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2024-04-17 02:49:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_053027 7699 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens myosin light chain kinase (MYLK), transcript variant
3A, mRNA.
ACCESSION NM_053027
VERSION NM_053027.3 GI:116008193
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7699)
AUTHORS Usatyuk,P.V., Singleton,P.A., Pendyala,S., Kalari,S.K., He,D.,
Gorshkova,I.A., Camp,S.M., Moitra,J., Dudek,S.M., Garcia,J.G. and
Natarajan,V.
TITLE Novel role for non-muscle myosin light chain kinase (MLCK) in
hyperoxia-induced recruitment of cytoskeletal proteins, NADPH
oxidase activation, and reactive oxygen species generation in lung
endothelium
JOURNAL J. Biol. Chem. 287 (12), 9360-9375 (2012)
PUBMED 22219181
REMARK GeneRIF: MLCK is essential for the translocation and association of
cortactin and p47phox.
REFERENCE 2 (bases 1 to 7699)
AUTHORS Han,Y.J., Ma,S.F., Wade,M.S., Flores,C. and Garcia,J.G.
TITLE An intronic MYLK variant associated with inflammatory lung disease
regulates promoter activity of the smooth muscle myosin light chain
kinase isoform
JOURNAL J. Mol. Med. 90 (3), 299-308 (2012)
PUBMED 22015949
REMARK GeneRIF: MYLK SNPs downregulate smooth muscle MLCK promoter
activity due to interruption of a FOXN1 binding site. These data
provide new insights into the contribution of MYLK SNPs to
inflammatory disease susceptibility.
REFERENCE 3 (bases 1 to 7699)
AUTHORS Lapointe,T.K. and Buret,A.G.
TITLE Interleukin-18 facilitates neutrophil transmigration via myosin
light chain kinase-dependent disruption of occludin, without
altering epithelial permeability
JOURNAL Am. J. Physiol. Gastrointest. Liver Physiol. 302 (3), G343-G351
(2012)
PUBMED 22135309
REMARK GeneRIF: IL-18 may potentiate inflammation in the context of
inflammatory bowel disease by facilitating neutrophil
transepithelial migration via MLCK-dependent disruption of tight
junctional occludin.
REFERENCE 4 (bases 1 to 7699)
AUTHORS Chen,L., Su,L., Li,J., Zheng,Y., Yu,B., Yu,Y., Yan,M., Gu,Q.,
Zhu,Z. and Liu,B.
TITLE Hypermethylated FAM5C and MYLK in serum as diagnosis and
pre-warning markers for gastric cancer
JOURNAL Dis. Markers 32 (3), 195-202 (2012)
PUBMED 22377736
REMARK GeneRIF: Hypermethylated FAM5C and MYLK in serum are strongly
associated with the development of gastric cancer and can be used
as potential biomarkers for diagnosis and pre-warning.
REFERENCE 5 (bases 1 to 7699)
AUTHORS Stepanova,O.V., Chadin,A.V., Masyutin,A.G., Kulikova,T.G.,
Poltavceva,R.A., Masenko,V.P. and Sukhikh,G.T.
TITLE Myosin-activating protein kinases are possible regulators of
nonmuscle myosin in developing human heart
JOURNAL Bull. Exp. Biol. Med. 152 (2), 198-201 (2011)
PUBMED 22808459
REMARK GeneRIF: The approximate time period of changes in the ratios of
MLCK-108 and MLCK-210 was revealed (between 8-9 and 13 weeks), that
can be associated with functional changes in the developing
myocardium.
REFERENCE 6 (bases 1 to 7699)
AUTHORS Torok,K. and Trentham,D.R.
TITLE Mechanism of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N-
diethylamino)phenyl]-1,3,5-triazin-4-yl]calmodulin interactions
with smooth muscle myosin light chain kinase and derived peptides
JOURNAL Biochemistry 33 (43), 12807-12820 (1994)
PUBMED 7947686
REFERENCE 7 (bases 1 to 7699)
AUTHORS Ikebe,M. and Reardon,S.
TITLE Phosphorylation of smooth myosin light chain kinase by smooth
muscle Ca2+/calmodulin-dependent multifunctional protein kinase
JOURNAL J. Biol. Chem. 265 (16), 8975-8978 (1990)
PUBMED 2160950
REFERENCE 8 (bases 1 to 7699)
AUTHORS Ikebe,M., Hartshorne,D.J. and Elzinga,M.
