2024-04-19 10:01:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_130833 6348 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens optic atrophy 1 (autosomal dominant) (OPA1), transcript variant 4, mRNA. ACCESSION NM_130833 VERSION NM_130833.2 GI:224831246 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6348) AUTHORS Kushnareva,Y.E., Gerencser,A.A., Bossy,B., Ju,W.K., White,A.D., Waggoner,J., Ellisman,M.H., Perkins,G. and Bossy-Wetzel,E. TITLE Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity JOURNAL Cell Death Differ. 20 (2), 353-365 (2013) PUBMED 23138851 REMARK GeneRIF: OPA1 is required for mitochondrial fusion, maintenance of crista morphology and oxidative phosphorylation, loss of OPA1 also results in defective Ca(2+) homeostasis. REFERENCE 2 (bases 1 to 6348) AUTHORS Zhao,X., Tian,C., Puszyk,W.M., Ogunwobi,O.O., Cao,M., Wang,T., Cabrera,R., Nelson,D.R. and Liu,C. TITLE OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma JOURNAL Lab. Invest. 93 (1), 8-19 (2013) PUBMED 23108376 REMARK GeneRIF: Show that sorafenib triggers apoptosis in HCC cells by targeting mitochondria. Treatment with sorafenib induces rapid mitochondrial fragmentation, which is associated with the deregulation of mitochondria fusion-related protein optic atrophy 1 (OPA1). REFERENCE 3 (bases 1 to 6348) AUTHORS Belenguer,P. and Pellegrini,L. TITLE The dynamin GTPase OPA1: more than mitochondria? JOURNAL Biochim. Biophys. Acta 1833 (1), 176-183 (2013) PUBMED 22902477 REMARK GeneRIF: OPA1 mediates adrenergic control of lipolysis by functioning as a cytosolic A-kinase anchoring protein (AKAP), on the hemimembrane that envelops the lipid droplet. Review article REFERENCE 4 (bases 1 to 6348) AUTHORS Sarzi,E., Angebault,C., Seveno,M., Gueguen,N., Chaix,B., Bielicki,G., Boddaert,N., Mausset-Bonnefont,A.L., Cazevieille,C., Rigau,V., Renou,J.P., Wang,J., Delettre,C., Brabet,P., Puel,J.L., Hamel,C.P., Reynier,P. and Lenaers,G. TITLE The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse JOURNAL Brain 135 (PT 12), 3599-3613 (2012) PUBMED 23250881 REMARK GeneRIF: the results of this study supported the concept that Opa1 protects against neuronal degeneration and opens new perspectives for the exploration and the treatment of mitochondrial diseases. REFERENCE 5 (bases 1 to 6348) AUTHORS Sitarz,K.S., Almind,G.J., Horvath,R., Czermin,B., Gronskov,K., Pyle,A., Taylor,R.W., Larsen,M., Chinnery,P.F. and Yu-Wai-Man,P. TITLE OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy JOURNAL Neurology 79 (14), 1515-1517 (2012) PUBMED 22993284 REMARK GeneRIF: This study has revealed significant mtDNA proliferation in blood leukocytes harboring pathogenic OPA1 mutations in 3 independent patient cohorts. REFERENCE 6 (bases 1 to 6348) AUTHORS Delettre,C., Griffoin,J.M., Kaplan,J., Dollfus,H., Lorenz,B., Faivre,L., Lenaers,G., Belenguer,P. and Hamel,C.P. TITLE Mutation spectrum and splicing variants in the OPA1 gene JOURNAL Hum. Genet. 109 (6), 584-591 (2001) PUBMED 11810270 REFERENCE 7 (bases 1 to 6348) AUTHORS Alexander,C., Votruba,M., Pesch,U.E., Thiselton,D.L., Mayer,S., Moore,A., Rodriguez,M., Kellner,U., Leo-Kottler,B., Auburger,G., Bhattacharya,S.S. and Wissinger,B. TITLE OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 JOURNAL Nat. Genet. 26 (2), 211-215 (2000) PUBMED 11017080 REFERENCE 8 (bases 1 to 6348) AUTHORS Delettre,C., Lenaers,G., Griffoin,J.M., Gigarel,N., Lorenzo,C., Belenguer,P., Pelloquin,L., Grosgeorge,J., Turc-Carel,C., Perret,E., Astarie-Dequeker,C., Lasquellec,L., Arnaud,B., Ducommun,B., Kaplan,J. and Hamel,C.P. TITLE Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy JOURNAL Nat. Genet. 26 (2), 207-210 (2000) PUBMED 11017079 REFERENCE 9 (bases 1 to 6348) AUTHORS Johnston,R.L., Seller,M.J., Behnam,J.T., Burdon,M.A. and Spalton,D.J. TITLE Dominant optic atrophy. Refining the clinical diagnostic criteria in light of genetic linkage studies JOURNAL Ophthalmology 106 (1), 123-128 (1999) PUBMED 9917792 REFERENCE 10 (bases 1 to 6348) AUTHORS Votruba,M., Moore,A.T. and Bhattacharya,S.S. TITLE Demonstration of a founder effect and fine mapping of dominant optic atrophy locus on 3q28-qter by linkage disequilibrium method: a study of 38 British Isles pedigrees JOURNAL Hum. Genet. 