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2024-04-25 16:20:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_080549 2464 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 6
(PTPN6), transcript variant 3, mRNA.
ACCESSION NM_080549
VERSION NM_080549.3 GI:166064065
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2464)
AUTHORS Hebeisen,M., Baitsch,L., Presotto,D., Baumgaertner,P., Romero,P.,
Michielin,O., Speiser,D.E. and Rufer,N.
TITLE SHP-1 phosphatase activity counteracts increased T cell receptor
affinity
JOURNAL J. Clin. Invest. 123 (3), 1044-1056 (2013)
PUBMED 23391724
REMARK GeneRIF: The global role of SHP-1 in regulating CD8 positive T cell
activation.
REFERENCE 2 (bases 1 to 2464)
AUTHORS Kim,S.H., Cho,Y.R., Kim,H.J., Oh,J.S., Ahn,E.K., Ko,H.J.,
Hwang,B.J., Lee,S.J., Cho,Y., Kim,Y.K., Stetler-Stevenson,W.G. and
Seo,D.W.
TITLE Antagonism of VEGF-A-induced increase in vascular permeability by
an integrin alpha3beta1-Shp-1-cAMP/PKA pathway
JOURNAL Blood 120 (24), 4892-4902 (2012)
PUBMED 23074279
REMARK GeneRIF: Data show that TIMP-2-mediated inhibition of vascular
endothelial cell permeability involves an integrin
alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular
endothelial cadherin cytoskeletal association.
REFERENCE 3 (bases 1 to 2464)
AUTHORS Evren,S., Ma,X.Z., Sakac,D. and Branch,D.R.
TITLE SHP-1 protein tyrosine phosphatase associates with the adaptor
protein CrkL
JOURNAL Exp. Hematol. 40 (12), 1055-1059 (2012)
PUBMED 22960265
REMARK GeneRIF: This study is the first to identify and define an
interaction between SHP-1 and an SH3 domain-containing protein. Our
findings provide an alternative way that SHP-1 can be linked to
potential substrates.
REFERENCE 4 (bases 1 to 2464)
AUTHORS de Almeida,A.C., Barbosa,S.M., de Lourdes Rios Barjas-Castro,M.,
Olalla-Saad,S.T. and Condino-Neto,A.
TITLE IFN-beta, IFN-gamma, and TNF-alpha decrease erythrophagocytosis by
human monocytes independent of SIRP-alpha or SHP-1 expression
JOURNAL Immunopharmacol Immunotoxicol 34 (6), 1054-1059 (2012)
PUBMED 22738830
REMARK GeneRIF: IFN-beta and IFN-gamma/TNF-alpha decrease
erythrophagocytosis by human monocytes in vitro, and this effect
does not apparently require an increase in SIRP-alpha or SHP-1
expression.
REFERENCE 5 (bases 1 to 2464)
AUTHORS Zhang,Y.Z., Zhao,D.D., Zhao,W.P., Zhao,H.F., Zhao,Z.G., Wang,Y.F.,
Wu,X.X., Han,X.P. and Da,W.M.
TITLE [Experimental study of SHP-1 promoter methylation in
myelodysplastic syndromes and its related mechanism]
JOURNAL Zhonghua Xue Ye Xue Za Zhi 33 (2), 108-112 (2012)
PUBMED 22730659
REMARK GeneRIF: Abnormal methylation of SHP-1 gene promoter might have
tentative role in the pathogenesis and progression of
myelodysplastic syndrome.
REFERENCE 6 (bases 1 to 2464)
AUTHORS Jin,Y.J., Yu,C.L. and Burakoff,S.J.
TITLE Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal
structure and catalytic activity
JOURNAL J. Biol. Chem. 274 (40), 28301-28307 (1999)
PUBMED 10497187
REFERENCE 7 (bases 1 to 2464)
AUTHORS Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G.,
Jani-Sait,S. and Shows,T.B.
