2024-03-28 17:18:54, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_058186 1384 bp mRNA linear PRI 15-JUN-2013 DEFINITION Homo sapiens family with sequence similarity 3, member B (FAM3B), transcript variant 1, mRNA. ACCESSION NM_058186 VERSION NM_058186.3 GI:46255029 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1384) AUTHORS Li,Z., Mou,H., Wang,T., Xue,J., Deng,B., Qian,L., Zhou,Y., Gong,W., Wang,J.M., Wu,G., Zhou,C.F., Fang,J. and Le,Y. TITLE A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression JOURNAL Cancer Lett. 328 (2), 278-284 (2013) PUBMED 23059759 REMARK GeneRIF: These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug. REFERENCE 2 (bases 1 to 1384) AUTHORS He,M., Wu,C., Xu,J., Guo,H., Yang,H., Zhang,X., Sun,J., Yu,D., Zhou,L., Peng,T., He,Y., Gao,Y., Yuan,J., Deng,Q., Dai,X., Tan,A., Feng,Y., Zhang,H., Min,X., Yang,X., Zhu,J., Zhai,K., Chang,J., Qin,X., Tan,W., Hu,Y., Lang,M., Tao,S., Li,Y., Li,Y., Feng,J., Li,D., Kim,S.T., Zhang,S., Zhang,H., Zheng,S.L., Gui,L., Wang,Y., Wei,S., Wang,F., Fang,W., Liang,Y., Zhai,Y., Chen,W., Miao,X., Zhou,G., Hu,F.B., Lin,D., Mo,Z. and Wu,T. TITLE A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and alpha fetoprotein and their associations with cancer risk JOURNAL Gut (2013) In press PUBMED 23300138 REMARK Publication Status: Available-Online prior to print REFERENCE 3 (bases 1 to 1384) AUTHORS Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J., Snippe,H., Hibberd,M.L. and Seielstad,M. TITLE New genetic associations detected in a host response study to hepatitis B vaccine JOURNAL Genes Immun. 11 (3), 232-238 (2010) PUBMED 20237496 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 4 (bases 1 to 1384) AUTHORS Yang,J., Robert,C.E., Burkhardt,B.R., Young,R.A., Wu,J., Gao,Z. and Wolf,B.A. TITLE Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells JOURNAL Diabetes 54 (11), 3217-3228 (2005) PUBMED 16249448 REMARK GeneRIF: PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin, and structure and conformation is vital for PANDER secretion. REFERENCE 5 (bases 1 to 1384) AUTHORS Yang,J., Gao,Z., Robert,C.E., Burkhardt,B.R., Gaweska,H., Wagner,A., Wu,J., Greene,S.R., Young,R.A. and Wolf,B.A. TITLE Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells JOURNAL Biochemistry 44 (34), 11342-11352 (2005) PUBMED 16114871 REMARK GeneRIF: Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death. REFERENCE 6 (bases 1 to 1384) AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J., Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B., Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E., Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S., Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C., Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V., Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K., Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z., Goddard,A., Wood,W.I., Godowski,P. and Gray,A. TITLE The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment JOURNAL Genome Res. 13 (10), 2265-2270 (2003) PUBMED 12975309 REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759] REFERENCE 7 (bases 1 to 1384) AUTHORS Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K., Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D., Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B., Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and Young,P.R. TITLE Cloning, expression, and initial characterization of a novel cytokine-like gene family JOURNAL Genomics 80 (2), 144-150 (2002) PUBMED 12160727 REMARK GeneRIF: Localized to the islets of Langerhans. REFERENCE 8 (bases 1 to 1384) AUTHORS Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S., Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E. TITLE From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map JOURNAL Genomics 78 (1-2), 46-54 (2001) PUBMED 11707072 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK125528.1, BI712971.1, BC057829.1, AY358459.1 and BF514643.1. On Apr 7, 2004 this sequence version replaced gi:21361797. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK125528.1, AL561378.3 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025085 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-361 AK125528.1 3-363 362-565 BI712971.1 324-527 566-928 BC057829.1 488-850 929-1088 AY358459.1 797-956 1089-1384 BF514643.1 145-440 FEATURES Location/Qualifiers source 1..1384 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="21" /map="21q22.3" gene 1..1384 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /note="family with sequence similarity 3, member B" /db_xref="GeneID:54097" /db_xref="HGNC:1253" /db_xref="HPRD:10552" /db_xref="MIM:608617" exon 1..165 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 92 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="g" /replace="t" /db_xref="dbSNP:148108671" CDS 147..854 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /note="isoform a precursor is encoded by transcript variant 1; pancreatic derived factor; D21M16SJHU19e; cytokine-like protein 2-21; pancreatic-derived factor; protein FAM3B" /codon_start=1 /product="protein FAM3B isoform a precursor" /protein_id="NP_478066.3" /db_xref="GI:46255030" /db_xref="CCDS:CCDS13671.1" /db_xref="GeneID:54097" /db_xref="HGNC:1253" /db_xref="HPRD:10552" /db_xref="MIM:608617" /translation="
MRPLAGGLLKVVFVVFASLCAWYSGYLLAELIPDAPLSSAAYSIRSIGERPVLKAPVPKRQKCDHWTPCPSDTYAYRLLSGGGRSKYAKICFEDNLLMGEQLGNVARGINIAIVNYVTGNVTATRCFDMYEGDNSGPMTKFIQSAAPKSLLFMVTYDDGSTRLNNDAKNAIEALGSKEIRNMKFRSSWVFIAAKGLELPSEIQREKINHSDAKNNRYSGWPAEIQIEGCIPKERS
