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2024-04-19 15:06:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_054027 8224 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens ANKH inorganic pyrophosphate transport regulator
(ANKH), mRNA.
ACCESSION NM_054027 NM_019847 XM_939587 XM_944214 XM_944218 XM_944222
XM_944225 XM_944228
VERSION NM_054027.4 GI:170671715
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8224)
AUTHORS Zhao,G., Xu,M.J., Zhao,M.M., Dai,X.Y., Kong,W., Wilson,G.M.,
Guan,Y., Wang,C.Y. and Wang,X.
TITLE Activation of nuclear factor-kappa B accelerates vascular
calcification by inhibiting ankylosis protein homolog expression
JOURNAL Kidney Int. 82 (1), 34-44 (2012)
PUBMED 22437419
REMARK GeneRIF: TNF-activated NF-kappaB promotes inflammation-accelerated
vascular calcification by inhibiting ankylosis protein homolog
expression and consequent pyrophosphate secretion.
REFERENCE 2 (bases 1 to 8224)
AUTHORS Gruber,B.L., Couto,A.R., Armas,J.B., Brown,M.A., Finzel,K. and
Terkeltaub,R.A.
TITLE Novel ANKH amino terminus mutation (Pro5Ser) associated with
early-onset calcium pyrophosphate disease with associated
phosphaturia
JOURNAL J Clin Rheumatol 18 (4), 192-195 (2012)
PUBMED 22647861
REMARK GeneRIF: We report a novel mutation, not previously described, in
ANKH exon 1, wherein serine replaces proline, in a case of
early-onset severe calcium pyrophosphate disease associated with
metabolic abnormalities, with similar findings in the proband's
father
REFERENCE 3 (bases 1 to 8224)
AUTHORS Dutra,E.H., Chen,I.P., McGregor,T.L., Ranells,J.D. and
Reichenberger,E.J.
TITLE Two novel large ANKH deletion mutations in sporadic cases with
craniometaphyseal dysplasia
JOURNAL Clin. Genet. 81 (1), 93-95 (2012)
PUBMED 22150416
REMARK GeneRIF: Two novel 18 and 12 base pair in-frame deletions are the
largest ANKH mutations causing craniometaphyseal dysplasia
identified to date.
REFERENCE 4 (bases 1 to 8224)
AUTHORS Pimentel-Santos FM, Ligeiro D, Matos M, Mourao AF, Vieira de Sousa
E, Pinto P, Ribeiro A, Santos H, Barcelos A, Godinho F, Cruz M,
Fonseca JE, Guedes-Pinto H, Trindade H, Brown MA and Branco JC.
CONSRTM CORPOREA Study Group
TITLE ANKH and susceptibility to and severity of ankylosing spondylitis
JOURNAL J. Rheumatol. 39 (1), 131-134 (2012)
PUBMED 22089454
REMARK GeneRIF: These results confirm data in white Europeans that ANKH is
probably not a major determinant of susceptibility to ankylosing
spondylitis.
REFERENCE 5 (bases 1 to 8224)
AUTHORS Huang,B., Takahashi,K., Sakata,T., Kiso,H., Sugai,M., Fujimura,K.,
Shimizu,A., Kosugi,S., Sato,T. and Bessho,K.
TITLE Increased risk of temporomandibular joint closed lock: a
case-control study of ANKH polymorphisms
JOURNAL PLoS ONE 6 (10), E25503 (2011)
PUBMED 22003394
REMARK GeneRIF: the relationship between the type of temporomandibular
disorders (TMD) and ANKH polymorphisms
REFERENCE 6 (bases 1 to 8224)
AUTHORS Ho,A.M., Johnson,M.D. and Kingsley,D.M.
TITLE Role of the mouse ank gene in control of tissue calcification and
arthritis
JOURNAL Science 289 (5477), 265-270 (2000)
PUBMED 10894769
REFERENCE 7 (bases 1 to 8224)
AUTHORS Rojas,K., Serrano de la Pena,L., Gallardo,T., Simmons,A., Nyce,K.,
McGrath,R., Considine,E., Vasko,A.J., Peterson,E., Grady,D.,
Cox,R., Andrew,L.J., Lovett,M., Overhauser,J. and Williams,C.J.
