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2024-04-20 03:20:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_130831 6237 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens optic atrophy 1 (autosomal dominant) (OPA1),
transcript variant 2, mRNA.
ACCESSION NM_130831
VERSION NM_130831.2 GI:224831244
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6237)
AUTHORS Kushnareva,Y.E., Gerencser,A.A., Bossy,B., Ju,W.K., White,A.D.,
Waggoner,J., Ellisman,M.H., Perkins,G. and Bossy-Wetzel,E.
TITLE Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes
for excitotoxicity
JOURNAL Cell Death Differ. 20 (2), 353-365 (2013)
PUBMED 23138851
REMARK GeneRIF: OPA1 is required for mitochondrial fusion, maintenance of
crista morphology and oxidative phosphorylation, loss of OPA1 also
results in defective Ca(2+) homeostasis.
REFERENCE 2 (bases 1 to 6237)
AUTHORS Zhao,X., Tian,C., Puszyk,W.M., Ogunwobi,O.O., Cao,M., Wang,T.,
Cabrera,R., Nelson,D.R. and Liu,C.
TITLE OPA1 downregulation is involved in sorafenib-induced apoptosis in
hepatocellular carcinoma
JOURNAL Lab. Invest. 93 (1), 8-19 (2013)
PUBMED 23108376
REMARK GeneRIF: Show that sorafenib triggers apoptosis in HCC cells by
targeting mitochondria. Treatment with sorafenib induces rapid
mitochondrial fragmentation, which is associated with the
deregulation of mitochondria fusion-related protein optic atrophy 1
(OPA1).
REFERENCE 3 (bases 1 to 6237)
AUTHORS Belenguer,P. and Pellegrini,L.
TITLE The dynamin GTPase OPA1: more than mitochondria?
JOURNAL Biochim. Biophys. Acta 1833 (1), 176-183 (2013)
PUBMED 22902477
REMARK GeneRIF: OPA1 mediates adrenergic control of lipolysis by
functioning as a cytosolic A-kinase anchoring protein (AKAP), on
the hemimembrane that envelops the lipid droplet.
Review article
REFERENCE 4 (bases 1 to 6237)
AUTHORS Sarzi,E., Angebault,C., Seveno,M., Gueguen,N., Chaix,B.,
Bielicki,G., Boddaert,N., Mausset-Bonnefont,A.L., Cazevieille,C.,
Rigau,V., Renou,J.P., Wang,J., Delettre,C., Brabet,P., Puel,J.L.,
Hamel,C.P., Reynier,P. and Lenaers,G.
TITLE The human OPA1delTTAG mutation induces premature age-related
systemic neurodegeneration in mouse
JOURNAL Brain 135 (PT 12), 3599-3613 (2012)
PUBMED 23250881
REMARK GeneRIF: the results of this study supported the concept that Opa1
protects against neuronal degeneration and opens new perspectives
for the exploration and the treatment of mitochondrial diseases.
REFERENCE 5 (bases 1 to 6237)
AUTHORS Sitarz,K.S., Almind,G.J., Horvath,R., Czermin,B., Gronskov,K.,
Pyle,A., Taylor,R.W., Larsen,M., Chinnery,P.F. and Yu-Wai-Man,P.
TITLE OPA1 mutations induce mtDNA proliferation in leukocytes of patients
with dominant optic atrophy
JOURNAL Neurology 79 (14), 1515-1517 (2012)
PUBMED 22993284
REMARK GeneRIF: This study has revealed significant mtDNA proliferation in
blood leukocytes harboring pathogenic OPA1 mutations in 3
independent patient cohorts.
REFERENCE 6 (bases 1 to 6237)
AUTHORS Delettre,C., Griffoin,J.M., Kaplan,J., Dollfus,H., Lorenz,B.,
Faivre,L., Lenaers,G., Belenguer,P. and Hamel,C.P.
