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2024-04-16 14:42:27, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_053053 2276 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens transcriptional adaptor 1 (TADA1), mRNA.
ACCESSION NM_053053
VERSION NM_053053.3 GI:211058419
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2276)
AUTHORS Gloria-Bottini,F., Nicotra,M., Amante,A., Ambrosi,S., Cozzoli,E.,
Saccucci,P., Bottini,E. and Magrini,A.
TITLE Effect of ADA1 mother-fetus and wife-husband phenotypic differences
on the ratio birth weight/placental weight in fertile women and on
reproductive success in couples with RSA
JOURNAL Am. J. Hum. Biol. 24 (2), 177-182 (2012)
PUBMED 22287124
REMARK GeneRIF: Differences between mother and fetus in ADA(1) phenotype
may influence the ratio BW/PW in healthy women and reproductive
success in RSA women.
REFERENCE 2 (bases 1 to 2276)
AUTHORS Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
TITLE Follow-up of a major linkage peak on chromosome 1 reveals
suggestive QTLs associated with essential hypertension: GenNet
study
JOURNAL Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
PUBMED 19536175
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 2276)
AUTHORS Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
TITLE Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
genetic association with bone mineral density variation
JOURNAL Hum. Mol. Genet. 18 (4), 679-687 (2009)
PUBMED 19064610
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2276)
AUTHORS Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
Kundu,T.K., Chait,B.T. and Roeder,R.G.
TITLE Human STAGA complex is a chromatin-acetylating transcription
coactivator that interacts with pre-mRNA splicing and DNA
damage-binding factors in vivo
JOURNAL Mol. Cell. Biol. 21 (20), 6782-6795 (2001)
PUBMED 11564863
REFERENCE 5 (bases 1 to 2276)
AUTHORS Martinez,E., Kundu,T.K., Fu,J. and Roeder,R.G.
TITLE A human SPT3-TAFII31-GCN5-L acetylase complex distinct from
transcription factor IID
JOURNAL J. Biol. Chem. 273 (37), 23781-23785 (1998)
PUBMED 9726987
REMARK Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CN399642.1 and BC015401.2.
On Nov 1, 2008 this sequence version replaced gi:37059729.
Summary: TADA1L is a protein subunit of the human STAGA complex
(SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301)
acetyltransferase complex), which is a chromatin-modifying
multiprotein complex (Martinez et al., 2001 [PubMed
11564863]).[supplied by OMIM, Apr 2009].
##Evidence-Data-START##
Transcript exon combination :: BC015401.2, AK291922.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-175 CN399642.1 3-177
176-2198 BC015401.2 1-2023
2199-2276 BC015401.2 2033-2110
FEATURES Location/Qualifiers
source 1..2276
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q24.1"
gene 1..2276
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/note="transcriptional adaptor 1"
/db_xref="GeneID:117143"
/db_xref="HGNC:30631"
/db_xref="HPRD:18114"
/db_xref="MIM:612763"
exon 1..258
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
CDS 185..1192
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/note="transcriptional adaptor 1 (HFI1 homolog, yeast);
SPT3-associated factor 42 (STAF42); transcriptional
adapter 1-like protein"
/codon_start=1
/product="transcriptional adapter 1"
/protein_id="NP_444281.1"
/db_xref="GI:16596696"
/db_xref="CCDS:CCDS1255.1"
/db_xref="GeneID:117143"
/db_xref="HGNC:30631"
/db_xref="HPRD:18114"
/db_xref="MIM:612763"
/translation="
MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPDGAGSLPWPGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFTAPCAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIITKLWHPNHEELQQDKVHRQRLAAKEGLLLC
"
misc_feature 200..769
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/note="Transcriptional regulator of RNA polII, SAGA,
subunit; Region: SAGA-Tad1; pfam12767"
/db_xref="CDD:205064"
STS 190..432
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/standard_name="D3S2967E"