TITLE Physical map and characterization of transcripts in the candidate
interval for familial chondrocalcinosis at chromosome 5p15.1
JOURNAL Genomics 62 (2), 177-183 (1999)
PUBMED 10610710
REFERENCE 8 (bases 1 to 8224)
AUTHORS Andrew,L.J., Brancolini,V., de la Pena,L.S., Devoto,M., Caeiro,F.,
Marchegiani,R., Reginato,A., Gaucher,A., Netter,P., Gillet,P.,
Loeuille,D., Prockop,D.J., Carr,A., Wordsworth,B.F., Lathrop,M.,
Butcher,S., Considine,E., Everts,K., Nicod,A., Walsh,S. and
Williams,C.J.
TITLE Refinement of the chromosome 5p locus for familial calcium
pyrophosphate dihydrate deposition disease
JOURNAL Am. J. Hum. Genet. 64 (1), 136-145 (1999)
PUBMED 9915952
REFERENCE 9 (bases 1 to 8224)
AUTHORS Nurnberg,P., Tinschert,S., Mrug,M., Hampe,J., Muller,C.R.,
Fuhrmann,E., Braun,H.S. and Reis,A.
TITLE The gene for autosomal dominant craniometaphyseal dysplasia maps to
chromosome 5p and is distinct from the growth hormone-receptor gene
JOURNAL Am. J. Hum. Genet. 61 (4), 918-923 (1997)
PUBMED 9382103
REFERENCE 10 (bases 1 to 8224)
AUTHORS Hughes,A.E., McGibbon,D., Woodward,E., Dixey,J. and Doherty,M.
TITLE Localisation of a gene for chondrocalcinosis to chromosome 5p
JOURNAL Hum. Mol. Genet. 4 (7), 1225-1228 (1995)
PUBMED 8528213
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BU193060.1, DA126651.1,
BC009835.2, AC010491.4 and BQ008340.1.
This sequence is a reference standard in the RefSeqGene project.
On or before Mar 22, 2008 this sequence version replaced
gi:21536393, gi:34452701.
Summary: This gene encodes a multipass transmembrane protein that
is expressed in joints and other tissues and controls pyrophosphate
levels in cultured cells. Progressive ankylosis-mediated control of
pyrophosphate levels has been suggested as a possible mechanism
regulating tissue calcification and susceptibility to arthritis in
higher animals. Mutations in this gene have been associated with
autosomal dominant craniometaphyseal dysplasia. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB046801.1, AY358503.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-259 BU193060.1 1-259
260-376 DA126651.1 223-339
377-1943 BC009835.2 302-1868
1944-7889 AC010491.4 97792-103737 c
7890-8224 BQ008340.1 1-335 c
FEATURES Location/Qualifiers
source 1..8224
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5p15.1"
gene 1..8224
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/note="ANKH inorganic pyrophosphate transport regulator"
/db_xref="GeneID:56172"
/db_xref="HGNC:15492"
/db_xref="MIM:605145"
exon 1..427
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
misc_feature 122..124
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/note="upstream in-frame stop codon"
CDS 332..1810
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/note="ankylosis, progressive homolog"
/codon_start=1
/product="progressive ankylosis protein homolog"
/protein_id="NP_473368.1"
/db_xref="GI:16905507"
/db_xref="CCDS:CCDS3885.1"
/db_xref="GeneID:56172"
/db_xref="HGNC:15492"
/db_xref="MIM:605145"
/translation="
MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVSTSNTVTAAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVVPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLIASLVVLPYLGVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKMENESATEGEDSAMTDMPPTEEVTDIVEMREENE
