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2019-03-25 14:31:51, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_053025               7852 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens myosin light chain kinase (MYLK), transcript variant
            1, mRNA.
ACCESSION   NM_053025
VERSION     NM_053025.3  GI:116008191
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7852)
  AUTHORS   Usatyuk,P.V., Singleton,P.A., Pendyala,S., Kalari,S.K., He,D.,
            Gorshkova,I.A., Camp,S.M., Moitra,J., Dudek,S.M., Garcia,J.G. and
            Natarajan,V.
  TITLE     Novel role for non-muscle myosin light chain kinase (MLCK) in
            hyperoxia-induced recruitment of cytoskeletal proteins, NADPH
            oxidase activation, and reactive oxygen species generation in lung
            endothelium
  JOURNAL   J. Biol. Chem. 287 (12), 9360-9375 (2012)
   PUBMED   22219181
  REMARK    GeneRIF: MLCK is essential for the translocation and association of
            cortactin and p47phox.
REFERENCE   2  (bases 1 to 7852)
  AUTHORS   Han,Y.J., Ma,S.F., Wade,M.S., Flores,C. and Garcia,J.G.
  TITLE     An intronic MYLK variant associated with inflammatory lung disease
            regulates promoter activity of the smooth muscle myosin light chain
            kinase isoform
  JOURNAL   J. Mol. Med. 90 (3), 299-308 (2012)
   PUBMED   22015949
  REMARK    GeneRIF: MYLK SNPs downregulate smooth muscle MLCK promoter
            activity due to interruption of a FOXN1 binding site. These data
            provide new insights into the contribution of MYLK SNPs to
            inflammatory disease susceptibility.
REFERENCE   3  (bases 1 to 7852)
  AUTHORS   Lapointe,T.K. and Buret,A.G.
  TITLE     Interleukin-18 facilitates neutrophil transmigration via myosin
            light chain kinase-dependent disruption of occludin, without
            altering epithelial permeability
  JOURNAL   Am. J. Physiol. Gastrointest. Liver Physiol. 302 (3), G343-G351
            (2012)
   PUBMED   22135309
  REMARK    GeneRIF: IL-18 may potentiate inflammation in the context of
            inflammatory bowel disease by facilitating neutrophil
            transepithelial migration via MLCK-dependent disruption of tight
            junctional occludin.
REFERENCE   4  (bases 1 to 7852)
  AUTHORS   Chen,L., Su,L., Li,J., Zheng,Y., Yu,B., Yu,Y., Yan,M., Gu,Q.,
            Zhu,Z. and Liu,B.
  TITLE     Hypermethylated FAM5C and MYLK in serum as diagnosis and
            pre-warning markers for gastric cancer
  JOURNAL   Dis. Markers 32 (3), 195-202 (2012)
   PUBMED   22377736
  REMARK    GeneRIF: Hypermethylated FAM5C and MYLK in serum are strongly
            associated with the development of gastric cancer and can be used
            as potential biomarkers for diagnosis and pre-warning.
REFERENCE   5  (bases 1 to 7852)
  AUTHORS   Stepanova,O.V., Chadin,A.V., Masyutin,A.G., Kulikova,T.G.,
            Poltavceva,R.A., Masenko,V.P. and Sukhikh,G.T.
  TITLE     Myosin-activating protein kinases are possible regulators of
            nonmuscle myosin in developing human heart
  JOURNAL   Bull. Exp. Biol. Med. 152 (2), 198-201 (2011)
   PUBMED   22808459
  REMARK    GeneRIF: The approximate time period of changes in the ratios of
            MLCK-108 and MLCK-210 was revealed (between 8-9 and 13 weeks), that
            can be associated with functional changes in the developing
            myocardium.
REFERENCE   6  (bases 1 to 7852)
  AUTHORS   Torok,K. and Trentham,D.R.
  TITLE     Mechanism of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N-
            diethylamino)phenyl]-1,3,5-triazin-4-yl]calmodulin interactions
            with smooth muscle myosin light chain kinase and derived peptides
  JOURNAL   Biochemistry 33 (43), 12807-12820 (1994)
   PUBMED   7947686
REFERENCE   7  (bases 1 to 7852)
  AUTHORS   Ikebe,M. and Reardon,S.
