2024-05-09 07:25:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_130832 6291 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens optic atrophy 1 (autosomal dominant) (OPA1), transcript variant 3, mRNA. ACCESSION NM_130832 VERSION NM_130832.2 GI:224831245 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6291) AUTHORS Kushnareva,Y.E., Gerencser,A.A., Bossy,B., Ju,W.K., White,A.D., Waggoner,J., Ellisman,M.H., Perkins,G. and Bossy-Wetzel,E. TITLE Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity JOURNAL Cell Death Differ. 20 (2), 353-365 (2013) PUBMED 23138851 REMARK GeneRIF: OPA1 is required for mitochondrial fusion, maintenance of crista morphology and oxidative phosphorylation, loss of OPA1 also results in defective Ca(2+) homeostasis. REFERENCE 2 (bases 1 to 6291) AUTHORS Zhao,X., Tian,C., Puszyk,W.M., Ogunwobi,O.O., Cao,M., Wang,T., Cabrera,R., Nelson,D.R. and Liu,C. TITLE OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma JOURNAL Lab. Invest. 93 (1), 8-19 (2013) PUBMED 23108376 REMARK GeneRIF: Show that sorafenib triggers apoptosis in HCC cells by targeting mitochondria. Treatment with sorafenib induces rapid mitochondrial fragmentation, which is associated with the deregulation of mitochondria fusion-related protein optic atrophy 1 (OPA1). REFERENCE 3 (bases 1 to 6291) AUTHORS Belenguer,P. and Pellegrini,L. TITLE The dynamin GTPase OPA1: more than mitochondria? JOURNAL Biochim. Biophys. Acta 1833 (1), 176-183 (2013) PUBMED 22902477 REMARK GeneRIF: OPA1 mediates adrenergic control of lipolysis by functioning as a cytosolic A-kinase anchoring protein (AKAP), on the hemimembrane that envelops the lipid droplet. Review article REFERENCE 4 (bases 1 to 6291) AUTHORS Sarzi,E., Angebault,C., Seveno,M., Gueguen,N., Chaix,B., Bielicki,G., Boddaert,N., Mausset-Bonnefont,A.L., Cazevieille,C., Rigau,V., Renou,J.P., Wang,J., Delettre,C., Brabet,P., Puel,J.L., Hamel,C.P., Reynier,P. and Lenaers,G. TITLE The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse JOURNAL Brain 135 (PT 12), 3599-3613 (2012) PUBMED 23250881 REMARK GeneRIF: the results of this study supported the concept that Opa1 protects against neuronal degeneration and opens new perspectives for the exploration and the treatment of mitochondrial diseases. REFERENCE 5 (bases 1 to 6291) AUTHORS Sitarz,K.S., Almind,G.J., Horvath,R., Czermin,B., Gronskov,K., Pyle,A., Taylor,R.W., Larsen,M., Chinnery,P.F. and Yu-Wai-Man,P. TITLE OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy JOURNAL Neurology 79 (14), 1515-1517 (2012) PUBMED 22993284 REMARK GeneRIF: This study has revealed significant mtDNA proliferation in blood leukocytes harboring pathogenic OPA1 mutations in 3 independent patient cohorts. REFERENCE 6 (bases 1 to 6291) AUTHORS Delettre,C., Griffoin,J.M., Kaplan,J., Dollfus,H., Lorenz,B., Faivre,L., Lenaers,G., Belenguer,P. and Hamel,C.P. TITLE Mutation spectrum and splicing variants in the OPA1 gene JOURNAL Hum. Genet. 109 (6), 584-591 (2001) PUBMED 11810270 REFERENCE 7 (bases 1 to 6291) AUTHORS Alexander,C., Votruba,M., Pesch,U.E., Thiselton,D.L., Mayer,S., Moore,A., Rodriguez,M., Kellner,U., Leo-Kottler,B., Auburger,G., Bhattacharya,S.S. and Wissinger,B. TITLE OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 JOURNAL Nat. Genet. 26 (2), 211-215 (2000) PUBMED 11017080 REFERENCE 8 (bases 1 to 6291) AUTHORS Delettre,C., Lenaers,G., Griffoin,J.M., Gigarel,N., Lorenzo,C., Belenguer,P., Pelloquin,L., Grosgeorge,J., Turc-Carel,C., Perret,E., Astarie-Dequeker,C., Lasquellec,L., Arnaud,B., Ducommun,B., Kaplan,J. and Hamel,C.P. TITLE Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy JOURNAL Nat. Genet. 26 (2), 207-210 (2000) PUBMED 11017079 REFERENCE 9 (bases 1 to 6291) AUTHORS Johnston,R.L., Seller,M.J., Behnam,J.T., Burdon,M.A. and Spalton,D.J. TITLE Dominant optic atrophy. Refining the clinical diagnostic criteria in light of genetic linkage studies JOURNAL Ophthalmology 106 (1), 123-128 (1999) PUBMED 9917792 REFERENCE 10 (bases 1 to 6291) AUTHORS Votruba,M., Moore,A.T. and Bhattacharya,S.S. TITLE Demonstration of a founder effect and fine mapping of dominant optic atrophy locus on 3q28-qter by linkage disequilibrium method: a study of 38 British Isles pedigrees JOURNAL Hum. Genet. 