TITLE Identification, phosphorylation, and dephosphorylation of a second
site for myosin light chain kinase on the 20,000-dalton light chain
of smooth muscle myosin
JOURNAL J. Biol. Chem. 261 (1), 36-39 (1986)
PUBMED 3079756
REFERENCE 9 (bases 1 to 7699)
AUTHORS Nishikawa,M., Shirakawa,S. and Adelstein,R.S.
TITLE Phosphorylation of smooth muscle myosin light chain kinase by
protein kinase C. Comparative study of the phosphorylated sites
JOURNAL J. Biol. Chem. 260 (15), 8978-8983 (1985)
PUBMED 3160694
REFERENCE 10 (bases 1 to 7699)
AUTHORS Nishikawa,M., de Lanerolle,P., Lincoln,T.M. and Adelstein,R.S.
TITLE Phosphorylation of mammalian myosin light chain kinases by the
catalytic subunit of cyclic AMP-dependent protein kinase and by
cyclic GMP-dependent protein kinase
JOURNAL J. Biol. Chem. 259 (13), 8429-8436 (1984)
PUBMED 6547441
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC064695.1, AC117381.5,
U48959.2, AC020634.16, AY339601.1, AC023165.20 and BC064420.1.
On Oct 10, 2006 this sequence version replaced gi:47132564.
Summary: This gene, a muscle member of the immunoglobulin gene
superfamily, encodes myosin light chain kinase which is a
calcium/calmodulin dependent enzyme. This kinase phosphorylates
myosin regulatory light chains to facilitate myosin interaction
with actin filaments to produce contractile activity. This gene
encodes both smooth muscle and nonmuscle isoforms. In addition,
using a separate promoter in an intron in the 3' region, it encodes
telokin, a small protein identical in sequence to the C-terminus of
myosin light chain kinase, that is independently expressed in
smooth muscle and functions to stabilize unphosphorylated myosin
filaments. A pseudogene is located on the p arm of chromosome 3.
Four transcript variants that produce four isoforms of the
calcium/calmodulin dependent enzyme have been identified as well as
two transcripts that produce two isoforms of telokin. Additional
variants have been identified but lack full length transcripts.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3A) does not utilize exon 30,
compared to variant 1, resulting in a shorter protein (isoform 3A),
compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AF069602.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-129 BC064695.1 2-130
130-130 AC117381.5 45518-45518 c
131-447 BC064695.1 132-448
448-720 U48959.2 285-557
721-721 AC020634.16 94026-94026
722-1767 U48959.2 559-1604
1768-1768 AC020634.16 100146-100146
1769-5243 AY339601.1 1487-4961
5244-5874 AY339601.1 5115-5745
5875-7665 AC023165.20 39793-41583
7666-7699 BC064420.1 2491-2524
FEATURES Location/Qualifiers
source 1..7699
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21"
gene 1..7699
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="myosin light chain kinase"
/db_xref="GeneID:4638"
/db_xref="HGNC:7590"
/db_xref="MIM:600922"
exon 1..97
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 98..156
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
misc_feature 139..141
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="upstream in-frame stop codon"
exon 157..279
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 280..447
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
CDS 283..5874
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/EC_number="2.7.11.18"
/note="isoform 3A is encoded by transcript variant 3A;
smooth muscle myosin light chain kinase; myosin, light
polypeptide kinase; telokin; kinase-related protein"
/codon_start=1
/product="myosin light chain kinase, smooth muscle isoform
3A"
/protein_id="NP_444255.3"
/db_xref="GI:116008194"
/db_xref="CCDS:CCDS3023.1"
/db_xref="GeneID:4638"
/db_xref="HGNC:7590"
/db_xref="MIM:600922"
/translation="
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE
"
misc_feature 379..651
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 445..642
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 763..1032
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 817..1023
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 1522..1794
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 1540..1794
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin; Region: IG; smart00409"
/db_xref="CDD:197707"
misc_feature 1822..2082