  TITLE     Phosphorylation of smooth myosin light chain kinase by smooth
            muscle Ca2+/calmodulin-dependent multifunctional protein kinase
  JOURNAL   J. Biol. Chem. 265 (16), 8975-8978 (1990)
   PUBMED   2160950
REFERENCE   8  (bases 1 to 7852)
  AUTHORS   Ikebe,M., Hartshorne,D.J. and Elzinga,M.
  TITLE     Identification, phosphorylation, and dephosphorylation of a second
            site for myosin light chain kinase on the 20,000-dalton light chain
            of smooth muscle myosin
  JOURNAL   J. Biol. Chem. 261 (1), 36-39 (1986)
   PUBMED   3079756
REFERENCE   9  (bases 1 to 7852)
  AUTHORS   Nishikawa,M., Shirakawa,S. and Adelstein,R.S.
  TITLE     Phosphorylation of smooth muscle myosin light chain kinase by
            protein kinase C. Comparative study of the phosphorylated sites
  JOURNAL   J. Biol. Chem. 260 (15), 8978-8983 (1985)
   PUBMED   3160694
REFERENCE   10 (bases 1 to 7852)
  AUTHORS   Nishikawa,M., de Lanerolle,P., Lincoln,T.M. and Adelstein,R.S.
  TITLE     Phosphorylation of mammalian myosin light chain kinases by the
            catalytic subunit of cyclic AMP-dependent protein kinase and by
            cyclic GMP-dependent protein kinase
  JOURNAL   J. Biol. Chem. 259 (13), 8429-8436 (1984)
   PUBMED   6547441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC064695.1, AC117381.5,
            U48959.2, AC020634.16, AY339601.1, AC023165.20 and BC064420.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 10, 2006 this sequence version replaced gi:47132560.
            
            Summary: This gene, a muscle member of the immunoglobulin gene
            superfamily, encodes myosin light chain kinase which is a
            calcium/calmodulin dependent enzyme. This kinase phosphorylates
            myosin regulatory light chains to facilitate myosin interaction
            with actin filaments to produce contractile activity. This gene
            encodes both smooth muscle and nonmuscle isoforms. In addition,
            using a separate promoter in an intron in the 3' region, it encodes
            telokin, a small protein identical in sequence to the C-terminus of
            myosin light chain kinase, that is independently expressed in
            smooth muscle and functions to stabilize unphosphorylated myosin
            filaments. A pseudogene is located on the p arm of chromosome 3.
            Four transcript variants that produce four isoforms of the
            calcium/calmodulin dependent enzyme have been identified as well as
            two transcripts that produce two isoforms of telokin. Additional
            variants have been identified but lack full length transcripts.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the full-length transcript
            and encodes the full-length nonmuscle isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U48959.2, AY424270.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support ERS025081,
                                    ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               BC064695.1         2-130
            130-130             AC117381.5         45518-45518         c
            131-447             BC064695.1         132-448
            448-720             U48959.2           285-557
            721-721             AC020634.16        94026-94026
            722-1767            U48959.2           559-1604
            1768-1768           AC020634.16        100146-100146
            1769-6027           AY339601.1         1487-5745
            6028-7818           AC023165.20        39793-41583
            7819-7852           BC064420.1         2491-2524
FEATURES             Location/Qualifiers
     source          1..7852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21"
     gene            1..7852
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="myosin light chain kinase"
                     /db_xref="GeneID:4638"
                     /db_xref="HGNC:7590"
                     /db_xref="MIM:600922"
     exon            1..97
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            98..156
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    139..141
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="upstream in-frame stop codon"
     exon            157..279
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            280..447
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     CDS             283..6027
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /EC_number="2.7.11.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     smooth muscle myosin light chain kinase; myosin, light
                     polypeptide kinase; telokin; kinase-related protein"
                     /codon_start=1
                     /product="myosin light chain kinase, smooth muscle isoform
                     1"
                     /protein_id="NP_444253.3"
                     /db_xref="GI:116008192"
                     /db_xref="CCDS:CCDS46896.1"
                     /db_xref="GeneID:4638"
                     /db_xref="HGNC:7590"
                     /db_xref="MIM:600922"
                     /translation="
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE
"
     misc_feature    334..336
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03995"
     misc_feature    379..651
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    445..642
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:143165"
     misc_feature    763..1032
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    817..1023
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:143165"
     misc_feature    973..975
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    1522..1794
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    1540..1794
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin; Region: IG; smart00409"
                     /db_xref="CDD:197707"
     misc_feature    1672..1674
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1 and SRC; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    1693..1695
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by SRC; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    1822..2082
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    1876..2073
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:143165"
     misc_feature    1948..1950
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    2104..2106
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); acetylation site"
     misc_feature    2113..2115
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    2149..2418
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    2200..2409
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:143165"
     misc_feature    2443..2709
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    2461..2709
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin; Region: IG; smart00409"
                     /db_xref="CDD:197707"
     misc_feature    2656..2658
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    2818..2820
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    2884..3276
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15746.4);
                     Region: 5 X 28 AA approximate tandem repeats"
     misc_feature    3049..3171
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15746.4);
                     Region: Actin-binding (calcium/calmodulin-sensitive) (By
                     similarity)"
     misc_feature    3124..3171
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15746.4);
                     Region: Calmodulin-binding (By similarity)"
     misc_feature    3277..3471
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15746.4);
                     Region: 6 X 12 AA approximate tandem repeats"
     misc_feature    3463..4662
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15746.4);
                     Region: Actin-binding (calcium/calmodulin-insensitive) (By
                     similarity)"
     misc_feature    3574..3843
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    3625..3828
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:143165"
     misc_feature    3904..3906
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:05428"
     misc_feature    3997..4287
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Eighth immunoglobulin (Ig)-like domain of human
                     myosin light-chain kinase (MLCK); Region: Ig8_MLCK;
                     cd05762"
                     /db_xref="CDD:143239"
     misc_feature    3997..4263
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    <4354..4551
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; Region: FN3; cd00063"
                     /db_xref="CDD:28945"
     misc_feature    order(4468..4470,4513..4515)
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Interdomain contacts; other site"
                     /db_xref="CDD:28945"
     misc_feature    order(4516..4521,4525..4530)
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Cytokine receptor motif; other site"
                     /db_xref="CDD:28945"
     misc_feature    4594..4596