102 (1), 79-86 (1998) PUBMED 9490303 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC048351.18, AC106710.8 and BQ774938.1. On Mar 11, 2009 this sequence version replaced gi:18860832. Summary: This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (3) is missing exon 4, but contains exon 4b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (3) of 942 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-266 AC048351.18 73700-73965 267-585 AC048351.18 95279-95597 586-682 AC048351.18 96230-96326 683-736 AC048351.18 98340-98393 737-804 AC048351.18 99425-99492 805-858 AC048351.18 112168-112221 859-963 AC048351.18 115974-116078 964-1050 AC048351.18 117751-117837 1051-1164 AC048351.18 118508-118621 1165-1245 AC048351.18 123321-123401 1246-1320 AC048351.18 123531-123605 1321-1392 AC048351.18 123929-124000 1393-1492 AC048351.18 124084-124183 1493-1623 AC048351.18 124531-124661 1624-1696 AC048351.18 126109-126181 1697-1769 AC048351.18 126284-126356 1770-1885 AC048351.18 127621-127736 1886-1950 AC048351.18 128626-128690 1951-2027 AC048351.18 129351-129427 2028-2193 AC048351.18 135418-135583 2194-2346 AC048351.18 137636-137788 2347-2455 AC048351.18 139443-139551 2456-2535 AC048351.18 140038-140117 2536-2676 AC048351.18 143378-143518 2677-2793 AC048351.18 145436-145552 2794-2887 AC048351.18 146852-146945 2888-2998 AC048351.18 147726-147836 2999-3068 AC106710.8 12971-13040 3069-5607 AC106710.8 15514-18052 5608-6291 BQ774938.1 1-684 c FEATURES Location/Qualifiers source 1..6291 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q28-q29" gene 1..6291 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="optic atrophy 1 (autosomal dominant)" /db_xref="GeneID:4976" /db_xref="HGNC:8140" /db_xref="HPRD:05596" /db_xref="MIM:605290" exon 1..266 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" misc_feature 22..24 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="upstream in-frame stop codon" CDS 235..3063 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /EC_number="3.6.5.5" /note="isoform 3 is encoded by transcript variant 3; mitochondrial dynamin-like GTPase; dynamin-like 120 kDa protein, mitochondrial; optic atrophy protein 1; dynamin-like guanosine triphosphatase" /codon_start=1 /product="dynamin-like 120 kDa protein, mitochondrial isoform 3" /protein_id="NP_570845.1" /db_xref="GI:18860833" /db_xref="GeneID:4976" /db_xref="HGNC:8140" /db_xref="HPRD:05596" /db_xref="MIM:605290" /translation="
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
" misc_feature 1039..1863 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Dynamin_like protein family includes dynamins and Mx proteins; Region: DLP_1; cd08771" /db_xref="CDD:206738" misc_feature 1051..1587 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Dynamin family; Region: Dynamin_N; pfam00350" /db_xref="CDD:201172" misc_feature 1063..1086 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G1 box; other site" /db_xref="CDD:206738" misc_feature order(1066..1068,1072..1089,1126..1131,1147..1149, 1372..1374,1582..1584,1588..1593,1684..1698) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="GTP/Mg2+ binding site [chemical binding]; other site" /db_xref="CDD:206738" misc_feature order(1069..1074,1384..1386,1423..1425,1498..1500, 1504..1506,1510..1521,1525..1530,1591..1593,1597..1608, 1693..1698) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="homodimer interface [polypeptide binding]; other site" /db_xref="CDD:206738" misc_feature 1147..1149 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G2 box; other site" /db_xref="CDD:206738" misc_feature 1159..1167 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Switch I region; other site" /db_xref="CDD:206738" misc_feature 1372..1383 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G3 