GGRNA Home | Help | Advanced search

2019-03-26 15:46:03, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_130393               8239 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens protein tyrosine phosphatase, receptor type, D
            (PTPRD), transcript variant 4, mRNA.
ACCESSION   NM_130393
VERSION     NM_130393.3  GI:283484021
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8239)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   2  (bases 1 to 8239)
  AUTHORS   Du,Y., Su,T., Tan,X., Li,X., Xie,J., Wang,G., Shen,J., Hou,J. and
            Cao,G.
  TITLE     Polymorphism in protein tyrosine phosphatase receptor delta is
            associated with the risk of clear cell renal cell carcinoma
  JOURNAL   Gene 512 (1), 64-69 (2013)
   PUBMED   23069849
  REMARK    GeneRIF: Polymorphism in protein tyrosine phosphatase receptor
            delta is associated with the risk of clear cell renal cell
            carcinoma.
REFERENCE   3  (bases 1 to 8239)
  AUTHORS   Meng,W., Butterworth,J., Bradley,D.T., Hughes,A.E., Soler,V.,
            Calvas,P. and Malecaze,F.
  TITLE     A genome-wide association study provides evidence for association
            of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in
            the French Population
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 53 (13), 7983-7988 (2012)
   PUBMED   23049088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8239)
  AUTHORS   Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
            Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
            Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
            Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
            Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
            Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
            Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
            Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
            Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
            Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
            Rotter,J.I., Artigas,M.S., Starr,J.M., Uitterlinden,A.G.,
            Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
            Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
            Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
            Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
            and Stricker,B.H.
  TITLE     Genome-wide association studies identify CHRNA5/3 and HTR4 in the
            development of airflow obstruction
  JOURNAL   Am. J. Respir. Crit. Care Med. 186 (7), 622-632 (2012)
   PUBMED   22837378
REFERENCE   5  (bases 1 to 8239)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 8239)
  AUTHORS   Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
  TITLE     Intra- and intermolecular interactions between intracellular
            domains of receptor protein-tyrosine phosphatases
  JOURNAL   J. Biol. Chem. 277 (49), 47263-47269 (2002)
   PUBMED   12376545
  REMARK    GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
            a common but specific mechanism that is likely to be regulated-
            domain2s and the wedge structures are crucial determinants of
            binding specificity, thus regulating cross-talk between RPTPs
REFERENCE   7  (bases 1 to 8239)
  AUTHORS   Wallace,M.J., Fladd,C., Batt,J. and Rotin,D.
  TITLE     The second catalytic domain of protein tyrosine phosphatase delta
            (PTP delta) binds to and inhibits the first catalytic domain of PTP
            sigma
  JOURNAL   Mol. Cell. Biol. 18 (5), 2608-2616 (1998)
   PUBMED   9566880
REFERENCE   8  (bases 1 to 8239)
  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
            PTP sigma isoforms are expressed in a tissue-specific manner and
            associate with the LAR-interacting protein LIP.1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
   PUBMED   8524829
REFERENCE   9  (bases 1 to 8239)
  AUTHORS   Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M.
  TITLE     Molecular characterization of the human transmembrane
            protein-tyrosine phosphatase delta. Evidence for tissue-specific
            expression of alternative human transmembrane protein-tyrosine
            phosphatase delta isoforms
  JOURNAL   J. Biol. Chem. 270 (12), 6722-6728 (1995)
   PUBMED   7896816
REFERENCE   10 (bases 1 to 8239)
  AUTHORS   Krueger,N.X., Streuli,M. and Saito,H.
  TITLE     Structural diversity and evolution of human receptor-like protein
            tyrosine phosphatases
  JOURNAL   EMBO J. 9 (10), 3241-3252 (1990)
   PUBMED   2170109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR001889.1, BC106716.1,
            AL590397.7, AL445926.5 and BM680342.1.