TITLE Chromosomal localization of an SH2-containing tyrosine phosphatase
(PTPN6)
JOURNAL Genomics 13 (3), 869-872 (1992)
PUBMED 1639416
REFERENCE 8 (bases 1 to 2464)
AUTHORS Plutzky,J., Neel,B.G. and Rosenberg,R.D.
TITLE Isolation of a src homology 2-containing tyrosine phosphatase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (3), 1123-1127 (1992)
PUBMED 1736296
REFERENCE 9 (bases 1 to 2464)
AUTHORS Yi,T.L., Cleveland,J.L. and Ihle,J.N.
TITLE Protein tyrosine phosphatase containing SH2 domains:
characterization, preferential expression in hematopoietic cells,
and localization to human chromosome 12p12-p13
JOURNAL Mol. Cell. Biol. 12 (2), 836-846 (1992)
PUBMED 1732748
REFERENCE 10 (bases 1 to 2464)
AUTHORS Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P.
TITLE A protein-tyrosine phosphatase with sequence similarity to the SH2
domain of the protein-tyrosine kinases
JOURNAL Nature 352 (6337), 736-739 (1991)
PUBMED 1652101
REMARK Erratum:[Nature 1991 Oct 31;353(6347):868]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC297194.1, BC007667.2,
AF178946.1 and BC002523.2.
On Jan 24, 2008 this sequence version replaced gi:34328902.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. N-terminal part of this PTP contains two
tandem Src homolog (SH2) domains, which act as protein
phospho-tyrosine binding domains, and mediate the interaction of
this PTP with its substrates. This PTP is expressed primarily in
hematopoietic cells, and functions as an important regulator of
multiple signaling pathways in hematopoietic cells. This PTP has
been shown to interact with, and dephosphorylate a wide spectrum of
phospho-proteins involved in hematopoietic cell signaling. Multiple
alternatively spliced variants of this gene, which encode distinct
isoforms, have been reported. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) uses an alternate 5' terminal
exon, and an alternate acceptor splice site at the penultimate
exon, compared to transcript variant 1, resulting in a longer
isoform (3, also known as 70 kDa SHP-1L protein) with distinct N_
and C_ termini, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF178946.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025093 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
NMD candidate :: PMID: 10497187
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-568 DC297194.1 1-568
569-1915 BC007667.2 468-1814
1916-2339 AF178946.1 1698-2121
2340-2464 BC002523.2 2096-2220
FEATURES Location/Qualifiers
source 1..2464
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13"
gene 1..2464
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="protein tyrosine phosphatase, non-receptor type 6"
/db_xref="GeneID:5777"
/db_xref="HGNC:9658"
/db_xref="HPRD:01475"
/db_xref="MIM:176883"
exon 1..250
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 88
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376332356"
variation 97..98
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace=""
/replace="g"
/db_xref="dbSNP:142439366"
variation 120
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45530144"
variation 129
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368379027"
misc_feature 162..164
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="upstream in-frame stop codon"
variation 214
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371595452"
variation 229
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:78416656"
CDS 243..2117
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/EC_number="3.1.3.48"
/note="isoform 3 is encoded by transcript variant 3;
protein-tyrosine phosphatase 1C; hematopoietic cell
protein-tyrosine phosphatase; tyrosine-protein phosphatase
non-receptor type 6; hematopoietic cell phosphatase;
protein-tyrosine phosphatase SHP-1"
/codon_start=1
/product="tyrosine-protein phosphatase non-receptor type 6
isoform 3"
/protein_id="NP_536859.1"
/db_xref="GI:18104993"
/db_xref="CCDS:CCDS44821.1"
/db_xref="GeneID:5777"
/db_xref="HGNC:9658"
/db_xref="HPRD:01475"
/db_xref="MIM:176883"
/translation="
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKSLESSAGTVAASPVRRGGQRGLPVPGPPVLSPDLHQLPVLAPLHPAADTRRMCMRTCTLRTRGRRK
"
misc_feature 249..545
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="N-terminal Src homology 2 (N-SH2) domain found in
SH2 domain Phosphatases (SHP) proteins; Region:
SH2_N-SH2_SHP_like; cd10340"
/db_xref="CDD:198203"
misc_feature order(273..275,330..332,393..395,399..401)
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198203"
misc_feature order(390..398,438..440,498..509,513..515)
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198203"
misc_feature 423..425
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 432..434
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (P29350.1); phosphorylation site"
misc_feature 432..434
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 567..887
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="C-terminal Src homology 2 (C-SH2) domain found in
SH2 domain Phosphatases (SHP) proteins; Region:
SH2_C-SH2_SHP_like; cd09931"
/db_xref="CDD:198185"
misc_feature order(651..653,657..659,672..677)
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198185"
misc_feature order(741..743,822..824)
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198185"
misc_feature 969..1784
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 1056..1784
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(1497..1499,1596..1601,1608..1610,1617..1622)
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/note="active site"
/db_xref="CDD:28929"
misc_feature 1599..1619
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P29350.1);
Region: Substrate binding (By similarity)"
misc_feature 1848..1850
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 251..373
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 276
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199996841"
variation 290
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374550116"
variation 300
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:377003393"
variation 325
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11547853"
variation 340
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369614203"
variation 368
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114945777"
variation 369
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377254990"
exon 374..568
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 399
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370939978"
variation 449
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200943423"
variation 465