102 (1), 79-86 (1998) PUBMED 9490303 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC048351.18, AC106710.8 and BQ774938.1. On Mar 11, 2009 this sequence version replaced gi:18860834. Summary: This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (4) is missing exon 4, but contains exon 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (4) of 961 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-266 AC048351.18 73700-73965 267-585 AC048351.18 95279-95597 586-682 AC048351.18 96230-96326 683-750 AC048351.18 99425-99492 751-861 AC048351.18 106648-106758 862-915 AC048351.18 112168-112221 916-1020 AC048351.18 115974-116078 1021-1107 AC048351.18 117751-117837 1108-1221 AC048351.18 118508-118621 1222-1302 AC048351.18 123321-123401 1303-1377 AC048351.18 123531-123605 1378-1449 AC048351.18 123929-124000 1450-1549 AC048351.18 124084-124183 1550-1680 AC048351.18 124531-124661 1681-1753 AC048351.18 126109-126181 1754-1826 AC048351.18 126284-126356 1827-1942 AC048351.18 127621-127736 1943-2007 AC048351.18 128626-128690 2008-2084 AC048351.18 129351-129427 2085-2250 AC048351.18 135418-135583 2251-2403 AC048351.18 137636-137788 2404-2512 AC048351.18 139443-139551 2513-2592 AC048351.18 140038-140117 2593-2733 AC048351.18 143378-143518 2734-2850 AC048351.18 145436-145552 2851-2944 AC048351.18 146852-146945 2945-3055 AC048351.18 147726-147836 3056-3125 AC106710.8 12971-13040 3126-5664 AC106710.8 15514-18052 5665-6348 BQ774938.1 1-684 c FEATURES Location/Qualifiers source 1..6348 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q28-q29" gene 1..6348 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="optic atrophy 1 (autosomal dominant)" /db_xref="GeneID:4976" /db_xref="HGNC:8140" /db_xref="HPRD:05596" /db_xref="MIM:605290" exon 1..266 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" misc_feature 22..24 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="upstream in-frame stop codon" CDS 235..3120 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /EC_number="3.6.5.5" /note="isoform 4 is encoded by transcript variant 4; mitochondrial dynamin-like GTPase; dynamin-like 120 kDa protein, mitochondrial; optic atrophy protein 1; dynamin-like guanosine triphosphatase" /codon_start=1 /product="dynamin-like 120 kDa protein, mitochondrial isoform 4" /protein_id="NP_570846.1" /db_xref="GI:18860835" /db_xref="GeneID:4976" /db_xref="HGNC:8140" /db_xref="HPRD:05596" /db_xref="MIM:605290" /translation="
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
" misc_feature 1096..1920 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Dynamin_like protein family includes dynamins and Mx proteins; Region: DLP_1; cd08771" /db_xref="CDD:206738" misc_feature 1108..1644 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Dynamin family; Region: Dynamin_N; pfam00350" /db_xref="CDD:201172" misc_feature 1120..1143 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G1 box; other site" /db_xref="CDD:206738" misc_feature order(1123..1125,1129..1146,1183..1188,1204..1206, 1429..1431,1639..1641,1645..1650,1741..1755) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="GTP/Mg2+ binding site [chemical binding]; other site" /db_xref="CDD:206738" misc_feature order(1126..1131,1441..1443,1480..1482,1555..1557, 1561..1563,1567..1578,1582..1587,1648..1650,1654..1665, 1750..1755) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="homodimer interface [polypeptide binding]; other site" /db_xref="CDD:206738" misc_feature 1204..1206 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G2 box; other site" /db_xref="CDD:206738" misc_feature 1216..1224 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Switch I region; other site" /db_xref="CDD:206738" misc_feature 1429..1440 