"
misc_feature 332..1366
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/note="Progressive ankylosis protein (ANKH); Region: ANKH;
pfam07260"
/db_xref="CDD:115886"
misc_feature 587..649
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 725..787
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 806..868
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 899..961
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 1310..1372
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 1382..1444
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 1541..1609
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
misc_feature 1619..1687
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HCJ1.2);
transmembrane region"
exon 428..644
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 645..763
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 764..847
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 848..1018
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 1019..1153
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 1154..1246
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
variation 1168
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="g"
/replace="t"
/db_xref="dbSNP:199806240"
exon 1247..1342
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 1343..1472
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 1473..1596
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
variation 1496
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="a"
/replace="g"
/db_xref="dbSNP:28939080"
variation 1503
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="c"
/replace="t"
/db_xref="dbSNP:267606658"
exon 1597..1696
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
exon 1697..8207
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/inference="alignment:Splign:1.39.8"
STS 1743..1901
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="RH16357"
/db_xref="UniSTS:4697"
STS 1791..1941
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="SHGC-35145"
/db_xref="UniSTS:60313"
variation 1908
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="g"
/replace="t"
/db_xref="dbSNP:11549562"
STS 2102..2248
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="D5S1665E"
/db_xref="UniSTS:151054"
STS 2215..2317
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="A009D34"
/db_xref="UniSTS:50056"
STS 2215..2317
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="G32452"
/db_xref="UniSTS:117038"
STS 2765..2951
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="IB363"
/db_xref="UniSTS:59025"
variation 3010
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="c"
/replace="t"
/db_xref="dbSNP:10570"
polyA_signal 3170..3175
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
polyA_site 3190
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
STS 3494..3678
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="RH12671"
/db_xref="UniSTS:45788"
polyA_signal 3738..3743
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
polyA_site 3756
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
variation 3757
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3180845"
STS 3883..3997
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="D10S16"
/db_xref="UniSTS:155756"