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15746.4); phosphorylation site"
     misc_feature    4627..4629
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    4672..5439
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    4690..5433
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Catalytic domain of Protein Kinases; Region: PKc;
                     cd00180"
                     /db_xref="CDD:173623"
     misc_feature    order(4690..4704,4714..4716,4753..4755,4759..4761,
                     4846..4848,4894..4905,4915..4917,4921..4923,5035..5037,
                     5041..5043,5047..5052,5056..5058,5095..5097,5104..5106,
                     5149..5160)
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(4690..4704,4714..4716,4753..4755,4759..4761,
                     4846..4848,4894..4905,4915..4917,5035..5037,5041..5043,
                     5047..5052,5056..5058,5095..5097)
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(4702..4704,4915..4917,4921..4923,5035..5037,
                     5041..5043,5047..5049,5104..5106,5149..5160)
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    5005..5007
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    order(5092..5112,5149..5160)
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173623"
     misc_feature    5185..5187
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL1; propagated from
                     UniProtKB/Swiss-Prot (Q15746.4); phosphorylation site"
     misc_feature    5413..5604
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15746.4);
                     Region: Calmodulin-binding"
     misc_feature    5560..5562
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[7]
                     /db_xref="HPRD:03672"
     misc_feature    5560..5562
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[7]
                     /db_xref="HPRD:05428"
     misc_feature    5707..5979
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    5758..5970
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /note="Immunoglobulin domain; Region: Ig; cd00096"
                     /db_xref="CDD:143165"
     exon            448..655
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            656..704
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            705..870
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            871..1036
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            1037..1055
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            1056..1591
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            1592..1798
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            1799..1933
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            1934..2086
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            2087..2224
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            2225..2422
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            2423..2672
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            2673..2744
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            2745..3730
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       2815
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3732485"
     variation       2864
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3732486"
     variation       2911
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34542174"
     variation       2976
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1064963"
     variation       2988
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1064964"
     variation       3024
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3732487"
     variation       3039
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1064965"
     variation       3060
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1064966"
     variation       3079
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1064967"
     variation       3129
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1064968"
     variation       3147
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1064969"
     variation       3153
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1064970"
     variation       3169
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3207817"
     variation       3466
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11558550"
     variation       3684
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:865358"
     exon            3731..3847
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       3840