TITLE Mutation spectrum and splicing variants in the OPA1 gene
JOURNAL Hum. Genet. 109 (6), 584-591 (2001)
PUBMED 11810270
REFERENCE 7 (bases 1 to 6237)
AUTHORS Alexander,C., Votruba,M., Pesch,U.E., Thiselton,D.L., Mayer,S.,
Moore,A., Rodriguez,M., Kellner,U., Leo-Kottler,B., Auburger,G.,
Bhattacharya,S.S. and Wissinger,B.
TITLE OPA1, encoding a dynamin-related GTPase, is mutated in autosomal
dominant optic atrophy linked to chromosome 3q28
JOURNAL Nat. Genet. 26 (2), 211-215 (2000)
PUBMED 11017080
REFERENCE 8 (bases 1 to 6237)
AUTHORS Delettre,C., Lenaers,G., Griffoin,J.M., Gigarel,N., Lorenzo,C.,
Belenguer,P., Pelloquin,L., Grosgeorge,J., Turc-Carel,C.,
Perret,E., Astarie-Dequeker,C., Lasquellec,L., Arnaud,B.,
Ducommun,B., Kaplan,J. and Hamel,C.P.
TITLE Nuclear gene OPA1, encoding a mitochondrial dynamin-related
protein, is mutated in dominant optic atrophy
JOURNAL Nat. Genet. 26 (2), 207-210 (2000)
PUBMED 11017079
REFERENCE 9 (bases 1 to 6237)
AUTHORS Johnston,R.L., Seller,M.J., Behnam,J.T., Burdon,M.A. and
Spalton,D.J.
TITLE Dominant optic atrophy. Refining the clinical diagnostic criteria
in light of genetic linkage studies
JOURNAL Ophthalmology 106 (1), 123-128 (1999)
PUBMED 9917792
REFERENCE 10 (bases 1 to 6237)
AUTHORS Votruba,M., Moore,A.T. and Bhattacharya,S.S.
TITLE Demonstration of a founder effect and fine mapping of dominant
optic atrophy locus on 3q28-qter by linkage disequilibrium method:
a study of 38 British Isles pedigrees
JOURNAL Hum. Genet. 102 (1), 79-86 (1998)
PUBMED 9490303
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC048351.18, AC106710.8 and
BQ774938.1.
On Mar 11, 2009 this sequence version replaced gi:18860830.
Summary: This gene product is a nuclear-encoded mitochondrial
protein with similarity to dynamin-related GTPases. It is a
component of the mitochondrial network. Mutations in this gene have
been associated with optic atrophy type 1, which is a dominantly
inherited optic neuropathy resulting in progressive loss of visual
acuity, leading in many cases to legal blindness. Multiple
transcript variants encoding different isoforms have been found for
this gene. [provided by RefSeq, Mar 2009].
Transcript Variant: This variant (2) is missing exon 4, compared to
transcript variant 1. It however, maintains the same reading frame
and encodes an isoform (2) of 924 aa. This variant is based on an
alternate splice pattern characterized by Delettre et al (2001,
PMID: 11810270), but the complete 5' to 3' exon combination is
inferred and not supported at the time of review by a single long
cDNA.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025083,
ERS025084 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-266 AC048351.18 73700-73965
267-585 AC048351.18 95279-95597
586-682 AC048351.18 96230-96326
683-750 AC048351.18 99425-99492
751-804 AC048351.18 112168-112221
805-909 AC048351.18 115974-116078
910-996 AC048351.18 117751-117837
997-1110 AC048351.18 118508-118621
1111-1191 AC048351.18 123321-123401
1192-1266 AC048351.18 123531-123605
1267-1338 AC048351.18 123929-124000
1339-1438 AC048351.18 124084-124183
1439-1569 AC048351.18 124531-124661
1570-1642 AC048351.18 126109-126181
1643-1715 AC048351.18 126284-126356
1716-1831 AC048351.18 127621-127736
1832-1896 AC048351.18 128626-128690
1897-1973 AC048351.18 129351-129427
1974-2139 AC048351.18 135418-135583
2140-2292 AC048351.18 137636-137788
2293-2401 AC048351.18 139443-139551
2402-2481 AC048351.18 140038-140117
2482-2622 AC048351.18 143378-143518
2623-2739 AC048351.18 145436-145552
2740-2833 AC048351.18 146852-146945
