Home |
Help |
Advanced search
2024-04-19 00:08:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_130834 6399 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens optic atrophy 1 (autosomal dominant) (OPA1),
transcript variant 5, mRNA.
ACCESSION NM_130834
VERSION NM_130834.2 GI:224831247
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6399)
AUTHORS Kushnareva,Y.E., Gerencser,A.A., Bossy,B., Ju,W.K., White,A.D.,
Waggoner,J., Ellisman,M.H., Perkins,G. and Bossy-Wetzel,E.
TITLE Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes
for excitotoxicity
JOURNAL Cell Death Differ. 20 (2), 353-365 (2013)
PUBMED 23138851
REMARK GeneRIF: OPA1 is required for mitochondrial fusion, maintenance of
crista morphology and oxidative phosphorylation, loss of OPA1 also
results in defective Ca(2+) homeostasis.
REFERENCE 2 (bases 1 to 6399)
AUTHORS Zhao,X., Tian,C., Puszyk,W.M., Ogunwobi,O.O., Cao,M., Wang,T.,
Cabrera,R., Nelson,D.R. and Liu,C.
TITLE OPA1 downregulation is involved in sorafenib-induced apoptosis in
hepatocellular carcinoma
JOURNAL Lab. Invest. 93 (1), 8-19 (2013)
PUBMED 23108376
REMARK GeneRIF: Show that sorafenib triggers apoptosis in HCC cells by
targeting mitochondria. Treatment with sorafenib induces rapid
mitochondrial fragmentation, which is associated with the
deregulation of mitochondria fusion-related protein optic atrophy 1
(OPA1).
REFERENCE 3 (bases 1 to 6399)
AUTHORS Belenguer,P. and Pellegrini,L.
TITLE The dynamin GTPase OPA1: more than mitochondria?
JOURNAL Biochim. Biophys. Acta 1833 (1), 176-183 (2013)
PUBMED 22902477
REMARK GeneRIF: OPA1 mediates adrenergic control of lipolysis by
functioning as a cytosolic A-kinase anchoring protein (AKAP), on
the hemimembrane that envelops the lipid droplet.
Review article
REFERENCE 4 (bases 1 to 6399)
AUTHORS Sarzi,E., Angebault,C., Seveno,M., Gueguen,N., Chaix,B.,
Bielicki,G., Boddaert,N., Mausset-Bonnefont,A.L., Cazevieille,C.,
Rigau,V., Renou,J.P., Wang,J., Delettre,C., Brabet,P., Puel,J.L.,
Hamel,C.P., Reynier,P. and Lenaers,G.
TITLE The human OPA1delTTAG mutation induces premature age-related
systemic neurodegeneration in mouse
JOURNAL Brain 135 (PT 12), 3599-3613 (2012)
PUBMED 23250881
REMARK GeneRIF: the results of this study supported the concept that Opa1
protects against neuronal degeneration and opens new perspectives
for the exploration and the treatment of mitochondrial diseases.
REFERENCE 5 (bases 1 to 6399)
AUTHORS Sitarz,K.S., Almind,G.J., Horvath,R., Czermin,B., Gronskov,K.,
Pyle,A., Taylor,R.W., Larsen,M., Chinnery,P.F. and Yu-Wai-Man,P.
TITLE OPA1 mutations induce mtDNA proliferation in leukocytes of patients
with dominant optic atrophy
JOURNAL Neurology 79 (14), 1515-1517 (2012)
PUBMED 22993284
REMARK GeneRIF: This study has revealed significant mtDNA proliferation in
blood leukocytes harboring pathogenic OPA1 mutations in 3
independent patient cohorts.
REFERENCE 6 (bases 1 to 6399)
AUTHORS Delettre,C., Griffoin,J.M., Kaplan,J., Dollfus,H., Lorenz,B.,
Faivre,L., Lenaers,G., Belenguer,P. and Hamel,C.P.