            On Jan 8, 2010 this sequence version replaced gi:104486447.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an extracellular
            region, a single transmembrane segment and two tandem
            intracytoplasmic catalytic domains, and thus represents a
            receptor-type PTP. The extracellular region of this protein is
            composed of three Ig-like and eight fibronectin type III-like
            domains. Studies of the similar genes in chicken and fly suggest
            the role of this PTP is in promoting neurite growth, and regulating
            neurons axon guidance. Multiple alternatively spliced transcript
            variants of this gene have been reported. A related pseudogene has
            been identified on chromosome 5. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (4) has multiple differences in
            the coding region, compared to variant 1, resulting in an isoform
            (4) that is shorter than isoform 1. The 5' UTR of this variant is
            incomplete because no 5' complete transcripts representing this
            variant exist, and there are alternate splicing choices in the
            upstream region.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106716.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DR001889.1         76-127
            53-3108             BC106716.1         1-3056
            3109-3109           AL590397.7         136670-136670       c
            3110-5054           BC106716.1         3058-5002
            5055-7583           AL445926.5         119217-121745       c
            7584-8239           BM680342.1         1-656               c
FEATURES             Location/Qualifiers
     source          1..8239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23-p24.3"
     gene            1..8239
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="protein tyrosine phosphatase, receptor type, D"
                     /db_xref="GeneID:5789"
                     /db_xref="HGNC:9668"
                     /db_xref="MIM:601598"
     exon            1..167
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    20..22
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="upstream in-frame stop codon"
     CDS             104..4594
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /EC_number="3.1.3.48"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; protein tyrosine phosphatase, receptor type,
                     delta polypeptide; receptor-type tyrosine-protein
                     phosphatase delta; R-PTP-delta; protein-tyrosine
                     phosphatase delta"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase delta
                     isoform 4 precursor"
                     /protein_id="NP_569077.2"
                     /db_xref="GI:283484022"
                     /db_xref="GeneID:5789"
                     /db_xref="HGNC:9668"
                     /db_xref="MIM:601598"
                     /translation="
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSTVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
"
     sig_peptide     104..163
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     164..4591
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /product="receptor-type tyrosine-protein phosphatase delta
                     isoform 4"
     misc_feature    173..448
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    191..448
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Immunoglobulin; Region: IG; smart00409"
                     /db_xref="CDD:197707"
     misc_feature    530..757
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Second immunoglobulin (Ig)-like domain of  the
                     receptor protein tyrosine phosphatase (RPTP)-F, also known
                     as LAR; Region: Ig2_RPTP_IIa_LAR_like; cd05738"
                     /db_xref="CDD:143215"
     misc_feature    797..1042
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    833..1039
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Third immunoglobulin (Ig)-like domain of the
                     receptor protein tyrosine phosphatase (RPTP)-F, also known
                     as LAR; Region: Ig3_RPTP_IIa_LAR_like; cd05739"
