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2024-03-29 16:56:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_080548               2234 bp    mRNA    linear   PRI 19-MAY-2013
DEFINITION  Homo sapiens protein tyrosine phosphatase, non-receptor type 6
            (PTPN6), transcript variant 2, mRNA.
ACCESSION   NM_080548
VERSION     NM_080548.4  GI:166064063
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Hebeisen,M., Baitsch,L., Presotto,D., Baumgaertner,P., Romero,P.,
            Michielin,O., Speiser,D.E. and Rufer,N.
  TITLE     SHP-1 phosphatase activity counteracts increased T cell receptor
            affinity
  JOURNAL   J. Clin. Invest. 123 (3), 1044-1056 (2013)
   PUBMED   23391724
  REMARK    GeneRIF: The global role of SHP-1 in regulating CD8 positive T cell
            activation.
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Kim,S.H., Cho,Y.R., Kim,H.J., Oh,J.S., Ahn,E.K., Ko,H.J.,
            Hwang,B.J., Lee,S.J., Cho,Y., Kim,Y.K., Stetler-Stevenson,W.G. and
            Seo,D.W.
  TITLE     Antagonism of VEGF-A-induced increase in vascular permeability by
            an integrin alpha3beta1-Shp-1-cAMP/PKA pathway
  JOURNAL   Blood 120 (24), 4892-4902 (2012)
   PUBMED   23074279
  REMARK    GeneRIF: Data show that TIMP-2-mediated inhibition of vascular
            endothelial cell permeability involves an integrin
            alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular
            endothelial cadherin cytoskeletal association.
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Evren,S., Ma,X.Z., Sakac,D. and Branch,D.R.
  TITLE     SHP-1 protein tyrosine phosphatase associates with the adaptor
            protein CrkL
  JOURNAL   Exp. Hematol. 40 (12), 1055-1059 (2012)
   PUBMED   22960265
  REMARK    GeneRIF: This study is the first to identify and define an
            interaction between SHP-1 and an SH3 domain-containing protein. Our
            findings provide an alternative way that SHP-1 can be linked to
            potential substrates.
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   de Almeida,A.C., Barbosa,S.M., de Lourdes Rios Barjas-Castro,M.,
            Olalla-Saad,S.T. and Condino-Neto,A.
  TITLE     IFN-beta, IFN-gamma, and TNF-alpha decrease erythrophagocytosis by
            human monocytes independent of SIRP-alpha or SHP-1 expression
  JOURNAL   Immunopharmacol Immunotoxicol 34 (6), 1054-1059 (2012)
   PUBMED   22738830
  REMARK    GeneRIF: IFN-beta and IFN-gamma/TNF-alpha decrease
            erythrophagocytosis by human monocytes in vitro, and this effect
            does not apparently require an increase in SIRP-alpha or SHP-1
            expression.
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Zhang,Y.Z., Zhao,D.D., Zhao,W.P., Zhao,H.F., Zhao,Z.G., Wang,Y.F.,
            Wu,X.X., Han,X.P. and Da,W.M.
  TITLE     [Experimental study of SHP-1 promoter methylation in
            myelodysplastic syndromes and its related mechanism]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 33 (2), 108-112 (2012)
   PUBMED   22730659
  REMARK    GeneRIF: Abnormal methylation of SHP-1 gene promoter might have
            tentative role in the pathogenesis and progression of
            myelodysplastic syndrome.
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Jin,Y.J., Yu,C.L. and Burakoff,S.J.
  TITLE     Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal
            structure and catalytic activity
  JOURNAL   J. Biol. Chem. 274 (40), 28301-28307 (1999)
   PUBMED   10497187
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G.,
            Jani-Sait,S. and Shows,T.B.
  TITLE     Chromosomal localization of an SH2-containing tyrosine phosphatase
            (PTPN6)
  JOURNAL   Genomics 13 (3), 869-872 (1992)
   PUBMED   1639416
REFERENCE   8  (bases 1 to 2234)
  AUTHORS   Plutzky,J., Neel,B.G. and Rosenberg,R.D.
  TITLE     Isolation of a src homology 2-containing tyrosine phosphatase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (3), 1123-1127 (1992)
   PUBMED   1736296
REFERENCE   9  (bases 1 to 2234)
  AUTHORS   Yi,T.L., Cleveland,J.L. and Ihle,J.N.
  TITLE     Protein tyrosine phosphatase containing SH2 domains:
            characterization, preferential expression in hematopoietic cells,
            and localization to human chromosome 12p12-p13
  JOURNAL   Mol. Cell. Biol. 12 (2), 836-846 (1992)
   PUBMED   1732748
REFERENCE   10 (bases 1 to 2234)
  AUTHORS   Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P.
  TITLE     A protein-tyrosine phosphatase with sequence similarity to the SH2
            domain of the protein-tyrosine kinases
  JOURNAL   Nature 352 (6337), 736-739 (1991)
   PUBMED   1652101
  REMARK    Erratum:[Nature 1991 Oct 31;353(6347):868]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA431502.1 and BC002523.2.