TITLE Mutation spectrum and splicing variants in the OPA1 gene
JOURNAL Hum. Genet. 109 (6), 584-591 (2001)
PUBMED 11810270
REFERENCE 7 (bases 1 to 6399)
AUTHORS Alexander,C., Votruba,M., Pesch,U.E., Thiselton,D.L., Mayer,S.,
Moore,A., Rodriguez,M., Kellner,U., Leo-Kottler,B., Auburger,G.,
Bhattacharya,S.S. and Wissinger,B.
TITLE OPA1, encoding a dynamin-related GTPase, is mutated in autosomal
dominant optic atrophy linked to chromosome 3q28
JOURNAL Nat. Genet. 26 (2), 211-215 (2000)
PUBMED 11017080
REFERENCE 8 (bases 1 to 6399)
AUTHORS Delettre,C., Lenaers,G., Griffoin,J.M., Gigarel,N., Lorenzo,C.,
Belenguer,P., Pelloquin,L., Grosgeorge,J., Turc-Carel,C.,
Perret,E., Astarie-Dequeker,C., Lasquellec,L., Arnaud,B.,
Ducommun,B., Kaplan,J. and Hamel,C.P.
TITLE Nuclear gene OPA1, encoding a mitochondrial dynamin-related
protein, is mutated in dominant optic atrophy
JOURNAL Nat. Genet. 26 (2), 207-210 (2000)
PUBMED 11017079
REFERENCE 9 (bases 1 to 6399)
AUTHORS Johnston,R.L., Seller,M.J., Behnam,J.T., Burdon,M.A. and
Spalton,D.J.
TITLE Dominant optic atrophy. Refining the clinical diagnostic criteria
in light of genetic linkage studies
JOURNAL Ophthalmology 106 (1), 123-128 (1999)
PUBMED 9917792
REFERENCE 10 (bases 1 to 6399)
AUTHORS Votruba,M., Moore,A.T. and Bhattacharya,S.S.
TITLE Demonstration of a founder effect and fine mapping of dominant
optic atrophy locus on 3q28-qter by linkage disequilibrium method:
a study of 38 British Isles pedigrees
JOURNAL Hum. Genet. 102 (1), 79-86 (1998)
PUBMED 9490303
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC048351.18, AC106710.8 and
BQ774938.1.
On Mar 11, 2009 this sequence version replaced gi:18860836.
Summary: This gene product is a nuclear-encoded mitochondrial
protein with similarity to dynamin-related GTPases. It is a
component of the mitochondrial network. Mutations in this gene have
been associated with optic atrophy type 1, which is a dominantly
inherited optic neuropathy resulting in progressive loss of visual
acuity, leading in many cases to legal blindness. Multiple
transcript variants encoding different isoforms have been found for
this gene. [provided by RefSeq, Mar 2009].
Transcript Variant: This variant (5) contains an additional exon
4b, compared to transcript variant 1. It however, maintains the
same reading frame and encodes an isoform (5) of 978 aa. This
variant is based on an alternate splice pattern characterized by
Delettre et al (2001, PMID: 11810270), but the complete 5' to 3'
exon combination is inferred and not supported at the time of
review by a single long cDNA.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025081,
ERS025082 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-266 AC048351.18 73700-73965
267-585 AC048351.18 95279-95597
586-682 AC048351.18 96230-96326
683-790 AC048351.18 97734-97841
791-844 AC048351.18 98340-98393
845-912 AC048351.18 99425-99492
913-966 AC048351.18 112168-112221
967-1071 AC048351.18 115974-116078
1072-1158 AC048351.18 117751-117837
1159-1272 AC048351.18 118508-118621
1273-1353 AC048351.18 123321-123401
1354-1428 AC048351.18 123531-123605
1429-1500 AC048351.18 123929-124000
1501-1600 AC048351.18 124084-124183
1601-1731 AC048351.18 124531-124661
1732-1804 AC048351.18 126109-126181
1805-1877 AC048351.18 126284-126356
1878-1993 AC048351.18 127621-127736
1994-2058 AC048351.18 128626-128690
2059-2135 AC048351.18 129351-129427
2136-2301 AC048351.18 135418-135583
2302-2454 AC048351.18 137636-137788
2455-2563 AC048351.18 139443-139551
2564-2643 AC048351.18 140038-140117
2644-2784 AC048351.18 143378-143518
2785-2901 AC048351.18 145436-145552
2902-2995 AC048351.18 146852-146945
