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2024-03-28 20:56:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_080838               4933 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens WNT1 inducible signaling pathway protein 1 (WISP1),
            transcript variant 2, mRNA.
ACCESSION   NM_080838
VERSION     NM_080838.2  GI:325910841
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4933)
  AUTHORS   Liu,J.F., Hou,S.M., Tsai,C.H., Huang,C.Y., Hsu,C.J. and Tang,C.H.
  TITLE     CCN4 induces vascular cell adhesion molecule-1 expression in human
            synovial fibroblasts and promotes monocyte adhesion
  JOURNAL   Biochim. Biophys. Acta 1833 (5), 966-975 (2013)
   PUBMED   23313051
  REMARK    GeneRIF: The CCN4-induced VCAM-1 expression promoted monocyte
            adhesion to human OASFs.
REFERENCE   2  (bases 1 to 4933)
  AUTHORS   Saxena,R., Saleheen,D., Been,L.F., Garavito,M.L., Braun,T.,
            Bjonnes,A., Young,R., Ho,W.K., Rasheed,A., Frossard,P., Sim,X.,
            Hassanali,N., Radha,V., Chidambaram,M., Liju,S., Rees,S.D.,
            Ng,D.P., Wong,T.Y., Yamauchi,T., Hara,K., Tanaka,Y., Hirose,H.,
            McCarthy,M.I., Morris,A.P., Basit,A., Barnett,A.H., Katulanda,P.,
            Matthews,D., Mohan,V., Wander,G.S., Singh,J.R., Mehra,N.K.,
            Ralhan,S., Kamboh,M.I., Mulvihill,J.J., Maegawa,H., Tobe,K.,
            Maeda,S., Cho,Y.S., Tai,E.S., Kelly,M.A., Chambers,J.C.,
            Kooner,J.S., Kadowaki,T., Deloukas,P., Rader,D.J., Danesh,J. and
            Sanghera,D.K.
  CONSRTM   DIAGRAM; MuTHER; AGEN
  TITLE     Genome-wide association study identifies a novel locus contributing
            to type 2 diabetes susceptibility in Sikhs of Punjabi origin from
            India
  JOURNAL   Diabetes 62 (5), 1746-1755 (2013)
   PUBMED   23300278
REFERENCE   3  (bases 1 to 4933)
  AUTHORS   Zemans,R.L., McClendon,J., Aschner,Y., Briones,N., Young,S.K.,
            Lau,L.F., Kahn,M. and Downey,G.P.
  TITLE     Role of beta-catenin-regulated CCN matricellular proteins in
            epithelial repair after inflammatory lung injury
  JOURNAL   Am. J. Physiol. Lung Cell Mol. Physiol. 304 (6), L415-L427 (2013)
   PUBMED   23316072
  REMARK    GeneRIF: Beta-catenin-dependent expression of WISP1 and Cyr61 is
            critical for epithelial repair.
REFERENCE   4  (bases 1 to 4933)
  AUTHORS   Hennemeier,I., Humpf,H.U., Gekle,M. and Schwerdt,G.
  TITLE     The food contaminant and nephrotoxin ochratoxin A enhances Wnt1
            inducible signaling protein 1 and tumor necrosis factor-alpha
            expression in human primary proximal tubule cells
  JOURNAL   Mol Nutr Food Res 56 (9), 1375-1384 (2012)
   PUBMED   22778029
  REMARK    GeneRIF: Prolonged exposure of kidney cells to ochratoxin A,
            expectable in human kidney due to a normal diet, leads to a marked
            ERK1/2-dependent upregulation of WISP1 gene expression, which,
            accompanied by increased ERK1/2- dependent TNF-alpha expression.
REFERENCE   5  (bases 1 to 4933)
  AUTHORS   Shao,H., Cai,L., Grichnik,J.M., Livingstone,A.S., Velazquez,O.C.
            and Liu,Z.J.
  TITLE     Activation of Notch1 signaling in stromal fibroblasts inhibits
            melanoma growth by upregulating WISP-1
  JOURNAL   Oncogene 30 (42), 4316-4326 (2011)
   PUBMED   21516124
  REMARK    GeneRIF: This study shows that constitutive activation of the
            Notch1 pathway confers fibroblasts with a suppressive phenotype to
            melanoma growth, partially through WISP-1.
REFERENCE   6  (bases 1 to 4933)
  AUTHORS   Xie,D., Nakachi,K., Wang,H., Elashoff,R. and Koeffler,H.P.