                     /db_xref="CDD:143216"
     misc_feature    1052..1321
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    order(1052..1054,1238..1240,1283..1285)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Interdomain contacts; other site"
                     /db_xref="CDD:28945"
     misc_feature    order(1286..1291,1295..1300)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Cytokine receptor motif; other site"
                     /db_xref="CDD:28945"
     misc_feature    1340..1618
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    order(1535..1537,1580..1582)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Interdomain contacts; other site"
                     /db_xref="CDD:28945"
     misc_feature    order(1583..1588,1592..1597)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Cytokine receptor motif; other site"
                     /db_xref="CDD:28945"
     misc_feature    1631..1897
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    order(1631..1633,1814..1816,1859..1861)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Interdomain contacts; other site"
                     /db_xref="CDD:28945"
     misc_feature    order(1862..1867,1871..1876)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Cytokine receptor motif; other site"
                     /db_xref="CDD:28945"
     misc_feature    1919..>2113
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    2921..3688
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Protein tyrosine phosphatase, catalytic domain;
                     Region: PTPc; smart00194"
                     /db_xref="CDD:197567"
     misc_feature    2999..3688
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Protein tyrosine phosphatases (PTP) catalyze the
                     dephosphorylation of phosphotyrosine peptides; they
                     regulate phosphotyrosine levels in signal transduction
                     pathways. The depth of the active site cleft renders the
                     enzyme specific for phosphorylated Tyr; Region: PTPc;
                     cd00047"
                     /db_xref="CDD:28929"
     misc_feature    order(3416..3418,3509..3514,3521..3523,3530..3535)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="active site"
                     /db_xref="CDD:28929"
     misc_feature    3782..4561
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Protein tyrosine phosphatase, catalytic domain;
                     Region: PTPc; smart00194"
                     /db_xref="CDD:197567"
     misc_feature    3869..4561
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="Protein tyrosine phosphatases (PTP) catalyze the
                     dephosphorylation of phosphotyrosine peptides; they
                     regulate phosphotyrosine levels in signal transduction
                     pathways. The depth of the active site cleft renders the
                     enzyme specific for phosphorylated Tyr; Region: PTPc;
                     cd00047"
                     /db_xref="CDD:28929"
     misc_feature    order(4283..4285,4382..4387,4394..4396,4403..4408)
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /note="active site"
                     /db_xref="CDD:28929"
     exon            168..313
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            314..455
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            456..644
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     STS             612..865
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="GDB:582179"
                     /db_xref="UniSTS:157878"
     exon            645..653
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            654..764
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            765..776
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            777..1046
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            1047..1628
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     variation       1081
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3763653"
     STS             1613..1981
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="GDB:582186"
                     /db_xref="UniSTS:157880"
     exon            1629..1762