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:181425111"
variation 494
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186239082"
variation 497
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1048596"
variation 498
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:1048597"
exon 569..758
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 593
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200471577"
variation 607
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201550362"
variation 608
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372601000"
variation 626
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377246131"
variation 638
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200355447"
variation 677
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202230542"
variation 679
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1048598"
variation 716
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183020942"
variation 722
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372380210"
variation 724
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373750986"
variation 725
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375220948"
variation 730
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369530834"
exon 759..875
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 805
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368426352"
variation 815
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1048599"
variation 842
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370626779"
variation 855
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375296528"
variation 871
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367551491"
exon 876..989
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 890
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140592255"
variation 917
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201345298"
variation 950
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199730259"
exon 990..1086
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1025
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374959527"
variation 1046
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368935562"
exon 1087..1166
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1101
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56111095"
variation 1139
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377270547"
exon 1167..1316
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1193
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200624825"
variation 1196
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147821940"
variation 1208
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372677554"
variation 1220
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2110072"
variation 1223
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368190355"
variation 1236
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199933225"
variation 1238
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372072330"
variation 1258
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201976465"
variation 1259
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:181711169"
variation 1275
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369337036"
exon 1317..1448
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1325
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190247406"
variation 1340..1341
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace=""
/replace="c"
/db_xref="dbSNP:36050455"
variation 1341
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377517197"
variation 1356
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370538000"
variation 1406
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374040175"
variation 1408
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376886181"
variation 1439
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116298095"
variation 1442
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375520775"
exon 1449..1603
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1556
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:374365975"
variation 1564
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200005925"
variation 1569
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368398907"
variation 1571
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371502084"
variation 1577
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375270811"
variation 1593
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:62621988"
exon 1604..1671
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1604
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376685795"
variation 1607
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370019783"
variation 1640
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113854853"
variation 1641
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376994439"
exon 1672..1823
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1730
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200112594"
variation 1750
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185835888"
variation 1763
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114388315"
variation 1769
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371456901"
exon 1824..1915
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1825
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200635165"
variation 1856
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201191540"
variation 1900
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200155138"
variation 1910
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373263834"
exon 1916..2198
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 1921
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189707299"
variation 1926
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61753202"
variation 1927
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:61753203"
variation 1941
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370716043"
variation 1948
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376526283"
variation 1949
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111262295"
variation 1954
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181341203"
variation 1999
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374350034"
variation 2050
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201288920"
variation 2051
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368556498"
variation 2058
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:112637607"
variation 2074
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370393336"
variation 2087
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375291511"
STS 2134..2366
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/standard_name="RH80060"
/db_xref="UniSTS:90394"
variation 2138
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367563603"
STS 2150..2332
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/standard_name="RH46958"
/db_xref="UniSTS:4816"
STS 2162..2390
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/standard_name="RH79905"
/db_xref="UniSTS:84041"
variation 2176
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:74057234"
exon 2199..2389
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/inference="alignment:Splign:1.39.8"
variation 2323
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377640230"
variation 2324
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804439"
variation 2340
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:112396722"
polyA_signal 2367..2372
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
polyA_site 2389
/gene="PTPN6"
/gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
SHP-1L; SHP1"
ORIGIN
gctctaaaacgagaagtacaagtgagttcccccaaggggtcggccgcgcctcttcctgtccccgccctgccggctgccccaggccagtggagtggcagccccagaactgggaccaccgggggtggtgaggcggcccggcactgggagctgcatctgaggcttagtccctgagctctctgcctgcccagactagctgcacctcctcattccctgcgcccccttcctctccggaagcccccaggatggtgaggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggccgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcgctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttctatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacactcagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctgaactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggcagagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagccagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctccccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggtttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgaggaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcggctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagccaaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcaccagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctcccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgactacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacctacatcgccagccagggctgtctggaggccacggtcaatgacttctggcagatggcgtggcaggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaatgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgaccaactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctggacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccatggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcaggaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcacaggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgtgacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcagacggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaagaagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacctatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaagagcttggagtctagtgcagggaccgtggctgcgtcacctgtgagacggggtggccagaggggactgccagtgccgggtccccctgtgctgtctcctgacctgcaccaactgcctgtacttgcccccctgcacccggctgcagacacaaggaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcagcggtcagcagacaaggagaagagcaagggttccctcaagaggaagtgagcggtgctgtcctcaggtggccatgcctcagccctgaccctgtggaagcatttcgcgatggacagactcacaacctgaacctaggagtgccccattcttttgtaatttaaatggctgcatcccccccacctctccctgaccctgtatatagcccagccaggccccaggcagggccaacccttctcctcttgtaaataaagccctgggatcactgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5777 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IEA
GeneID:5777 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: TAS
GeneID:5777 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: IDA
GeneID:5777 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5777 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
GeneID:5777 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
GeneID:5777 -> Molecular function: GO:0042169 [SH2 domain binding] evidence: IEA
GeneID:5777 -> Biological process: GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin] evidence: IEA
GeneID:5777 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA
GeneID:5777 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5777 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:5777 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
GeneID:5777 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
GeneID:5777 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: NAS
GeneID:5777 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IMP
GeneID:5777 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:5777 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0030154 [cell differentiation] evidence: IDA
GeneID:5777 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
GeneID:5777 -> Biological process: GO:0042130 [negative regulation of T cell proliferation] evidence: IEA
GeneID:5777 -> Biological process: GO:0042267 [natural killer cell mediated cytotoxicity] evidence: IEA
GeneID:5777 -> Biological process: GO:0043407 [negative regulation of MAP kinase activity] evidence: IEA
GeneID:5777 -> Biological process: GO:0045577 [regulation of B cell differentiation] evidence: IEA
GeneID:5777 -> Biological process: GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] evidence: IMP
GeneID:5777 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: IEA
GeneID:5777 -> Biological process: GO:0050860 [negative regulation of T cell receptor signaling pathway] evidence: IEA
GeneID:5777 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
GeneID:5777 -> Biological process: GO:0060333 [interferon-gamma-mediated signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0060337 [type I interferon-mediated signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0060338 [regulation of type I interferon-mediated signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] evidence: TAS
GeneID:5777 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: IDA
GeneID:5777 -> Biological process: GO:2000045 [regulation of G1/S transition of mitotic cell cycle] evidence: IMP
GeneID:5777 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5777 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5777 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5777 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:5777 -> Cellular component: GO:0042105 [alpha-beta T cell receptor complex] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_536859 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
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