  TITLE     Elevated levels of connective tissue growth factor, WISP-1, and
            CYR61 in primary breast cancers associated with more advanced
            features
  JOURNAL   Cancer Res. 61 (24), 8917-8923 (2001)
   PUBMED   11751417
  REMARK    GeneRIF: Elevated levels of connective tissue growth factor,
            WISP-1, and CYR61 in primary breast cancers associated with more
            advanced features.
REFERENCE   7  (bases 1 to 4933)
  AUTHORS   Desnoyers,L., Arnott,D. and Pennica,D.
  TITLE     WISP-1 binds to decorin and biglycan
  JOURNAL   J. Biol. Chem. 276 (50), 47599-47607 (2001)
   PUBMED   11598131
REFERENCE   8  (bases 1 to 4933)
  AUTHORS   Tanaka,S., Sugimachi,K., Saeki,H., Kinoshita,J., Ohga,T.,
            Shimada,M., Maehara,Y. and Sugimachi,K.
  TITLE     A novel variant of WISP1 lacking a Von Willebrand type C module
            overexpressed in scirrhous gastric carcinoma
  JOURNAL   Oncogene 20 (39), 5525-5532 (2001)
   PUBMED   11571650
REFERENCE   9  (bases 1 to 4933)
  AUTHORS   Xu,L., Corcoran,R.B., Welsh,J.W., Pennica,D. and Levine,A.J.
  TITLE     WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene
  JOURNAL   Genes Dev. 14 (5), 585-595 (2000)
   PUBMED   10716946
REFERENCE   10 (bases 1 to 4933)
  AUTHORS   Pennica,D., Swanson,T.A., Welsh,J.W., Roy,M.A., Lawrence,D.A.,
            Lee,J., Brush,J., Taneyhill,L.A., Deuel,B., Lew,M., Watanabe,C.,
            Cohen,R.L., Melhem,M.F., Finley,G.G., Quirke,P., Goddard,A.D.,
            Hillan,K.J., Gurney,A.L., Botstein,D. and Levine,A.J.
  TITLE     WISP genes are members of the connective tissue growth factor
            family that are up-regulated in wnt-1-transformed cells and
            aberrantly expressed in human colon tumors
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (25), 14717-14722 (1998)
   PUBMED   9843955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX476382.1, AB034725.1,
            DN997366.1, AF192304.6 and AI347990.1.
            On Mar 11, 2011 this sequence version replaced gi:18490999.
            
            Summary: This gene encodes a member of the WNT1 inducible signaling
            pathway (WISP) protein subfamily, which belongs to the connective
            tissue growth factor (CTGF) family. WNT1 is a member of a family of
            cysteine-rich, glycosylated signaling proteins that mediate diverse
            developmental processes. The CTGF family members are characterized
            by four conserved cysteine-rich domains: insulin-like growth
            factor-binding domain, von Willebrand factor type C module,
            thrombospondin domain and C-terminal cystine knot-like domain. This
            gene may be downstream in the WNT1 signaling pathway that is
            relevant to malignant transformation. It is expressed at a high
            level in fibroblast cells, and overexpressed in colon tumors. The
            encoded protein binds to decorin and biglycan, two members of a
            family of small leucine-rich proteoglycans present in the
            extracellular matrix of connective tissue, and possibly prevents
            the inhibitory activity of decorin and biglycan in tumor cell
            proliferation. It also attenuates p53-mediated apoptosis in
            response to DNA damage through activation of the Akt kinase. It is
            83% identical to the mouse protein at the amino acid level.