2996-3106 AC048351.18 147726-147836
3107-3176 AC106710.8 12971-13040
3177-5715 AC106710.8 15514-18052
5716-6399 BQ774938.1 1-684 c
FEATURES Location/Qualifiers
source 1..6399
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q28-q29"
gene 1..6399
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="optic atrophy 1 (autosomal dominant)"
/db_xref="GeneID:4976"
/db_xref="HGNC:8140"
/db_xref="MIM:605290"
exon 1..266
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
misc_feature 22..24
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="upstream in-frame stop codon"
CDS 235..3171
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/EC_number="3.6.5.5"
/note="isoform 5 is encoded by transcript variant 5;
mitochondrial dynamin-like GTPase; dynamin-like 120 kDa
protein, mitochondrial; optic atrophy protein 1;
dynamin-like guanosine triphosphatase"
/codon_start=1
/product="dynamin-like 120 kDa protein, mitochondrial
isoform 5"
/protein_id="NP_570847.2"
/db_xref="GI:224831248"
/db_xref="GeneID:4976"
/db_xref="HGNC:8140"
/db_xref="MIM:605290"
/translation="
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
"
misc_feature 523..573
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O60313.3);
transmembrane region"
misc_feature 970..972
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (O60313.3); acetylation site"
misc_feature 1147..1971
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Dynamin_like protein family includes dynamins and
Mx proteins; Region: DLP_1; cd08771"
/db_xref="CDD:206738"
misc_feature 1159..1695
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Dynamin family; Region: Dynamin_N; pfam00350"
/db_xref="CDD:201172"
misc_feature 1171..1194
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G1 box; other site"
/db_xref="CDD:206738"
misc_feature order(1174..1176,1180..1197,1234..1239,1255..1257,
1480..1482,1690..1692,1696..1701,1792..1806)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206738"
misc_feature order(1177..1182,1492..1494,1531..1533,1606..1608,
1612..1614,1618..1629,1633..1638,1699..1701,1705..1716,
1801..1806)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:206738"
misc_feature 1255..1257
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G2 box; other site"
/db_xref="CDD:206738"
misc_feature 1267..1275
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Switch I region; other site"
/db_xref="CDD:206738"
misc_feature 1480..1491
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G3 box; other site"
/db_xref="CDD:206738"
misc_feature order(1486..1491,1579..1584)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Switch II region; other site"
/db_xref="CDD:206738"
misc_feature 1687..1698
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G4 box; other site"
/db_xref="CDD:206738"
misc_feature 1792..1800
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G5 box; other site"
/db_xref="CDD:206738"
misc_feature 3073..3075
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O60313.3); phosphorylation site"
exon 267..585
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 586..682
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 683..790
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 791..844
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 845..912
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
variation complement(863)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/replace="c"
/replace="t"
/db_xref="dbSNP:34307082"
exon 913..966
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 967..1071
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1072..1158