            On Jan 24, 2008 this sequence version replaced gi:94557302.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. N-terminal part of this PTP contains two
            tandem Src homolog (SH2) domains, which act as protein
            phospho-tyrosine binding domains, and mediate the interaction of
            this PTP with its substrates. This PTP is expressed primarily in
            hematopoietic cells, and functions as an important regulator of
            multiple signaling pathways in hematopoietic cells. This PTP has
            been shown to interact with, and dephosphorylate a wide spectrum of
            phospho-proteins involved in hematopoietic cell signaling. Multiple
            alternatively spliced variants of this gene, which encode distinct
            isoforms, have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate 5' terminal
            exon compared to transcript variant 1, resulting in an isoform (2)
            with a distinct and longer (by 2 aa) N-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002523.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               DA431502.1         1-566
            567-2234            BC002523.2         553-2220
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13"
     gene            1..2234
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="protein tyrosine phosphatase, non-receptor type 6"
                     /db_xref="GeneID:5777"
                     /db_xref="HGNC:9658"
                     /db_xref="HPRD:01475"
                     /db_xref="MIM:176883"
     exon            1..163
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    36..38
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="upstream in-frame stop codon"
     variation       107
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371485894"
     variation       121
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2301262"
     variation       124
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374587354"
     variation       125
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368780606"
     variation       143
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371889526"
     CDS             150..1943
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein-tyrosine phosphatase 1C; hematopoietic cell
                     protein-tyrosine phosphatase; tyrosine-protein phosphatase
                     non-receptor type 6; hematopoietic cell phosphatase;
                     protein-tyrosine phosphatase SHP-1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 6
                     isoform 2"
                     /protein_id="NP_536858.1"
                     /db_xref="GI:18104991"
                     /db_xref="CCDS:CCDS41744.1"
                     /db_xref="GeneID:5777"
                     /db_xref="HGNC:9658"
                     /db_xref="HPRD:01475"
                     /db_xref="MIM:176883"
                     /translation="
MLSRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
"
     misc_feature    165..458
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="N-terminal Src homology 2 (N-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_N-SH2_SHP_like; cd10340"
                     /db_xref="CDD:198203"
     misc_feature    order(186..188,243..245,306..308,312..314)
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198203"
     misc_feature    order(303..311,351..353,411..422,426..428)
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198203"
     misc_feature    336..338
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    345..347
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    480..800
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="C-terminal Src homology 2 (C-SH2) domain found in
                     SH2 domain Phosphatases (SHP) proteins; Region:
                     SH2_C-SH2_SHP_like; cd09931"
                     /db_xref="CDD:198185"
     misc_feature    order(564..566,570..572,585..590)
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198185"
     misc_feature    order(654..656,735..737)
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198185"
     misc_feature    882..1697
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="Protein tyrosine phosphatase, catalytic domain;
                     Region: PTPc; smart00194"
                     /db_xref="CDD:197567"
     misc_feature    969..1697
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="Protein tyrosine phosphatases (PTP) catalyze the
                     dephosphorylation of phosphotyrosine peptides; they
                     regulate phosphotyrosine levels in signal transduction
                     pathways. The depth of the active site cleft renders the
                     enzyme specific for phosphorylated Tyr; Region: PTPc;
                     cd00047"
                     /db_xref="CDD:28929"
     misc_feature    order(1410..1412,1509..1514,1521..1523,1530..1535)
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /note="active site"
                     /db_xref="CDD:28929"
     misc_feature    1761..1763
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01080"
     misc_feature    1761..1763
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00975"
     misc_feature    1845..1847
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01080"
     exon            164..286
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       189
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199996841"
     variation       203
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374550116"
     variation       213
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377003393"
     variation       238
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11547853"
     variation       253
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369614203"
     variation       281
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114945777"
     variation       282
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377254990"
     exon            287..481
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       312
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370939978"
     variation       362
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200943423"
     variation       378
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181425111"
     variation       407
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186239082"
     variation       410
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1048596"
     variation       411
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1048597"
     exon            482..671
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       506
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200471577"
     variation       520
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201550362"
     variation       521
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372601000"
     variation       539
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377246131"
     variation       551
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200355447"
     variation       590
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202230542"
     variation       592
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1048598"
     variation       629
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183020942"
     variation       635
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372380210"
     variation       637
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373750986"
     variation       638
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375220948"
     variation       643
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369530834"
     exon            672..788
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       718
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368426352"
     variation       728
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1048599"
     variation       755
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370626779"
     variation       768
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375296528"
     variation       784
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367551491"
     exon            789..902
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       803
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140592255"
     variation       830
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201345298"
     variation       863
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199730259"
     exon            903..999
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       938
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374959527"
     variation       959
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368935562"
     exon            1000..1079
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1014
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56111095"
     variation       1052
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377270547"
     exon            1080..1229
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1106
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200624825"
     variation       1109
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147821940"
     variation       1121
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372677554"
     variation       1133
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2110072"
     variation       1136
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368190355"
     variation       1149
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199933225"
     variation       1151
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372072330"
     variation       1171
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201976465"