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 1876..2073
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 2149..2418
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 2200..2409
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 2443..2709
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 2461..2709
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin; Region: IG; smart00409"
/db_xref="CDD:197707"
misc_feature 3574..3843
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 3625..3828
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 3997..4287
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Eighth immunoglobulin (Ig)-like domain of human
myosin light-chain kinase (MLCK); Region: Ig8_MLCK;
cd05762"
/db_xref="CDD:143239"
misc_feature 3997..4263
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature <4354..4551
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(4468..4470,4513..4515)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(4516..4521,4525..4530)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 4672..5697
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Serine/threonine protein kinase [General function
prediction only / Signal transduction mechanisms /
Transcription / DNA replication, recombination, and
repair]; Region: SPS1; COG0515"
/db_xref="CDD:30861"
misc_feature 4690..5280
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(4690..4704,4714..4716,4753..4755,4759..4761,
4846..4848,4894..4905,4915..4917,4921..4923,5035..5037,
5041..5043,5047..5052,5056..5058,5095..5097,5104..5106,
5149..5160)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(4690..4704,4714..4716,4753..4755,4759..4761,
4846..4848,4894..4905,4915..4917,5035..5037,5041..5043,
5047..5052,5056..5058,5095..5097)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(4702..4704,4915..4917,4921..4923,5035..5037,
5041..5043,5047..5049,5104..5106,5149..5160)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(5092..5112,5149..5160)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 5554..5826
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 5605..5817
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
exon 448..655
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 656..704
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 705..870
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 871..1036
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1037..1055
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1056..1591
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1592..1798
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1799..1933
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1934..2086
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2087..2224
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2225..2422
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2423..2672
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2673..2744
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2745..3730
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 2815
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3732485"
variation 2864
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3732486"
variation 2911
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:34542174"
variation 2976
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:1064963"
variation 2988
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="g"
/db_xref="dbSNP:1064964"
variation 3024
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3732487"
variation 3039
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064965"
variation 3060
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1064966"
variation 3079
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064967"
variation 3129
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064968"
variation 3147
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1064969"
variation 3153
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064970"
variation 3169
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3207817"
variation 3466
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:11558550"
variation 3684
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:865358"
