2024-03-29 16:56:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_080548 2234 bp mRNA linear PRI 19-MAY-2013 DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 2, mRNA. ACCESSION NM_080548 VERSION NM_080548.4 GI:166064063 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2234) AUTHORS Hebeisen,M., Baitsch,L., Presotto,D., Baumgaertner,P., Romero,P., Michielin,O., Speiser,D.E. and Rufer,N. TITLE SHP-1 phosphatase activity counteracts increased T cell receptor affinity JOURNAL J. Clin. Invest. 123 (3), 1044-1056 (2013) PUBMED 23391724 REMARK GeneRIF: The global role of SHP-1 in regulating CD8 positive T cell activation. REFERENCE 2 (bases 1 to 2234) AUTHORS Kim,S.H., Cho,Y.R., Kim,H.J., Oh,J.S., Ahn,E.K., Ko,H.J., Hwang,B.J., Lee,S.J., Cho,Y., Kim,Y.K., Stetler-Stevenson,W.G. and Seo,D.W. TITLE Antagonism of VEGF-A-induced increase in vascular permeability by an integrin alpha3beta1-Shp-1-cAMP/PKA pathway JOURNAL Blood 120 (24), 4892-4902 (2012) PUBMED 23074279 REMARK GeneRIF: Data show that TIMP-2-mediated inhibition of vascular endothelial cell permeability involves an integrin alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association. REFERENCE 3 (bases 1 to 2234) AUTHORS Evren,S., Ma,X.Z., Sakac,D. and Branch,D.R. TITLE SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL JOURNAL Exp. Hematol. 40 (12), 1055-1059 (2012) PUBMED 22960265 REMARK GeneRIF: This study is the first to identify and define an interaction between SHP-1 and an SH3 domain-containing protein. Our findings provide an alternative way that SHP-1 can be linked to potential substrates. REFERENCE 4 (bases 1 to 2234) AUTHORS de Almeida,A.C., Barbosa,S.M., de Lourdes Rios Barjas-Castro,M., Olalla-Saad,S.T. and Condino-Neto,A. TITLE IFN-beta, IFN-gamma, and TNF-alpha decrease erythrophagocytosis by human monocytes independent of SIRP-alpha or SHP-1 expression JOURNAL Immunopharmacol Immunotoxicol 34 (6), 1054-1059 (2012) PUBMED 22738830 REMARK GeneRIF: IFN-beta and IFN-gamma/TNF-alpha decrease erythrophagocytosis by human monocytes in vitro, and this effect does not apparently require an increase in SIRP-alpha or SHP-1 expression. REFERENCE 5 (bases 1 to 2234) AUTHORS Zhang,Y.Z., Zhao,D.D., Zhao,W.P., Zhao,H.F., Zhao,Z.G., Wang,Y.F., Wu,X.X., Han,X.P. and Da,W.M. TITLE [Experimental study of SHP-1 promoter methylation in myelodysplastic syndromes and its related mechanism] JOURNAL Zhonghua Xue Ye Xue Za Zhi 33 (2), 108-112 (2012) PUBMED 22730659 REMARK GeneRIF: Abnormal methylation of SHP-1 gene promoter might have tentative role in the pathogenesis and progression of myelodysplastic syndrome. REFERENCE 6 (bases 1 to 2234) AUTHORS Jin,Y.J., Yu,C.L. and Burakoff,S.J. TITLE Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity JOURNAL J. Biol. Chem. 274 (40), 28301-28307 (1999) PUBMED 10497187 REFERENCE 7 (bases 1 to 2234) AUTHORS Plutzky,J., Neel,B.G., Rosenberg,R.D., Eddy,R.L., Byers,M.G., Jani-Sait,S. and Shows,T.B. TITLE Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6) JOURNAL Genomics 13 (3), 869-872 (1992) PUBMED 1639416 REFERENCE 8 (bases 1 to 2234) AUTHORS Plutzky,J., Neel,B.G. and Rosenberg,R.D. TITLE Isolation of a src homology 2-containing tyrosine phosphatase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (3), 1123-1127 (1992) PUBMED 1736296 REFERENCE 9 (bases 1 to 2234) AUTHORS Yi,T.L., Cleveland,J.L. and Ihle,J.N. TITLE Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13 JOURNAL Mol. Cell. Biol. 12 (2), 836-846 (1992) PUBMED 1732748 REFERENCE 10 (bases 1 to 2234) AUTHORS Shen,S.H., Bastien,L., Posner,B.I. and Chretien,P. TITLE A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases JOURNAL Nature 352 (6337), 736-739 (1991) PUBMED 1652101 REMARK Erratum:[Nature 1991 Oct 31;353(6347):868] COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA431502.1 and BC002523.2. On Jan 24, 2008 this sequence version replaced gi:94557302. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) uses an alternate 5' terminal exon compared to transcript variant 1, resulting in an isoform (2) with a distinct and longer (by 2 aa) N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002523.2 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025085 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-566 DA431502.1 1-566 567-2234 BC002523.2 553-2220 FEATURES Location/Qualifiers source 1..2234 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12p13" gene 1..2234 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="protein tyrosine phosphatase, non-receptor type 6" /db_xref="GeneID:5777" /db_xref="HGNC:9658" /db_xref="HPRD:01475" /db_xref="MIM:176883" exon 1..163 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" misc_feature 36..38 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="upstream in-frame stop codon" variation 107 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="c" /db_xref="dbSNP:371485894" variation 121 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:2301262" variation 124 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:374587354" variation 125 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:368780606" variation 143 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:371889526" CDS 150..1943 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /EC_number="3.1.3.48" /note="isoform 2 is encoded by transcript variant 2; protein-tyrosine phosphatase 1C; hematopoietic cell protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 6; hematopoietic cell phosphatase; protein-tyrosine phosphatase SHP-1" /codon_start=1 /product="tyrosine-protein phosphatase non-receptor type 6 isoform 2" /protein_id="NP_536858.1" /db_xref="GI:18104991" /db_xref="CCDS:CCDS41744.1" /db_xref="GeneID:5777" /db_xref="HGNC:9658" /db_xref="HPRD:01475" /db_xref="MIM:176883" /translation="
MLSRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
" misc_feature 165..458 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins; Region: SH2_N-SH2_SHP_like; cd10340" /db_xref="CDD:198203" misc_feature order(186..188,243..245,306..308,312..314) /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="phosphotyrosine binding pocket [polypeptide binding]; other site" /db_xref="CDD:198203" misc_feature order(303..311,351..353,411..422,426..428) /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="hydrophobic binding pocket [polypeptide binding]; other site" /db_xref="CDD:198203" misc_feature 336..338 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 345..347 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 480..800 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins; Region: SH2_C-SH2_SHP_like; cd09931" /db_xref="CDD:198185" misc_feature order(564..566,570..572,585..590) /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="phosphotyrosine binding pocket [polypeptide binding]; other site" /db_xref="CDD:198185" misc_feature order(654..656,735..737) /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="hydrophobic binding pocket [polypeptide binding]; other