     variation       1172
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181711169"
     variation       1188
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369337036"
     exon            1230..1361
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1238
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190247406"
     variation       1253..1254
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36050455"
     variation       1254
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377517197"
     variation       1269
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370538000"
     variation       1319
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374040175"
     variation       1321
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376886181"
     variation       1352
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116298095"
     variation       1355
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375520775"
     exon            1362..1516
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1469
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374365975"
     variation       1477
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200005925"
     variation       1482
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368398907"
     variation       1484
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371502084"
     variation       1490
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375270811"
     variation       1506
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62621988"
     exon            1517..1584
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1517
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376685795"
     variation       1520
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370019783"
     variation       1553
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113854853"
     variation       1554
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376994439"
     exon            1585..1736
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1643
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200112594"
     variation       1663
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185835888"
     variation       1676
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114388315"
     variation       1682
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371456901"
     exon            1737..1828
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1738
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200635165"
     variation       1769
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201191540"
     variation       1813
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200155138"
     variation       1823
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373263834"
     exon            1829..1968
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1844
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370393336"
     variation       1857
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375291511"
     STS             1904..2136
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /standard_name="RH80060"
                     /db_xref="UniSTS:90394"
     variation       1908
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367563603"
     STS             1920..2102
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /standard_name="RH46958"
                     /db_xref="UniSTS:4816"
     STS             1932..2160
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /standard_name="RH79905"
                     /db_xref="UniSTS:84041"
     variation       1946
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74057234"
     exon            1969..2159
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /inference="alignment:Splign:1.39.8"
     variation       2093
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377640230"
     variation       2094
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1804439"
     variation       2110
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112396722"
     polyA_signal    2137..2142
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
     polyA_site      2159
                     /gene="PTPN6"
                     /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1;
                     SHP-1L; SHP1"
ORIGIN      
attggcctggcaggcaggatcgaggaggaagtggctgattactgagcggttcttcctcacctggcttgggccactgtgcacagctgtgccgctggctcagccccgccccctgcggccctctgccgtggcttccccctccctacagagagatgctgtcccgtgggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggccgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcgctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttctatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacactcagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctgaactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggcagagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagccagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctccccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggtttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgaggaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcggctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagccaaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcaccagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctcccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgactacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacctacatcgccagccagggctgtctggaggccacggtcaatgacttctggcagatggcgtggcaggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaatgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgaccaactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctggacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccatggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcaggaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcacaggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgtgacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcagacggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaagaagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacctatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaaacacaaggaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcagcggtcagcagacaaggagaagagcaagggttccctcaagaggaagtgagcggtgctgtcctcaggtggccatgcctcagccctgaccctgtggaagcatttcgcgatggacagactcacaacctgaacctaggagtgccccattcttttgtaatttaaatggctgcatcccccccacctctccctgaccctgtatatagcccagccaggccccaggcagggccaacccttctcctcttgtaaataaagccctgggatcactgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5777 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IEA
            GeneID:5777 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: TAS
            GeneID:5777 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: IDA
            GeneID:5777 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5777 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
            GeneID:5777 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:5777 -> Molecular function: GO:0042169 [SH2 domain binding] evidence: IEA
            GeneID:5777 -> Biological process: GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin] evidence: IEA
            GeneID:5777 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA
            GeneID:5777 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5777 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:5777 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:5777 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
            GeneID:5777 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: NAS
            GeneID:5777 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IMP
            GeneID:5777 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
            GeneID:5777 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0030154 [cell differentiation] evidence: IDA
            GeneID:5777 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
            GeneID:5777 -> Biological process: GO:0042130 [negative regulation of T cell proliferation] evidence: IEA
            GeneID:5777 -> Biological process: GO:0042267 [natural killer cell mediated cytotoxicity] evidence: IEA
            GeneID:5777 -> Biological process: GO:0043407 [negative regulation of MAP kinase activity] evidence: IEA
            GeneID:5777 -> Biological process: GO:0045577 [regulation of B cell differentiation] evidence: IEA
            GeneID:5777 -> Biological process: GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] evidence: IMP
            GeneID:5777 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: IEA
            GeneID:5777 -> Biological process: GO:0050860 [negative regulation of T cell receptor signaling pathway] evidence: IEA
            GeneID:5777 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
            GeneID:5777 -> Biological process: GO:0060333 [interferon-gamma-mediated signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0060337 [type I interferon-mediated signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0060338 [regulation of type I interferon-mediated signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] evidence: TAS
            GeneID:5777 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: IDA
            GeneID:5777 -> Biological process: GO:2000045 [regulation of G1/S transition of mitotic cell cycle] evidence: IMP
            GeneID:5777 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5777 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5777 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5777 -> Cellular component: GO:0016020 [membrane] evidence: TAS
            GeneID:5777 -> Cellular component: GO:0042105 [alpha-beta T cell receptor complex] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_536858 -> EC 3.1.3.48

by @meso_cacase at DBCLS
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