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2024-03-28 22:58:29, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_133471               4615 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens protein phosphatase 1, regulatory subunit 18
            (PPP1R18), transcript variant 1, mRNA.
ACCESSION   NM_133471 XM_929867 XM_936086 XM_936160 XM_936203 XM_941654
VERSION     NM_133471.3  GI:213417747
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4615)
  AUTHORS   Lin,Y.S., Huang,K.Y., Wang,T.F., Huang,H.L., Yu,H.C., Yen,J.Y.,
            Hung,S.H., Liu,S.Q., Lai,N.S. and Huang,H.B.
  TITLE     Immunolocalization of phostensin in lymphatic cells and tissues
  JOURNAL   J. Histochem. Cytochem. 59 (8), 741-749 (2011)
   PUBMED   21804078
  REMARK    GeneRIF: phostensin is a ubiquitous protein in leukocytes, and it
            may play an important role in modulating the cellular functions of
            leukocytes.
REFERENCE   2  (bases 1 to 4615)
  AUTHORS   Lai,N.S., Wang,T.F., Wang,S.L., Chen,C.Y., Yen,J.Y., Huang,H.L.,
            Li,C., Huang,K.Y., Liu,S.Q., Lin,T.H. and Huang,H.B.
  TITLE     Phostensin caps to the pointed end of actin filaments and modulates
            actin dynamics
  JOURNAL   Biochem. Biophys. Res. Commun. 387 (4), 676-681 (2009)
   PUBMED   19622346
  REMARK    GeneRIF: phostensin is an actin filament pointed end-capping
            protein that is capable of modulating actin dynamics.
REFERENCE   3  (bases 1 to 4615)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet. 5 (10), E1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4615)
  AUTHORS   Kao,S.C., Chen,C.Y., Wang,S.L., Yang,J.J., Hung,W.C., Chen,Y.C.,
            Lai,N.S., Liu,H.T., Huang,H.L., Chen,H.C., Lin,T.H. and Huang,H.B.
  TITLE     Identification of phostensin, a PP1 F-actin cytoskeleton targeting
            subunit
  JOURNAL   Biochem. Biophys. Res. Commun. 356 (3), 594-598 (2007)
   PUBMED   17374523
  REMARK    GeneRIF: our data shows that phostensin targets PP1 to F-actin
            cytoskeleton.
REFERENCE   5  (bases 1 to 4615)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   6  (bases 1 to 4615)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK124880.1, DB278980.1, AB075829.1 and BC006176.1.
            On Nov 19, 2008 this sequence version replaced gi:199559786.
            
            Summary: Protein phosphatase-1 (PP1; see MIM 176875) interacts with
            regulatory subunits that target the enzyme to different cellular
            locations and change its activity toward specific substrates.
            Phostensin is a regulatory subunit that targets PP1 to F-actin (see
            MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed
            17374523]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents a longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124880.1, AB075829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AK124880.1         1-298
            299-563             DB278980.1         252-516
            564-1141            AK124880.1         564-1141
            1142-4597           AB075829.1         560-4015
            4598-4615           BC006176.1         1406-1423
FEATURES             Location/Qualifiers
     source          1..4615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.3"
     gene            1..4615
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /note="protein phosphatase 1, regulatory subunit 18"
                     /db_xref="GeneID:170954"
                     /db_xref="HGNC:29413"
                     /db_xref="MIM:610990"
     exon            1..3488
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1728..1730
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /note="upstream in-frame stop codon"
     CDS             1878..3719
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /note="protein phosphatase 1 regulatory subunit 18;
                     protein phosphatase 1 F-actin cytoskeleton targeting
                     subunit"
                     /codon_start=1
                     /product="phostensin"
                     /protein_id="NP_597728.1"