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:40305"
     exon            3848..3934
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            3935..3985
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            3986..4113
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            4114..4267
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       4122
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3205951"
     variation       4134
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1142295"
     exon            4268..4570
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       4303
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41530452"
     STS             4394..4514
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="SHGC-77269"
                     /db_xref="UniSTS:53737"
     exon            4571..4603
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       4599
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1254392"
     exon            4604..4697
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       4631
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41366751"
     exon            4698..4901
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            4902..5119
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            5120..5243
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            5244..5396
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            5397..5520
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            5521..5650
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     exon            5651..5782
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       5751
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1804614"
     exon            5783..7836
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /inference="alignment:Splign:1.39.8"
     variation       5806
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804613"
     STS             5850..5999
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="RH77851"
                     /db_xref="UniSTS:45321"
     variation       5972
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1065022"
     variation       6639
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:9422"
     variation       7380
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3190420"
     STS             7397..7571
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="RH45477"
                     /db_xref="UniSTS:10789"
     STS             7397..7571
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="stSG16293"
     STS             7444..7577
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="A004V23"
                     /db_xref="UniSTS:57532"
     STS             7444..7577
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="TIGR-A004V23"
     STS             7563..7708
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="A006U08"
     STS             7563..7708
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="A006U08"
                     /db_xref="UniSTS:28559"
     polyA_signal    7577..7582
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
     polyA_site      7596
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
     STS             7601..7769
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="RH36624"
                     /db_xref="UniSTS:67934"
     STS             7601..7769
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
                     /standard_name="stSG15806"
     polyA_signal    7802..7807
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
     polyA_site      7822
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
     polyA_site      7836
                     /gene="MYLK"
                     /gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
                     MSTP083; MYLK1; smMLCK"
ORIGIN      
ggcgctgagcgagctcggagcccgcgctgtgcgcctgcggccggggcgccccgccgagcgccggtgccccggctcccgggccgccttcgccgcgcgggaaggattcttcaaaattaacagaaaccaattcgggccagctgaagagaaaaaataaaggtggctcccggctgcctctgctgcagttcagagcaacttcaggagcttcccagccgagagcttcaggacgcctttcctgtcccactggcccagttgccacaacaaacaacagagaagacggtgaccatgggggatgtgaagctggttgcctcgtcacacatttccaaaacctccctcagtgtggatccctcaagagttgactccatgcccctgacagaggcccctgctttcattttgccccctcggaacctctgcatcaaagaaggagccaccgccaagttcgaagggcgggtccggggttacccagagccccaggtgacatggcacagaaacgggcaacccatcaccagcgggggccgcttcctgctggattgcggcatccgggggactttcagccttgtgattcatgctgtccatgaggaggacaggggaaagtatacctgtgaagccaccaatggcagtggtgctcgccaggtgacagtggagttgacagtagaaggaagttttgcgaagcagcttggtcagcctgttgtttccaaaaccttaggggatagattttcagctccagcagtggagacccgtcctagcatctggggggagtgcccaccaaagtttgctaccaagctgggccgagttgtggtcaaagaaggacagatgggacgattctcctgcaagatcactggccggccccaaccgcaggtcacctggctcaagggaaatgttccactgcagccgagtgcccgtgtgtctgtgtctgagaagaacggcatgcaggttctggaaatccatggagtcaaccaagatgacgtgggagtgtacacgtgcctggtggtgaacgggtcggggaaggcctcgatgtcagctgaactttccatccaaggtttggacagtgccaataggtcatttgtgagagaaacaaaagccaccaattcagatgtcaggaaagaggtgaccaatgtaatctcaaaggagtcgaagctggacagtctggaggctgcagccaaaagcaagaactgctccagcccccagagaggtggctccccaccctgggctgcaaacagccagcctcagcccccaagggagtccaagctggagtcatgcaaggactcgcccagaacggccccgcagaccccggtccttcagaagacttccagctccatcaccctgcaggccgcaagagttcagccggaaccaagagcaccaggcctgggggtcctatcaccttctggagaagagaggaagaggccagctcctccccgtccagccaccttccccaccaggcagcctggcctggggagccaagatgttgtgagcaaggctgctaacaggagaatccccatggagggccagagggattcagcattccccaaatttgagagcaagccccaaagccaggaggtcaaggaaaatcaaactgtcaagttcagatgtgaagtttccgggattccaaagcctgaagtggcctggttcctggaaggcacccccgtgaggagacaggaaggcagcattgaggtttatgaagatgctggctcccattacctctgcctgctgaaagcccggaccagggacagtgggacatacagctgcactgcttccaacgcccaaggccagctgtcctgtagctggaccctccaagtggaaaggcttgccgtgatggaggtggccccctccttctccagtgtcctgaaggactgcgctgttattgagggccaggattttgtgctgcagtgctccgtacgggggaccccagtgccccggatcacttggctgctgaatgggcagcccatccagtacgctcgctccacctgcgaggccggcgtggctgagctccacatccaggatgccctgccggaggaccatggcacctacacctgcctagctgagaatgccttggggcaggtgtcctgcagcgcctgggtcaccgtccatgaaaagaagagtagcaggaagagtgagtaccttctgcctgtggctcccagcaagcccactgcacccatcttcctgcagggcctctctgatctcaaagtcatggatggaagccaggtcactatgactgtccaagtgtcagggaatccaccccctgaagtcatctggctgcacaatgggaatgagatccaagagtcagaggacttccactttgaacagagaggaactcagcacagcctttgtatccaggaagtgttcccggaggacacgggcacgtacacctgcgaggcctggaacagcgctggagaggtccgcacccaggccgtgctcacggtacaagagcctcacgatggcacccagccctggttcatcagtaagcctcgctcagtgacagcctccctgggccagagtgtcctcatctcctgcgccatagctggtgacccctttcctaccgtgcactggctcagagatggcaaagccctctgcaaagacactggccacttcgaggtgcttcagaatgaggacgtgttcaccctggttctaaagaaggtgcagccctggcatgccggccagtatgagatcctgctcaagaaccgggttggcgaatgcagttgccaggtgtcactgatgctacagaacagctctgccagagcccttccacgggggagggagcctgccagctgcgaggacctctgtggtggaggagttggtgctgatggtggtggtagtgaccgctatgggtccctgaggcctggctggccagcaagagggcagggttggctagaggaggaagacggcgaggacgtgcgaggggtgctgaagaggcgcgtggagacgaggcagcacactgaggaggcgatccgccagcaggaggtggagcagctggacttccgagacctcctggggaagaaggtgagtacaaagaccctatcggaagacgacctgaaggagatcccagccgagcagatggatttccgtgccaacctgcagcggcaagtgaagccaaagactgtgtctgaggaagagaggaaggtgcacagcccccagcaggtcgattttcgctctgtcctggccaagaaggggacttccaagacccccgtgcctgagaaggtgccaccgccaaaacctgccaccccggattttcgctcagtgctgggtggcaagaagaaattaccagcagagaatggcagcagcagtgccgagaccctgaatgccaaggcagtggagagttccaagcccctgagcaatgcacagccttcagggcccttgaaacccgtgggcaacgccaagcctgctgagaccctgaagccaatgggcaacgccaagcctgccgagaccctgaagcccatgggcaatgccaagcctgatgagaacctgaaatccgctagcaaagaagaactcaagaaagacgttaagaatgatgtgaactgcaagagaggccatgcagggaccacagataatgaaaagagatcagagagccaggggacagccccagccttcaagcagaagctgcaagatgttcatgtggcagagggcaagaagctgctgctccagtgccaggtgtcttctgaccccccagccaccatcatctggacgctgaacggaaagaccctcaagaccaccaagttcatcatcctctcccaggaaggctcactctgctccgtctccatcgagaaggcactgcctgaggacagaggcttatacaagtgtgtagccaagaatgacgctggccaggcggagtgctcctgccaagtcaccgtggatgatgctccagccagtgagaacaccaaggccccagagatgaaatcccggaggcccaagagctctcttcctcccgtgctaggaactgagagtgatgcgactgtgaaaaagaaacctgcccccaagacacctccgaaggcagcaatgccccctcagatcatccagttccctgaggaccagaaggtacgcgcaggagagtcagtggagctgtttggcaaagtgacaggcactcagcccatcacctgtacctggatgaagttccgaaagcagatccaggaaagcgagcacatgaaggtggagaacagcgagaatggcagcaagctcaccatcctggccgcgcgccaggagcactgcggctgctacacactgctggtggagaacaagctgggcagcaggcaggcccaggtcaacctcactgtcgtggataagccagaccccccagctggcacaccttgtgcctctgacattcggagctcctcactgaccctgtcctggtatggctcctcatatgatgggggcagtgctgtacagtcctacagcatcgagatctgggactcagccaacaagacgtggaaggaactagccacatgccgcagcacctctttcaacgtccaggacctgctgcctgaccacgaatataagttccgtgtacgtgcaatcaacgtgtatggaaccagtgagccaagccaggagtctgaactcacaacggtaggagagaaacctgaagagccgaaggatgaagtggaggtgtcagatgatgatgagaaggagcccgaggttgattaccggacagtgacaatcaatactgaacaaaaagtatctgacttctacgacattgaggagagattaggatctgggaaatttggacaggtctttcgacttgtagaaaagaaaactcgaaaagtctgggcagggaagttcttcaaggcatattcagcaaaagagaaagagaatatccggcaggagattagcatcatgaactgcctccaccaccctaagctggtccagtgtgtggatgcctttgaagaaaaggccaacatcgtcatggtcctggagatcgtgtcaggaggggagctgtttgagcgcatcattgacgaggactttgagctgacggagcgtgagtgcatcaagtacatgcggcagatctcggagggagtggagtacatccacaagcagggcatcgtgcacctggacctcaagccggagaacatcatgtgtgtcaacaagacgggcaccaggatcaagctcatcgactttggtctggccaggaggctggagaatgcggggtctctgaaggtcctctttggcaccccagaatttgtggctcctgaagtgatcaactatgagcccatcggctacgccacagacatgtggagcatcggggtcatctgctacatcctagtcagtggcctttcccccttcatgggagacaacgataacgaaaccttggccaacgttacctcagccacctgggacttcgacgacgaggcattcgatgagatctccgacgatgccaaggatttcatcagcaatctgctgaagaaagatatgaaaaaccgcctggactgcacgcagtgccttcagcatccatggctaatgaaagataccaagaacatggaggccaagaaactctccaaggaccggatgaagaagtacatggcaagaaggaaatggcagaaaacgggcaatgctgtgagagccattggaagactgtcctctatggcaatgatctcagggctcagtggcaggaaatcctcaacagggtcaccaaccagcccgctcaatgcagaaaaactagaatctgaagaagatgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatttctctaagaccattcgcgatttagaagttgtggagggaagtgctgctagatttgactgcaagattgaaggatacccagaccccgaggttgtctggttcaaagatgaccagtcaatcagggagtcccgccacttccagatagactacgatgaggacgggaactgctctttaattattagtgatgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtcttggagaagccacctgcacagcagagctcattgtggaaacgatggaggaaggtgaaggggaaggggaagaggaagaagagtgaaacaaagccagagaaaagcagtttctaagtcatattaaaaggactatttctctaaaactcaaaaaaaaaaaaaaaactcaagatagtaaaagcacctagtgtgatagattatcggttaggtcatttgtgggttgattcttcagaaacagcagttgatacctagcagcgttattgatgggcattaatctatgttagttggcaccttaagatactagtgcagctagatttcatttagggaaatcaccagtaacttgactgaccaattgattttagagagaaagtaaccaaaccaaatatttatctgggcaaagtcataaattctccacttgaatgcgctcatgaaaaataaggccaaaacaagagttctgggccacagctcagcccagagggttcctggggatgggaggcctctctctccccaccccctgactctagagaactgggttttctcccagtactccagcaattcatttctgaaagcagttgagccactttattccaaagtacactgcagatgttcaaactctccatttctctttccccttccacctgccagttttgctgactctcaacttgtcatgagtgtaagcattaaggacattatgcttcttcgattctgaagacaggtccctgctcatggatgactctggcttccttaggaaaatatttttcttccaaaatcagtaggaaatctaaacttatcccctctttgcagatgtctagcagcttcagacatttggttaagaacccatgggaaaaaaaaaatccttgctaatgtggtttcctttgtaaaccaggattcttatttgtgctgttatagaatatcagctctgaacgtgtggtaaagatttttgtgtttgaatataggagaaatcagtttgctgaaaagttagtcttaattatctattggccacgatgaaacagatttcaactgataaagagctggagaactccatgtactttggaatctcctccaagatagccagagtttaatacatcttcattctcaacactctccaaagaacttgacctaccttatgggttccatatttttcttcttaaatgtgcatcaatcatgccttgcccccaacctttaaatatattcttagacctggtaaatgcactcagacttgcgtctttaggaatttttaactttctttcactacattggcacttaaattttttctttataaagctttttgaaggtcataaacaaagaccataattgatgatagacctaatacatttcctctgtgtgtgtgtgtaacattccaaatactttttttttcttttccactgtttgtaaggtgcaacaatttaatatttttaagggactttttaagagttccttaagaaccaatttaaaattacttcagtgcaatcctacacagtatcaacattagaattttgatattagtcttatgttatcttccattctatttttatctgctttttgctgctagtttcaaactgccagtatttttccttttgcttttaaaatagttacaatatttttcatgatagccacagtattgccacagtttattataataaagggtttttatttgatttagcgcattcaaagcttttttctatcacttttgtgttcagaatataacctttgtgtgcgtgtatgttgtgtgtgtgcatgtgtggcgtatatgtgtgttacaggttaatgccttcttggaattgtgttaatgttctcttggtttattatgccatcagaatggtaaatgagaacactacaactgtagtcagctcacaatttttaaataaaggataccacagtgcatgctgtttgttcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4638 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
            GeneID:4638 -> Molecular function: GO:0004687 [myosin light chain kinase activity] evidence: IDA
            GeneID:4638 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4638 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
            GeneID:4638 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:4638 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:4638 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
            GeneID:4638 -> Biological process: GO:0006936 [muscle contraction] evidence: TAS
            GeneID:4638 -> Biological process: GO:0006939 [smooth muscle contraction] evidence: ISS
            GeneID:4638 -> Biological process: GO:0014820 [tonic smooth muscle contraction] evidence: ISS
            GeneID:4638 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IDA
            GeneID:4638 -> Biological process: GO:0032060 [bleb assembly] evidence: IMP
            GeneID:4638 -> Biological process: GO:0051928 [positive regulation of calcium ion transport] evidence: IDA
            GeneID:4638 -> Biological process: GO:0060414 [aorta smooth muscle tissue morphogenesis] evidence: IMP
            GeneID:4638 -> Biological process: GO:0071476 [cellular hypotonic response] evidence: IDA
            GeneID:4638 -> Biological process: GO:0090303 [positive regulation of wound healing] evidence: IDA
            GeneID:4638 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
            GeneID:4638 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:4638 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:4638 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:4638 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
            GeneID:4638 -> Cellular component: GO:0032154 [cleavage furrow] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_444253 -> EC 2.7.11.18

by @meso_cacase at DBCLS
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