GeneID:1385 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0010033 [response to organic substance] evidence: IDA
            GeneID:1385 -> Biological process: GO:0010944 [negative regulation of transcription by competitive promoter binding] evidence: IDA
            GeneID:1385 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:1385 -> Biological process: GO:0021983 [pituitary gland development] evidence: IEA
            GeneID:1385 -> Biological process: GO:0033363 [secretory granule organization] evidence: IEA
            GeneID:1385 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0040018 [positive regulation of multicellular organism growth] evidence: IEA
            GeneID:1385 -> Biological process: GO:0042493 [response to drug] evidence: IEA
            GeneID:1385 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:1385 -> Biological process: GO:0045600 [positive regulation of fat cell differentiation] evidence: ISS
            GeneID:1385 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: ISS
            GeneID:1385 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:1385 -> Biological process: GO:0046887 [positive regulation of hormone secretion] evidence: IEA
            GeneID:1385 -> Biological process: GO:0046889 [positive regulation of lipid biosynthetic process] evidence: ISS
            GeneID:1385 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:1385 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
            GeneID:1385 -> Biological process: GO:0050821 [protein stabilization] evidence: ISS
            GeneID:1385 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:1385 -> Biological process: GO:0060430 [lung saccule development] evidence: IEA
            GeneID:1385 -> Biological process: GO:0060509 [Type I pneumocyte differentiation] evidence: IEA
            GeneID:1385 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:1385 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:1385 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:1385 -> Cellular component: GO:0005719 [nuclear euchromatin] evidence: IDA
            GeneID:1385 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA

by @meso_cacase at DBCLS
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