2834-2944 AC048351.18 147726-147836
2945-3014 AC106710.8 12971-13040
3015-5553 AC106710.8 15514-18052
5554-6237 BQ774938.1 1-684 c
FEATURES Location/Qualifiers
source 1..6237
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q28-q29"
gene 1..6237
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="optic atrophy 1 (autosomal dominant)"
/db_xref="GeneID:4976"
/db_xref="HGNC:8140"
/db_xref="HPRD:05596"
/db_xref="MIM:605290"
exon 1..266
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
misc_feature 22..24
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="upstream in-frame stop codon"
CDS 235..3009
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/EC_number="3.6.5.5"
/note="isoform 2 is encoded by transcript variant 2;
mitochondrial dynamin-like GTPase; dynamin-like 120 kDa
protein, mitochondrial; optic atrophy protein 1;
dynamin-like guanosine triphosphatase"
/codon_start=1
/product="dynamin-like 120 kDa protein, mitochondrial
isoform 2"
/protein_id="NP_570844.1"
/db_xref="GI:18860831"
/db_xref="GeneID:4976"
/db_xref="HGNC:8140"
/db_xref="HPRD:05596"
/db_xref="MIM:605290"
/translation="
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
"
misc_feature 985..1809
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Dynamin_like protein family includes dynamins and
Mx proteins; Region: DLP_1; cd08771"
/db_xref="CDD:206738"
misc_feature 997..1533
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Dynamin family; Region: Dynamin_N; pfam00350"
/db_xref="CDD:201172"
misc_feature 1009..1032
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G1 box; other site"
/db_xref="CDD:206738"
misc_feature order(1012..1014,1018..1035,1072..1077,1093..1095,
1318..1320,1528..1530,1534..1539,1630..1644)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206738"
misc_feature order(1015..1020,1330..1332,1369..1371,1444..1446,
1450..1452,1456..1467,1471..1476,1537..1539,1543..1554,
1639..1644)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:206738"
misc_feature 1093..1095
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G2 box; other site"
/db_xref="CDD:206738"
misc_feature 1105..1113
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Switch I region; other site"
/db_xref="CDD:206738"
misc_feature 1318..1329
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G3 box; other site"
/db_xref="CDD:206738"
misc_feature order(1324..1329,1417..1422)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="Switch II region; other site"
/db_xref="CDD:206738"
misc_feature 1525..1536
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G4 box; other site"
/db_xref="CDD:206738"
misc_feature 1630..1638
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/note="G5 box; other site"
/db_xref="CDD:206738"
misc_feature 2911..2913
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 267..585
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 586..682
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 683..750
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
variation complement(701)
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/replace="c"
/replace="t"
/db_xref="dbSNP:34307082"
exon 751..804
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 805..909
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 910..996
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 997..1110
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1111..1191
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1192..1266
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1267..1338