box; other site" /db_xref="CDD:206738" misc_feature order(1378..1383,1471..1476) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="Switch II region; other site" /db_xref="CDD:206738" misc_feature 1579..1590 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G4 box; other site" /db_xref="CDD:206738" misc_feature 1684..1692 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /note="G5 box; other site" /db_xref="CDD:206738" misc_feature 2965..2967 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 267..585 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 586..682 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 683..736 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 737..804 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" variation complement(755) /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /replace="c" /replace="t" /db_xref="dbSNP:34307082" exon 805..858 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 859..963 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 964..1050 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1051..1164 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1165..1245 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1246..1320 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1321..1392 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1393..1492 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1493..1623 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1624..1696 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1697..1769 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1770..1885 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1886..1950 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 1951..2027 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2028..2193 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2194..2346 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2347..2455 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2456..2535 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2536..2676 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2677..2793 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2794..2887 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2888..2998 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 2999..3068 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" exon 3069..6274 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /inference="alignment:Splign:1.39.8" polyA_signal 3171..3176 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 3194 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_signal 4201..4206 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 4238 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" STS 4427..5217 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="OPA1__6114" /db_xref="UniSTS:463662" STS 4752..5031 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="SGC38140" /db_xref="UniSTS:81567" STS 4945..5071 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="SHGC-37414" /db_xref="UniSTS:21796" polyA_signal 5069..5074 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 5093 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_signal 5696..5701 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 5715 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" STS 5790..5952 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="SHGC-77667" /db_xref="UniSTS:70071" polyA_signal 5969..5974 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" polyA_site 5996 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" STS 6038..6135 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" /standard_name="RH78614" /db_xref="UniSTS:11888" polyA_site 6274 /gene="OPA1" /gene_synonym="largeG; MGM1; NPG; NTG" ORIGIN