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G3 box; other site" /db_xref="CDD:206738" misc_feature order(1435..1440,1528..1533) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Switch II region; other site" /db_xref="CDD:206738" misc_feature 1636..1647 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G4 box; other site" /db_xref="CDD:206738" misc_feature 1741..1749 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G5 box; other site" /db_xref="CDD:206738" misc_feature 3022..3024 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 267..585 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 586..682 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 683..750 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" variation complement(701) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /replace="c" /replace="t" /db_xref="dbSNP:34307082" exon 751..861 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 862..915 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 916..1020 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1021..1107 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1108..1221 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1222..1302 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1303..1377 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1378..1449 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1450..1549 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1550..1680 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1681..1753 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1754..1826 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1827..1942 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1943..2007 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2008..2084 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2085..2250 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2251..2403 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2404..2512 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2513..2592 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2593..2733 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2734..2850 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2851..2944 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2945..3055 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 3056..3125 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 3126..6331 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" polyA_signal 3228..3233 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 3251 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_signal 4258..4263 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 4295 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" STS 4484..5274 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="OPA1__6114" /db_xref="UniSTS:463662" STS 4809..5088 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="SGC38140" /db_xref="UniSTS:81567" STS 5002..5128 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="SHGC-37414" /db_xref="UniSTS:21796" polyA_signal 5126..5131 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 5150 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_signal 5753..5758 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 5772 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" STS 5847..6009 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="SHGC-77667" /db_xref="UniSTS:70071" polyA_signal 6026..6031 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 6053 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" STS 6095..6192 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="RH78614" /db_xref="UniSTS:11888" polyA_site 6331 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" ORIGIN