                     /db_xref="GI:145386517"
                     /db_xref="CCDS:CCDS43444.1"
                     /db_xref="GeneID:170954"
                     /db_xref="HGNC:29413"
                     /db_xref="MIM:610990"
                     /translation="
MATIPDWKLQLLARRRQEEASVRGREKAERERLSQMPAWKRGLLERRRAKLGLSPGEPSPVLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEARERRPSPGEMRDQSPKGRESREERLSPRETRERRLGIGGAQELSLRPLEARDWRQSPGEVGDRSSRLSEAWKWRLSPGETPERSLRLAESREQSPRRKEVESRLSPGESAYQKLGLTEAHKWRPDSRESQEQSLVQLEATEWRLRSGEERQDYSEECGRKEEWPVPGVAPKETAELSETLTREAQGNSSAGVEAAEQRPVEDGERGMKPTEGWKWTLNSGKAREWTPRDIEAQTQKPEPPESAEKLLESPGVEAGEGEAEKEEAGAQGRPLRALQNCCSVPSPLPPEDAGTGGLRQQEEEAVELQPPPPAPLSPPPPAPTAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTFTVNPRRSVPPATPATPTSPATVDAAVPGAGKKRYPTAEEILVLGGYLRLSRSCLAKGSPERHHKQLKISFSETALETTYQYPSESSVLEELGPEPEVPSAPNPPAAQPDDEEDEEELLLLQPELQGGLRTKALIVDESCRR
"
     misc_feature    1959..2225
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /note="PP1-regulatory protein, Phostensin N-terminal;
                     Region: Phostensin_N; pfam13916"
                     /db_xref="CDD:206087"
     misc_feature    2037..2039
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q6NYC8.1); phosphorylation site"
     misc_feature    2250..2252
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2274..2276
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q6NYC8.1); phosphorylation site"
     misc_feature    2274..2276
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2310..2312
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2400..2402
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q6NYC8.1); phosphorylation site"
     misc_feature    2460..2462
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q6NYC8.1); phosphorylation site"
     misc_feature    2472..2474
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site"
     misc_feature    2547..2549
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q6NYC8.1); phosphorylation site"
     misc_feature    2670..2672
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2979..2981
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q6NYC8.1); phosphorylation site"
     misc_feature    3210..3536
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /note="Phostensin PP1-binding and SH3-binding region;
                     Region: Phostensin; pfam13914"
                     /db_xref="CDD:206085"
     variation       2801
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2269706"
     exon            3489..3699
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /inference="alignment:Splign:1.39.8"
     exon            3700..4599
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /inference="alignment:Splign:1.39.8"
     STS             4005..4109
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /standard_name="D6S1376"
                     /db_xref="UniSTS:153697"
     variation       4241
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2269707"
     STS             4389..4594
                     /gene="PPP1R18"
                     /gene_synonym="HKMT1098; KIAA1949"
                     /standard_name="RH81008"
                     /db_xref="UniSTS:88485"
ORIGIN      
actttgccagagcggccgggtccccattcccattccttcaaatcccctttttcccggcagccgacctgtagacccaagggagacaggttgaagctagaaagagtcggggcagcagctctggtaggggagggagcatccaaaacctctggcttctgagcgcctctcctgccgcccatccacaaagccccccacagcctggcggctgccctcgaccccgcaaaacaaaggacttcagaggctggacctacagacccagatgagaaggcaaaagcgtagggaggagcggcaggagatgggaagggcgggccccgctcggagcagctgccgcttcctcccaaagtcccacgaggggcctgagtcacgggccaccgccctgggtcggcgagctgggggaagggatctggacacctggcgtgtccgggcgggaagctggtgagggcccctggggacagagcggaggaccagtggttggggcgagaagagggcagtcccgcagcgagtcccacgcggggtgggagggatctaggccccgccctctcctcggctccgccctgcgcccccttccctctcctcattgtccttagacaaagcggtcgccgcccccgcccggccccctggtctctgtctccgtccctcctcctttgctgcctctttccctcctcctctccctccctcctcccctccctccagtctccggatctccctcggtccctctctcctcctcttcctctctctggacgcccggctcctccgcaccccctcccccgggggtcccgcggcctgtgagttgactgaggggctcagacttggggagtgggtgtctcctcgcccctgtccttgctcccgtccctggcccggaccttggctgtctcctctttgtgccgagattgtcagtctgtgcggctacagcggggtggagacggccggctctgtcacggcttcatgagagcggggacggggcgcaggacttgcaggcgccggggagaagagacatggagccggcccttggcactctggggtcgcgtggggcagtcggtgggggaggcaggcggtggtgacaggacagggtgggggtggacgccagggttctgggaacgcgctggcagccctgacgcccgggttccgaaagtctcgggggtggctatttcccccgacccgcctcgggggcggagtgcggggcagaggggtgggggctggggagaggcgtggcccgagcggtgctggaagcggagccgggacctttggggcccgcgctgagacgcgcccggctgctgccgccgccctcctttcccctcttccctggtttcccttctcctctagacctgttcgctctccgcccctccttgcctccccaacaccccctcaggtcccgttgcctcctggtcctttcagggattcctggtccttccttcccacactagcctccctggggtatcgctgaggcagcctggcctgcacccaggttcccctcacccctgccacatttctctcttctccctcacgccaactttccttttcgcccttctctctctttctcacatcctagagacggtctttaatacgcattaaccctgtgctgccacatctggctcctgccctcattgcctccaatccggactcttcctctcacatcacccccaccacccccaacttgggctcacaacttctcttcactttttccatttccccagttctctgccttccgtctttccctctgtcctcatccttagcccctctgccctgctttgtgtcccacctctccccctccacttcctctcctcccaccctcagtctcacccccgggctgtctcactctctggagcctctccttcctgttctctgtccccagtgctccctaccctcacctcaagacgaccatggccaccatcccagactggaagctacagctgctagcccggcgccggcaggaggaggcgtccgttcgaggccgagagaaagcagaacgggagcgcctgtcccagatgccagcctggaaacgagggctcctggagcgccgccgggccaagcttgggctgtcccctggggagcctagccctgtgctagggactgtagaggctggacctccagacccggatgagtctgcggtccttctggaggccatcgggccagtgcaccagaaccgattcatccggcaggagcggcagcagcagcagcagcaacaacaacggagtgaagagctgctagcagagagaaagcctgggcctctggaggcccgggagcggagacccagccctggggagatgcgggatcagagccccaagggaagagagtcaagagaagagagactaagtccgagggagaccagagagaggaggctggggatagggggagcccaagagttgagcctgaggcctctggaggctcgggactggaggcaaagcccaggagaggtgggagacaggagctcccgactgtcagaggcatggaaatggaggctgagtcctggagaaactccagagcggagtctgagactagcagagtctcgagagcaaagccccaggagaaaagaggtggaaagtagactgagcccaggggaatctgcctaccagaagttgggcctgacagaggcccataaatggagacctgactccagagagtctcaggaacagagtttggtacaactggaggcaacagagtggaggctgaggtcaggagaagaaagacaagactactcggaagaatgtgggagaaaagaagagtggccagttccaggggtagctccaaaagagactgcagagctgtccgagaccctgacaagggaggcccaaggcaacagttccgcaggagtggaggcagcagagcagaggcctgtggaagatggcgagaggggcatgaagccaacagaagggtggaaatggaccctgaactccgggaaggctcgagaatggacacccagggacatagaggctcaaactcagaaaccagaacctccagagtcagcagagaagcttctggaatctcccggtgtggaggctggagaaggggaggctgagaaggaggaggcgggggctcagggcaggcctctgagagccctgcagaactgctgctctgtgccctcccccctcccaccagaggacgctgggactggaggcctgagacagcaggaagaggaagcagtggagctccagcccccaccaccagcccctctgtctcccccacccccagccccaactgccccccaacctcctggggatcccctcatgagccgcctgttctatggggtgaaggcagggccaggggtgggggccccccgccgcagtggacacaccttcaccgtcaacccccggcggtctgtgccccctgcgaccccagccaccccaacctctccagccacagttgatgctgcagtcccgggggctgggaagaagcggtacccaactgccgaggagatcttggttctggggggctacctccgtctcagccgcagctgccttgccaaggggtcccccgaaagacaccacaaacagcttaagatctccttcagcgagacagccctggagaccacgtaccaatacccctccgagagttcggtactggaggagctgggcccggagcctgaggtccccagtgcccccaaccctccagcagcccaacccgacgacgaagaggatgaggaagagctgctgctgctgcagccagagctccagggcgggctgcgcaccaaggccctgattgtggatgagtcctgccggcggtgaccatcttccaacatagggatatacctccctccttcttataactgaagatcctggagcccggaagattcagggcagacagaccctgataatgagcctggcagggaagggcaaccaacatcttgtaacttgctttccccaccctgtttctgggggcagagccaattgcccaatttctaccctaatccaaagtccctggtgtgggtggggttaaacgtgctggtgcatcctaggtcatccaagagtgagcgccaagtcctgagaaggggcacagaactccctggagggtggagatggagcacctgccccccatggcagggtacactctccccacagccttcctccccaccatcccgtggggactctcgggatttaagcactcgtctctctgggaggcccagaccccactccatttataggcacatctccttcatttcctaggtcactgcccctttgtttacagctcctgcctcctcccttgaccacagcctggtttacaaattccatcagctcccagccccacctgccaaagtcccaggtttacaagccacgcttacttgctgtgtctgcgtggaattctctcctctgtcccctccagtctcctcattggagtgacctgaaggtgtggcttcctccactttttctcagtattactttgccttagttttccccaagagggaaggctggaactcttaactctgtaccccttgatagttatttaattctgtttctcctagtggttcacaattgaactgaattgagatggtgtcgggtggctaaggagacacctcacctctccttccccattgtgccgcctttatcaattgcctgttttgttttgtttgttttttaactttccataataaaatggagttctcttcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:170954 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
            GeneID:170954 -> Molecular function: GO:0019902 [phosphatase binding] evidence: IEA
            GeneID:170954 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:170954 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA

by @meso_cacase at DBCLS
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