            Multiple alternatively spliced transcript variants have been
            identified. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, as compared to variant 1. Isoform 2 encoded by this
            variant thus lacks a von Willbrand type C module that is thought to
            participate in protein complex formation. This variant is
            overexpressed in scirrhous carcinomas.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB034725.1, DN997366.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025083, ERS025084 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BX476382.1         1-98
            99-210              AB034725.1         1-112
            211-678             DN997366.1         198-665
            679-4653            AF192304.6         65563-69537
            4654-4933           AI347990.1         1-280               c
FEATURES             Location/Qualifiers
     source          1..4933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..4933
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="WNT1 inducible signaling pathway protein 1"
                     /db_xref="GeneID:8840"
                     /db_xref="HGNC:12769"
                     /db_xref="MIM:603398"
     exon            1..175
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       22
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35244636"
     variation       55
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116716037"
     STS             57..999
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /db_xref="UniSTS:481399"
     variation       58
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113859079"
     variation       60
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201515187"
     variation       76
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370168550"
     variation       77
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373840690"
     STS             78..970
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /db_xref="UniSTS:482064"
     misc_feature    95..97
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="upstream in-frame stop codon"
     CDS             107..949
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Wnt-1 inducible signaling pathway protein 1;
                     WNT1 induced secreted protein 1; CCN family member 4"
                     /codon_start=1
                     /product="WNT1-inducible-signaling pathway protein 1
                     isoform 2 precursor"
                     /protein_id="NP_543028.1"
                     /db_xref="GI:18491000"
                     /db_xref="CCDS:CCDS6372.1"
                     /db_xref="GeneID:8840"
                     /db_xref="HGNC:12769"
                     /db_xref="MIM:603398"
                     /translation="
MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAHAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN
"
     sig_peptide     107..172
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     173..946
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /product="WNT1-inducible-signaling pathway protein 1
                     isoform 2"
     misc_feature    <299..409
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="Insulin-like growth factor binding protein; Region:
                     IGFBP; pfam00219"
                     /db_xref="CDD:201091"
     misc_feature    503..622
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="Thrombospondin type 1 domain; Region: TSP_1;
                     cl15278"
                     /db_xref="CDD:199489"
     misc_feature    683..931
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB_like; cl00070"
                     /db_xref="CDD:200610"
     variation       128
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145302227"
     variation       130
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147864416"
     variation       134
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141541463"
     variation       135
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147047617"
     variation       140
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145240649"
     variation       144
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149172980"
     variation       155
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375956639"
     variation       174
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370536589"
     variation       175
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374241755"
     exon            176..455
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       190
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201677592"
     variation       195
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148354420"
     variation       200
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371604351"
     variation       229
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73711808"
     variation       247
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200725711"
     variation       285
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145895971"
     variation       286
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138500919"
     variation       292
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61526601"
     variation       344
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150518640"
     variation       359
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202221836"
     variation       397
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73711810"
     variation       403
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114585111"
     variation       436
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367939319"
     exon            456..649
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       458
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35513885"
     variation       459
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369847225"
     variation       472
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141179228"
     variation       478
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377427275"
     variation       516
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373574457"
     variation       527
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199564945"
     variation       535
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150744504"
     variation       536
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139602125"
     variation       564
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199672029"
     variation       571
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201767438"