/db_xref="UniSTS:150951"
variation 215
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132732"
exon 259..350
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
exon 351..416
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
exon 417..514
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
exon 515..724
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
variation 574
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/replace="c"
/replace="g"
/db_xref="dbSNP:11559158"
STS 691..916
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/standard_name="SHGC-57163"
/db_xref="UniSTS:73173"
exon 725..876
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
exon 877..1039
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
exon 1040..2249
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/inference="alignment:Splign:1.39.8"
STS 1517..1642
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/standard_name="RH16504"
/db_xref="UniSTS:22693"
STS 1633..1782
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/standard_name="SGC34611"
/db_xref="UniSTS:75966"
variation 2159
/gene="TADA1"
/gene_synonym="ADA1; hADA1; HFI1; RP1-9E21.4; STAF42;
TADA1L"
/replace="c"
/replace="t"
/db_xref="dbSNP:6718"
ORIGIN
gggcaccttccctgcgaaaaggcgggcggagccgaaaaccaaacaaacgacttctgagagattgggggcgggactgacggcggccggcttagcttccagagccaaggccttccgccgagttggtttttgggttgttgatcgcggtggccgggcggtctgcggtcgggctgagacacgcggagcaatggcgacctttgtgagcgagctggaggcggccaagaagaacttaagcgaggccctgggggacaacgtgaaacaatactgggctaacctaaagctgtggttcaagcagaagatcagcaaagaggagtttgaccttgaagctcatagacttctcacacaggataatgtccattctcacaatgatttcctcctggccattctcacgcgttgtcagattttggtttctacaccagatggtgctggatctttgccttggccagggggttccgcagcaaaacctggaaaacccaagggaaagaaaaagctttcttctgttcgtcagaaatttgatcatagattccagcctcaaaatcctctctcaggagcccagcaatttgtggcaaaggatccccaagatgatgacgacttgaaactttgttcccacacaatgatgcttcccactcgaggccagcttgaagggagaatgatagtgactgcttatgagcatgggctggacaatgtcaccgaggaggctgtttcagctgttgtctatgctgtggagaatcaccttaaagatatactgacgtcagttgtgtcaagaaggaaagcttatcggttacgagatggtcattttaaatatgcctttggcagtaacgtgaccccgcagccatacctgaagaatagtgtagtagcttacaacaacttaatagaaagccctccagcttttactgctccctgtgctggtcagaatccagcttctcacccaccccctgatgatgctgagcagcaggctgcactcctgctggcatgctccggagacactctacctgcatctttgcctccggtgaacatgtacgatctttttgaagctttgcaggtgcacagggaagtcatccctacacatactgtctatgctcttaacattgaaaggatcatcacgaaactctggcatccaaatcatgaagagctgcagcaagacaaagttcaccgccagcgcttggcagccaaggaggggcttttgctgtgctaaattaggatttgagggtgtgggaccctcaccgaattcattgattactgaaaattgaatgttttttgggtccacatttcaaggctgaagtgtatagtgtatatataacctttcctatggaaatgtgacattgagtacattttgtgttgctgttgtgaagccattaatataaatctttggtaatgacccatatctctatatgtatgtgttcccagttgtgggagcaggcactaatgaaatcctgtgcctggaatggagatatttaggtacctgaggcttagtgtcctgtggtctgcatgtaagatagatgacatcctagaacaaagaagctgttttaacttaatccccctgatcagcaggatatctgtgtgttcagtgacatcatacattctgtatctagaagtctaaaatttctgcctttctcctaaagaatgtgttcttgcattttggttgaaataacctacacagtgttaaaaatcagatacctcctttagtgaccagttcaaattttaatagcgataggtagcccctgagaaatttatcactataactccacaggaaatatgacttggaagtgctctgtgtactaaacaaaataaagcccctctttgcatttaaaaccaaagtcaaaacaaaactcttgtaatgcaattaattaactttatgtcttcccatgactcaagttttgttaaatatgcccaaaaactttgattggcagtttcttcggttaattattcctatagaatgtattttaagaaatctatacaaattggatatatgcttggtaattctccagtttctaggaggtacctatttctaccgtttcaagtgatgaagtgaaaataatttacattcgatagtgttactgataacaaacctacttaagagatatgttgctttttacttaagggatagtgttgatagataaattagaatgtatagataggtttgtgaaagtctaaataatggttgtatagatatgtatatatggttcacatatctggatctgtgtatttgattttgtactttaaatgtgacaaataaaccttttgggagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:117143 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: IDA
GeneID:117143 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
GeneID:117143 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:117143 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:117143 -> Biological process: GO:0043966 [histone H3 acetylation] evidence: IDA
GeneID:117143 -> Cellular component: GO:0030914 [STAGA complex] evidence: IDA
by
@meso_cacase at
DBCLS
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