exon 3731..3847
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 3840
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:40305"
exon 3848..3934
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 3935..3985
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 3986..4113
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 4114..4267
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4122
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3205951"
variation 4134
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="g"
/db_xref="dbSNP:1142295"
exon 4268..4570
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4303
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:41530452"
STS 4394..4514
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="SHGC-77269"
/db_xref="UniSTS:53737"
exon 4571..4603
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4599
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1254392"
exon 4604..4697
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4631
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:41366751"
exon 4698..4901
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 4902..5119
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5120..5243
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5244..5367
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5368..5497
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5498..5629
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 5598
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804614"
exon 5630..7683
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 5653
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804613"
STS 5697..5846
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="RH77851"
/db_xref="UniSTS:45321"
variation 5819
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="t"
/db_xref="dbSNP:1065022"
variation 6486
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:9422"
variation 7227
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="t"
/db_xref="dbSNP:3190420"
STS 7244..7418
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="RH45477"
/db_xref="UniSTS:10789"
STS 7244..7418
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="stSG16293"
STS 7291..7424
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="A004V23"
/db_xref="UniSTS:57532"
STS 7291..7424
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="TIGR-A004V23"
STS 7410..7555
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="A006U08"
STS 7410..7555
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="A006U08"
/db_xref="UniSTS:28559"
polyA_signal 7424..7429
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
polyA_site 7443
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
STS 7448..7616
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="RH36624"
/db_xref="UniSTS:67934"
STS 7448..7616
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="stSG15806"
polyA_signal 7649..7654
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
polyA_site 7669
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
polyA_site 7683
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
ORIGIN
ggcgctgagcgagctcggagcccgcgctgtgcgcctgcggccggggcgccccgccgagcgccggtgccccggctcccgggccgccttcgccgcgcgggaaggattcttcaaaattaacagaaaccaattcgggccagctgaagagaaaaaataaaggtggctcccggctgcctctgctgcagttcagagcaacttcaggagcttcccagccgagagcttcaggacgcctttcctgtcccactggcccagttgccacaacaaacaacagagaagacggtgaccatgggggatgtgaagctggttgcctcgtcacacatttccaaaacctccctcagtgtggatccctcaagagttgactccatgcccctgacagaggcccctgctttcattttgccccctcggaacctctgcatcaaagaaggagccaccgccaagttcgaagggcgggtccggggttacccagagccccaggtgacatggcacagaaacgggcaacccatcaccagcgggggccgcttcctgctggattgcggcatccgggggactttcagccttgtgattcatgctgtccatgaggaggacaggggaaagtatacctgtgaagccaccaatggcagtggtgctcgccaggtgacagtggagttgacagtagaaggaagttttgcgaagcagcttggtcagcctgttgtttccaaaaccttaggggatagattttcagctccagcagtggagacccgtcctagcatctggggggagtgcccaccaaagtttgctaccaagctgggccgagttgtggtcaaagaaggacagatgggacgattctcctgcaagatcactggccggccccaaccgcaggtcacctggctcaagggaaatgttccactgcagccgagtgcccgtgtgtctgtgtctgagaagaacggcatgcaggttctggaaatccatggagtcaaccaagatgacgtgggagtgtacacgtgcctggtggtgaacgggtcggggaaggcctcgatgtcagctgaactttccatccaaggtttggacagtgccaataggtcatttgtgagagaaacaaaagccaccaattcagatgtcaggaaagaggtgaccaatgtaatctcaaaggagtcgaagctggacagtctggaggctgcagccaaaagcaagaactgctccagcccccagagaggtggctccccaccctgggctgcaaacagccagcctcagcccccaagggagtccaagctggagtcatgcaaggactcgcccagaacggccccgcagaccccggtccttcagaagacttccagctccatcaccctgcaggccgcaagagttcagccggaaccaagagcaccaggcctgggggtcctatcaccttctggagaagagaggaagaggccagctcctccccgtccagccaccttccccaccaggcagcctggcctggggagccaagatgttgtgagcaaggctgctaacaggagaatccccatggagggccagagggattcagcattccccaaatttgagagcaagccccaaagccaggaggtcaaggaaaatcaaactgtcaagttcagatgtgaagtttccgggattccaaagcctgaagtggcctggttcctggaaggcacccccgtgaggagacaggaaggcagcattgaggtttatgaagatgctggctcccattacctctgcctgctgaaagcccggaccagggacagtgggacatacagctgcactgcttccaacgcccaaggccagctgtcctgtagctggaccctccaagtggaaaggcttgccgtgatggaggtggccccctccttctccagtgtcctgaaggactgcgctgttattgagggccaggattttgtgctgcagtgctccgtacgggggaccccagtgccccggatcacttggctgctgaatgggcagcccatccagtacgctcgctccacctgcgaggccggcgtggctgagctccacatccaggatgccctgccggaggaccatggcacctacacctgcctagctgagaatgccttggggcaggtgtcctgcagcgcctgggtcaccgtccatgaaaagaagagtagcaggaagagtgagtaccttctgcctgtggctcccagcaagcccactgcacccatcttcctgcagggcctctctgatctcaaagtcatggatggaagccaggtcactatgactgtccaagtgtcagggaatccaccccctgaagtcatctggctgcacaatgggaatgagatccaagagtcagaggacttccactttgaacagagaggaactcagcacagcctttgtatccaggaagtgttcccggaggacacgggcacgtacacctgcgaggcctggaacagcgctggagaggtccgcacccaggccgtgctcacggtacaagagcctcacgatggcacccagccctggttcatcagtaagcctcgctcagtgacagcctccctgggccagagtgtcctcatctcctgcgccatagctggtgacccctttcctaccgtgcactggctcagagatggcaaagccctctgcaaagacactggccacttcgaggtgcttcagaatgaggacgtgttcaccctggttctaaagaaggtgcagccctggcatgccggccagtatgagatcctgctcaagaaccgggttggcgaatgcagttgccaggtgtcactgatgctacagaacagctctgccagagcccttccacgggggagggagcctgccagctgcgaggacctctgtggtggaggagttggtgctgatggtggtggtagtgaccgctatgggtccctgaggcctggctggccagcaagagggcagggttggctagaggaggaagacggcgaggacgtgcgaggggtgctgaagaggcgcgtggagacgaggcagcacactgaggaggcgatccgccagcaggaggtggagcagctggacttccgagacctcctggggaagaaggtgagtacaaagaccctatcggaagacgacctgaaggagatcccagccgagcagatggatttccgtgccaacctgcagcggcaagtgaagccaaagactgtgtctgaggaagagaggaaggtgcacagcccccagcaggtcgattttcgctctgtcctggccaagaaggggacttccaagacccccgtgcctgagaaggtgccaccgccaaaacctgccaccccggattttcgctcagtgctgggtggcaagaagaaattaccagcagagaatggcagcagcagtgccgagaccctgaatgccaaggcagtggagagttccaagcccctgagcaatgcacagccttcagggcccttgaaacccgtgggcaacgccaagcctgctgagaccctgaagccaatgggcaacgccaagcctgccgagaccctgaagcccatgggcaatgccaagcctgatgagaacctgaaatccgctagcaaagaagaactcaagaaagacgttaagaatgatgtgaactgcaagagaggccatgcagggaccacagataatgaaaagagatcagagagccaggggacagccccagccttcaagcagaagctgcaagatgttcatgtggcagagggcaagaagctgctgctccagtgccaggtgtcttctgaccccccagccaccatcatctggacgctgaacggaaagaccctcaagaccaccaagttcatcatcctctcccaggaaggctcactctgctccgtctccatcgagaaggcactgcctgaggacagaggcttatacaagtgtgtagccaagaatgacgctggccaggcggagtgctcctgccaagtcaccgtggatgatgctccagccagtgagaacaccaaggccccagagatgaaatcccggaggcccaagagctctcttcctcccgtgctaggaactgagagtgatgcgactgtgaaaaagaaacctgcccccaagacacctccgaaggcagcaatgccccctcagatcatccagttccctgaggaccagaaggtacgcgcaggagagtcagtggagctgtttggcaaagtgacaggcactcagcccatcacctgtacctggatgaagttccgaaagcagatccaggaaagcgagcacatgaaggtggagaacagcgagaatggcagcaagctcaccatcctggccgcgcgccaggagcactgcggctgctacacactgctggtggagaacaagctgggcagcaggcaggcccaggtcaacctcactgtcgtggataagccagaccccccagctggcacaccttgtgcctctgacattcggagctcctcactgaccctgtcctggtatggctcctcatatgatgggggcagtgctgtacagtcctacagcatcgagatctgggactcagccaacaagacgtggaaggaactagccacatgccgcagcacctctttcaacgtccaggacctgctgcctgaccacgaatataagttccgtgtacgtgcaatcaacgtgtatggaaccagtgagccaagccaggagtctgaactcacaacggtaggagagaaacctgaagagccgaaggatgaagtggaggtgtcagatgatgatgagaaggagcccgaggttgattaccggacagtgacaatcaatactgaacaaaaagtatctgacttctacgacattgaggagagattaggatctgggaaatttggacaggtctttcgacttgtagaaaagaaaactcgaaaagtctgggcagggaagttcttcaaggcatattcagcaaaagagaaagagaatatccggcaggagattagcatcatgaactgcctccaccaccctaagctggtccagtgtgtggatgcctttgaagaaaaggccaacatcgtcatggtcctggagatcgtgtcaggaggggagctgtttgagcgcatcattgacgaggactttgagctgacggagcgtgagtgcatcaagtacatgcggcagatctcggagggagtggagtacatccacaagcagggcatcgtgcacctggacctcaagccggagaacatcatgtgtgtcaacaagacgggcaccaggatcaagctcatcgactttggtctggccaggaggctggagaatgcggggtctctgaaggtcctctttggcaccccagaatttgtggctcctgaagtgatcaactatgagcccatcggctacgccacagacatgtggagcatcggggtcatctgctacatcctaaaccgcctggactgcacgcagtgccttcagcatccatggctaatgaaagataccaagaacatggaggccaagaaactctccaaggaccggatgaagaagtacatggcaagaaggaaatggcagaaaacgggcaatgctgtgagagccattggaagactgtcctctatggcaatgatctcagggctcagtggcaggaaatcctcaacagggtcaccaaccagcccgctcaatgcagaaaaactagaatctgaagaagatgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatttctctaagaccattcgcgatttagaagttgtggagggaagtgctgctagatttgactgcaagattgaaggatacccagaccccgaggttgtctggttcaaagatgaccagtcaatcagggagtcccgccacttccagatagactacgatgaggacgggaactgctctttaattattagtgatgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtcttggagaagccacctgcacagcagagctcattgtggaaacgatggaggaaggtgaaggggaaggggaagaggaagaagagtgaaacaaagccagagaaaagcagtttctaagtcatattaaaaggactatttctctaaaactcaaaaaaaaaaaaaaaactcaagatagtaaaagcacctagtgtgatagattatcggttaggtcatttgtgggttgattcttcagaaacagcagttgatacctagcagcgttattgatgggcattaatctatgttagttggcaccttaagatactagtgcagctagatttcatttagggaaatcaccagtaacttgactgaccaattgattttagagagaaagtaaccaaaccaaatatttatctgggcaaagtcataaattctccacttgaatgcgctcatgaaaaataaggccaaaacaagagttctgggccacagctcagcccagagggttcctggggatgggaggcctctctctccccaccccctgactctagagaactgggttttctcccagtactccagcaattcatttctgaaagcagttgagccactttattccaaagtacactgcagatgttcaaactctccatttctctttccccttccacctgccagttttgctgactctcaacttgtcatgagtgtaagcattaaggacattatgcttcttcgattctgaagacaggtccctgctcatggatgactctggcttccttaggaaaatatttttcttccaaaatcagtaggaaatctaaacttatcccctctttgcagatgtctagcagcttcagacatttggttaagaacccatgggaaaaaaaaaatccttgctaatgtggtttcctttgtaaaccaggattcttatttgtgctgttatagaatatcagctctgaacgtgtggtaaagatttttgtgtttgaatataggagaaatcagtttgctgaaaagttagtcttaattatctattggccacgatgaaacagatttcaactgataaagagctggagaactccatgtactttggaatctcctccaagatagccagagtttaatacatcttcattctcaacactctccaaagaacttgacctaccttatgggttccatatttttcttcttaaatgtgcatcaatcatgccttgcccccaacctttaaatatattcttagacctggtaaatgcactcagacttgcgtctttaggaatttttaactttctttcactacattggcacttaaattttttctttataaagctttttgaaggtcataaacaaagaccataattgatgatagacctaatacatttcctctgtgtgtgtgtgtaacattccaaatactttttttttcttttccactgtttgtaaggtgcaacaatttaatatttttaagggactttttaagagttccttaagaaccaatttaaaattacttcagtgcaatcctacacagtatcaacattagaattttgatattagtcttatgttatcttccattctatttttatctgctttttgctgctagtttcaaactgccagtatttttccttttgcttttaaaatagttacaatatttttcatgatagccacagtattgccacagtttattataataaagggtttttatttgatttagcgcattcaaagcttttttctatcacttttgtgttcagaatataacctttgtgtgcgtgtatgttgtgtgtgtgcatgtgtggcgtatatgtgtgttacaggttaatgccttcttggaattgtgttaatgttctcttggtttattatgccatcagaatggtaaatgagaacactacaactgtagtcagctcacaatttttaaataaaggataccacagtgcatgctgtttgttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4638 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
GeneID:4638 -> Molecular function: GO:0004687 [myosin light chain kinase activity] evidence: IDA
GeneID:4638 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4638 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
GeneID:4638 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4638 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:4638 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:4638 -> Biological process: GO:0006936 [muscle contraction] evidence: TAS
GeneID:4638 -> Biological process: GO:0006939 [smooth muscle contraction] evidence: ISS
GeneID:4638 -> Biological process: GO:0014820 [tonic smooth muscle contraction] evidence: ISS
GeneID:4638 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IDA
GeneID:4638 -> Biological process: GO:0032060 [bleb assembly] evidence: IMP
GeneID:4638 -> Biological process: GO:0051928 [positive regulation of calcium ion transport] evidence: IDA
GeneID:4638 -> Biological process: GO:0060414 [aorta smooth muscle tissue morphogenesis] evidence: IMP
GeneID:4638 -> Biological process: GO:0071476 [cellular hypotonic response] evidence: IDA
GeneID:4638 -> Biological process: GO:0090303 [positive regulation of wound healing] evidence: IDA
GeneID:4638 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
GeneID:4638 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:4638 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:4638 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:4638 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
GeneID:4638 -> Cellular component: GO:0032154 [cleavage furrow] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_444255 -> EC 2.7.11.18
by
@meso_cacase at
DBCLS
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