gtgctgcccgcctagaaagggtgaagtggttgtttccgtgacggactgagtacgggtgcctgtcaggctcttgcggaagtccatgcgccattgggagggcctcggccgcggctctgtgcccttgctgctgagggccacttcctgggtcattcctggaccgggagccgggctggggctcacacgggggctcccgcgtggccgtctcggcgcctgcgtgacctccccgccggcgggatgtggcgactacgtcgggccgctgtggcctgtgaggtctgccagtctttagtgaaacacagctctggaataaaaggaagtttaccactacaaaaactacatctggtttcacgaagcatttatcattcacatcatcctaccttaaagcttcaacgaccccaattaaggacatcctttcagcagttctcttctctgacaaaccttcctttacgtaaactgaaattctctccaattaaatatggctaccagcctcgcaggaatttttggccagcaagattagctacgagactcttaaaacttcgctatctcatactaggatcggctgttgggggtggctacacagccaaaaagacttttgatcagtggaaagatatgataccggaccttagtgaatataaatggattgtgcctgacattgtgtgggaaattgatgagtatatcgattttggtcacaaattggttagtgaagtcataggagcttctgacctacttctcttgttaggttctccggaagaaacggcgtttagagcaacagatcgtggatctgaaagtgacaagcattttagaaaggtgtcagacaaagagaaaattgaccaacttcaggaagaacttctgcacactcagttgaagtatcagagaatcttggaacgattagaaaaggagaacaaagaattgagaaaattagtattgcagaaagatgacaaaggcattcatcatagaaagcttaagaaatctttgattgacatgtattctgaagttcttgatgttctctctgattatgatgccagttataatacgcaagatcatctgccacgggttgttgtggttggagatcagagtgctggaaagactagtgtgttggaaatgattgcccaagctcgaatattcccaagaggatctggggagatgatgacacgttctccagttaaggtgactctgagtgaaggtcctcaccatgtggccctatttaaagatagttctcgggagtttgatcttaccaaagaagaagatcttgcagcattaagacatgaaatagaacttcgaatgaggaaaaatgtgaaagaaggctgtaccgttagccctgagaccatatccttaaatgtaaaaggccctggactacagaggatggtgcttgttgacttaccaggtgtgattaatactgtgacatcaggcatggctcctgacacaaaggaaactattttcagtatcagcaaagcttacatgcagaatcctaatgccatcatactgtgtattcaagatggatctgtggatgctgaacgcagtattgttacagacttggtcagtcaaatggaccctcatggaaggagaaccatattcgttttgaccaaagtagacctggcagagaaaaatgtagccagtccaagcaggattcagcagataattgaaggaaagctcttcccaatgaaagctttaggttattttgctgttgtaacaggaaaagggaacagctctgaaagcattgaagctataagagaatatgaagaagagttttttcagaattcaaagctcctaaagacaagcatgctaaaggcacaccaagtgactacaagaaatttaagccttgcagtatcagactgcttttggaaaatggtacgagagtctgttgaacaacaggctgatagtttcaaagcaacacgttttaaccttgaaactgaatggaagaataactatcctcgcctgcgggaacttgaccggaatgaactatttgaaaaagctaaaaatgaaatccttgatgaagttatcagtctgagccaggttacaccaaaacattgggaggaaatccttcaacaatctttgtgggaaagagtatcaactcatgtgattgaaaacatctaccttccagctgcgcagaccatgaattcaggaacttttaacaccacagtggatatcaagcttaaacagtggactgataaacaacttcctaataaagcagtagaggttgcttgggagaccctacaagaagaattttcccgctttatgacagaaccgaaagggaaagagcatgatgacatatttgataaacttaaagaggctgttaaggaagaaagtattaaacgacacaagtggaatgactttgcggaggacagcttgagggttattcaacacaatgctttggaagaccgatccatatctgataaacagcaatgggatgcagctatttattttatggaagaggctctgcaggctcgtctcaaggatactgaaaatgcaattgaaaacatggtgggtccagactggaaaaagaggtggttatactggaagaatcggacccaagaacagtgtgttcacaatgaaaccaagaatgaattggagaagatgttgaaatgtaatgaggagcacccagcttatcttgcaagtgatgaaataaccacagtccggaagaaccttgaatcccgaggagtagaagtagatccaagcttgattaaggatacttggcatcaagtttatagaagacattttttaaaaacagctctaaaccattgtaacctttgtcgaagaggtttttattactaccaaaggcattttgtagattctgagttggaatgcaatgatgtggtcttgttttggcgtatacagcgcatgcttgctatcaccgcaaatactttaaggcaacaacttacaaatactgaagttaggcgattagagaaaaatgttaaagaggtattggaagattttgctgaagatggtgagaagaagattaaattgcttactggtaaacgcgttcaactggcggaagacctcaagaaagttagagaaattcaagaaaaacttgatgctttcattgaagctcttcatcaggagaaataaattaaaatcgtactcataatcagctctgcatacatctgaagaacaaaaacatcaacgtcttttgtccagcctctttttcttctgctgttccacctttctaaacatacaataaagtcatgggataaaaataatcgatgtatgttacgggcgctttaaccatcagctgcctctcgaatggaagaacagtggtaatggattaacatcctattttgttgtactaaagtgacaaatcggaataatataattggtatggccattaggttcagtccttgaagataagaaacttgttctctgtttgttgtcttatttgtggtggcactcgtttaatggattaactgaggttgctcaatgttcagtttcttttccagaaatacaatgctaggtgttttgaaataaaacttatatagcaattgtttaaagttatcaattgtatataaaatcacagtagcctgctaaatcattgtatgtgtctgtagtattctattcccagaaactatttgaccatgataattcagtttatattcaccacatgaaagaaaaatgggtaacagaagaacccttaaaacaggttaatttggattgtaacgttcagtgaaagaaatttcaacccttcatagccagcgaagaaatttgccttggaagccaagtcagtaccagcttacctatttgattcagttgctgttttctcactctctatatccatttgaaattgatttattttagatgttgtatacttacgttaggctttctgttaatagtggtttttctcctgttgacagagccaccggattatgacacaggatgaggaagattaaggataatcaattgactaatttcatttagaatattatcaaacatttcaactaggtatcagaaaaaggctttctttcataagactattttaaatagaaattatttcaacaattaaagtaatgttgaccatccccctctcagctgaataaagaaaaatttagttcaatttattgcaatttaattacaatactaccttcacaacattttcatgtgttttaaataaatattttttaattggctaaaggacattcaagcaaagaaatgctttctttacttaaaatgtctatctcatttgctgccttttcactaagcctttactttgttaataaaagtgtccattgtgtgatgtttttgattttacagtttgctaaatcttattttcttggagttgctttttggtaacagccccattgctactccccattttattgttttacatcaatgcatgcttcgttgtgatccctcaagatgtaacacttggtatgctcggttgaggatatgaaaaaatacttccgaaaccaggaattcaatgtatgtttgttttatactgtttgataagaaaagtaggtccagccttaagcagcacagatgcgctggtagatgcatagtcaggaactttttttatttcttttaggtctagggacaggagtgaatagaaagggaggagagctctattatgttctatacacagattaggagatgaccttactgggtacacccctctaaccagtgcttacaggttaatgcatgttaatgaatatttttgcagttgtaaagcataacaattacaactacacatctatttctaaagaataaaacaggaccatatttatttacttctgtcaactatagaaagaaagaccttcagctgtatttccacagatttctcccaaggaaaaggctaatattagtcactactgttatcacatccctttgtataagttttaaaaagagatggagggagatcttcatttctttgaggagatcagtattgtaacgtatgtgaatagatgataacaattaatattactaaaagtcccacatgagagtcctgacgccctctccatgccccacagtaatgtggcttctttcatgggtttttttttcttctttttagctgatctcatcctaagcatgctttatttttccttgaaagctaggtatttatcaactgcagatgttattgaaagaaaataaaattcagtctcaagagtaaaccctgtgtcttgtgtctgtagttcaaaagtcagaaatgattctaatttaaacaaaaagatactaaatatacagaagttaaattcgaactagccacagaatcatttgtttttatgtcagaatttgcaaagagtggagtggacaaagctctgtatggaagactgaacaactgtaaatagatgatatccaaacttaatttggctaggacttcaattttaaaaatcagtgtacctaggcagtgcacagcacgaaataagtggcccttgcagcttccccgtttaacccactgtgctatagttgcgggtggaacagtcaacctttctagtagtttatgatattgccctctttgtattcccattttctacagttttttccgcagacttctttctgcaaattattcagcctccaaatgcaaatgaatgatataaaaataagtagggaacatggcagagagtggtgcttcccagcctcacaatgtgggaatttgacataggatgagagtcagagtataggtttaaaagataaaatctttagttaataattttgtatttatttattctagatgtatgtatctgaggaaagaaatctggtatttttgctttccaataaaggggatcaaagtaatggtttttctctcagttctctaagctggtctatgttatagctctagcagtatggaaatgtgctttaaaatatgcttaccttttgaatgatcatggctatatgttgttgagatatttgaaacttaccttgttttcacttgtgcactgtgaatgaactttgtattatttttttaaaaccttcacattacgtgtagatattattgcaacttatattttgcctgagcttgatcaaaggtcatttgtgtagatgagtaattaaaaaatatttaaatcacattataattctattattggagagcatcttttaaatttttttctgttttaacgagggaaagagaaacctgtatacctagggtcattatttgaccccatagtataaccagattcatggtctaacaagctctcagtgtggcttttctctgaatgcttgaatttcacatgccttgcatttcacagttgtactccatggtcaaccggtgctttttttcacatcgtggtacttgtcaaaacattttgttattttccttggtaaaatatataaaaaaggttttctaatttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4976 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: NAS GeneID:4976 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS GeneID:4976 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4976 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA GeneID:4976 -> Biological process: GO:0000266 [mitochondrial fission] evidence: TAS GeneID:4976 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA GeneID:4976 -> Biological process: GO:0006184 [GTP catabolic process] evidence: TAS GeneID:4976 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: IMP GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: NAS GeneID:4976 -> Biological process: GO:0007007 [inner mitochondrial membrane organization] evidence: IDA GeneID:4976 -> Biological process: GO:0007601 [visual perception] evidence: IMP GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IDA GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IMP GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: TAS GeneID:4976 -> Biological process: GO:0019896 [axon transport of mitochondrion] evidence: TAS GeneID:4976 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IMP GeneID:4976 -> Biological process: GO:0090398 [cellular senescence] evidence: IDA GeneID:4976 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:4976 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IDA GeneID:4976 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: NAS GeneID:4976 -> Cellular component: GO:0005758 [mitochondrial intermembrane space] evidence: ISS GeneID:4976 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA GeneID:4976 -> Cellular component: GO:0030061 [mitochondrial crista] evidence: IDA GeneID:4976 -> Cellular component: GO:0030425 [dendrite] evidence: ISS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_570845 -> EC 3.6.5.5
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