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1339..1438
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1439..1569
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1570..1642
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1643..1715
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1716..1831
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1832..1896
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1897..1973
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 1974..2139
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2140..2292
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2293..2401
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2402..2481
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2482..2622
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2623..2739
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2740..2833
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2834..2944
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 2945..3014
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
exon 3015..6220
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/inference="alignment:Splign:1.39.8"
polyA_signal 3117..3122
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 3140
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_signal 4147..4152
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 4184
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
STS 4373..5163
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="OPA1__6114"
/db_xref="UniSTS:463662"
STS 4698..4977
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="SGC38140"
/db_xref="UniSTS:81567"
STS 4891..5017
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="SHGC-37414"
/db_xref="UniSTS:21796"
polyA_signal 5015..5020
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 5039
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_signal 5642..5647
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 5661
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
STS 5736..5898
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="SHGC-77667"
/db_xref="UniSTS:70071"
polyA_signal 5915..5920
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
polyA_site 5942
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
STS 5984..6081
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
/standard_name="RH78614"
/db_xref="UniSTS:11888"
polyA_site 6220
/gene="OPA1"
/gene_synonym="largeG; MGM1; NPG; NTG"
ORIGIN
gtgctgcccgcctagaaagggtgaagtggttgtttccgtgacggactgagtacgggtgcctgtcaggctcttgcggaagtccatgcgccattgggagggcctcggccgcggctctgtgcccttgctgctgagggccacttcctgggtcattcctggaccgggagccgggctggggctcacacgggggctcccgcgtggccgtctcggcgcctgcgtgacctccccgccggcgggatgtggcgactacgtcgggccgctgtggcctgtgaggtctgccagtctttagtgaaacacagctctggaataaaaggaagtttaccactacaaaaactacatctggtttcacgaagcatttatcattcacatcatcctaccttaaagcttcaacgaccccaattaaggacatcctttcagcagttctcttctctgacaaaccttcctttacgtaaactgaaattctctccaattaaatatggctaccagcctcgcaggaatttttggccagcaagattagctacgagactcttaaaacttcgctatctcatactaggatcggctgttgggggtggctacacagccaaaaagacttttgatcagtggaaagatatgataccggaccttagtgaatataaatggattgtgcctgacattgtgtgggaaattgatgagtatatcgattttggttctccggaagaaacggcgtttagagcaacagatcgtggatctgaaagtgacaagcattttagaaaggtgtcagacaaagagaaaattgaccaacttcaggaagaacttctgcacactcagttgaagtatcagagaatcttggaacgattagaaaaggagaacaaagaattgagaaaattagtattgcagaaagatgacaaaggcattcatcatagaaagcttaagaaatctttgattgacatgtattctgaagttcttgatgttctctctgattatgatgccagttataatacgcaagatcatctgccacgggttgttgtggttggagatcagagtgctggaaagactagtgtgttggaaatgattgcccaagctcgaatattcccaagaggatctggggagatgatgacacgttctccagttaaggtgactctgagtgaaggtcctcaccatgtggccctatttaaagatagttctcgggagtttgatcttaccaaagaagaagatcttgcagcattaagacatgaaatagaacttcgaatgaggaaaaatgtgaaagaaggctgtaccgttagccctgagaccatatccttaaatgtaaaaggccctggactacagaggatggtgcttgttgacttaccaggtgtgattaatactgtgacatcaggcatggctcctgacacaaaggaaactattttcagtatcagcaaagcttacatgcagaatcctaatgccatcatactgtgtattcaagatggatctgtggatgctgaacgcagtattgttacagacttggtcagtcaaatggaccctcatggaaggagaaccatattcgttttgaccaaagtagacctggcagagaaaaatgtagccagtccaagcaggattcagcagataattgaaggaaagctcttcccaatgaaagctttaggttattttgctgttgtaacaggaaaagggaacagctctgaaagcattgaagctataagagaatatgaagaagagttttttcagaattcaaagctcctaaagacaagcatgctaaaggcacaccaagtgactacaagaaatttaagccttgcagtatcagactgcttttggaaaatggtacgagagtctgttgaacaacaggctgatagtttcaaagcaacacgttttaaccttgaaactgaatggaagaataactatcctcgcctgcgggaacttgaccggaatgaactatttgaaaaagctaaaaatgaaatccttgatgaagttatcagtctgagccaggttacaccaaaacattgggaggaaatccttcaacaatctttgtgggaaagagtatcaactcatgtgattgaaaacatctaccttccagctgcgcagaccatgaattcaggaacttttaacaccacagtggatatcaagcttaaacagtggactgataaacaacttcctaataaagcagtagaggttgcttgggagaccctacaagaagaattttcccgctttatgacagaaccgaaagggaaagagcatgatgacatatttgataaacttaaagaggctgttaaggaagaaagtattaaacgacacaagtggaatgactttgcggaggacagcttgagggttattcaacacaatgctttggaagaccgatccatatctgataaacagcaatgggatgcagctatttattttatggaagaggctctgcaggctcgtctcaaggatactgaaaatgcaattgaaaacatggtgggtccagactggaaaaagaggtggttatactggaagaatcggacccaagaacagtgtgttcacaatgaaaccaagaatgaattggagaagatgttgaaatgtaatgaggagcacccagcttatcttgcaagtgatgaaataaccacagtccggaagaaccttgaatcccgaggagtagaagtagatccaagcttgattaaggatacttggcatcaagtttatagaagacattttttaaaaacagctctaaaccattgtaacctttgtcgaagaggtttttattactaccaaaggcattttgtagattctgagttggaatgcaatgatgtggtcttgttttggcgtatacagcgcatgcttgctatcaccgcaaatactttaaggcaacaacttacaaatactgaagttaggcgattagagaaaaatgttaaagaggtattggaagattttgctgaagatggtgagaagaagattaaattgcttactggtaaacgcgttcaactggcggaagacctcaagaaagttagagaaattcaagaaaaacttgatgctttcattgaagctcttcatcaggagaaataaattaaaatcgtactcataatcagctctgcatacatctgaagaacaaaaacatcaacgtcttttgtccagcctctttttcttctgctgttccacctttctaaacatacaataaagtcatgggataaaaataatcgatgtatgttacgggcgctttaaccatcagctgcctctcgaatggaagaacagtggtaatggattaacatcctattttgttgtactaaagtgacaaatcggaataatataattggtatggccattaggttcagtccttgaagataagaaacttgttctctgtttgttgtcttatttgtggtggcactcgtttaatggattaactgaggttgctcaatgttcagtttcttttccagaaatacaatgctaggtgttttgaaataaaacttatatagcaattgtttaaagttatcaattgtatataaaatcacagtagcctgctaaatcattgtatgtgtctgtagtattctattcccagaaactatttgaccatgataattcagtttatattcaccacatgaaagaaaaatgggtaacagaagaacccttaaaacaggttaatttggattgtaacgttcagtgaaagaaatttcaacccttcatagccagcgaagaaatttgccttggaagccaagtcagtaccagcttacctatttgattcagttgctgttttctcactctctatatccatttgaaattgatttattttagatgttgtatacttacgttaggctttctgttaatagtggtttttctcctgttgacagagccaccggattatgacacaggatgaggaagattaaggataatcaattgactaatttcatttagaatattatcaaacatttcaactaggtatcagaaaaaggctttctttcataagactattttaaatagaaattatttcaacaattaaagtaatgttgaccatccccctctcagctgaataaagaaaaatttagttcaatttattgcaatttaattacaatactaccttcacaacattttcatgtgttttaaataaatattttttaattggctaaaggacattcaagcaaagaaatgctttctttacttaaaatgtctatctcatttgctgccttttcactaagcctttactttgttaataaaagtgtccattgtgtgatgtttttgattttacagtttgctaaatcttattttcttggagttgctttttggtaacagccccattgctactccccattttattgttttacatcaatgcatgcttcgttgtgatccctcaagatgtaacacttggtatgctcggttgaggatatgaaaaaatacttccgaaaccaggaattcaatgtatgtttgttttatactgtttgataagaaaagtaggtccagccttaagcagcacagatgcgctggtagatgcatagtcaggaactttttttatttcttttaggtctagggacaggagtgaatagaaagggaggagagctctattatgttctatacacagattaggagatgaccttactgggtacacccctctaaccagtgcttacaggttaatgcatgttaatgaatatttttgcagttgtaaagcataacaattacaactacacatctatttctaaagaataaaacaggaccatatttatttacttctgtcaactatagaaagaaagaccttcagctgtatttccacagatttctcccaaggaaaaggctaatattagtcactactgttatcacatccctttgtataagttttaaaaagagatggagggagatcttcatttctttgaggagatcagtattgtaacgtatgtgaatagatgataacaattaatattactaaaagtcccacatgagagtcctgacgccctctccatgccccacagtaatgtggcttctttcatgggtttttttttcttctttttagctgatctcatcctaagcatgctttatttttccttgaaagctaggtatttatcaactgcagatgttattgaaagaaaataaaattcagtctcaagagtaaaccctgtgtcttgtgtctgtagttcaaaagtcagaaatgattctaatttaaacaaaaagatactaaatatacagaagttaaattcgaactagccacagaatcatttgtttttatgtcagaatttgcaaagagtggagtggacaaagctctgtatggaagactgaacaactgtaaatagatgatatccaaacttaatttggctaggacttcaattttaaaaatcagtgtacctaggcagtgcacagcacgaaataagtggcccttgcagcttccccgtttaacccactgtgctatagttgcgggtggaacagtcaacctttctagtagtttatgatattgccctctttgtattcccattttctacagttttttccgcagacttctttctgcaaattattcagcctccaaatgcaaatgaatgatataaaaataagtagggaacatggcagagagtggtgcttcccagcctcacaatgtgggaatttgacataggatgagagtcagagtataggtttaaaagataaaatctttagttaataattttgtatttatttattctagatgtatgtatctgaggaaagaaatctggtatttttgctttccaataaaggggatcaaagtaatggtttttctctcagttctctaagctggtctatgttatagctctagcagtatggaaatgtgctttaaaatatgcttaccttttgaatgatcatggctatatgttgttgagatatttgaaacttaccttgttttcacttgtgcactgtgaatgaactttgtattatttttttaaaaccttcacattacgtgtagatattattgcaacttatattttgcctgagcttgatcaaaggtcatttgtgtagatgagtaattaaaaaatatttaaatcacattataattctattattggagagcatcttttaaatttttttctgttttaacgagggaaagagaaacctgtatacctagggtcattatttgaccccatagtataaccagattcatggtctaacaagctctcagtgtggcttttctctgaatgcttgaatttcacatgccttgcatttcacagttgtactccatggtcaaccggtgctttttttcacatcgtggtacttgtcaaaacattttgttattttccttggtaaaatatataaaaaaggttttctaatttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4976 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: NAS
GeneID:4976 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS
GeneID:4976 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4976 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:4976 -> Biological process: GO:0000266 [mitochondrial fission] evidence: TAS
GeneID:4976 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA
GeneID:4976 -> Biological process: GO:0006184 [GTP catabolic process] evidence: TAS
GeneID:4976 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: IMP
GeneID:4976 -> Biological process: GO:0007005 [mitochondrion organization] evidence: NAS
GeneID:4976 -> Biological process: GO:0007007 [inner mitochondrial membrane organization] evidence: IDA
GeneID:4976 -> Biological process: GO:0007601 [visual perception] evidence: IMP
GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IDA
GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: IMP
GeneID:4976 -> Biological process: GO:0008053 [mitochondrial fusion] evidence: TAS
GeneID:4976 -> Biological process: GO:0019896 [axon transport of mitochondrion] evidence: TAS
GeneID:4976 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IMP
GeneID:4976 -> Biological process: GO:0090398 [cellular senescence] evidence: IDA
GeneID:4976 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:4976 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IDA
GeneID:4976 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: NAS
GeneID:4976 -> Cellular component: GO:0005758 [mitochondrial intermembrane space] evidence: ISS
GeneID:4976 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:4976 -> Cellular component: GO:0030061 [mitochondrial crista] evidence: IDA
GeneID:4976 -> Cellular component: GO:0030425 [dendrite] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_570844 -> EC 3.6.5.5
by
@meso_cacase at
DBCLS
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