gtgctgcccgcctagaaagggtgaagtggttgtttccgtgacggactgagtacgggtgcctgtcaggctcttgcggaagtccatgcgccattgggagggcctcggccgcggctctgtgcccttgctgctgagggccacttcctgggtcattcctggaccgggagccgggctggggctcacacgggggctcccgcgtggccgtctcggcgcctgcgtgacctccccgccggcgggatgtggcgactacgtcgggccgctgtggcctgtgaggtctgccagtctttagtgaaacacagctctggaataaaaggaagtttaccactacaaaaactacatctggtttcacgaagcatttatcattcacatcatcctaccttaaagcttcaacgaccccaattaaggacatcctttcagcagttctcttctctgacaaaccttcctttacgtaaactgaaattctctccaattaaatatggctaccagcctcgcaggaatttttggccagcaagattagctacgagactcttaaaacttcgctatctcatactaggatcggctgttgggggtggctacacagccaaaaagacttttgatcagtggaaagatatgataccggaccttagtgaatataaatggattgtgcctgacattgtgtgggaaattgatgagtatatcgattttggttctccggaagaaacggcgtttagagcaacagatcgtggatctgaaagtgacaagcattttagaaagggtctgcttggtgagctcattctcttacaacaacaaattcaagagcatgaagaggaagcgcgcagagccgctggccaatatagcacgagctatgcccaacagaagcgcaaggtgtcagacaaagagaaaattgaccaacttcaggaagaacttctgcacactcagttgaagtatcagagaatcttggaacgattagaaaaggagaacaaagaattgagaaaattagtattgcagaaagatgacaaaggcattcatcatagaaagcttaagaaatctttgattgacatgtattctgaagttcttgatgttctctctgattatgatgccagttataatacgcaagatcatctgccacgggttgttgtggttggagatcagagtgctggaaagactagtgtgttggaaatgattgcccaagctcgaatattcccaagaggatctggggagatgatgacacgttctccagttaaggtgactctgagtgaaggtcctcaccatgtggccctatttaaagatagttctcgggagtttgatcttaccaaagaagaagatcttgcagcattaagacatgaaatagaacttcgaatgaggaaaaatgtgaaagaaggctgtaccgttagccctgagaccatatccttaaatgtaaaaggccctggactacagaggatggtgcttgttgacttaccaggtgtgattaatactgtgacatcaggcatggctcctgacacaaaggaaactattttcagtatcagcaaagcttacatgcagaatcctaatgccatcatactgtgtattcaagatggatctgtggatgctgaacgcagtattgttacagacttggtcagtcaaatggaccctcatggaaggagaaccatattcgttttgaccaaagtagacctggcagagaaaaatgtagccagtccaagcaggattcagcagataattgaaggaaagctcttcccaatgaaagctttaggttattttgctgttgtaacaggaaaagggaacagctctgaaagcattgaagctataagagaatatgaagaagagttttttcagaattcaaagctcctaaagacaagcatgctaaaggcacaccaagtgactacaagaaatttaagccttgcagtatcagactgcttttggaaaatggtacgagagtctgttgaacaacaggctgatagtttcaaagcaacacgttttaaccttgaaactgaatggaagaataactatcctcgcctgcgggaacttgaccggaatgaactatttgaaaaagctaaaaatgaaatccttgatgaagttatcagtctgagccaggttacaccaaaacattgggaggaaatccttcaacaatctttgtgggaaagagtatcaactcatgtgattgaaaacatctaccttccagctgcgcagaccatgaattcaggaacttttaacaccacagtggatatcaagcttaaacagtggactgataaacaacttcctaataaagcagtagaggttgcttgggagaccctacaagaagaattttcccgctttatgacagaaccgaaagggaaagagcatgatgacatatttgataaacttaaagaggctgttaaggaagaaagtattaaacgacacaagtggaatgactttgcggaggacagcttgagggttattcaacacaatgctttggaagaccgatccatatctgataaacagcaatgggatgcagctatttattttatggaagaggctctgcaggctcgtctcaaggatactgaaaatgcaattgaaaacatggtgggtccagactggaaaaagaggtggttatactggaagaatcggacccaagaacagtgtgttcacaatgaaaccaagaatgaattggagaagatgttgaaatgtaatgaggagcacccagcttatcttgcaagtgatgaaataaccacagtccggaagaaccttgaatcccgaggagtagaagtagatccaagcttgattaaggatacttggcatcaagtttatagaagacattttttaaaaacagctctaaaccattgtaacctttgtcgaagaggtttttattactaccaaaggcattttgtagattctgagttggaatgcaatgatgtggtcttgttttggcgtatacagcgcatgcttgctatcaccgcaaatactttaaggcaacaacttacaaatactgaagttaggcgattagagaaaaatgttaaagaggtattggaagattttgctgaagatggtgagaagaagattaaattgcttactggtaaacgcgttcaactggcggaagacctcaagaaagttagagaaattcaagaaaaacttgatgctttcattgaagctcttcatcaggagaaataaattaaaatcgtactcataatcagctctgcatacatctgaagaacaaaaacatcaacgtcttttgtccagcctctttttcttctgctgttccacctttctaaacatacaataaagtcatgggataaaaataatcgatgtatgttacgggcgctttaaccatcagctgcctctcgaatggaagaacagtggtaatggattaacatcctattttgttgtactaaagtgacaaatcggaataatataattggtatggccattaggttcagtccttgaagataagaaacttgttctctgtttgttgtcttatttgtggtggcactcgtttaatggattaactgaggttgctcaatgttcagtttcttttccagaaatacaatgctaggtgttttgaaataaaacttatatagcaattgtttaaagttatcaattgtatataaaatcacagtagcctgctaaatcattgtatgtgtctgtagtattctattcccagaaactatttgaccatgataattcagtttatattcaccacatgaaagaaaaatgggtaacagaagaacccttaaaacaggttaatttggattgtaacgttcagtgaaagaaatttcaacccttcatagccagcgaagaaatttgccttggaagccaagtcagtaccagcttacctatttgattcagttgctgttttctcactctctatatccatttgaaattgatttattttagatgttgtatacttacgttaggctttctgttaatagtggtttttctcctgttgacagagccaccggattatgacacaggatgaggaagattaaggataatcaattgactaatttcatttagaatattatcaaacatttcaactaggtatcagaaaaaggctttctttcataagactattttaaatagaaattatttcaacaattaaagtaatgttgaccatccccctctcagctgaataaagaaaaatttagttcaatttattgcaatttaattacaatactaccttcacaacattttcatgtgttttaaataaatattttttaattggctaaaggacattcaagcaaagaaatgctttctttacttaaaatgtctatctcatttgctgccttttcactaagcctttactttgttaataaaagtgtccattgtgtgatgtttttgattttacagtttgctaaatcttattttcttggagttgctttttggtaacagccccattgctactccccattttattgttttacatcaatgcatgcttcgttgtgatccctcaagatgtaacacttggtatgctcggttgaggatatgaaaaaatacttccgaaaccaggaattcaatgtatgtttgttttatactgtttgataagaaaagtaggtccagccttaagcagcacagatgcgctggtagatgcatagtcaggaactttttttatttcttttaggtctagggacaggagtgaatagaaagggaggagagctctattatgttctatacacagattaggagatgaccttactgggtacacccctctaaccagtgcttacaggttaatgcatgttaatgaatatttttgcagttgtaaagcataacaattacaactacacatctatttctaaagaataaaacaggaccatatttatttacttctgtcaactatagaaagaaagaccttcagctgtatttccacagatttctcccaaggaaaaggctaatattagtcactactgttatcacatccctttgtataagttttaaaaagagatggagggagatcttcatttctttgaggagatcagtattgtaacgtatgtgaatagatgataacaattaatattactaaaagtcccacatgagagtcctgacgccctctccatgccccacagtaatgtggcttctttcatgggtttttttttcttctttttagctgatctcatcctaagcatgctttatttttccttgaaagctaggtatttatcaactgcagatgttattgaaagaaaataaaattcagtctcaagagtaaaccctgtgtcttgtgtctgtagttcaaaagtcagaaatgattctaatttaaacaaaaagatactaaatatacagaagttaaattcgaactagccacagaatcatttgtttttatgtcagaatttgcaaagagtggagtggacaaagctctgtatggaagactgaacaactgtaaatagatgatatccaaacttaatttggctaggacttcaattttaaaaatcagtgtacctaggcagtgcacagcacgaaataagtggcccttgcagcttccccgtttaacccactgtgctatagttgcgggtggaacagtcaacctttctagtagtttatgatattgccctctttgtattcccattttctacagttttttccgcagacttctttctgcaaattattcagcctccaaatgcaaatgaatgatataaaaataagtagggaacatggcagagagtggtgcttcccagcctcacaatgtgggaatttgacataggatgagagtcagagtataggtttaaaagataaaatctttagttaataattttgtatttatttattctagatgtatgtatctgaggaaagaaatctggtatttttgctttccaataaaggggatcaaagtaatggtttttctctcagttctctaagctggtctatgttatagctctagcagtatggaaatgtgctttaaaatatgcttaccttttgaatgatcatggctatatgttgttgagatatttgaaacttaccttgttttcacttgtgcactgtgaatgaactttgtattatttttttaaaaccttcacattacgtgtagatattattgcaacttatattttgcctgagcttgatcaaaggtcatttgtgtagatgagtaattaaaaaatatttaaatcacattataattctattattggagagcatcttttaaatttttttctgttttaacgagggaaagagaaacctgtatacctagggtcattatttgaccccatagtataaccagattcatggtctaacaagctctcagtgtggcttttctctgaatgcttgaatttcacatgccttgcatttcacagttgtactccatggtcaaccggtgctttttttcacatcgtggtacttgtcaaaacattttgttattttccttggtaaaatatataaaaaaggttttctaatttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4976 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: NAS GeneID:4976 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS GeneID:4976 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4976 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA GeneID:4976 -> Biological process: GO:0000266 [mitochondrial fission] evidence: TAS GeneID:4976 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA GeneID:4976 -> Biological process: GO:0006184 [GTP catabolic process] evidence: TAS GeneID:4976 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: IMP GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: NAS GeneID:4976 -> Biological process: GO:0007007 [inner mitochondrial membrane organization] evidence: IDA GeneID:4976 -> Biological process: GO:0007601 [visual perception] evidence: IMP GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IDA GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IMP GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: TAS GeneID:4976 -> Biological process: GO:0019896 [axon transport of mitochondrion] evidence: TAS GeneID:4976 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IMP GeneID:4976 -> Biological process: GO:0090398 [cellular senescence] evidence: IDA GeneID:4976 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:4976 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IDA GeneID:4976 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: NAS GeneID:4976 -> Cellular component: GO:0005758 [mitochondrial intermembrane space] evidence: ISS GeneID:4976 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA GeneID:4976 -> Cellular component: GO:0030061 [mitochondrial crista] evidence: IDA GeneID:4976 -> Cellular component: GO:0030425 [dendrite] evidence: ISS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_570846 -> EC 3.6.5.5
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