polyA_signal 5272..5277
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
polyA_site 5297
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
variation 6992
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1664964"
STS 8056..8166
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
/standard_name="A004S29"
/db_xref="UniSTS:76904"
polyA_site 8203
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
polyA_site 8207
/gene="ANKH"
/gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK"
ORIGIN
agagcgcttataatggagccgctgtcagcagaaccttctgccgccgccgccgccgccgccgtccctcctcttttttttcccggcagatctttgttgtgtgggagggcagcagggatggacttgagcttgcggatcccctgctagagcagccgcgctcggagaaggcgccgcagccgcgaggaggagccgccgccgccgcgcccgaggccccgccgcccgcggcctctgtcggcccgcgccccgctcgccccgtcgccccgtcgcccctcgcctccccgcagagtcccctcgcggcagcagatgtgtgtggggtcagcccacggcggggactatggtgaaattcccggcgctcacgcactactggcccctgatccggttcttggtgcccctgggcatcaccaacatagccatcgacttcggggagcaggccttgaaccggggcattgctgctgtcaaggaggatgcagtcgagatgctggccagctacgggctggcgtactccctcatgaagttcttcacgggtcccatgagtgacttcaaaaatgtgggcctggtgtttgtgaacagcaagagagacaggaccaaagccgtcctgtgtatggtggtggcaggggccatcgctgccgtctttcacacactgatagcttatagtgatttaggatactacattatcaataaactgcaccatgtggacgagtcggtggggagcaagacgagaagggccttcctgtacctcgccgcctttcctttcatggacgcaatggcatggacccatgctggcattctcttaaaacacaaatacagtttcctggtgggatgtgcctcaatctcagatgtcatagctcaggttgtttttgtagccattttgcttcacagtcacctggaatgccgggagcccctgctcatcccgatcctctccttgtacatgggcgcacttgtgcgctgcaccaccctgtgcctgggctactacaagaacattcacgacatcatccctgacagaagtggcccggagctggggggagatgcaacaataagaaagatgctgagcttctggtggcctttggctctaattctggccacacagagaatcagtcggcctattgtcaacctctttgtttcccgggaccttggtggcagttctgcagccacagaggcagtggcgattttgacagccacataccctgtgggtcacatgccatacggctggttgacggaaatccgtgctgtgtatcctgctttcgacaagaataaccccagcaacaaactggtgagcacgagcaacacagtcacggcagcccacatcaagaagttcaccttcgtctgcatggctctgtcactcacgctctgtttcgtgatgttttggacacccaacgtgtctgagaaaatcttgatagacatcatcggagtggactttgcctttgcagaactctgtgttgttcctttgcggatcttctccttcttcccagttccagtcacagtgagggcgcatctcaccgggtggctgatgacactgaagaaaaccttcgtccttgcccccagctctgtgctgcggatcatcgtcctcatcgccagcctcgtggtcctaccctacctgggggtgcacggtgcgaccctgggcgtgggctccctcctggcgggctttgtgggagaatccaccatggtcgccatcgctgcgtgctatgtctaccggaagcagaaaaagaagatggagaatgagtcggccacggagggggaagactctgccatgacagacatgcctccgacagaggaggtgacagacatcgtggaaatgagagaggagaatgaataaggcacgggacgccatgggcactgcagggacagtcagtcaggatgacacttcggcatcatctcttccctctcccatcgtattttgttcccttttttttgttttgttttggtaatgaaagaggccttgatttaaaggtttcgtgtcaattctctagcatactgggtatgctcacactgacggggggacctagtgaatggtctttactgttgctatgtaaaaacaaacgaaacaactgacttcatacccctgcctcacgaaaacccaaaagacacagctgcctcacggttgacgttgtgtcctcctcccctggacaatctcctcttggaaccaaaggactgcagctgtgccatcgcgcctcggtcaccctgcacagcaggccacagactctcctgtcccccttcatcgctcttaagaatcaacaggttaaaactcggcttcctttgatttgcttcccagtcacatggccgtacaaagagatggagccccggtggcctcttaaatttcccttccgccacggagttcgaaaccatctactccacacatgcaggaggcgggtggcacgctgcagcccggagtccccgttcacactgaggaacggagacctgtgaccacagcaggctgacagatggacagaatctcccgtagaaaggtttggtttgaaatgccccgggggcagcaaactgacatggttgaatgatagcatttcactctgcgttctcctagatctgagcaagctgtcagttctcacccccaccgtgtatatacatgagctaacttttttaaattgtcacaaaagcgcatctccagattccagaccctgccgcatgacttttcctgaaggcttgcttttccctcgcctttcctgaaggtcgcattagagcgagtcacatggagcatcctaactttgcattttagtttttacagtgaactgaagctttaagtctcatccagcattctaatgccaggttgctgtagggtaacttttgaagtagatatattacctggttctgctatccttagtcataactctgcggtacaggtaattgagaatgtactacggtacttccctcccacaccatacgataaagcaagacattttataacgataccagagtcactatgtggtcctccctgaaataacgcattcgaaatccatgcagtgcagtatatttttctaagttttggaaagcaggttttttcctttaaaaaaattatagacacggttcactaaattgatttagtcagaattcctagactgaaagaacctaaaaaaaaaaatattttaaagatataaatatatgctgtatatgttatgtaatttattttaggctataatacatttcctattttcgcattttcaataaaatgtctctaatacaatacggtgattgcttgtgtgctcaacatacctgcagttgaaacgtattgtatcaatgaacattgtaccttattggcagcagttttataaagtccgtcatttgcatttgaatgtaaggctcagtaaatgacagaactatttttcattatgggtaactggggaataaatgggtcactggagtaggaatagaagtgcaagctggaaaggcaaaaatgagaaagaaaaaggcaggccctttgtgtctaccgttttcagtgctgtgtgatcatattgttcctcacagcaaaaaagaatgcaagggcataatgttagctgtgaacatgccagggttgcattcacattcctgggtacccagtgctgatggggtgtgcccacgtggggacatgtccttggcgtgcttcctcagagtggcttttcctccattaatacatatatgagtactgaaaaattaagttgcatagctgctttgcagtggtttcagaggcagatctgagaagattaaaaaaaaatctcaatgtatcagctttttttaaaggacattactagaaaattaaacagtattttttaacatgtgtgactttcatgcttctggggttggagcttaaagatccaaactgagaaagcaggccgggcatggtggctcatgcctgtaatcccaacactttgggaggccaaggagggtggatcacttaaggtcaggagtttgagaccagcctggccaacatggcaaaaccctgtctctactaaaaacataaaaattagctgggggtggtagcacatacctgtaatcccagctactcaggaggctgaggcaggagaatttgcttgatcctgggaggcagaggttgtagtgagccgagatcgcgccatcgcactccagcctgggtgacaagagcaaaactccatctcaaaaaaaaaaaaaatcctttccctctaaatccaggaaggatcagcaagggcctcctcattatgagatgaggaaatacaactccagagattccttcagtgatcaagatcagtgggccataatatttggttagagtttctgagaacacaggaagcaatgccacactcaggccaccacaatggagctgatttggcaggacttgttcaaacctttcaccttaaagcacgtgatccttcttcgtacattttcttcacttgggctgcttaagtcacagcctaacaactttgaggcaaaactgagaactggcatattctcctgcgtttcttctaatcgagtcccatcatccagctagacatgagagatcaaaccagggagggtgacctttctccttcccacttttcagagtcattggggcaactttttgacttttgtgaccaaagaaacattcccccaaaacatttatttttcattgtagggcattcagctgacagctgcattttagaaagttaccatgcctgtgagattctcatgtcaaagaccagggaaagaccaggtgtgactttctccaaaactgagtgattgcttgtggatgaatacaatctaaaaatacaaggccatgaagtagtttttcatttagatgctgagaaataataggtttgggcagctcaaagcataggaaatagtaagggttttctagagctcctcctttggtggcctgtttgagtagcacaagggacgtcatcctaaatgtgcagttgccatttgttctgtagtgacttacagggatctcagtggcaaagggcgtcagtgagacaacaactgagcaaaaagaactagacgaggcttgcgcttggaaagtcacggtaggattggacctgccggccacatggctcagggagtattgacggatttgcacattggcaggaaactctcccgtttgggattctttaaatggggcacagaaggccacttgtttgcatttctgggtaaaaaacagtcatcccccatgactgcctgcatcgggtttgtcttgtgccaaagttactcttcctttgtttttactttgccttgatttttagcattagctggtagtttggcttggaaatgtcctggatagccgattccctaagaaactgaaacatttaatattggcttaggatgtatcagatggggccaaataaagcttctttacaatagtaaaagcactttatacttcactctctgagtcttcccaataaataaccttgggaggtgcagggggtggggggcccaggatggggaggcctgggagctcccagggtagtgacagagttgggctgagttctccagacgccaggatgcgtcgcagcggggccagctcaggagtgctcactcccagccctctggatctctctcctggttggaataatcattacatatcgtaactctcaaaatttattcacttatattttcagaataagaagtgtgaaatgttaacagctctctgctctcttacttgttccccatttggggatcttctggagggaaggggcagggggagagtaacttttctatatccttggtttctaggaacacatcgatttgaagactcagtagctgactggtttttttttttcccccttcaaactgaagtgcgagtgtgcgtgtgttccacaaaatagcaagtatttatagtgttgtaattacatttccttgagaaatattttcttgtatttaaaaatctttctacttcagtaactcccagcagaacagtgcccaggacagcatgtgccggttagtaccagctttgcaggtgagctgacttctaaacttaggacgacgtcttcatcaatcaaactagtgcacagtccagaaaaaggggtcctttatcttctaagttctgctcctcacctttctttggaaccaaaattgcagtggagtgtgaggaagagctttgaaagacgtggagtgttgagatgtctgcattgcacattcagccggttcaaagccagcagctcctgcctgcattctgtagacatcgccctcacacacagtcctctgatggctctcatataaagcactcaaaccgtaggaaagcatgtttttgagcaacgtgtctgggatactcctctgtgtggttattttgaatctctatttctgtcattgaagcagcaaaaaacatcatgtgactcatcaactgatctaatcacacttaaaacaggatgtagagaaaaatctgatgagaaacgtaaaagggcctgttgcctgcccttttaaaggcaaaatgtctaaaatcatgcaaatgttcaaaatgagagaaattgcattgtggaatcaaaataacccaaactccactcagaaaagtcacaaatatatagtatactatctgatctcaaaagggaaaaacgagatgataagaccttaagtttagactttattttcttctcaagagtggacattaaatctattaacttgcaactttctgctgggaagagcatcaaaggtgggcctcctaaatcatttttgaaaaacctctgtcaagtccaagtggttccaggagaattatagccagtatcttttaaaatatttcattttagtgataatgtttttctctgcttcatttgcaatcaaccaggatctctaaaagactgcataagatatatgcacttttataggtggctgtcagctacacatagattcagcaaattttttttatatagtacctgtttttaagttaggctacataacttaaagtgcactttactaacaagacttgacattagcgtctacaatatgtatatgtaaacaaaagcacacaagaactaggcaccctttctctctccaagagtttaagtggtttccttaggttaaagaaggggacagaccagctaaaaatggttgtaccactcactgtacaacctcatggaaattctcactataagatttagaggcaatgttccctagctataagccagggcaagaaatggcgcctctggagttggggaacattaggggaacattacaaccgggtagatgctggttccctgaagtgtggggccatgaacatgcagggacccacggtttgaatgaaacagctactgaaagctaagttcaaaccacccttgcgtaacaaaggagtacagggtacacatcaacaccaatcacccagcaccccacagcgatggtcatgtcaccgtgcagcaggtcccttaccccagggctgccacatccacaagccttgcagtggcaaatacgctgctccttggatttaatgagatattttggttgcttaatgatgtactgatcagggaactgtctaaagctagtagggccaaggagttaatcaaagggcttcgggaaagtggacaagagccacacacgtgattctgttccatgccgacactcattcatttaagaagtgtattcaagctggaggcttccatatcactcacgcttcttggcctcaccttgctcatctgtccaatgggaggcttgagccattattgctaaggccccttcctgatctaacattctgtttatgatctaggatttagaacgtcgtatgagatcctacaatggaagaataaaatcacctcattcttcatttcagatctgaacattagcagtgatctagatttttttttttttaaacaaaattaagtgtgcttagagtcattcctctacatgggctgtggctgtcagcccataggtttgtcagtttcacatcaaaactgtgggtataaactgttgaaaccaatcacattaaaatatttagctgggcacagtggtgtgcatctgtagtcccagctacttgggaggctgaggcaggaggatcgcttaagcacaggagttggaatccagcctgagcaacagagcaaaaccccgtctctaaaatacaaataaaatatttgtgtagtttttgattaaaattgactacagcggtcagtataaaatacatgtcgcttttaaggaagtgctctttatgtatctaacagatggaagtttttgcattggtaagagcatttatatatgctttgtttcagggtttatggatttgtattcatatattgtcaaataggtttcatactctaattttactttaagtaaagcttaaacacttggcatacaactgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56172 -> Molecular function: GO:0005315 [inorganic phosphate transmembrane transporter activity] evidence: IDA
GeneID:56172 -> Molecular function: GO:0015114 [phosphate ion transmembrane transporter activity] evidence: IEA
GeneID:56172 -> Molecular function: GO:0030504 [inorganic diphosphate transmembrane transporter activity] evidence: IDA
GeneID:56172 -> Biological process: GO:0001501 [skeletal system development] evidence: NAS
GeneID:56172 -> Biological process: GO:0007626 [locomotory behavior] evidence: NAS
GeneID:56172 -> Biological process: GO:0030500 [regulation of bone mineralization] evidence: ISS
GeneID:56172 -> Biological process: GO:0030500 [regulation of bone mineralization] evidence: TAS
GeneID:56172 -> Cellular component: GO:0005886 [plasma membrane] evidence: ISS
GeneID:56172 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: ISS
GeneID:56172 -> Cellular component: GO:0016021 [integral to membrane] evidence: IDA
GeneID:56172 -> Cellular component: GO:0019867 [outer membrane] evidence: TAS
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