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            1763..1907
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            1908..2008
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2009..2268
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2269..2359
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2360..2569
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2570..2730
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2731..2843
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2844..2941
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            2942..3065
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            3066..3241
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            3242..3361
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            3362..3516
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            3517..3802
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            3803..3981
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     STS             3875..4093
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="PTPRD"
                     /db_xref="UniSTS:512659"
     exon            3982..4108
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     STS             4069..4574
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="Ptprd"
                     /db_xref="UniSTS:545976"
     exon            4109..4234
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            4235..4389
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            4390..4525
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     exon            4526..8222
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /inference="alignment:Splign:1.39.8"
     STS             4605..5045
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="SGC35386"
                     /db_xref="UniSTS:31522"
     variation       5495
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1051863"
     STS             5559..5577
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /db_xref="UniSTS:98954"
     variation       6190
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11542527"
     polyA_signal    6210..6215
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
     polyA_site      6234
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
     STS             6532..6712
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="D9S1044E"
                     /db_xref="UniSTS:151264"
     STS             6567..6739
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="RH47322"
                     /db_xref="UniSTS:12791"
     variation       6808
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1065682"
     STS             7168..7285
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="A003M12"
                     /db_xref="UniSTS:64813"
     STS             7231..7372
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /standard_name="G31002"
                     /db_xref="UniSTS:79310"
     variation       7480
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3739579"
     polyA_signal    8200..8205
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
     polyA_site      8222
                     /gene="PTPRD"
                     /gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
ORIGIN      
gctctgaaagtgttccagctgaaatttcagatcggacagactcgctgcggctccggaggcagtgattccaagctgctcgcgcacgctgctgccaagctgcaggatggtgcacgtagccaggctgctgctgctgctcctcactttcttcctccgcacggatgctgagacacctccaaggtttacacgaacacccgttgatcagacaggggtctctggcggagttgcctctttcatctgccaagctacgggagacccaagacctaaaattgtctggaacaaaaaaggaaagaaagtcagcaatcagagatttgaggtaatagagtttgacgatgggtctggatcagttctcagaatacaacccttacggactccgagggatgaggccatttatgaatgtgtggcctcaaataatgtgggagaaataagtgtatccaccagactcacagttttgcgggaagatcaaattcccaggggcttccctaccattgacatgggcccacagttgaaggtggttgagcgtactcgcacggccaccatgctttgtgcagccagtggtaatccggatccagaaatcacttggtttaaagatttcttacctgtggacacaagcaacaacaatggtcgtattaagcagttacgatcagaatctattggagcccttcagattgagcagagtgaagagtctgaccaaggaaaatatgagtgtgttgccaccaacagcgcgggcactcgctattccgctcctgccaatttatatgtcagagagctgcgagaagttcgccgtgtcccaccaagattctctatcccacccactaatcatgaaatcatgccaggcggaagcgttaatatcacctgtgtggccgtggggtcaccaatgccttatgtaaagtggatgttgggggcagaagatctgacacctgaagatgatatgccaataggaagaaatgtgctagaactgaatgatgtaagacagtcagcaaattacacctgtgttgctatgtcaacactgggtgtcattgaagcaatagcacagatcactgtcaaagccttacccaaacctccaggaactcctgtagtgaccgagagcacagctacaagcatcacactgacgtgggactctgggaaccctgagcctgtttcttattacataattcagcataaacctaaaaactctgaggaactttacaaagaaattgatggggtggcgaccacacgctacagtgtcgctggactaagtccctactcggattatgaattcagggttgttgctgtcaataacattgggcgggggcctcccagcgaacctgtgctaacacaaacctcagagcaagcaccatccagtgccccgagggatgtccaggcacgaatgttgagttcgaccaccattttggtacagtggaaggaacctgaagagccaaatggacagatccaaggatatagagtttattatacaatggatcccactcaacatgtcaacaactggatgaaacacaatgtagctgacagccaaatcactactattggcaacttagtgccccagaaaacatattctgtcaaagtcctggcttttacctcaattggagatggtcccctttcaagtgacatacaagtcatcactcagacaggagtaccagggcagccactaaacttcaaagcagaacctgagtctgaaacaagtattttgctctcttggacacctccacgttcagataccattgccaactatgaactggtctacaaagatggggagcatggagaggagcaacgaattaccattgagccagggacatcatataggctgcaaggactgaaaccaaacagcttatactatttccgtctggctgcacgctcccctcaaggcctgggtgcttctactgcagaaatatcagctagaaccatgcagtcaacagtgtttgcaaaaaattttcatgtcaaagcagtaatgaagacttccgtgttgctgtcttgggagattccagagaattataactccgccatgcctttcaaaattctttatgatgatgggaaaatggtagaagaagtggatggccgagccacacagaagttaattgtcaacctgaagcctgagaaatcatattcatttgtgctgacaaatcgtggaaacagtgctggtgggctgcagcacagggtcacggcaaagactgcaccagatgtattacgtaccaagcctgccttcattgggaagaccaacttggatggcatgattactgtgcaactgcctgaagtacctgcaaatgagaatataaaaggttactacataataattgtgcctttgaagaaatctcgcgggaaatttatcaagccatgggagagtccagatgaaatggaattagatgagctgcttaaggagatatctaggaagcgcagaagcatccgttatgggagagaagttgaattaaagccatatattgccgctcactttgatgtccttcccactgagttcaccctgggggatgacaagcattatggtggatttacaaacaagcaactccaaagtggtcaagaatatgtcttctttgtgttagcagtaatggaacatgcagagtctaagatgtatgcaaccagcccttactccgaccccgtggtgtcaatggatctggatccgcagccaatcacggatgaagaagaaggcttgatctgggttgtaggtcctgtccttgcagtggtctttatcatctgcattgtcattgctattcttctttataaaaggaagagggcagagtccgactctagaaaaagcagcataccgaacaataaggagatcccttcacaccacccaacagaccctgtagaactgaggcgccttaactttcaaacaccgggtatggctagccatcctccaatacccatcttggaacttgcagaccacattgaaagattgaaagcaaatgacaacttgaagttttcccaggaatatgagtcaattgaccctggccagcagttcacttgggaacattcaaacttggaagtaaacaaaccaaagaatagatacgcgaatgtaatcgcatatgatcattcccgggttctcctatcagctatagaagggatcccaggaagtgactatgtgaatgccaactacatagatgggtataggaagcaaaatgcctatattgcaacacagggatctctccccgaaacatttggggacttttggagaatgatatgggaacaacggagtgccacagttgtcatgatgacaaaactagaagaaagatcaagggtgaagtgtgaccagtattggcctagcagaggcacagaaacccacggactcgttcaagtaacgctgcttgatactgtggagctggccacatattgtgttcgaacatttgcactttacaagaatggttcaagtgagaagagagaagtgagacaattccagttcaccgcctggcctgatcatggtgttccagaacaccctacaccttttctagctttcttacgtagagtcaaaacctgtaaccctcccgatgctggtccgatggttgtgcactgcagtgcgggagttggccggactggttgcttcatcgtcatagatgccatgttagaaagaataaagcatgaaaaaactgtagatatttatggccatgtaactttaatgagagcccagaggaactatatggttcaaacagaagaccaatacatctttatccatgatgcactgttagaagcagtgacttgtggaaataccgaagtgccagctagaaacttgtatgcctacattcagaagctgacacaaatagaaacgggagagaatgtcacaggaatggagctcgaatttaagcgtctagccagctcaaaagctcacacctcaaggtttatcagtgccaatcttccatgtaataaattcaaaaatcgccttgttaatattatgccatatgaatccacaagggtatgcctgcagcctatccgtggagtagaaggatctgattacatcaatgccagttttattgatggatacagacaacagaaagcctacatcgctacccaggggcccttggcagagaccactgaagacttctggcggatgctctgggaacacaattccaccatagttgtgatgctcaccaagctgcgtgaaatgggcagagagaaatgtcaccaatactggccagcagaacggtctgcaagataccagtactttgttgtagatcccatggctgagtacaacatgccacagtatatcctaagggaattcaaggtcacagatgccagggacggccagtcccgaacagtaaggcagttccagttcactgactggccagagcaaggagtgccaaagtccggagaaggatttattgacttcatcggccaagtccataaaacaaaagaacagtttggccaagatggacccatttcagtccattgcagcgcgggcgttggaagaactggagtcttcataacgctaagcattgttttggaaagaatgagatatgaaggagttgtagatatcttccagactgtcaaaatgttaagaacacaacgaccagctatggtacagacagaggatcaatatcagttttcctatcgtgccgcactagagtacctgggcagctttgaccactatgcaacgtagaaacccctgacccattctggatttttactacaggcccttcaatatccatggagtctcttctgagccatacagggcacttgagaagtccttcttaacttctagctaacaactacttagtgggactattacacacaaaacaaattaaaaacaaattattccaggtggaccaagaattcacagtttaataatctaacctgaaaaataatgaagagaatcctgactgatgaggcatctgaaggattttatttacagatacctcaaggattcaaaatcaagggaagaagaaatcacagcaaagaaccaccatcttattcaggattgcttgaaaggtgcaaggagaaattgccagaatgctgcagttcagcacaagatatgtgctggtgtggcttctcacaatgaaacggactctgctttgacatcgccccttcccaccatactgctcataataacattttagggggaaaggggagggaatgtttaaaaagaaagtccttgatttagttttttagtattgtaaagatactgctgacctgtgcttcatttctaactgtgtaaacttttttttaacaaaatgtatcattcgataaagtgaattttaaaaaagttacataactcttcatttttttatttccaaatcgtaggtttttttaagctgtagaactgttatctgtaatatcttgctgtagaaatatcaaatcatttgaaaatttgcacatttttgtgcaaaactcaatctacagtatcagtctcgtcagatatattaattttacacttcagttttgattggtgagaaagtacccattctcttcaaataatcaaagataattattattttgttttgtttttggaatcaacagggaggcgcaaagtataaagttgctgctaacatatatacatatatatccatattttataagggtgtctatgtatatatagacagtgtgtccacacaaaaaatagatacagttatcagtcagtcagttcttccatgatttagtttttttaaacgtagaaaagctattgtaaacatctctttccatttattcttaattttttgacatattggtatttctttaaagggaaatgaggaatgcacatcagtgattgattgtcaaacctcaccccctgatttcctacctaatctacccccacctaaccaatcaatcacatccacaaattgttttgtttgtttgttagtcaggcttccaacaaagttcaatatttctaacactctagtgcaataaaaattattattaaatagctaagaggtgtgcatgtgggaaaggtcagtgcatatccctttaggaggggagaatgttgtaatatatcagctatcgagttgtttaaaaaaagtgtattcaatcgtatattgtctatagtatgtgctatgaaatttgcatttatgatatgtaacaggggcaaagccaaattcatgttactctgttcagtcagaaacattttgtggcatacagcattcctgggaagtgctgtactttgtttcgttttggttttagttttgcatttagagtgccttataattgatgcctattttaatagcatttctttttagcttttggttcgtatttccattcactgttcgtatctgttactttctattaaagcattatctgtttaccacatgtacaaaaactctttgaataatatgcattcctagttttcagccaagtcggggatgttagtgattgtaccagcccaaagcacttggataatcagggcccttcttccttttataatcaatcatcaacatcagaaaaagctacttgttttatttatattcccttccaaatccgctctggaacatgcagtaactgcaccaaacttattttagtaacaaatatcattggcaactttggaatatatttgatattccattaggatttttctaaaaggggaaataaactatatatatatatgtatcttacccccaattcttccaacagaatttctataggaagccatggatgatggcataagtttgccacatattacatgattttaaataatcctcaaaatacccaaggaactcttaaagagttttggtatgagtatactactttggtttaattttagcttcatggatgttctgcatggaaggatttttgttttccacattttcccattgctagcagagtgaaatccaagagaccaaacatttgcaagcattgtatttgagcacttttgtaaaaaacaaagaaaaagaaaaaaaagaaaatatatataatactaaaaaaaagtatctagaaggctacctcagaatgagactctctaacctacatcagaaccagagaagaatgtgcactatgtgggtctgttatcattattttcttttagtttgtatctttttggagatttatccaagtgccagattactcagtgctataattttcttttagttaaacaaagggggtcagacagacattgcatcatccagacatgccttgttggacatgtagaatccgatggagcactgcacaccagaatgattggccaatgagcagcttctctccctgaaacaataactgcccatttggcaaagggaaagatgacaataatcagaagaagaaaatgaatgggatgcataccatagacgaacgaggcggagactattgcgggaatcttactgttcaggagctgttcctagaactaactcccttactgtcattgatgtgcattccactctgtgcttttctgtacaaccattcaagttttaatttcccaggtgaaccatctttatctgccattaccacaagctttcaagtttccagttattttcatcatcataaccagtacggtgctattatttacctatgtacgtgtagttatgtataattttgtaattagttacaatggtaaaaaaaatcaaaatatataaaaagtgatttgtacagaactttattttagctcttttttaaaaatgatttgcatggttagaaaacggcgaggacagccaggggagggaagggcctctagggaactttgcactttctatacctttgtactatgcactgccctattgattctacacccaataatgatattacttgaacccatctgtaagaaactgcttcggaaattcatttgtgtgtatgtaaataacacaacatagaaacaggaagggaaaaaagtctgcagtaatgcacgtattttttttctttcctgtttattttcggttttgctttaagtccttttatttttaattccctttttgtttttctttttgggttttggttccttttgggtttatgggtgccctgatactccagcagagatcagaaggctacagatccattctatccatccgttatgtggctttgccatcccagcttggagtgtctttacaaagataataacagttgtgttctttgctctcgttttggatgcatagactgaaaaattaaaacaaataacttgtaaaatggcttgttaaaaaatacaattacctctaattagtagtacgcgtaaatgttttacagaatgaaaggcgtgctttttattttcttacttcgttacattggtggcgaaagaagtctgtatgaaaatcagttctttgctgacacaagttccatttgttacaaatgaattctaataaaaatgtcagtgttatgcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5789 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: TAS
            GeneID:5789 -> Molecular function: GO:0005102 [receptor binding] evidence: ISS
            GeneID:5789 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5789 -> Molecular function: GO:0050839 [cell adhesion molecule binding] evidence: ISS
            GeneID:5789 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: TAS
            GeneID:5789 -> Biological process: GO:0006796 [phosphate-containing compound metabolic process] evidence: NAS
            GeneID:5789 -> Biological process: GO:0007157 [heterophilic cell-cell adhesion] evidence: ISS
            GeneID:5789 -> Biological process: GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] evidence: TAS
            GeneID:5789 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
            GeneID:5789 -> Biological process: GO:0050775 [positive regulation of dendrite morphogenesis] evidence: ISS
            GeneID:5789 -> Biological process: GO:0097105 [presynaptic membrane assembly] evidence: ISS
            GeneID:5789 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_569077 -> EC 3.1.3.48

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.