     variation       572
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200522670"
     variation       595
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200030526"
     variation       599
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370235023"
     variation       615
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201197950"
     variation       623
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202087900"
     variation       640
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113292639"
     exon            650..4929
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       693
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370616029"
     variation       700
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35938742"
     variation       708
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374293123"
     variation       709
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34279368"
     variation       738
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368398252"
     variation       742
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150347257"
     variation       766
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3739261"
     variation       781
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369316693"
     variation       815
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200845163"
     variation       840
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371947572"
     variation       850
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34665171"
     variation       901
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146812236"
     variation       943
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140629356"
     variation       951
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192420341"
     variation       971
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200836970"
     variation       976
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374163879"
     variation       1094
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138013484"
     variation       1204
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57390041"
     variation       1318
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:142394577"
     variation       1400
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113549310"
     variation       1425
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184580529"
     variation       1542
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190313906"
     variation       1590
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142461254"
     variation       1693
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929969"
     variation       1919
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12164193"
     variation       1928
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145960909"
     variation       1934
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73362554"
     variation       2003
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182003497"
     variation       2082
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:4265166"
     variation       2133
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929970"
     variation       2202
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374010309"
     variation       2207
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4577938"
     variation       2298
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377032724"
     variation       2412
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146162433"
     variation       2467
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185849289"
     variation       2763
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188945068"
     variation       2772
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181057409"
     variation       2775
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148796937"
     variation       2996
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117072299"
     variation       3029
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977549"
     variation       3332
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73362557"
     variation       3334
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76779268"
     variation       3368
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2929971"
     variation       3375
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373530385"
     variation       3399
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142427022"
     variation       3451
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929972"
     variation       3504
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2929973"
     variation       3528
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151300566"
     variation       3676
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:16904856"
     variation       3707..3708
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36017627"
     variation       3763
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370468302"
     variation       3805
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977550"
     variation       3920
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9649971"
     variation       3922
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186406622"
     variation       3952
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16904857"
     variation       4041
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191533905"
     variation       4075
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200715437"
     variation       4103
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145461011"
     variation       4244
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16904858"
     variation       4352
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114925013"
     variation       4362
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16904859"
     variation       4418
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:73711826"
     variation       4420..4421
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35647766"
     variation       4425
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16904860"
     variation       4438..4441
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="ctga"
                     /db_xref="dbSNP:372155216"
     variation       4440..4443
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="gact"
                     /db_xref="dbSNP:367926394"
     variation       4464
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182511484"