" sig_peptide 147..233 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P58499.2)" mat_peptide 234..851 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /product="Protein FAM3B" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P58499.2)" exon 166..309 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 179 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:374924359" variation 185 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:186901119" variation 186 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:2838012" variation 194 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:61734881" variation 195 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:371282791" variation 208 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:112776726" variation 237 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="c" /db_xref="dbSNP:138471782" variation 269 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="g" /db_xref="dbSNP:149569625" variation 278 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:149282476" variation 280 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:369146230" variation 287 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:148283845" exon 310..433 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 319 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:141359085" variation 367 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:191085667" variation 386 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:371339927" variation 387 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:146229700" variation 407 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:376038821" exon 434..492 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 439 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:369029304" variation 491 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="c" /db_xref="dbSNP:373278221" exon 493..543 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 497 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="t" /db_xref="dbSNP:370579027" variation 519 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:139331735" variation 523 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:142423610" variation 542 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:417708" variation 543 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:199919585" exon 544..631 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 548..549 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="" /replace="ct" /db_xref="dbSNP:369832982" variation 556 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:139452370" variation 557 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:149676623" variation 604 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:145464636" variation 615 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:148783965" variation 617 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:144944684" exon 632..764 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 633 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:187262938" variation 641 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:370045496" variation 685 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:200388472" variation 692 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:111988437" variation 725 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:377117970" variation 730 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:147056375" variation 746 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:201305246" variation 757 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:371623376" exon 765..1384 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /inference="alignment:Splign:1.39.8" variation 765 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="t" /db_xref="dbSNP:183635372" variation 802 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:141735671" variation 847 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:59821562" variation 855 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:376707862" variation 877 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="g" /replace="t" /db_xref="dbSNP:140493581" variation 976 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="g" /db_xref="dbSNP:188174846" polyA_site 1002 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /experiment="experimental evidence, no additional details recorded" variation 1041 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:191346748" polyA_site 1088 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /experiment="experimental evidence, no additional details recorded" variation 1134 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:377647313" variation 1157 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="g" /db_xref="dbSNP:73905337" variation 1166 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:142776996" variation 1207 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:2838024" variation 1225 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="t" /db_xref="dbSNP:369859121" variation 1321 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="c" /replace="g" /db_xref="dbSNP:757368" variation 1343 /gene="FAM3B" /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44" /replace="a" /replace="g" /db_xref="dbSNP:116810029" ORIGIN
tttgcccgactggccgcgcacccagctggcccgcccctgcccgacacgaccgctgcccgccccttgccttcctgacccaggggctccgctggctgcggtcgcctgggagctgccgccagggccaggaggggagcggcacctggaagatgcgcccattggctggtggcctgctcaaggtggtgttcgtggtcttcgcctccttgtgtgcctggtattcggggtacctgctcgcagagctcattccagatgcacccctgtccagtgctgcctatagcatccgcagcatcggggagaggcctgtcctcaaagctccagtccccaaaaggcaaaaatgtgaccactggactccctgcccatctgacacctatgcctacaggttactcagcggaggtggcagaagcaagtacgccaaaatctgctttgaggataacctacttatgggagaacagctgggaaatgttgccagaggaataaacattgccattgtcaactatgtaactgggaatgtgacagcaacacgatgttttgatatgtatgaaggtgataactctggaccgatgacaaagtttattcagagtgctgctccaaaatccctgctcttcatggtgacctatgacgacggaagcacaagactgaataacgatgccaagaatgccatagaagcacttggaagtaaagaaatcaggaacatgaaattcaggtctagctgggtatttattgcagcaaaaggcttggaactcccttccgaaattcagagagaaaagatcaaccactctgatgctaagaacaacagatattctggctggcctgcagagatccagatagaaggctgcatacccaaagaacgaagctgacactgcagggtcctgagtaaatgtgttctgtataaacaaatgcagctggaatcgctcaagaatcttatttttctaaatccaacagcccatatttgatgagtattttgggtttgttgtaaaccaatgaacatttgctagttgtatcaaatcttggtacgcagtatttttataccagtattttatgtagtgaagatgtcaattagcaggaaactaaaatgaatggaaattcttaaagggaatgatgtgattcaagctggaaagagggttgggagaaacagcttgtccaggtggagctatgttatgatcagatcgaagtgtgacccctgtgtggtccagacagccctgcagagagaaaacctttattccattatcaccaagcacctcctagtttccgacagtcatctccttctgctgggagaattagcagcagttcagggggcttatgttatgtccttgttcaactcaacttgagctcttgaactcctcctgtgggcctgtgaatgtattcattcattccacaactctgggtg
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:54097 -> Molecular function: GO:0005125 [cytokine activity] evidence: NAS GeneID:54097 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:54097 -> Biological process: GO:0030073 [insulin secretion] evidence: IDA GeneID:54097 -> Cellular component: GO:0005576 [extracellular region] evidence: NAS GeneID:54097 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
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