site" /db_xref="CDD:198185" misc_feature 882..1697 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194" /db_xref="CDD:197567" misc_feature 969..1697 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047" /db_xref="CDD:28929" misc_feature order(1410..1412,1509..1514,1521..1523,1530..1535) /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /note="active site" /db_xref="CDD:28929" misc_feature 1761..1763 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:01080" misc_feature 1761..1763 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:00975" misc_feature 1845..1847 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:01080" exon 164..286 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 189 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:199996841" variation 203 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:374550116" variation 213 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="g" /replace="t" /db_xref="dbSNP:377003393" variation 238 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:11547853" variation 253 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:369614203" variation 281 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:114945777" variation 282 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:377254990" exon 287..481 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 312 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:370939978" variation 362 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:200943423" variation 378 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:181425111" variation 407 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:186239082" variation 410 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1048596" variation 411 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="g" /db_xref="dbSNP:1048597" exon 482..671 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 506 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:200471577" variation 520 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:201550362" variation 521 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:372601000" variation 539 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:377246131" variation 551 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:200355447" variation 590 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:202230542" variation 592 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="t" /db_xref="dbSNP:1048598" variation 629 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:183020942" variation 635 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:372380210" variation 637 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:373750986" variation 638 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:375220948" variation 643 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:369530834" exon 672..788 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 718 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:368426352" variation 728 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:1048599" variation 755 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:370626779" variation 768 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:375296528" variation 784 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:367551491" exon 789..902 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 803 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:140592255" variation 830 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="c" /db_xref="dbSNP:201345298" variation 863 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:199730259" exon 903..999 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 938 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:374959527" variation 959 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:368935562" exon 1000..1079 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1014 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:56111095" variation 1052 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:377270547" exon 1080..1229 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1106 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:200624825" variation 1109 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:147821940" variation 1121 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:372677554" variation 1133 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:2110072" variation 1136 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:368190355" variation 1149 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:199933225" variation 1151 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="g" /db_xref="dbSNP:372072330" variation 1171 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:201976465" variation 1172 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:181711169" variation 1188 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:369337036" exon 1230..1361 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1238 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:190247406" variation 1253..1254 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="" /replace="c" /db_xref="dbSNP:36050455" variation 1254 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:377517197" variation 1269 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:370538000" variation 1319 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:374040175" variation 1321 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="c" /db_xref="dbSNP:376886181" variation 1352 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:116298095" variation 1355 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:375520775" exon 1362..1516 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1469 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="g" /replace="t" /db_xref="dbSNP:374365975" variation 1477 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:200005925" variation 1482 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="g" /db_xref="dbSNP:368398907" variation 1484 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:371502084" variation 1490 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:375270811" variation 1506 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:62621988" exon 1517..1584 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1517 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:376685795" variation 1520 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:370019783" variation 1553 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:113854853" variation 1554 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:376994439" exon 1585..1736 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1643 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:200112594" variation 1663 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:185835888" variation 1676 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:114388315" variation 1682 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:371456901" exon 1737..1828 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1738 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:200635165" variation 1769 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:201191540" variation 1813 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:200155138" variation 1823 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:373263834" exon 1829..1968 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 1844 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:370393336" variation 1857 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="t" /db_xref="dbSNP:375291511" STS 1904..2136 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /standard_name="RH80060" /db_xref="UniSTS:90394" variation 1908 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:367563603" STS 1920..2102 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /standard_name="RH46958" /db_xref="UniSTS:4816" STS 1932..2160 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /standard_name="RH79905" /db_xref="UniSTS:84041" variation 1946 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:74057234" exon 1969..2159 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /inference="alignment:Splign:1.39.8" variation 2093 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="a" /replace="g" /db_xref="dbSNP:377640230" variation 2094 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="g" /replace="t" /db_xref="dbSNP:1804439" variation 2110 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" /replace="c" /replace="g" /db_xref="dbSNP:112396722" polyA_signal 2137..2142 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" polyA_site 2159 /gene="PTPN6" /gene_synonym="HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1" ORIGIN
attggcctggcaggcaggatcgaggaggaagtggctgattactgagcggttcttcctcacctggcttgggccactgtgcacagctgtgccgctggctcagccccgccccctgcggccctctgccgtggcttccccctccctacagagagatgctgtcccgtgggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggccgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcgctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttctatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacactcagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctgaactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggcagagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagccagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctccccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggtttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgaggaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcggctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagccaaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcaccagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctcccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgactacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacctacatcgccagccagggctgtctggaggccacggtcaatgacttctggcagatggcgtggcaggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaatgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgaccaactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctggacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccatggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcaggaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcacaggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgtgacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcagacggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaagaagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacctatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaaacacaaggaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcagcggtcagcagacaaggagaagagcaagggttccctcaagaggaagtgagcggtgctgtcctcaggtggccatgcctcagccctgaccctgtggaagcatttcgcgatggacagactcacaacctgaacctaggagtgccccattcttttgtaatttaaatggctgcatcccccccacctctccctgaccctgtatatagcccagccaggccccaggcagggccaacccttctcctcttgtaaataaagccctgggatcactgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5777 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IEA GeneID:5777 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: TAS GeneID:5777 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: IDA GeneID:5777 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5777 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA GeneID:5777 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI GeneID:5777 -> Molecular function: GO:0042169 [SH2 domain binding] evidence: IEA GeneID:5777 -> Biological process: GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin] evidence: IEA GeneID:5777 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA GeneID:5777 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5777 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS GeneID:5777 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:5777 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP GeneID:5777 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: NAS GeneID:5777 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IMP GeneID:5777 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA GeneID:5777 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0030154 [cell differentiation] evidence: IDA GeneID:5777 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS GeneID:5777 -> Biological process: GO:0042130 [negative regulation of T cell proliferation] evidence: IEA GeneID:5777 -> Biological process: GO:0042267 [natural killer cell mediated cytotoxicity] evidence: IEA GeneID:5777 -> Biological process: GO:0043407 [negative regulation of MAP kinase activity] evidence: IEA GeneID:5777 -> Biological process: GO:0045577 [regulation of B cell differentiation] evidence: IEA GeneID:5777 -> Biological process: GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] evidence: IMP GeneID:5777 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: IEA GeneID:5777 -> Biological process: GO:0050860 [negative regulation of T cell receptor signaling pathway] evidence: IEA GeneID:5777 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS GeneID:5777 -> Biological process: GO:0060333 [interferon-gamma-mediated signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0060337 [type I interferon-mediated signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0060338 [regulation of type I interferon-mediated signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] evidence: TAS GeneID:5777 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: IDA GeneID:5777 -> Biological process: GO:2000045 [regulation of G1/S transition of mitotic cell cycle] evidence: IMP GeneID:5777 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5777 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5777 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5777 -> Cellular component: GO:0016020 [membrane] evidence: TAS GeneID:5777 -> Cellular component: GO:0042105 [alpha-beta T cell receptor complex] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_536858 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.