     variation       4481
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186242527"
     variation       4527
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74818902"
     variation       4546
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977551"
     STS             4611..4777
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /standard_name="RH102883"
                     /db_xref="UniSTS:97217"
     STS             4625..4836
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /standard_name="RH76344"
                     /db_xref="UniSTS:92556"
     variation       4658
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147688784"
     variation       4670
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191950359"
     variation       4835
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77866098"
     polyA_signal    4907..4912
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
     polyA_site      4929
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
ORIGIN      
atatctggtgctcctgatgggccggccagtctgggcccagctcccccgagaggtggtcggatcctctgggctgctcggtcgatgcctgtgccactgacgtccaggcatgaggtggttcctgccctggacgctggcagcagtgacagcagcagccgccagcaccgtcctggccacggccctctctccagcccctacgaccatggactttaccccagctccactggaggacacctcctcacgcccccaattctgcaagtggccatgtgagtgcccgccatccccaccccgctgcccgctgggggtcagcctcatcacagatggctgtgagtgctgtaagatgtgcgctcagcagcttggggacaactgcacggaggctgccatctgtgacccccaccggggcctctactgtgactacagcggggaccgcccgaggtacgcaataggagtgtgtgcacatgctgtgggtgaggtggaggcatggcacaggaactgcatagcctacacaagcccctggagcccttgctccaccagctgcggcctgggggtctccactcggatctccaatgttaacgcccagtgctggcctgagcaagagagccgcctctgcaacttgcggccatgcgatgtggacatccatacactcattaaggcagggaagaagtgtctggctgtgtaccagccagaggcatccatgaacttcacacttgcgggctgcatcagcacacgctcctatcaacccaagtactgtggagtttgcatggacaataggtgctgcatcccctacaagtctaagactatcgacgtgtccttccagtgtcctgatgggcttggcttctcccgccaggtcctatggattaatgcctgcttctgtaacctgagctgtaggaatcccaatgacatctttgctgacttggaatcctaccctgacttctcagaaattgccaactaggcaggcacaaatcttgggtcttggggactaacccaatgcctgtgaagcagtcagcccttatggccaataacttttcaccaatgagccttagttaccctgatctggacccttggcctccatttctgtctctaaccattcaaatgacgcctgatggtgctgctcaggcccatgctatgagttttctccttgatatcattcagcatctactctaaagaaaaatgcctgtctctagctgttctggactacacccaagcctgatccagcctttccaagtcactagaagtcctgctggatcttgcctaaatcccaagaaatggaatcaggtagacttttaatatcactaatttcttctttagatgccaaaccacaagactctttgggtccattcagatgaatagatggaatttggaacaatagaataatctattatttggagcctgccaagaggtactgtaatgggtaattctgacgtcagcgcaccaaaactatcctgattccaaatatgtatgcacctcaaggtcatcaaacatttgccaagtgagttgaatagttgcttaattttgatttttaatggaaagttgtatccattaacctgggcattgttgaggttaagtttctcttcacccctacactgtgaagggtacagattaggtttgtcccagtcagaaataaaatttgataaacattcctgttgatgggaaaagcccccagttaatactccagagacagggaaaggtcagcccgtttcagaaggaccaattgactctcacactgaatcagctgctgactggcagggctttgggcagttggccaggctcttccttgaatcttctcccttgtcctgcttggggttcataggaattggtaaggcctctggactggcctgtctggcccctgagagtggtgccctggaacactcctctactcttacagagccttgagagacccagctgcagaccatgccagacccactgaaatgaccaagacaggttcaggtaggggtgtgggtcaaaccaagaagtgggtgcccttggtagcagcctggggtgacctctagagctggaggctgtgggactccaggggcccccgtgttcaggacacatctattgcagagactcatttcacagcctttcgttctgctgaccaaatggccagttttctggtaggaagatggaggtttaccggttgtttagaaacagaaatagacttaataaaggtttaaagctgaagaggttgaagctaaaaggaaaaggttgttgttaatgaatatcaggctattatttattgtattaggaaaatataatatttactgttagaattcttttatttagggccttttctgtgccagacattgctctcagtgctttgcatgtattagctcactgaatcttcacgacaatgttgagaagttcccattattatttctgttcttacaaatgtgaaacggaagctcatagaggtgagaaaactcaaccagagtcacccagttggtgactgggaaagttaggattcagatcgaaattggactgtctttataacccatattttccccctgtttttagagcttccaaatgtgtcagaataggaaaacattgcaataaatggcttgattttttaatgtcatttttccctcttatagtctttctagctccttttcaaaagacgagaatatctgattttctgataatttaggtgcttaagcatccaaaatacatgggacacacaaaaatccaggaatcccctgtagcttattccctctttcccatcggaaccagctctcatcacacatttaaaagatgattctgtttacccaatgctgcatattgaatgttgtgtagttattcacagggaattctgtgcagtgtgcagagagattcctaaacgggaaaaggactgggaatacatcctccttactgtgacctccccaaaacctagtccagtgcaaggtatacagtggtgctcattaaatacttgatgaatacaggaagctgtgcatgtgttcctacttttattcgaagctctcttcttccaaagctacatgaaaatagaattttaacagtcaaaattttatattaagtgccttagcaaaagagacatttaatatttcaaagaaatgcatatgtatgtatacatatatttgtgtatgcgtatgcaagaattcttgtataaagagaattcactccatgaatgatctcttctgtaagtcagtgtgaatcatgttagattttctgagagtgaaaacacctgccatctacaaattacaaggctggataacagctcactccatttgaaattcagtggaaacccaagagctaggttcttactgaatttgcatctcaatttgggaaactgaacttagctttcaaagatcataggaagtctggttggagaaactagggattattctggcaatgggtgcaggaaggtggtcagaataacccagtcgccattggttttgagaaacggaactatcttatgcagagcccggagggcaagtctcagacccatgggttgaagccatggagaaggaaatttggatccaatgtaatgaagcgctttctaagtcagaatttccctgcaatggtgtggcctgattcaataaaaattaagaataataaatataatggaaaaaaatctccactgattgagtgtttacttggtgccaagcactatgctaagttgttcattattttatttaattgttacagcaattttgagtatgcatctttcactattttataagtggaaaagagaagtgcccccaaaaagttagagctcaaacagcagcttattctaccagcccctgctcttgcggaggcctctggaaaagacctgaatgacacctattggagaattacatctacaaggggcttcaaacagaccaaatagatcatcacctctgtggtcccttgttaactatatgttctgagacaaaggaaagctaccctaagggttagttaacctttgctgaggaaatttacattcatacttagagtgaattactcaggtgtgcttaggtgtgcaaaagggaaggagacctgaattcaccaagttaaatcttgctaaaccttatcataagcattttttgagcgcttagcatacaccaagccttgtggaaggtgctttcctgccatatctcatttaatcctcacagcaaacctatagaatatggcattatcatctgagtctcacagaagtttagtcgtgtactcaaggtcttaccagctagtgaacagcagaccaagactggaaacccaggatagtctgatacctgagccatctcttcttgtgctacgcctagttattctgtcccccaaatcaaaaggcatgacctttataagaggcgctttactgacaatagctgcaattttaactttgaaaatgattcagaattatcaaagatagtagattcgaatgacatgattgtctataatctcgctagccttgtactgtgtgtgcatagcaattacagggaagtaatctagctcctgactattatgttgaactatgtcgctgctttttacaaacttgtcttgatccaaagcagtcacaatgataaccctgcatatctgggaatcataagtcaactatgtatccctgtgtgtgtatatatatgtatgtatgtatctattttcaaactgtgatttaatatttaaatattcctactgccatttttgtgactgaaaaactacacatgaggaaacgtcttagaattttccaatagaggaaaaataacacttgggcaatctgtcatgtttcacaacagttctcatttttctcatgatttgtgtagcgtggaatgtgtttgctcaatgtgaagggttttcattgctcaatttctctgtgtaagtcttttccttaaggtaataaaccatcagcaaagtcacatactggagttggtggcttttcttgtacaggcagttgttatgagacaatgatggagcattgagcatgttcaataaatgtgcagatggtggaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8840 -> Molecular function: GO:0005520 [insulin-like growth factor binding] evidence: IEA
            GeneID:8840 -> Biological process: GO:0001558 [regulation of cell growth] evidence: IEA
            GeneID:8840 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:8840 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:8840 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
            GeneID:8840 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
            GeneID:8840 -> Cellular component: GO:0005615 [extracellular space] evidence: NAS
            GeneID:8840 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

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