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1159..1272
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1273..1353
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1354..1428
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1429..1500
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1501..1600
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1601..1731
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1732..1804
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1805..1877
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1878..1993
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1994..2058
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2059..2135
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2136..2301
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2302..2454
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2455..2563
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2564..2643
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2644..2784
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2785..2901
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2902..2995
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2996..3106
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 3107..3176
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 3177..6382
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
polyA_signal 3279..3284
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 3302
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_signal 4309..4314
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 4346
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
STS 4535..5325
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="OPA1__6114"
/db_xref="UniSTS:463662"
STS 4860..5139
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="SGC38140"
/db_xref="UniSTS:81567"
STS 5053..5179
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="SHGC-37414"
/db_xref="UniSTS:21796"
polyA_signal 5177..5182
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 5201
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_signal 5804..5809
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 5823
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
STS 5898..6060
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="SHGC-77667"
/db_xref="UniSTS:70071"
polyA_signal 6077..6082
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 6104
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
STS 6146..6243
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="RH78614"
/db_xref="UniSTS:11888"
polyA_site 6382
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
ORIGIN
gtgctgcccgcctagaaagggtgaagtggttgtttccgtgacggactgagtacgggtgcctgtcaggctcttgcggaagtccatgcgccattgggagggcctcggccgcggctctgtgcccttgctgctgagggccacttcctgggtcattcctggaccgggagccgggctggggctcacacgggggctcccgcgtggccgtctcggcgcctgcgtgacctccccgccggcgggatgtggcgactacgtcgggccgctgtggcctgtgaggtctgccagtctttagtgaaacacagctctggaataaaaggaagtttaccactacaaaaactacatctggtttcacgaagcatttatcattcacatcatcctaccttaaagcttcaacgaccccaattaaggacatcctttcagcagttctcttctctgacaaaccttcctttacgtaaactgaaattctctccaattaaatatggctaccagcctcgcaggaatttttggccagcaagattagctacgagactcttaaaacttcgctatctcatactaggatcggctgttgggggtggctacacagccaaaaagacttttgatcagtggaaagatatgataccggaccttagtgaatataaatggattgtgcctgacattgtgtgggaaattgatgagtatatcgattttgagaaaattagaaaagcccttcctagttcagaagaccttgtaaagttagcaccagactttgacaagattgttgaaagccttagcttattgaaggacttttttacctcaggtcacaaattggttagtgaagtcataggagcttctgacctacttctcttgttaggttctccggaagaaacggcgtttagagcaacagatcgtggatctgaaagtgacaagcattttagaaaggtgtcagacaaagagaaaattgaccaacttcaggaagaacttctgcacactcagttgaagtatcagagaatcttggaacgattagaaaaggagaacaaagaattgagaaaattagtattgcagaaagatgacaaaggcattcatcatagaaagcttaagaaatctttgattgacatgtattctgaagttcttgatgttctctctgattatgatgccagttataatacgcaagatcatctgccacgggttgttgtggttggagatcagagtgctggaaagactagtgtgttggaaatgattgcccaagctcgaatattcccaagaggatctggggagatgatgacacgttctccagttaaggtgactctgagtgaaggtcctcaccatgtggccctatttaaagatagttctcgggagtttgatcttaccaaagaagaagatcttgcagcattaagacatgaaatagaacttcgaatgaggaaaaatgtgaaagaaggctgtaccgttagccctgagaccatatccttaaatgtaaaaggccctggactacagaggatggtgcttgttgacttaccaggtgtgattaatactgtgacatcaggcatggctcctgacacaaaggaaactattttcagtatcagcaaagcttacatgcagaatcctaatgccatcatactgtgtattcaagatggatctgtggatgctgaacgcagtattgttacagacttggtcagtcaaatggaccctcatggaaggagaaccatattcgttttgaccaaagtagacctggcagagaaaaatgtagccagtccaagcaggattcagcagataattgaaggaaagctcttcccaatgaaagctttaggttattttgctgttgtaacaggaaaagggaacagctctgaaagcattgaagctataagagaatatgaagaagagttttttcagaattcaaagctcctaaagacaagcatgctaaaggcacaccaagtgactacaagaaatttaagccttgcagtatcagactgcttttggaaaatggtacgagagtctgttgaacaacaggctgatagtttcaaagcaacacgttttaaccttgaaactgaatggaagaataactatcctcgcctgcgggaacttgaccggaatgaactatttgaaaaagctaaaaatgaaatccttgatgaagttatcagtctgagccaggttacaccaaaacattgggaggaaatccttcaacaatctttgtgggaaagagtatcaactcatgtgattgaaaacatctaccttccagctgcgcagaccatgaattcaggaacttttaacaccacagtggatatcaagcttaaacagtggactgataaacaacttcctaataaagcagtagaggttgcttgggagaccctacaagaagaattttcccgctttatgacagaaccgaaagggaaagagcatgatgacatatttgataaacttaaagaggctgttaaggaagaaagtattaaacgacacaagtggaatgactttgcggaggacagcttgagggttattcaacacaatgctttggaagaccgatccatatctgataaacagcaatgggatgcagctatttattttatggaagaggctctgcaggctcgtctcaaggatactgaaaatgcaattgaaaacatggtgggtccagactggaaaaagaggtggttatactggaagaatcggacccaagaacagtgtgttcacaatgaaaccaagaatgaattggagaagatgttgaaatgtaatgaggagcacccagcttatcttgcaagtgatgaaataaccacagtccggaagaaccttgaatcccgaggagtagaagtagatccaagcttgattaaggatacttggcatcaagtttatagaagacattttttaaaaacagctctaaaccattgtaacctttgtcgaagaggtttttattactaccaaaggcattttgtagattctgagttggaatgcaatgatgtggtcttgttttggcgtatacagcgcatgcttgctatcaccgcaaatactttaaggcaacaacttacaaatactgaagttaggcgattagagaaaaatgttaaagaggtattggaagattttgctgaagatggtgagaagaagattaaattgcttactggtaaacgcgttcaactggcggaagacctcaagaaagttagagaaattcaagaaaaacttgatgctttcattgaagctcttcatcaggagaaataaattaaaatcgtactcataatcagctctgcatacatctgaagaacaaaaacatcaacgtcttttgtccagcctctttttcttctgctgttccacctttctaaacatacaataaagtcatgggataaaaataatcgatgtatgttacgggcgctttaaccatcagctgcctctcgaatggaagaacagtggtaatggattaacatcctattttgttgtactaaagtgacaaatcggaataatataattggtatggccattaggttcagtccttgaagataagaaacttgttctctgtttgttgtcttatttgtggtggcactcgtttaatggattaactgaggttgctcaatgttcagtttcttttccagaaatacaatgctaggtgttttgaaataaaacttatatagcaattgtttaaagttatcaattgtatataaaatcacagtagcctgctaaatcattgtatgtgtctgtagtattctattcccagaaactatttgaccatgataattcagtttatattcaccacatgaaagaaaaatgggtaacagaagaacccttaaaacaggttaatttggattgtaacgttcagtgaaagaaatttcaacccttcatagccagcgaagaaatttgccttggaagccaagtcagtaccagcttacctatttgattcagttgctgttttctcactctctatatccatttgaaattgatttattttagatgttgtatacttacgttaggctttctgttaatagtggtttttctcctgttgacagagccaccggattatgacacaggatgaggaagattaaggataatcaattgactaatttcatttagaatattatcaaacatttcaactaggtatcagaaaaaggctttctttcataagactattttaaatagaaattatttcaacaattaaagtaatgttgaccatccccctctcagctgaataaagaaaaatttagttcaatttattgcaatttaattacaatactaccttcacaacattttcatgtgttttaaataaatattttttaattggctaaaggacattcaagcaaagaaatgctttctttacttaaaatgtctatctcatttgctgccttttcactaagcctttactttgttaataaaagtgtccattgtgtgatgtttttgattttacagtttgctaaatcttattttcttggagttgctttttggtaacagccccattgctactccccattttattgttttacatcaatgcatgcttcgttgtgatccctcaagatgtaacacttggtatgctcggttgaggatatgaaaaaatacttccgaaaccaggaattcaatgtatgtttgttttatactgtttgataagaaaagtaggtccagccttaagcagcacagatgcgctggtagatgcatagtcaggaactttttttatttcttttaggtctagggacaggagtgaatagaaagggaggagagctctattatgttctatacacagattaggagatgaccttactgggtacacccctctaaccagtgcttacaggttaatgcatgttaatgaatatttttgcagttgtaaagcataacaattacaactacacatctatttctaaagaataaaacaggaccatatttatttacttctgtcaactatagaaagaaagaccttcagctgtatttccacagatttctcccaaggaaaaggctaatattagtcactactgttatcacatccctttgtataagttttaaaaagagatggagggagatcttcatttctttgaggagatcagtattgtaacgtatgtgaatagatgataacaattaatattactaaaagtcccacatgagagtcctgacgccctctccatgccccacagtaatgtggcttctttcatgggtttttttttcttctttttagctgatctcatcctaagcatgctttatttttccttgaaagctaggtatttatcaactgcagatgttattgaaagaaaataaaattcagtctcaagagtaaaccctgtgtcttgtgtctgtagttcaaaagtcagaaatgattctaatttaaacaaaaagatactaaatatacagaagttaaattcgaactagccacagaatcatttgtttttatgtcagaatttgcaaagagtggagtggacaaagctctgtatggaagactgaacaactgtaaatagatgatatccaaacttaatttggctaggacttcaattttaaaaatcagtgtacctaggcagtgcacagcacgaaataagtggcccttgcagcttccccgtttaacccactgtgctatagttgcgggtggaacagtcaacctttctagtagtttatgatattgccctctttgtattcccattttctacagttttttccgcagacttctttctgcaaattattcagcctccaaatgcaaatgaatgatataaaaataagtagggaacatggcagagagtggtgcttcccagcctcacaatgtgggaatttgacataggatgagagtcagagtataggtttaaaagataaaatctttagttaataattttgtatttatttattctagatgtatgtatctgaggaaagaaatctggtatttttgctttccaataaaggggatcaaagtaatggtttttctctcagttctctaagctggtctatgttatagctctagcagtatggaaatgtgctttaaaatatgcttaccttttgaatgatcatggctatatgttgttgagatatttgaaacttaccttgttttcacttgtgcactgtgaatgaactttgtattatttttttaaaaccttcacattacgtgtagatattattgcaacttatattttgcctgagcttgatcaaaggtcatttgtgtagatgagtaattaaaaaatatttaaatcacattataattctattattggagagcatcttttaaatttttttctgttttaacgagggaaagagaaacctgtatacctagggtcattatttgaccccatagtataaccagattcatggtctaacaagctctcagtgtggcttttctctgaatgcttgaatttcacatgccttgcatttcacagttgtactccatggtcaaccggtgctttttttcacatcgtggtacttgtcaaaacattttgttattttccttggtaaaatatataaaaaaggttttctaatttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4976 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: NAS
GeneID:4976 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS
GeneID:4976 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4976 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:4976 -> Biological process: GO:0000266 [mitochondrial fission] evidence: TAS
GeneID:4976 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA
GeneID:4976 -> Biological process: GO:0006184 [GTP catabolic process] evidence: TAS
GeneID:4976 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: IMP
GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: NAS
GeneID:4976 -> Biological process: GO:0007007 [inner mitochondrial membrane organization] evidence: IDA
GeneID:4976 -> Biological process: GO:0007601 [visual perception] evidence: IMP
GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IDA
GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IMP
GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: TAS
GeneID:4976 -> Biological process: GO:0019896 [axon transport of mitochondrion] evidence: TAS
GeneID:4976 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IMP
GeneID:4976 -> Biological process: GO:0090398 [cellular senescence] evidence: IDA
GeneID:4976 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:4976 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IDA
GeneID:4976 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: NAS
GeneID:4976 -> Cellular component: GO:0005758 [mitochondrial intermembrane space] evidence: ISS
GeneID:4976 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:4976 -> Cellular component: GO:0030061 [mitochondrial crista] evidence: IDA
GeneID:4976 -> Cellular component: GO:0030425 [dendrite] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_570847 -> EC 3.6.5.5
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.